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The map label for this gene is pdxH

Identifier: 157370458

GI number: 157370458

Start: 2418836

End: 2419489

Strand: Direct

Name: pdxH

Synonym: Spro_2218

Alternate gene names: 157370458

Gene position: 2418836-2419489 (Clockwise)

Preceding gene: 157370457

Following gene: 157370459

Centisome position: 44.39

GC content: 55.66

Gene sequence:

>654_bases
ATGATTGAAAATAATGAATTTGATGTTGCGGACCTGCGCCGCGAATATACCCGTGGCGGCCTGCGCCGTAACGATCTGAC
CACCAATCCCCTGGAACTGTTCGAGCATTGGCTGAAACAGGCCTGTGACGCCCGCCTGGCGGATCCGACCGCCATGTGCG
TGGCGACGGTGGATGAAAACGGCCAACCTTACCAGCGCATTGTGTTGCTCAAGCATTTTGATGACAAAGGGCTGGTGTTC
TACACCAATCTGGGCAGCCGCAAGGCGCAGCAACTGGCGAATAACCCGCACATCAGCCTGTTGTTCCCGTGGCACATGCT
TGATCGTCAGGTCATTTTCCTCGGTAAAGCGGAGCGCCTGTCCACGTTCGAAGTTATGAAATACTTTGCCAGCCGGCCGA
AGGACAGTCAGATCGGCGCCTGGGTCTCGCAGCAGTCATCGCGTATTTCAGCGCGCGGCGTGCTGGAGAGCAAATTCCTC
GAACTGAAGCAAAAATTCCAACAGGGCGAAGTGCCATTGCCGAGTTTCTGGGGTGGATTCCGGGTTAATTTCGACTCCGT
CGAGTTTTGGCAGGGCGGTGCCAACCGTCTGCATGACCGTTTCCTGTATCAACGGGACGGGAATGACTGGAAAATTGACC
GACTGGCACCCTGA

Upstream 100 bases:

>100_bases
GCTGACGAATTGATCCGGTCGTTGCGGCGTCAGAGCGATTGAGATCCTGACGCCGCAGGCGCAGAATAGAATCACGATTT
TTCAGTTGGTTGATAACCGA

Downstream 100 bases:

>100_bases
TCGGTGAAAATCCCCCTTAAGCGCTGGCACTGATGTCGCCGGCGCTTTATTCTATGCGTTATTCTGAATTTAATATTTCG
CCAGTGGGCGAAAGGTCGTG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MIENNEFDVADLRREYTRGGLRRNDLTTNPLELFEHWLKQACDARLADPTAMCVATVDENGQPYQRIVLLKHFDDKGLVF
YTNLGSRKAQQLANNPHISLLFPWHMLDRQVIFLGKAERLSTFEVMKYFASRPKDSQIGAWVSQQSSRISARGVLESKFL
ELKQKFQQGEVPLPSFWGGFRVNFDSVEFWQGGANRLHDRFLYQRDGNDWKIDRLAP

Sequences:

>Translated_217_residues
MIENNEFDVADLRREYTRGGLRRNDLTTNPLELFEHWLKQACDARLADPTAMCVATVDENGQPYQRIVLLKHFDDKGLVF
YTNLGSRKAQQLANNPHISLLFPWHMLDRQVIFLGKAERLSTFEVMKYFASRPKDSQIGAWVSQQSSRISARGVLESKFL
ELKQKFQQGEVPLPSFWGGFRVNFDSVEFWQGGANRLHDRFLYQRDGNDWKIDRLAP
>Mature_217_residues
MIENNEFDVADLRREYTRGGLRRNDLTTNPLELFEHWLKQACDARLADPTAMCVATVDENGQPYQRIVLLKHFDDKGLVF
YTNLGSRKAQQLANNPHISLLFPWHMLDRQVIFLGKAERLSTFEVMKYFASRPKDSQIGAWVSQQSSRISARGVLESKFL
ELKQKFQQGEVPLPSFWGGFRVNFDSVEFWQGGANRLHDRFLYQRDGNDWKIDRLAP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=230, Percent_Identity=40, Blast_Score=158, Evalue=4e-39,
Organism=Escherichia coli, GI1787926, Length=218, Percent_Identity=77.5229357798165, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17553712, Length=227, Percent_Identity=34.8017621145374, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319509, Length=209, Percent_Identity=38.2775119617225, Blast_Score=148, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24644901, Length=233, Percent_Identity=38.1974248927039, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI45551845, Length=233, Percent_Identity=38.1974248927039, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24644903, Length=168, Percent_Identity=31.547619047619, Blast_Score=88, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_SERP5 (A8GDX9)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478447.1
- ProteinModelPortal:   A8GDX9
- SMR:   A8GDX9
- STRING:   A8GDX9
- GeneID:   5605265
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2218
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   PRK05679
- BioCyc:   SPRO399741:SPRO_2218-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25240; Mature: 25240

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 66-66 BINDING 69-69 BINDING 71-71 BINDING 88-88 BINDING 128-128 BINDING 132-132 BINDING 136-136

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIENNEFDVADLRREYTRGGLRRNDLTTNPLELFEHWLKQACDARLADPTAMCVATVDEN
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
GQPYQRIVLLKHFDDKGLVFYTNLGSRKAQQLANNPHISLLFPWHMLDRQVIFLGKAERL
CCCHHEEEEEEEECCCCEEEEECCCCHHHHHHHCCCCEEEEECHHHHCCEEEEEECCHHH
STFEVMKYFASRPKDSQIGAWVSQQSSRISARGVLESKFLELKQKFQQGEVPLPSFWGGF
HHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
RVNFDSVEFWQGGANRLHDRFLYQRDGNDWKIDRLAP
EEECCCCCCCCCCHHHHHHHHHEEECCCCEEECCCCC
>Mature Secondary Structure
MIENNEFDVADLRREYTRGGLRRNDLTTNPLELFEHWLKQACDARLADPTAMCVATVDEN
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
GQPYQRIVLLKHFDDKGLVFYTNLGSRKAQQLANNPHISLLFPWHMLDRQVIFLGKAERL
CCCHHEEEEEEEECCCCEEEEECCCCHHHHHHHCCCCEEEEECHHHHCCEEEEEECCHHH
STFEVMKYFASRPKDSQIGAWVSQQSSRISARGVLESKFLELKQKFQQGEVPLPSFWGGF
HHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
RVNFDSVEFWQGGANRLHDRFLYQRDGNDWKIDRLAP
EEECCCCCCCCCCHHHHHHHHHEEECCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA