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The map label for this gene is aroP [H]

Identifier: 157371065

GI number: 157371065

Start: 3105727

End: 3107094

Strand: Reverse

Name: aroP [H]

Synonym: Spro_2825

Alternate gene names: 157371065

Gene position: 3107094-3105727 (Counterclockwise)

Preceding gene: 157371066

Following gene: 157371063

Centisome position: 57.02

GC content: 55.19

Gene sequence:

>1368_bases
ATGGGCGGTCAGCAGCAGGATACCCCGCTAAAACGCGGTTTAAAAAACAGACATATACAACTTATCGCCCTGGGCGGCGC
CATTGGCACCGGCCTGTTTCTCGGCATTGCACAGACCATTAAAATGGCTGGCCCTTCGGTGCTGCTGGGCTATGCCATCG
GCGGCTTTATCGCTTTTTTGATCATGCGGCAATTGGGTGAGATGGTGGTTGAGGAGCCGGTTGCGGGTTCGTTCAGCCAC
TTTGCCTATAAATACTGGGGTGATTTTGCCGGTTTTCTTTCCGGCTGGAACTACTGGGCGATGTTCATTTTGGTCGGCAT
GGCCGAACTGACCGCGGTTGGCATCTACATTCAATATTGGTGGCCGGACATCCCTACCTGGGTTTCCGCCGCGGTATTCT
TTGTCCTGATAAATCTGATCAACCTGGTTAATGTGCGGCTGTACGGCGAAACCGAGTTTTGGTTTGCCATTATCAAGGTG
GTGGCGATTGTCGGCATGATTGTTTTCGGTGCCTGGCTTTTGGCCAGCGGCAACGGTGGTCCGCAAGCCAGTATCAACAA
CCTGTGGGAGCAGGGCGGCTTTATGCCACACGGCATCGAAGGGTTGGTGATGGCGATGGCGGTGATCATGTTCTCATTCG
GTGGGCTGGAGATGGTGGGTATTACCGCCGCCGAAGCGGCCGATCCGCGTCGCAGCATTCCCAAGGCCACCAATCAGGTG
GTGTACCGCATCCTGATTTTTTATATCGGTTCGTTGACGGTACTGCTTTCACTCTATCCCTGGCACAAAGTGGTGGAAGG
CGGCAGCCCGTTCGTGATGATTTTCCATGCGTTGAACAGCAACCTGGTGGCGACCCTGCTGAACGTGGTGGTGCTGACTG
CAGCGCTGTCGGTGTATAACAGCGGGGTCTATGCCAATAGCCGTATGCTGTTCGGGCTGGCGACACAGGGGAATGCGCCC
AAGGCATTGAGCCGGGTGAATAAGCGTGGTGTCCCGGTATTGTCGATCGCGCTGTCGGCGCTGGTGACCTCCATCGGCGT
ATTGATCAACTATGTCATGCCCGGTAAGGCGTTTGAATTGCTGATGGCGCTGGTGGTGTCCACCCTGGTGATTAACTGGG
TGATGATTTGTCTGGCACACCTGCGATTCCGCGCGGCGAAAAACCGCCAGGGCGTGATCCCGGTCTTCAAGGCTTTGTGG
TACCCCTTCGGCAACTATCTGTGCCTGGTGTTCCTGAGCCTGATTCTGGTGATTATGTATTTCAGCGAGGGGATCCGTAT
CTCGGTATTACTGATGCCGGTGTGGATCTTGCTGTTGTGGGTTGGCTTTATGCTGACGCGCCGCAAAGGCGCTAAAGTAC
GGCGCTAA

Upstream 100 bases:

>100_bases
GCTCACGGGGTTAAGTGTTAAAAAGCCGCCCGCAGATACATTTATTGATTGGCGAAATCTTGCGCAAAAGCGACAGGATC
CCACGCCATATGAGGATAAG

Downstream 100 bases:

>100_bases
TTTTAACGGAGGCGCTATCTGGCGCCTCCGTTCCATCCATTAGCTGCGTGGCATAAAGGCATTGCCTGGGTTGGCACGGC
CCAATCCCAACAGCTTCCTG

Product: amino acid permease-associated protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MGGQQQDTPLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYWWPDIPTWVSAAVFFVLINLINLVNVRLYGETEFWFAIIKV
VAIVGMIVFGAWLLASGNGGPQASINNLWEQGGFMPHGIEGLVMAMAVIMFSFGGLEMVGITAAEAADPRRSIPKATNQV
VYRILIFYIGSLTVLLSLYPWHKVVEGGSPFVMIFHALNSNLVATLLNVVVLTAALSVYNSGVYANSRMLFGLATQGNAP
KALSRVNKRGVPVLSIALSALVTSIGVLINYVMPGKAFELLMALVVSTLVINWVMICLAHLRFRAAKNRQGVIPVFKALW
YPFGNYLCLVFLSLILVIMYFSEGIRISVLLMPVWILLLWVGFMLTRRKGAKVRR

Sequences:

>Translated_455_residues
MGGQQQDTPLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYWWPDIPTWVSAAVFFVLINLINLVNVRLYGETEFWFAIIKV
VAIVGMIVFGAWLLASGNGGPQASINNLWEQGGFMPHGIEGLVMAMAVIMFSFGGLEMVGITAAEAADPRRSIPKATNQV
VYRILIFYIGSLTVLLSLYPWHKVVEGGSPFVMIFHALNSNLVATLLNVVVLTAALSVYNSGVYANSRMLFGLATQGNAP
KALSRVNKRGVPVLSIALSALVTSIGVLINYVMPGKAFELLMALVVSTLVINWVMICLAHLRFRAAKNRQGVIPVFKALW
YPFGNYLCLVFLSLILVIMYFSEGIRISVLLMPVWILLLWVGFMLTRRKGAKVRR
>Mature_454_residues
GGQQQDTPLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSHF
AYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYWWPDIPTWVSAAVFFVLINLINLVNVRLYGETEFWFAIIKVV
AIVGMIVFGAWLLASGNGGPQASINNLWEQGGFMPHGIEGLVMAMAVIMFSFGGLEMVGITAAEAADPRRSIPKATNQVV
YRILIFYIGSLTVLLSLYPWHKVVEGGSPFVMIFHALNSNLVATLLNVVVLTAALSVYNSGVYANSRMLFGLATQGNAPK
ALSRVNKRGVPVLSIALSALVTSIGVLINYVMPGKAFELLMALVVSTLVINWVMICLAHLRFRAAKNRQGVIPVFKALWY
PFGNYLCLVFLSLILVIMYFSEGIRISVLLMPVWILLLWVGFMLTRRKGAKVRR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=349, Percent_Identity=24.0687679083095, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI258645169, Length=415, Percent_Identity=20.9638554216867, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=70.704845814978, Blast_Score=660, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=70.4035874439462, Blast_Score=647, Evalue=0.0,
Organism=Escherichia coli, GI48994972, Length=437, Percent_Identity=42.5629290617849, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1790653, Length=458, Percent_Identity=38.8646288209607, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1786602, Length=456, Percent_Identity=43.421052631579, Blast_Score=337, Evalue=8e-94,
Organism=Escherichia coli, GI87081915, Length=455, Percent_Identity=36.043956043956, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=35, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1789017, Length=434, Percent_Identity=35.2534562211982, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1788480, Length=469, Percent_Identity=31.5565031982942, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082023, Length=267, Percent_Identity=25.0936329588015, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=25.4335260115607, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=379, Percent_Identity=23.2189973614776, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320772, Length=477, Percent_Identity=34.1719077568134, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6324061, Length=440, Percent_Identity=35.4545454545455, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322892, Length=401, Percent_Identity=34.9127182044888, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324924, Length=486, Percent_Identity=30.6584362139918, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6319824, Length=404, Percent_Identity=32.4257425742574, Blast_Score=206, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6324059, Length=441, Percent_Identity=34.6938775510204, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320717, Length=404, Percent_Identity=30.9405940594059, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=32.9145728643216, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=31.6049382716049, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321053, Length=454, Percent_Identity=31.2775330396476, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6319608, Length=442, Percent_Identity=30.316742081448, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=451, Percent_Identity=29.7117516629712, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320251, Length=476, Percent_Identity=28.3613445378151, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=31.4070351758794, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6319543, Length=398, Percent_Identity=29.6482412060301, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=401, Percent_Identity=28.6783042394015, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6324981, Length=398, Percent_Identity=29.6482412060301, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=26.4112903225806, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24667468, Length=431, Percent_Identity=23.8979118329466, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24668806, Length=416, Percent_Identity=25.2403846153846, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356285, Length=416, Percent_Identity=25.2403846153846, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668802, Length=416, Percent_Identity=25.2403846153846, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=21.1904761904762, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=21.1904761904762, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49988; Mature: 49856

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS00024 HEMOPEXIN ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGQQQDTPLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFL
CCCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEE
WPDIPTWVSAAVFFVLINLINLVNVRLYGETEFWFAIIKVVAIVGMIVFGAWLLASGNGG
CCCCCHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PQASINNLWEQGGFMPHGIEGLVMAMAVIMFSFGGLEMVGITAAEAADPRRSIPKATNQV
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHCCCHHHHHH
VYRILIFYIGSLTVLLSLYPWHKVVEGGSPFVMIFHALNSNLVATLLNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHH
SGVYANSRMLFGLATQGNAPKALSRVNKRGVPVLSIALSALVTSIGVLINYVMPGKAFEL
CCCEECCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LMALVVSTLVINWVMICLAHLRFRAAKNRQGVIPVFKALWYPFGNYLCLVFLSLILVIMY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSEGIRISVLLMPVWILLLWVGFMLTRRKGAKVRR
HCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GGQQQDTPLKRGLKNRHIQLIALGGAIGTGLFLGIAQTIKMAGPSVLLGYAIGGFIAFL
CCCCCCCHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEE
WPDIPTWVSAAVFFVLINLINLVNVRLYGETEFWFAIIKVVAIVGMIVFGAWLLASGNGG
CCCCCHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PQASINNLWEQGGFMPHGIEGLVMAMAVIMFSFGGLEMVGITAAEAADPRRSIPKATNQV
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCCHHCCCHHHHHH
VYRILIFYIGSLTVLLSLYPWHKVVEGGSPFVMIFHALNSNLVATLLNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHH
SGVYANSRMLFGLATQGNAPKALSRVNKRGVPVLSIALSALVTSIGVLINYVMPGKAFEL
CCCEECCEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LMALVVSTLVINWVMICLAHLRFRAAKNRQGVIPVFKALWYPFGNYLCLVFLSLILVIMY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSEGIRISVLLMPVWILLLWVGFMLTRRKGAKVRR
HCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]