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The map label for this gene is lpxA [H]

Identifier: 157370592

GI number: 157370592

Start: 2564260

End: 2565048

Strand: Reverse

Name: lpxA [H]

Synonym: Spro_2352

Alternate gene names: 157370592

Gene position: 2565048-2564260 (Counterclockwise)

Preceding gene: 157370593

Following gene: 157370583

Centisome position: 47.08

GC content: 58.81

Gene sequence:

>789_bases
ATGATTTCTGCTTCTGCCCGTATTGCCGACAACAGCGTGATTGAGCCAGGCGTGATTATCGGTGCCCGCGTGAGTATCGG
CCCTTTTTGCTTCATTTCCGCCGGGGTTGAGATAGGTGAAGGCACCACTATCGCCTCGCACACGGTGATTAATGGCCTAA
CGCGCATCGGCCGCGACAATGTTATCGGTCAGTTTTCCTCGATCGGCGAAGCCAGTCAGGATCTGAAATATGCCGGTGAG
CCGACCACGCTGACCATCGGCGATCGCAATCGCATCGGCAAATACGCCACCCTGCATCGCGGTACGCTGCAAGGCTGCCA
ACGCACCGTCATCGGTCATGACAACGACCTGCGCGACAATGTGCATGTTGCCCATGACTGCATCATCGGTGACGGCGCTT
ACCTTGGCGATCACAGCGGCCTGGCGGGTCATGTTGAATTAGGCGATGCCGTCTGGGTCGGCGTTCGGTGCGCGGTACAT
CAGTTTTGCATTATCGGTGCCCATGCGCGATTAGCCGACGCCACCCTTCTGGTGCAGGACCTGCCTCCCTTTGTGCAGGC
TGGCGGTCATCGCGCCAAACCTGATGGTCTGAATCTGGCTGCATCGGCTTTTCTGGCCGCCGATCCGCAACAGCAACGGG
TGATTCACTCGCTGTATGACATGCTCTACCACCGGGCGATGCCGCTGGAGGAGGTTCGGCAGGAAGTGACTCACCTCAGC
GTGGAATACCCGCTGCTGAGCCTGTTCCTCGACTTCTTCACGCGCTCGACGCGCGGCATTATCCGCTGA

Upstream 100 bases:

>100_bases
CTTTCCTGTTCCCCCCTTAATTAATCCAGAATCCGGCTTAATACTTAACCGATGACTGGCCTGGCTGATGGATAGCCATG
CGCCGCCATCAGGATGCGTC

Downstream 100 bases:

>100_bases
GCAACGTGGCCGCTATGCCACCTTATGGCAACGCACCGCTGAGCCACCCAGATTAACCCGCAAGTTTTGCGGCAGTTGGC
AGCCTTCTCCGGCATAAGGG

Product: acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MISASARIADNSVIEPGVIIGARVSIGPFCFISAGVEIGEGTTIASHTVINGLTRIGRDNVIGQFSSIGEASQDLKYAGE
PTTLTIGDRNRIGKYATLHRGTLQGCQRTVIGHDNDLRDNVHVAHDCIIGDGAYLGDHSGLAGHVELGDAVWVGVRCAVH
QFCIIGAHARLADATLLVQDLPPFVQAGGHRAKPDGLNLAASAFLAADPQQQRVIHSLYDMLYHRAMPLEEVRQEVTHLS
VEYPLLSLFLDFFTRSTRGIIR

Sequences:

>Translated_262_residues
MISASARIADNSVIEPGVIIGARVSIGPFCFISAGVEIGEGTTIASHTVINGLTRIGRDNVIGQFSSIGEASQDLKYAGE
PTTLTIGDRNRIGKYATLHRGTLQGCQRTVIGHDNDLRDNVHVAHDCIIGDGAYLGDHSGLAGHVELGDAVWVGVRCAVH
QFCIIGAHARLADATLLVQDLPPFVQAGGHRAKPDGLNLAASAFLAADPQQQRVIHSLYDMLYHRAMPLEEVRQEVTHLS
VEYPLLSLFLDFFTRSTRGIIR
>Mature_262_residues
MISASARIADNSVIEPGVIIGARVSIGPFCFISAGVEIGEGTTIASHTVINGLTRIGRDNVIGQFSSIGEASQDLKYAGE
PTTLTIGDRNRIGKYATLHRGTLQGCQRTVIGHDNDLRDNVHVAHDCIIGDGAYLGDHSGLAGHVELGDAVWVGVRCAVH
QFCIIGAHARLADATLLVQDLPPFVQAGGHRAKPDGLNLAASAFLAADPQQQRVIHSLYDMLYHRAMPLEEVRQEVTHLS
VEYPLLSLFLDFFTRSTRGIIR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=262, Percent_Identity=48.0916030534351, Blast_Score=252, Evalue=2e-68,
Organism=Escherichia coli, GI1786376, Length=186, Percent_Identity=27.4193548387097, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28194; Mature: 28194

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISASARIADNSVIEPGVIIGARVSIGPFCFISAGVEIGEGTTIASHTVINGLTRIGRDN
CCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCEEECCCCEEHHHHHHHHHHHHCCCC
VIGQFSSIGEASQDLKYAGEPTTLTIGDRNRIGKYATLHRGTLQGCQRTVIGHDNDLRDN
HHHHHHHHCCHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
VHVAHDCIIGDGAYLGDHSGLAGHVELGDAVWVGVRCAVHQFCIIGAHARLADATLLVQD
EEEEEEEEEECCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LPPFVQAGGHRAKPDGLNLAASAFLAADPQQQRVIHSLYDMLYHRAMPLEEVRQEVTHLS
CCHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VEYPLLSLFLDFFTRSTRGIIR
HHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MISASARIADNSVIEPGVIIGARVSIGPFCFISAGVEIGEGTTIASHTVINGLTRIGRDN
CCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCEEECCCCEEHHHHHHHHHHHHCCCC
VIGQFSSIGEASQDLKYAGEPTTLTIGDRNRIGKYATLHRGTLQGCQRTVIGHDNDLRDN
HHHHHHHHCCHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCC
VHVAHDCIIGDGAYLGDHSGLAGHVELGDAVWVGVRCAVHQFCIIGAHARLADATLLVQD
EEEEEEEEEECCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LPPFVQAGGHRAKPDGLNLAASAFLAADPQQQRVIHSLYDMLYHRAMPLEEVRQEVTHLS
CCHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VEYPLLSLFLDFFTRSTRGIIR
HHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA