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The map label for this gene is fimB [H]

Identifier: 157370649

GI number: 157370649

Start: 2631924

End: 2632517

Strand: Reverse

Name: fimB [H]

Synonym: Spro_2409

Alternate gene names: 157370649

Gene position: 2632517-2631924 (Counterclockwise)

Preceding gene: 157370650

Following gene: 157370648

Centisome position: 48.31

GC content: 58.92

Gene sequence:

>594_bases
TTGATAAAATTACCACAGCACCGCAAACACCTCACCCGGGGTGAAGTCGGGCGTCTGCTGCTGCAAGCCGCCGCCGGCCG
GGCGCCCGAGCGTGACACCTGCCTGATCTGGATGGGTTTCATTCATGGCTGTCGCGTCAGCGAACTCACCGGCTTGCGCC
TCGCCGACCTCGACATGGACGACGGCTGCCTTTACATCAGCCGTCTTAAAAACGGCCTGTCCACCACCCACCCGCTGGAA
ACCACCGAGAAACGCCTGTTGCAGCGTTGGCTGGAAAAACGCCAATCCTGCCGCAACCTGGACGACCAGGACTGGCTGTT
TCTGTCACAAAAGGGCTATCGCCTGTCGCGCCAGCGTATTTTTCGTATGCTGCGTGAGTATGGCCGTCGGGCCGGGCTGG
ACGTCGAGGCGCACCCGCACATGTTGCGTCATGCCTGTGGCTATGCGCTGGCGGATAACGGCGCGGATACGCGGGTGATT
CAGGATTATCTGGGGCATCGCAACATTCAACACACGGTACTGTACACCGCCGCCAATGCCGGACGATTCAGGGACTTATG
GGAGGAAAAACGCCAAAAAAATGTAACACTTTGA

Upstream 100 bases:

>100_bases
TTCCCCGTTGCCGGGGTAACGTTAGGCTATACTCCTCCCACTCTGTCTGTGACAGACCACGGTCGGCACCCGCCGGCCGT
TTCTTTTCGAGGAAAATACT

Downstream 100 bases:

>100_bases
GCCAAACTGACACATAAACTAAGAATTACCCGAAAAGAAGTCAATACCGCCGTCGTATTTTTTTCATCCCTCCAATAAAC
ATCACATTATCAGTAAGATA

Product: integrase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMDDGCLYISRLKNGLSTTHPLE
TTEKRLLQRWLEKRQSCRNLDDQDWLFLSQKGYRLSRQRIFRMLREYGRRAGLDVEAHPHMLRHACGYALADNGADTRVI
QDYLGHRNIQHTVLYTAANAGRFRDLWEEKRQKNVTL

Sequences:

>Translated_197_residues
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMDDGCLYISRLKNGLSTTHPLE
TTEKRLLQRWLEKRQSCRNLDDQDWLFLSQKGYRLSRQRIFRMLREYGRRAGLDVEAHPHMLRHACGYALADNGADTRVI
QDYLGHRNIQHTVLYTAANAGRFRDLWEEKRQKNVTL
>Mature_197_residues
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMDDGCLYISRLKNGLSTTHPLE
TTEKRLLQRWLEKRQSCRNLDDQDWLFLSQKGYRLSRQRIFRMLREYGRRAGLDVEAHPHMLRHACGYALADNGADTRVI
QDYLGHRNIQHTVLYTAANAGRFRDLWEEKRQKNVTL

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=184, Percent_Identity=51.6304347826087, Blast_Score=194, Evalue=2e-51,
Organism=Escherichia coli, GI1790768, Length=190, Percent_Identity=50, Blast_Score=194, Evalue=4e-51,
Organism=Escherichia coli, GI1789261, Length=191, Percent_Identity=34.0314136125654, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1790244, Length=175, Percent_Identity=30.2857142857143, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 22963; Mature: 22963

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCHHHHCCCEEECCCCC
DGCLYISRLKNGLSTTHPLETTEKRLLQRWLEKRQSCRNLDDQDWLFLSQKGYRLSRQRI
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHH
FRMLREYGRRAGLDVEAHPHMLRHACGYALADNGADTRVIQDYLGHRNIQHTVLYTAANA
HHHHHHHHHHCCCCCCCCHHHHHHHHCHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCC
GRFRDLWEEKRQKNVTL
CHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIKLPQHRKHLTRGEVGRLLLQAAAGRAPERDTCLIWMGFIHGCRVSELTGLRLADLDMD
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHCCCCHHHHCCCEEECCCCC
DGCLYISRLKNGLSTTHPLETTEKRLLQRWLEKRQSCRNLDDQDWLFLSQKGYRLSRQRI
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHH
FRMLREYGRRAGLDVEAHPHMLRHACGYALADNGADTRVIQDYLGHRNIQHTVLYTAANA
HHHHHHHHHHCCCCCCCCHHHHHHHHCHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCC
GRFRDLWEEKRQKNVTL
CHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]