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The map label for this gene is rnd [H]

Identifier: 157370999

GI number: 157370999

Start: 3038070

End: 3039242

Strand: Reverse

Name: rnd [H]

Synonym: Spro_2759

Alternate gene names: 157370999

Gene position: 3039242-3038070 (Counterclockwise)

Preceding gene: 157371000

Following gene: 157370995

Centisome position: 55.78

GC content: 54.82

Gene sequence:

>1173_bases
ATGCCGGCGTTGTTGTGTTTGAATCATGAAAGCGACCAAGAGAATGACGTTTTGAACTATCAGTTGATCACTACCGATGC
CGGATTGCAGCAGGTCTGCGATCAGGCGAAAAAGCATGCCCAGATTGCGCTGGACACCGAATTTGTCAGAACGCGCACTT
ACTATCCGCAGTTAGGCCTGATTCAGTTATACGATGGTGAACAACTCTCCCTGATTGACCCCTTGCCAATCAAGCAGTGG
CAGCCGTTTATCGAGCTGCTGAGCAACACTCAGGTGGTGAAATTCCTGCACGCCGGCAGTGAGGATCTGGAAGTGTTCCT
CAACGCGTTCAAAACGCTACCGACGCCAATGGTGGATACCCAGATCCTGGCGGCCTTTACCGGTCGTCCGATGTCTTGTG
GCTTCGCTACCCTGGTGGCGGAGTACATGGAGGTAGAGCTGGATAAAAGCGAAGCCCGGACTGACTGGCTGGCGCGTCCG
CTGACGGAAAAACAGTGTGTCTACGCTGCGGCGGACGTGTTCTATCTGTTGCCAATGGCCAAACGGCTGGTGCAGGAGAC
GGAAGAGGCCGGTTGGACGGCGGCTGCCAGCAATGAATGCCTGCTGTTGTGTCAACGCCGTAGCGAGACGCTGGCGCCGG
AATTGGCCTATCGCGAAATTACCAACGCCTGGCAATTACGTCCCCGCCAGTTGGGTTGCTTGCAGAAACTGGCTGAATGG
CGACTGCGTCAGGCGCGTGAGCGTGATCTGGCGGTGAACTTCGTGGTACGTGAGGAGAACCTCTGGCAGGTAGCGCGTCA
TATGCCGACCTCGCTGGGTGAACTGGACTCGCTGGGGCTGAGCGGCCCTGAAATTCGTTATCATGGTAAAACGCTGGTGG
CGTTGGTGGCAGAGGCCGCCGAGCTGGAAGAATCGGCATTGCCGGAGCCGTTACCGAACCTGATCGACCAGCCGGGTTAT
AAGAAAGTATTTAAGGAAATCAAAGCGGCGATCGTCATTGCCAGTGAGCAAAGCGGGTTGAGCAGCGAATTGTTGGCATC
GCGTCGGCAGATTAACCAGTTGCTGAACTGGCATTGGAAATTGAAGGTTGGCGACAATTTGCCAGAATTAGTCAGCGGAT
GGCGCGGTGATTTATTAGCGGCACCACTTCAGGACATTTTGAAGGGTTATTAA

Upstream 100 bases:

>100_bases
AAATTTTGCGGCGAGAACTGCGTGATGAGCAGAAAAAACCTGTGGCAGCCGATGCCGCCTAGGCTATCATCTACGCCTTA
CAGATCAACAACGCCGGTGA

Downstream 100 bases:

>100_bases
TCGGGCTGTAAAACGTTGGGGTAGGGTAAGGAAACCCTGCTCTGATTATTTATTAGAAATAGTCGAAGTCAAAACACTTA
TCGGTAGCTTTTACTTTAAA

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MPALLCLNHESDQENDVLNYQLITTDAGLQQVCDQAKKHAQIALDTEFVRTRTYYPQLGLIQLYDGEQLSLIDPLPIKQW
QPFIELLSNTQVVKFLHAGSEDLEVFLNAFKTLPTPMVDTQILAAFTGRPMSCGFATLVAEYMEVELDKSEARTDWLARP
LTEKQCVYAAADVFYLLPMAKRLVQETEEAGWTAAASNECLLLCQRRSETLAPELAYREITNAWQLRPRQLGCLQKLAEW
RLRQARERDLAVNFVVREENLWQVARHMPTSLGELDSLGLSGPEIRYHGKTLVALVAEAAELEESALPEPLPNLIDQPGY
KKVFKEIKAAIVIASEQSGLSSELLASRRQINQLLNWHWKLKVGDNLPELVSGWRGDLLAAPLQDILKGY

Sequences:

>Translated_390_residues
MPALLCLNHESDQENDVLNYQLITTDAGLQQVCDQAKKHAQIALDTEFVRTRTYYPQLGLIQLYDGEQLSLIDPLPIKQW
QPFIELLSNTQVVKFLHAGSEDLEVFLNAFKTLPTPMVDTQILAAFTGRPMSCGFATLVAEYMEVELDKSEARTDWLARP
LTEKQCVYAAADVFYLLPMAKRLVQETEEAGWTAAASNECLLLCQRRSETLAPELAYREITNAWQLRPRQLGCLQKLAEW
RLRQARERDLAVNFVVREENLWQVARHMPTSLGELDSLGLSGPEIRYHGKTLVALVAEAAELEESALPEPLPNLIDQPGY
KKVFKEIKAAIVIASEQSGLSSELLASRRQINQLLNWHWKLKVGDNLPELVSGWRGDLLAAPLQDILKGY
>Mature_389_residues
PALLCLNHESDQENDVLNYQLITTDAGLQQVCDQAKKHAQIALDTEFVRTRTYYPQLGLIQLYDGEQLSLIDPLPIKQWQ
PFIELLSNTQVVKFLHAGSEDLEVFLNAFKTLPTPMVDTQILAAFTGRPMSCGFATLVAEYMEVELDKSEARTDWLARPL
TEKQCVYAAADVFYLLPMAKRLVQETEEAGWTAAASNECLLLCQRRSETLAPELAYREITNAWQLRPRQLGCLQKLAEWR
LRQARERDLAVNFVVREENLWQVARHMPTSLGELDSLGLSGPEIRYHGKTLVALVAEAAELEESALPEPLPNLIDQPGYK
KVFKEIKAAIVIASEQSGLSSELLASRRQINQLLNWHWKLKVGDNLPELVSGWRGDLLAAPLQDILKGY

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Escherichia coli, GI1788105, Length=373, Percent_Identity=67.5603217158177, Blast_Score=524, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17531757, Length=261, Percent_Identity=25.6704980842912, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324574, Length=309, Percent_Identity=23.9482200647249, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161078302, Length=291, Percent_Identity=25.085910652921, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 44039; Mature: 43908

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALLCLNHESDQENDVLNYQLITTDAGLQQVCDQAKKHAQIALDTEFVRTRTYYPQLGL
CCCEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCEEEECHHHHHHHCCCCCCCE
IQLYDGEQLSLIDPLPIKQWQPFIELLSNTQVVKFLHAGSEDLEVFLNAFKTLPTPMVDT
EEEECCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHH
QILAAFTGRPMSCGFATLVAEYMEVELDKSEARTDWLARPLTEKQCVYAAADVFYLLPMA
HHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KRLVQETEEAGWTAAASNECLLLCQRRSETLAPELAYREITNAWQLRPRQLGCLQKLAEW
HHHHHHHHHCCCEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RLRQARERDLAVNFVVREENLWQVARHMPTSLGELDSLGLSGPEIRYHGKTLVALVAEAA
HHHHHHCCCEEEEEEEECCHHHHHHHHCCCHHHHHHHCCCCCCCEEECCHHHHHHHHHHH
ELEESALPEPLPNLIDQPGYKKVFKEIKAAIVIASEQSGLSSELLASRRQINQLLNWHWK
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHCEEEE
LKVGDNLPELVSGWRGDLLAAPLQDILKGY
EEECCCCHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
PALLCLNHESDQENDVLNYQLITTDAGLQQVCDQAKKHAQIALDTEFVRTRTYYPQLGL
CCEEEECCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCEEEECHHHHHHHCCCCCCCE
IQLYDGEQLSLIDPLPIKQWQPFIELLSNTQVVKFLHAGSEDLEVFLNAFKTLPTPMVDT
EEEECCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHH
QILAAFTGRPMSCGFATLVAEYMEVELDKSEARTDWLARPLTEKQCVYAAADVFYLLPMA
HHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
KRLVQETEEAGWTAAASNECLLLCQRRSETLAPELAYREITNAWQLRPRQLGCLQKLAEW
HHHHHHHHHCCCEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
RLRQARERDLAVNFVVREENLWQVARHMPTSLGELDSLGLSGPEIRYHGKTLVALVAEAA
HHHHHHCCCEEEEEEEECCHHHHHHHHCCCHHHHHHHCCCCCCCEEECCHHHHHHHHHHH
ELEESALPEPLPNLIDQPGYKKVFKEIKAAIVIASEQSGLSSELLASRRQINQLLNWHWK
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHCEEEE
LKVGDNLPELVSGWRGDLLAAPLQDILKGY
EEECCCCHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]