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The map label for this gene is tppB

Identifier: 157370473

GI number: 157370473

Start: 2432574

End: 2434094

Strand: Reverse

Name: tppB

Synonym: Spro_2233

Alternate gene names: 157370473

Gene position: 2434094-2432574 (Counterclockwise)

Preceding gene: 157370474

Following gene: 157370470

Centisome position: 44.67

GC content: 56.8

Gene sequence:

>1521_bases
GTGTCAACAGCAAACAACAACAGCGAACACCCTGAAAGCGTTAGTCTCAATGCCTTCAAACAGCCCAAGGCGTTTTACCT
GATCTTCTCTATTGAGCTCTGGGAACGTTTTGGTTATTACGGTCTGCAAGGCATCATGGCGGTTTATCTGGTCAAGATGC
TGGGCCTGAGCGAAGCCGACTCGATCACCCTGTTCTCCTCCTTCAGCGCGCTGGTCTATGGCTTCGTTGCCATCGGTGGC
TGGCTTGGGGATAAAGTACTGGGCTCCAAGCGCGTGATCGTGCTGGGTGCGCTGGTGCTGGCCGTCGGCTATGCCATGGT
GGCTTACTCCGGCCATGAGATCTTCTGGGTATACCTGGGTATGGCGACCATCGCCGTGGGCAGTGGCCTGTTCAAGGCTA
ACCCGTCCTCCCTGCTGTCAACCTGCTACGAGAAAGACGATCCGCGTTTGGACGGTGCATTCACCATGTACTATATGTCC
GTCAATATCGGTTCTTTCCTGTCCATGCTGGCCACGCCGTGGTTGGCGGCCAAATATGGCTGGAGCGTCGCGTTCTCTCT
GAGCGTCGTCGGCATGCTGATCACCCTGGTCAACTTTATGGTGTGTCACAAGTGGGTGAAACAACACGGTTCCAAGCCTG
ACTTTAAACCGCTGCAGGTTAAAAAACTGCTGATGGTGCTGGTGGGCGTGGTGGCGCTGGTCGCACTTTCAAGCTGGCTG
CTGCATAACCAGATCATTGCTCGCTGGGCGCTGGCGATTGTTTCCATCGGTATCGTGATTGTATTCGCCAAAGAAACCTT
CGCGCTGCACGGCGCGGCACGTCGCAAGATGATCGTTGCCTTCCTGTTGATGCTGGAAGCCGTCGTGTTCTTCGTGCTGT
ACAGCCAGATGCCAACCTCGTTGAACTTCTTCGCCATCCACAACGTTGAGCACAACATTCTCGGTCTGGCGTTTGAACCC
GAACAGTATCAGGCACTGAACCCGTTCTGGATCATGCTGGCCAGCCCGATTCTGGCGGCGCTGTATAACAAGATGGGCGA
CCGTCTGCCGATGCCGCACAAGTTCGCCTTCGGTATGATCCTGTGCTCCGGCGCCTTCCTGGTGTTGCCGTGGGGCGCCA
GCTTCGCCAATGAGCAGGGTATCGTTTCGGTGAACTGGCTGATCCTGAGCTATGCGCTGCAGAGTATCGGCGAACTGATG
ATCTCCGGCCTGGGCCTGGCGATGGTCGCGCAGTTGGTGCCACAACGTCTGATGGGCTTTATCATGGGTTCCTGGTTCCT
GACCACCGCCGCCGCCGCGCTGATTGCCGGTAAAGTGGCAGGTCTGACCGCCGTGCCTGGCGACGTCAACGATGCGCACG
CTTCACTGGCTATCTACAGCCACGTGTTTATGCAAATCGGTATCGCTACCGCCGTGATCGCCATCCTGATGATGCTGACC
GCGCCGAAGCTGCATCGCATGACGCTGGACACCGCAGAAGATACCGAGAAGAAAGCTCAGGCGGCCGCTATCACCAACTG
A

Upstream 100 bases:

>100_bases
GTCATCCCATCCTATAACAACGCAGAAGGATGCAGTCCTGCATCACCTTTTGCAATTTCCCGTCTTTCTGAGTCGGGGCA
GTGAAAAATCAGAGGTACCA

Downstream 100 bases:

>100_bases
TTGCTGACAACGGATTCAGACAGGTAAAAGAAAGCCGGGGCATTAATTTGCCCCGGCTTTTTTATGTCATCAGGCTGTGG
ATTTTGCGCTCAAATTGTCC

Product: putative tripeptide transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSTANNNSEHPESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGLSEADSITLFSSFSALVYGFVAIGG
WLGDKVLGSKRVIVLGALVLAVGYAMVAYSGHEIFWVYLGMATIAVGSGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMS
VNIGSFLSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFMVCHKWVKQHGSKPDFKPLQVKKLLMVLVGVVALVALSSWL
LHNQIIARWALAIVSIGIVIVFAKETFALHGAARRKMIVAFLLMLEAVVFFVLYSQMPTSLNFFAIHNVEHNILGLAFEP
EQYQALNPFWIMLASPILAALYNKMGDRLPMPHKFAFGMILCSGAFLVLPWGASFANEQGIVSVNWLILSYALQSIGELM
ISGLGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAGLTAVPGDVNDAHASLAIYSHVFMQIGIATAVIAILMMLT
APKLHRMTLDTAEDTEKKAQAAAITN

Sequences:

>Translated_506_residues
MSTANNNSEHPESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGLSEADSITLFSSFSALVYGFVAIGG
WLGDKVLGSKRVIVLGALVLAVGYAMVAYSGHEIFWVYLGMATIAVGSGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMS
VNIGSFLSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFMVCHKWVKQHGSKPDFKPLQVKKLLMVLVGVVALVALSSWL
LHNQIIARWALAIVSIGIVIVFAKETFALHGAARRKMIVAFLLMLEAVVFFVLYSQMPTSLNFFAIHNVEHNILGLAFEP
EQYQALNPFWIMLASPILAALYNKMGDRLPMPHKFAFGMILCSGAFLVLPWGASFANEQGIVSVNWLILSYALQSIGELM
ISGLGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAGLTAVPGDVNDAHASLAIYSHVFMQIGIATAVIAILMMLT
APKLHRMTLDTAEDTEKKAQAAAITN
>Mature_505_residues
STANNNSEHPESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGLSEADSITLFSSFSALVYGFVAIGGW
LGDKVLGSKRVIVLGALVLAVGYAMVAYSGHEIFWVYLGMATIAVGSGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSV
NIGSFLSMLATPWLAAKYGWSVAFSLSVVGMLITLVNFMVCHKWVKQHGSKPDFKPLQVKKLLMVLVGVVALVALSSWLL
HNQIIARWALAIVSIGIVIVFAKETFALHGAARRKMIVAFLLMLEAVVFFVLYSQMPTSLNFFAIHNVEHNILGLAFEPE
QYQALNPFWIMLASPILAALYNKMGDRLPMPHKFAFGMILCSGAFLVLPWGASFANEQGIVSVNWLILSYALQSIGELMI
SGLGLAMVAQLVPQRLMGFIMGSWFLTTAAAALIAGKVAGLTAVPGDVNDAHASLAIYSHVFMQIGIATAVIAILMMLTA
PKLHRMTLDTAEDTEKKAQAAAITN

Specific function: Proton-dependent permease that transports di- and tripeptides

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily

Homologues:

Organism=Homo sapiens, GI4827008, Length=387, Percent_Identity=24.5478036175711, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI226371746, Length=359, Percent_Identity=25.0696378830084, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1787922, Length=488, Percent_Identity=78.483606557377, Blast_Score=796, Evalue=0.0,
Organism=Escherichia coli, GI1789911, Length=480, Percent_Identity=51.25, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1790572, Length=471, Percent_Identity=31.8471337579618, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1786927, Length=478, Percent_Identity=28.6610878661088, Blast_Score=185, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17541704, Length=378, Percent_Identity=25.1322751322751, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17569141, Length=372, Percent_Identity=25.5376344086022, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71987453, Length=331, Percent_Identity=21.4501510574018, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639585, Length=345, Percent_Identity=26.9565217391304, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24639581, Length=353, Percent_Identity=26.3456090651558, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24639583, Length=336, Percent_Identity=26.7857142857143, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28571102, Length=370, Percent_Identity=25.9459459459459, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28571100, Length=370, Percent_Identity=25.9459459459459, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28571098, Length=370, Percent_Identity=25.9459459459459, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTPA_SERP5 (A8GDZ4)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478462.1
- ProteinModelPortal:   A8GDZ4
- STRING:   A8GDZ4
- GeneID:   5605180
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2233
- eggNOG:   COG3104
- HOGENOM:   HBG586603
- OMA:   VFFVLYS
- ProtClustDB:   PRK09584
- BioCyc:   SPRO399741:SPRO_2233-MONOMER
- HAMAP:   MF_01878
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456
- PANTHER:   PTHR11654:SF6
- TIGRFAMs:   TIGR00924

Pfam domain/function: PF00854 PTR2; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 55132; Mature: 55001

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS50850 MFS; PS01022 PTR2_1; PS01023 PTR2_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x2549effc)-; HASH(0x251c3070)-; HASH(0x4054642c)-; HASH(0x25062b24)-; HASH(0x2538b77c)-; HASH(0x254f4bc8)-; HASH(0x240d388c)-; HASH(0x2503796c)-; HASH(0x2418b178)-; HASH(0x253f49d8)-; HASH(0x25584c90)-; HASH(0x24a57ff0)-; HASH(0x405625c0)-; HASH(0x24d3fa9c)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTANNNSEHPESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGLSEAD
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
SITLFSSFSALVYGFVAIGGWLGDKVLGSKRVIVLGALVLAVGYAMVAYSGHEIFWVYLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHH
MATIAVGSGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSVNIGSFLSMLATPWLAAKYG
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHCCHHHHHCC
WSVAFSLSVVGMLITLVNFMVCHKWVKQHGSKPDFKPLQVKKLLMVLVGVVALVALSSWL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LHNQIIARWALAIVSIGIVIVFAKETFALHGAARRKMIVAFLLMLEAVVFFVLYSQMPTS
HHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNFFAIHNVEHNILGLAFEPEQYQALNPFWIMLASPILAALYNKMGDRLPMPHKFAFGMI
CEEEEEECCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LCSGAFLVLPWGASFANEQGIVSVNWLILSYALQSIGELMISGLGLAMVAQLVPQRLMGF
HHCCCEEEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IMGSWFLTTAAAALIAGKVAGLTAVPGDVNDAHASLAIYSHVFMQIGIATAVIAILMMLT
HHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APKLHRMTLDTAEDTEKKAQAAAITN
CCHHHHEECCCHHHHHHHHHHHCCCH
>Mature Secondary Structure 
STANNNSEHPESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKMLGLSEAD
CCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC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CCHHHHEECCCHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA