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The map label for this gene is fadR

Identifier: 157370988

GI number: 157370988

Start: 3028885

End: 3029604

Strand: Reverse

Name: fadR

Synonym: Spro_2748

Alternate gene names: 157370988

Gene position: 3029604-3028885 (Counterclockwise)

Preceding gene: 157370991

Following gene: 157370986

Centisome position: 55.6

GC content: 52.08

Gene sequence:

>720_bases
ATGGTCATAAAGGCGCAGAGTCCTGCCGGTTTCGCGGAAGAATACATTATCGAGAGTATCTGGAATAATCGCTTCCCTCC
TGGCACTATTTTGCCCGCGGAGCGTGAGCTTTCAGAACTGATTGGTGTCACGCGCACCACGTTACGTGAAGTTTTACAAC
GCCTGGCGCGTGATGGCTGGTTGACCATTCAGCATGGCAAACCGACCAAAGTAAATAATTTCTGGGAAACATCCGGCCTC
AATATTCTTGAGACGGTGGCACGCCTCGACCATCAGAGCGTTCCACAATTGATCGACAACCTGCTGTCTGTGCGAACCAA
TATTGCGGCGATCTTTATTCGCGCAGCGGTGCGTAACCATCCAGAGGCCGCTCAGGAAGTGTTGGCGAAAGCCACTCAGG
TGGAAGATCAGGCGGATGCTTTCAACCTGTTGGACTACGAAATTTTCCGTGGTCTGGCGTTTGCCTCCGGCAACCCGATT
TACGGTCTGATCTTCAACGGTCTGAAAGGCTTGTATACCCGCGTTGGCCGTTACTACTTCTCAAACCCGGAGTCTCGCAA
ACTGGCGCTGACTTTCTATAGCAAGCTGTCGACGCTGTGCCATGAGAAGTCATACGATCAGGTAATGGACTGCGTGCGTA
ACTACGGTAAAGATAGCGGCGCCATTTGGCAAAGCATGCAAGGCACTATGCCAAGCGATCTGACCGAAGCCCGTCGTTAA

Upstream 100 bases:

>100_bases
TCGTTCAATGTTTTTCGCTCACGCTAGGTCATGCAATAGCGATCTGGTATGATCAGCCGACTACTATTACTGATTATCGT
CGCTACGGAACGTCAAACAC

Downstream 100 bases:

>100_bases
CCTCAACACCGCATTACGTAAAAGGGGCGCCATTTGGCGCCCCTTTAGTTTTTAGTTATTGAACAGTCTTACAGTGGTGT
TGGGCGCGGTGGGCAACGCT

Product: fatty acid metabolism regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL
NILETVARLDHQSVPQLIDNLLSVRTNIAAIFIRAAVRNHPEAAQEVLAKATQVEDQADAFNLLDYEIFRGLAFASGNPI
YGLIFNGLKGLYTRVGRYYFSNPESRKLALTFYSKLSTLCHEKSYDQVMDCVRNYGKDSGAIWQSMQGTMPSDLTEARR

Sequences:

>Translated_239_residues
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL
NILETVARLDHQSVPQLIDNLLSVRTNIAAIFIRAAVRNHPEAAQEVLAKATQVEDQADAFNLLDYEIFRGLAFASGNPI
YGLIFNGLKGLYTRVGRYYFSNPESRKLALTFYSKLSTLCHEKSYDQVMDCVRNYGKDSGAIWQSMQGTMPSDLTEARR
>Mature_239_residues
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSGL
NILETVARLDHQSVPQLIDNLLSVRTNIAAIFIRAAVRNHPEAAQEVLAKATQVEDQADAFNLLDYEIFRGLAFASGNPI
YGLIFNGLKGLYTRVGRYYFSNPESRKLALTFYSKLSTLCHEKSYDQVMDCVRNYGKDSGAIWQSMQGTMPSDLTEARR

Specific function: Multifunctional regulator of fatty acid metabolism

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787436, Length=234, Percent_Identity=81.1965811965812, Blast_Score=402, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FADR_SERP5 (A8GFF9)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478977.1
- ProteinModelPortal:   A8GFF9
- SMR:   A8GFF9
- STRING:   A8GFF9
- GeneID:   5607057
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2748
- eggNOG:   COG2186
- HOGENOM:   HBG296777
- OMA:   IVRSIWE
- ProtClustDB:   PRK04984
- BioCyc:   SPRO399741:SPRO_2748-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00696
- InterPro:   IPR014178
- InterPro:   IPR008920
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00345
- TIGRFAMs:   TIGR02812

Pfam domain/function: PF07840 FadR_C; PF00392 GntR; SSF48008 FadR_C

EC number: NA

Molecular weight: Translated: 26972; Mature: 26972

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGW
CEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIQHGKPTKVNNFWETSGLNILETVARLDHQSVPQLIDNLLSVRTNIAAIFIRAAVRNH
EEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEAAQEVLAKATQVEDQADAFNLLDYEIFRGLAFASGNPIYGLIFNGLKGLYTRVGRYYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
SNPESRKLALTFYSKLSTLCHEKSYDQVMDCVRNYGKDSGAIWQSMQGTMPSDLTEARR
CCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHCC
>Mature Secondary Structure
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGW
CEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
LTIQHGKPTKVNNFWETSGLNILETVARLDHQSVPQLIDNLLSVRTNIAAIFIRAAVRNH
EEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PEAAQEVLAKATQVEDQADAFNLLDYEIFRGLAFASGNPIYGLIFNGLKGLYTRVGRYYF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHC
SNPESRKLALTFYSKLSTLCHEKSYDQVMDCVRNYGKDSGAIWQSMQGTMPSDLTEARR
CCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA