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The map label for this gene is str [H]

Identifier: 157370467

GI number: 157370467

Start: 2426415

End: 2427269

Strand: Direct

Name: str [H]

Synonym: Spro_2227

Alternate gene names: 157370467

Gene position: 2426415-2427269 (Clockwise)

Preceding gene: 157370465

Following gene: 157370471

Centisome position: 44.53

GC content: 60.58

Gene sequence:

>855_bases
ATGAATCAGGCCTTAATTCCCTATATGCAACGCTGGCAGTTGCAGCCCGACGGTCAGGCATTTGAAACTCACAGCAGCCT
GCTGATGCCGGTACGCTATCAGGGGGCCGCCGCCATGTTGAAAATTGCCCGTGAACAGGAAGAGAAGTTCGGCGGGTTAT
TGATGTGCTGGTGGCAGGGCGATGGTGCTGCTCGAGTGCTGGCCTGGCATGACGACGGCATTTTGCTGGAGCGTGCGCAA
GGCCGCCTCTCGCTGGCGCAGATGGTACGTGATGGCGAAGATCGACAGGCCACGGCGATTTTGTGCCAGGTGGTTGCCCG
CCTGCATGCGCCGCGTGCCGAGCCTTTGCCGGAGCTTATTCCCCTGGACCAGTGGTTCAACTCACTGTGGCCAGCGGCGC
AGGCGCATGGCGGCATGTTGCGTCTCAGTGCCAGCGTGGCGGCTGAGTTACTGACCAGCCCGCGCGAACAGACGGTGCTG
CACGGCGATATTCATCATGATAACGTGCTGGACTTCGCTGAGCGCGGTTGGTTGGCGATCGATCCCAAACGTCTGTATGG
CGAGCGTGCTTTCGATTACGCCAATATCTTCTGCAATCCCAACTACGGTATCGCTACCGATCCCGACATTTTTCTTTGTC
GGGTCGAGCAGGTCTGCCGGTTGGCCGGACTGGATCGCCAGCGGCTGCTGCGGTGGATCCTCGCCTGGGCCGGATTGTCC
GCGGCCTGGTTTATGGAAGACGGCGAGGCGGCGGATATCGATTTTCGCGTCGCAGAACAGGCCGCCCGTGCGTTGGGGCT
TTCGCTCCCGGAAGGGGACTCAGGGTTCATCCTGCCAGTAATCGAGCGAGGCTGA

Upstream 100 bases:

>100_bases
GTTAGGATAGTGAGACGAACATCAGAAGTACGCAGAGATTTATTGTTTTTTAATAATATCACTAACATTTATTTATAACT
GTGAAGGACCTTTCAGGGTA

Downstream 100 bases:

>100_bases
GGGGCGTTGCACATAGCGCACCGCTTTACCTTCACGCAGCGCCGTCGCCTGGAACTTGCCTGAGTCCGGATACTCCACCA
GTTCAGGCTGTTCGCGGGTA

Product: aminoglycoside/hydroxyurea antibiotic resistance kinase

Products: NA

Alternate protein names: Streptomycin 3''-phosphotransferase; SPH [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNQALIPYMQRWQLQPDGQAFETHSSLLMPVRYQGAAAMLKIAREQEEKFGGLLMCWWQGDGAARVLAWHDDGILLERAQ
GRLSLAQMVRDGEDRQATAILCQVVARLHAPRAEPLPELIPLDQWFNSLWPAAQAHGGMLRLSASVAAELLTSPREQTVL
HGDIHHDNVLDFAERGWLAIDPKRLYGERAFDYANIFCNPNYGIATDPDIFLCRVEQVCRLAGLDRQRLLRWILAWAGLS
AAWFMEDGEAADIDFRVAEQAARALGLSLPEGDSGFILPVIERG

Sequences:

>Translated_284_residues
MNQALIPYMQRWQLQPDGQAFETHSSLLMPVRYQGAAAMLKIAREQEEKFGGLLMCWWQGDGAARVLAWHDDGILLERAQ
GRLSLAQMVRDGEDRQATAILCQVVARLHAPRAEPLPELIPLDQWFNSLWPAAQAHGGMLRLSASVAAELLTSPREQTVL
HGDIHHDNVLDFAERGWLAIDPKRLYGERAFDYANIFCNPNYGIATDPDIFLCRVEQVCRLAGLDRQRLLRWILAWAGLS
AAWFMEDGEAADIDFRVAEQAARALGLSLPEGDSGFILPVIERG
>Mature_284_residues
MNQALIPYMQRWQLQPDGQAFETHSSLLMPVRYQGAAAMLKIAREQEEKFGGLLMCWWQGDGAARVLAWHDDGILLERAQ
GRLSLAQMVRDGEDRQATAILCQVVARLHAPRAEPLPELIPLDQWFNSLWPAAQAHGGMLRLSASVAAELLTSPREQTVL
HGDIHHDNVLDFAERGWLAIDPKRLYGERAFDYANIFCNPNYGIATDPDIFLCRVEQVCRLAGLDRQRLLRWILAWAGLS
AAWFMEDGEAADIDFRVAEQAARALGLSLPEGDSGFILPVIERG

Specific function: The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation [H]

COG id: COG3570

COG function: function code V; Streptomycin 6-kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aminoglycoside phosphotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006748 [H]

Pfam domain/function: PF04655 APH_6_hur [H]

EC number: =2.7.1.87 [H]

Molecular weight: Translated: 31825; Mature: 31825

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQALIPYMQRWQLQPDGQAFETHSSLLMPVRYQGAAAMLKIAREQEEKFGGLLMCWWQG
CCCCCCCHHHHCCCCCCCCHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEC
DGAARVLAWHDDGILLERAQGRLSLAQMVRDGEDRQATAILCQVVARLHAPRAEPLPELI
CCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHC
PLDQWFNSLWPAAQAHGGMLRLSASVAAELLTSPREQTVLHGDIHHDNVLDFAERGWLAI
CHHHHHHHHCCHHHHCCCEEEEHHHHHHHHHHCCCHHCEEECCCCCCHHHHHHHCCCEEE
DPKRLYGERAFDYANIFCNPNYGIATDPDIFLCRVEQVCRLAGLDRQRLLRWILAWAGLS
CHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
AAWFMEDGEAADIDFRVAEQAARALGLSLPEGDSGFILPVIERG
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MNQALIPYMQRWQLQPDGQAFETHSSLLMPVRYQGAAAMLKIAREQEEKFGGLLMCWWQG
CCCCCCCHHHHCCCCCCCCHHHCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEEEEEEC
DGAARVLAWHDDGILLERAQGRLSLAQMVRDGEDRQATAILCQVVARLHAPRAEPLPELI
CCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHC
PLDQWFNSLWPAAQAHGGMLRLSASVAAELLTSPREQTVLHGDIHHDNVLDFAERGWLAI
CHHHHHHHHCCHHHHCCCEEEEHHHHHHHHHHCCCHHCEEECCCCCCHHHHHHHCCCEEE
DPKRLYGERAFDYANIFCNPNYGIATDPDIFLCRVEQVCRLAGLDRQRLLRWILAWAGLS
CHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
AAWFMEDGEAADIDFRVAEQAARALGLSLPEGDSGFILPVIERG
EEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3889831 [H]