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The map label for this gene is mdtH

Identifier: 157371036

GI number: 157371036

Start: 3076036

End: 3077241

Strand: Direct

Name: mdtH

Synonym: Spro_2796

Alternate gene names: 157371036

Gene position: 3076036-3077241 (Clockwise)

Preceding gene: 157371031

Following gene: 157371037

Centisome position: 56.45

GC content: 58.79

Gene sequence:

>1206_bases
ATGTCTCTGGTATCGCAAGCTCGGAGCTTGGGTAAGTATTTTCTATTACTCGATAACCTGTTAGTGGTTTTAGGCTTTTT
TGTAGTCTTTCCACTTATTTCGATTCGCTTTGTCGATCAGCTTGGCTGGGCGGCCGTGGTGGTCGGTGCCGCACTGGGTT
TACGGCAATTAATCCAACAGGGATTGGGCATTTTTGGCGGAGCAATCGCCGACCGATTTGGTGCCAAACCGATGATTGTC
ACCGGCATGCTGATGCGCGCGGCCGGTTTCGCCACCATGGCAATGGCCGATCAGCCCTGGCTGCTGTGGTTCTCCTGCGC
CCTTTCCGCCCTCGGTGGCACCTTGTTTGACCCACCGCGCACCGCGCTGGTGATTAAGCTCACCCGTCCGCATGAGCGCG
GCCGTTTTTACTCTCTGTTAATGATGCAGGACAGTGCCGGGGCGGTGATTGGCGCCCTGATCGGCAGTTGGCTGCTGCAA
TATGATTTCCACTTCGTTTGCTGGGTCGGCGCGGGCATTTTCGTGTTGGCCGCGGGTTGGAACGCCTGGCTGCTGCCGGC
ATACCGTATTTCTACCGTCCGCACCCCAATGAAGGAAGGCATGATGCGCGTACTGCGCGACCGCCGTTTCCTGACCTACG
TGCTGACGCTGACCGGCTACTACATGCTGTCGGTACAGGTGATGCTGATGCTGCCGATCGTGGTCAATGAAATCGCCGGT
TCACCCACGGCGGTAAAATGGATGTATGCCATCGAAGCCGCGCTGTCGCTGTCACTGCTGTATCCACTGGCTCGCTGGAG
TGAAAAACGTTTTCGGCTGGAGCAACGCTTGATGGCCGGCCTGCTGCTGATGACCCTCAGCCTGATGCCGGTTGGGCTGG
CAACCAGCCTGCAGGGCGTCTTTACCCTGATCTGCTGTTTCTATCTCGGTTCCATTATCGCCGAACCGGCGCGTGAAACC
CTCAGCGCCTCGCTGGCCGATCCCCGCGCACGCGGCAGTTACATGGGGTTCAGCCGCCTGGGGCTGGCATTGGGCGGCGC
ACTGGGTTACACCGGTGGCGGCTGGATGTACGACACCGGCCACTCGATGAACATGCCGGAACTGCCGTGGATACTGCTGG
GTATCGTAGGCTTTATTACCCTGTTTGCACTTTACTGGCAGTTCAACCCGCGCAGCAGCGCACCGGCAGTTGCCCCCGGC
GGCTAA

Upstream 100 bases:

>100_bases
ATAAAAAAATATTATCTTCCTCGCCCCTATCGGCAATCCGGGAATGGGTACAAACTAGAGCGGTCGCACTCCTCTCCCCC
TTAATTGCTCGTGGTGAAGC

Downstream 100 bases:

>100_bases
TTTTCTCTCTAAGTTGCCAGAAAATCAGCCGAATTTCCCATAGCTGCTATCCTGATAGTAAAAACATAAACAGGAGAAGT
TGGCGATGACCGATGAATCA

Product: multidrug resistance protein MdtH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSLVSQARSLGKYFLLLDNLLVVLGFFVVFPLISIRFVDQLGWAAVVVGAALGLRQLIQQGLGIFGGAIADRFGAKPMIV
TGMLMRAAGFATMAMADQPWLLWFSCALSALGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQ
YDFHFVCWVGAGIFVLAAGWNAWLLPAYRISTVRTPMKEGMMRVLRDRRFLTYVLTLTGYYMLSVQVMLMLPIVVNEIAG
SPTAVKWMYAIEAALSLSLLYPLARWSEKRFRLEQRLMAGLLLMTLSLMPVGLATSLQGVFTLICCFYLGSIIAEPARET
LSASLADPRARGSYMGFSRLGLALGGALGYTGGGWMYDTGHSMNMPELPWILLGIVGFITLFALYWQFNPRSSAPAVAPG
G

Sequences:

>Translated_401_residues
MSLVSQARSLGKYFLLLDNLLVVLGFFVVFPLISIRFVDQLGWAAVVVGAALGLRQLIQQGLGIFGGAIADRFGAKPMIV
TGMLMRAAGFATMAMADQPWLLWFSCALSALGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQ
YDFHFVCWVGAGIFVLAAGWNAWLLPAYRISTVRTPMKEGMMRVLRDRRFLTYVLTLTGYYMLSVQVMLMLPIVVNEIAG
SPTAVKWMYAIEAALSLSLLYPLARWSEKRFRLEQRLMAGLLLMTLSLMPVGLATSLQGVFTLICCFYLGSIIAEPARET
LSASLADPRARGSYMGFSRLGLALGGALGYTGGGWMYDTGHSMNMPELPWILLGIVGFITLFALYWQFNPRSSAPAVAPG
G
>Mature_400_residues
SLVSQARSLGKYFLLLDNLLVVLGFFVVFPLISIRFVDQLGWAAVVVGAALGLRQLIQQGLGIFGGAIADRFGAKPMIVT
GMLMRAAGFATMAMADQPWLLWFSCALSALGGTLFDPPRTALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQY
DFHFVCWVGAGIFVLAAGWNAWLLPAYRISTVRTPMKEGMMRVLRDRRFLTYVLTLTGYYMLSVQVMLMLPIVVNEIAGS
PTAVKWMYAIEAALSLSLLYPLARWSEKRFRLEQRLMAGLLLMTLSLMPVGLATSLQGVFTLICCFYLGSIIAEPARETL
SASLADPRARGSYMGFSRLGLALGGALGYTGGGWMYDTGHSMNMPELPWILLGIVGFITLFALYWQFNPRSSAPAVAPGG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily

Homologues:

Organism=Escherichia coli, GI87081828, Length=394, Percent_Identity=78.1725888324873, Blast_Score=612, Evalue=1e-177,
Organism=Escherichia coli, GI87081738, Length=347, Percent_Identity=22.478386167147, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MDTH_SERP5 (A8GFK7)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479025.1
- ProteinModelPortal:   A8GFK7
- STRING:   A8GFK7
- GeneID:   5602463
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2796
- eggNOG:   COG0477
- HOGENOM:   HBG403347
- OMA:   LSMIPIG
- ProtClustDB:   PRK11646
- BioCyc:   SPRO399741:SPRO_2796-MONOMER
- HAMAP:   MF_01529
- InterPro:   IPR020846
- InterPro:   IPR022855
- InterPro:   IPR011701
- InterPro:   IPR016196

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 43901; Mature: 43770

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2650e5b8)-; HASH(0x2490457c)-; HASH(0x266866e8)-; HASH(0x25e8ce28)-; HASH(0x2670c580)-; HASH(0x22396d68)-; HASH(0x2630b038)-; HASH(0x26560d5c)-; HASH(0x237bae00)-; HASH(0x214ac404)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVSQARSLGKYFLLLDNLLVVLGFFVVFPLISIRFVDQLGWAAVVVGAALGLRQLIQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAMADQPWLLWFSCALSALGGTLFDPPR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
TALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQYDFHFVCWVGAGIFVLAAGW
CEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
NAWLLPAYRISTVRTPMKEGMMRVLRDRRFLTYVLTLTGYYMLSVQVMLMLPIVVNEIAG
CHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPTAVKWMYAIEAALSLSLLYPLARWSEKRFRLEQRLMAGLLLMTLSLMPVGLATSLQGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTLICCFYLGSIIAEPARETLSASLADPRARGSYMGFSRLGLALGGALGYTGGGWMYDTG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCEEECC
HSMNMPELPWILLGIVGFITLFALYWQFNPRSSAPAVAPGG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
>Mature Secondary Structure 
SLVSQARSLGKYFLLLDNLLVVLGFFVVFPLISIRFVDQLGWAAVVVGAALGLRQLIQQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAMADQPWLLWFSCALSALGGTLFDPPR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCC
TALVIKLTRPHERGRFYSLLMMQDSAGAVIGALIGSWLLQYDFHFVCWVGAGIFVLAAGW
CEEEEEEECCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
NAWLLPAYRISTVRTPMKEGMMRVLRDRRFLTYVLTLTGYYMLSVQVMLMLPIVVNEIAG
CHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPTAVKWMYAIEAALSLSLLYPLARWSEKRFRLEQRLMAGLLLMTLSLMPVGLATSLQGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTLICCFYLGSIIAEPARETLSASLADPRARGSYMGFSRLGLALGGALGYTGGGWMYDTG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCEEECC
HSMNMPELPWILLGIVGFITLFALYWQFNPRSSAPAVAPGG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA