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The map label for this gene is 157370636

Identifier: 157370636

GI number: 157370636

Start: 2618011

End: 2618772

Strand: Direct

Name: 157370636

Synonym: Spro_2396

Alternate gene names: NA

Gene position: 2618011-2618772 (Clockwise)

Preceding gene: 157370635

Following gene: 157370637

Centisome position: 48.05

GC content: 58.14

Gene sequence:

>762_bases
ATGCACTTTACTCAAGCCATTGCCAGACTCCCTGCCGATAGCTGCGCCAGCGGCCAGACCACCGCCCAATTGGGGGCGCC
GGATATTGCCGTCACCGGCCACCAGTTTTTGGCCTATGTAGACACCTTGCTCCGCTTGGGGCTAAAAGTGACAGTGTTAC
CGGCTGCCCCGGCATTTCCTGACGCCCACTTTGTTGAAGACACCGCGGTGGTGATGCCGGAGCTGGCGGTGATCACCCAT
CCGGGCGCGCCAAGCCGCCAGGGCGAAGTGGCCACCATTGCACCGCTGTTCGAAGGAGAACGCCCGGTAGTGCGCATGAG
CCAACGCGGCCATCTTGATGGTGGGGATGTGCTGCTGGTCGATCGCCAGTTTTTTGTCGGCCTGACGTCTCGCACCGATG
AGGCCGGTATCGGCGAATTTGCCGCGGCGGTAGAACCCTACGGCTATCGGGTCACGGCCATTGATGTGAGCGCCGGGCTG
CACCTGAAATCAATCGTCAATTACGTGGGTCGCAATACCCTGTTGTTGACGGAAGACTACCAGCACCATGCTGCCTTTAG
CGGTTTTAACAGCATCGTCATTCCGGAAGCGGAGTCCTACGCCGGTAATACGCTGTGGATCAACGATACGCTGATCACCC
CACAGGGTTACCCGCAAACGCTGGCGCAAATCGAAAAATTAGGCATGCCAATCGTTCAACTCGACACCAGCGAATTTAAA
AAAATGGACGGCGGCCTGACCTGCCTGTCACTGCGTTTCTGA

Upstream 100 bases:

>100_bases
AATGTAGAGTGCCGGTGAGTGGATTCAGCCTGATTGGTACGGGTATCTGTTTGATAATCGAAGCAACAGTGACCGTCCTT
TTCAACCGAGAGAATCGCCC

Downstream 100 bases:

>100_bases
CACTTTCTTTTACCGGGGATCTCAGCCATGAAAAAAACATTAGCGGTTTTACTGACCAGTCTGGCATTAAGCGGCCCTGC
GGCGGCTCAGACCTTCGACA

Product: dimethylargininase

Products: NA

Alternate protein names: DDAH; Dimethylarginine dimethylaminohydrolase; Dimethylargininase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MHFTQAIARLPADSCASGQTTAQLGAPDIAVTGHQFLAYVDTLLRLGLKVTVLPAAPAFPDAHFVEDTAVVMPELAVITH
PGAPSRQGEVATIAPLFEGERPVVRMSQRGHLDGGDVLLVDRQFFVGLTSRTDEAGIGEFAAAVEPYGYRVTAIDVSAGL
HLKSIVNYVGRNTLLLTEDYQHHAAFSGFNSIVIPEAESYAGNTLWINDTLITPQGYPQTLAQIEKLGMPIVQLDTSEFK
KMDGGLTCLSLRF

Sequences:

>Translated_253_residues
MHFTQAIARLPADSCASGQTTAQLGAPDIAVTGHQFLAYVDTLLRLGLKVTVLPAAPAFPDAHFVEDTAVVMPELAVITH
PGAPSRQGEVATIAPLFEGERPVVRMSQRGHLDGGDVLLVDRQFFVGLTSRTDEAGIGEFAAAVEPYGYRVTAIDVSAGL
HLKSIVNYVGRNTLLLTEDYQHHAAFSGFNSIVIPEAESYAGNTLWINDTLITPQGYPQTLAQIEKLGMPIVQLDTSEFK
KMDGGLTCLSLRF
>Mature_253_residues
MHFTQAIARLPADSCASGQTTAQLGAPDIAVTGHQFLAYVDTLLRLGLKVTVLPAAPAFPDAHFVEDTAVVMPELAVITH
PGAPSRQGEVATIAPLFEGERPVVRMSQRGHLDGGDVLLVDRQFFVGLTSRTDEAGIGEFAAAVEPYGYRVTAIDVSAGL
HLKSIVNYVGRNTLLLTEDYQHHAAFSGFNSIVIPEAESYAGNTLWINDTLITPQGYPQTLAQIEKLGMPIVQLDTSEFK
KMDGGLTCLSLRF

Specific function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS [H]

COG id: COG1834

COG function: function code E; N-Dimethylarginine dimethylaminohydrolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DDAH family [H]

Homologues:

Organism=Homo sapiens, GI6912328, Length=268, Percent_Identity=34.7014925373134, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI197313763, Length=166, Percent_Identity=31.3253012048193, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859791, Length=244, Percent_Identity=31.9672131147541, Blast_Score=103, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003198 [H]

Pfam domain/function: PF02274 Amidinotransf [H]

EC number: =3.5.3.18 [H]

Molecular weight: Translated: 27206; Mature: 27206

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFTQAIARLPADSCASGQTTAQLGAPDIAVTGHQFLAYVDTLLRLGLKVTVLPAAPAFP
CCHHHHHHHCCCCCCCCCCCEEECCCCCEEECHHHHHHHHHHHHHCCCEEEEEECCCCCC
DAHFVEDTAVVMPELAVITHPGAPSRQGEVATIAPLFEGERPVVRMSQRGHLDGGDVLLV
CCHHHCCHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCEEEE
DRQFFVGLTSRTDEAGIGEFAAAVEPYGYRVTAIDVSAGLHLKSIVNYVGRNTLLLTEDY
CCCEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCEEEEECCC
QHHAAFSGFNSIVIPEAESYAGNTLWINDTLITPQGYPQTLAQIEKLGMPIVQLDTSEFK
HHHHHHCCCCEEEECCCCCCCCCEEEEECEEECCCCCHHHHHHHHHHCCCEEEECHHHHH
KMDGGLTCLSLRF
HCCCCEEEEEEEC
>Mature Secondary Structure
MHFTQAIARLPADSCASGQTTAQLGAPDIAVTGHQFLAYVDTLLRLGLKVTVLPAAPAFP
CCHHHHHHHCCCCCCCCCCCEEECCCCCEEECHHHHHHHHHHHHHCCCEEEEEECCCCCC
DAHFVEDTAVVMPELAVITHPGAPSRQGEVATIAPLFEGERPVVRMSQRGHLDGGDVLLV
CCHHHCCHHHHCCCEEEEECCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCEEEE
DRQFFVGLTSRTDEAGIGEFAAAVEPYGYRVTAIDVSAGLHLKSIVNYVGRNTLLLTEDY
CCCEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCEEEEECCC
QHHAAFSGFNSIVIPEAESYAGNTLWINDTLITPQGYPQTLAQIEKLGMPIVQLDTSEFK
HHHHHHCCCCEEEECCCCCCCCCEEEEECEEECCCCCHHHHHHHHHHCCCEEEECHHHHH
KMDGGLTCLSLRF
HCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 11473257 [H]