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The map label for this gene is lolC [H]

Identifier: 157370243

GI number: 157370243

Start: 2191799

End: 2193001

Strand: Direct

Name: lolC [H]

Synonym: Spro_2001

Alternate gene names: 157370243

Gene position: 2191799-2193001 (Clockwise)

Preceding gene: 157370242

Following gene: 157370244

Centisome position: 40.22

GC content: 59.43

Gene sequence:

>1203_bases
ATGTATCAACCTGTCGCGTTATTCATTGGCCTGCGCTACATGCGCGGGCGAGCTTCAGACCGCTTCGGGCGGTTTGTCTC
CTGGCTTTCCACCATCGGCATTACGCTGGGGGTGATGGCGTTGGTTACCGTCTTGTCGGTGATGAACGGTTTTGAAAAGG
ATCTGGAGAACAACATCCTCGGCCTGATGCCGCAGGCGTTGATTACCAGTCCCCAGGGGTCAGTCAATCCTCAACAGATC
CCGGCATCGGCGGTGCAGAGCCTGCAGGGCGTCAGCCGCGTGGCGCCCTTGACCACCGGTGACGTGGTGCTGCAAAGCGC
CCGCAGCGTGGCGGTGGGGGTGATGCTGGGGGTGAACCCGGACGAAGCCGATCCGCTGACGCCGTTTTTGGTGAACGTCA
AACAGCAACAGCTGCAGCCGGGCCAATACAACATCATCATCGGCGAACAGTTAGCTGGGCAACTTGGCGTTAAACGTGGC
GATCCGCTGCGGGTGATGGTGCCGAGCGCCAGCCAGTTCACGCCGATGGGCCGCATTCCGATCCAGCGTCTGTTTACCGT
GGTTGGCACCTTCCACGCCAATAGTGAAGTAGACGGTACCCAGATGCTGGTCAATCAGCAGGACGCTTCGCGCCTGTTGC
GCTATCCGGCCGGCAATATCACCGGTTGGCGCCTGTTCCTGCAGCAGCCGCTGACGGTGGATACCCTCAGCCAACAGAAA
TTGCCGCAGGGTACCGAATGGAAAGACTGGCGCGAACGCAAGGGCGAGCTGTTCCAGGCGGTGCGTATGGAGAAGAACAT
GATGGGGCTGTTGCTTAGCCTGATCGTGGCGGTGGCGGCATTTAACATTATTACTTCCCTTGGCCTGCTGGTAATGGAAA
AGCAGGGCGAAGTGGCTATTTTGCAGACCCAGGGCCTGACGCGTCGACAGGTGATGTCGGTGTTTATGGTACAGGGTGCC
AGCGCCGGTATTATCGGTTCGCTGCTCGGCACGCTGCTCGGGGTGTTACTGGCCAGCAATCTTAATAACCTGATGCCGAT
CCTCGGCGCATTGATTGACGGCGCATCGCTGCCGGTGGCGGTGGATCCGCTGCAGGTGACGGTCATTGCCGTAGCGGCGA
TGGCGGTTTCCCTGTTGTCCACGCTTTACCCTTCATGGCGCGCTGCCGCCGTACAACCCGCTGAGGCTTTACGTTATGAG
TAA

Upstream 100 bases:

>100_bases
ATCGGCGGAATAAAAGGCGTCAGGGTGGTTCCCTAAACGGGGTATAGCCTTTATTATCCTTGATCACTTTCGCTTAAGCT
ACGGCAACAAAACGGATTTC

Downstream 100 bases:

>100_bases
CCATCTTTTGTTGCAGTGCGACAACCTGTGCAAGACTTATCAGGAAGGCAACCTGCATACCGACGTACTGCGTAATGTAA
GCTTTGCCATGCAGCCGGGC

Product: outer membrane-specific lipoprotein transporter subunit LolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MYQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFEKDLENNILGLMPQALITSPQGSVNPQQI
PASAVQSLQGVSRVAPLTTGDVVLQSARSVAVGVMLGVNPDEADPLTPFLVNVKQQQLQPGQYNIIIGEQLAGQLGVKRG
DPLRVMVPSASQFTPMGRIPIQRLFTVVGTFHANSEVDGTQMLVNQQDASRLLRYPAGNITGWRLFLQQPLTVDTLSQQK
LPQGTEWKDWRERKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLLVMEKQGEVAILQTQGLTRRQVMSVFMVQGA
SAGIIGSLLGTLLGVLLASNLNNLMPILGALIDGASLPVAVDPLQVTVIAVAAMAVSLLSTLYPSWRAAAVQPAEALRYE

Sequences:

>Translated_400_residues
MYQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFEKDLENNILGLMPQALITSPQGSVNPQQI
PASAVQSLQGVSRVAPLTTGDVVLQSARSVAVGVMLGVNPDEADPLTPFLVNVKQQQLQPGQYNIIIGEQLAGQLGVKRG
DPLRVMVPSASQFTPMGRIPIQRLFTVVGTFHANSEVDGTQMLVNQQDASRLLRYPAGNITGWRLFLQQPLTVDTLSQQK
LPQGTEWKDWRERKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLLVMEKQGEVAILQTQGLTRRQVMSVFMVQGA
SAGIIGSLLGTLLGVLLASNLNNLMPILGALIDGASLPVAVDPLQVTVIAVAAMAVSLLSTLYPSWRAAAVQPAEALRYE
>Mature_400_residues
MYQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFEKDLENNILGLMPQALITSPQGSVNPQQI
PASAVQSLQGVSRVAPLTTGDVVLQSARSVAVGVMLGVNPDEADPLTPFLVNVKQQQLQPGQYNIIIGEQLAGQLGVKRG
DPLRVMVPSASQFTPMGRIPIQRLFTVVGTFHANSEVDGTQMLVNQQDASRLLRYPAGNITGWRLFLQQPLTVDTLSQQK
LPQGTEWKDWRERKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLLVMEKQGEVAILQTQGLTRRQVMSVFMVQGA
SAGIIGSLLGTLLGVLLASNLNNLMPILGALIDGASLPVAVDPLQVTVIAVAAMAVSLLSTLYPSWRAAAVQPAEALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=400, Percent_Identity=81.25, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1787362, Length=415, Percent_Identity=28.6746987951807, Blast_Score=145, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 43139; Mature: 43139

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFEKDLENNIL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
GLMPQALITSPQGSVNPQQIPASAVQSLQGVSRVAPLTTGDVVLQSARSVAVGVMLGVNP
HHCCHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCC
DEADPLTPFLVNVKQQQLQPGQYNIIIGEQLAGQLGVKRGDPLRVMVPSASQFTPMGRIP
CCCCCCCHHHHHCHHHHCCCCCEEEEECHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCH
IQRLFTVVGTFHANSEVDGTQMLVNQQDASRLLRYPAGNITGWRLFLQQPLTVDTLSQQK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHC
LPQGTEWKDWRERKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLLVMEKQGEVAI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEE
LQTQGLTRRQVMSVFMVQGASAGIIGSLLGTLLGVLLASNLNNLMPILGALIDGASLPVA
EECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VDPLQVTVIAVAAMAVSLLSTLYPSWRAAAVQPAEALRYE
ECHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHCCC
>Mature Secondary Structure
MYQPVALFIGLRYMRGRASDRFGRFVSWLSTIGITLGVMALVTVLSVMNGFEKDLENNIL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
GLMPQALITSPQGSVNPQQIPASAVQSLQGVSRVAPLTTGDVVLQSARSVAVGVMLGVNP
HHCCHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCC
DEADPLTPFLVNVKQQQLQPGQYNIIIGEQLAGQLGVKRGDPLRVMVPSASQFTPMGRIP
CCCCCCCHHHHHCHHHHCCCCCEEEEECHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCH
IQRLFTVVGTFHANSEVDGTQMLVNQQDASRLLRYPAGNITGWRLFLQQPLTVDTLSQQK
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHHC
LPQGTEWKDWRERKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLLVMEKQGEVAI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEE
LQTQGLTRRQVMSVFMVQGASAGIIGSLLGTLLGVLLASNLNNLMPILGALIDGASLPVA
EECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VDPLQVTVIAVAAMAVSLLSTLYPSWRAAAVQPAEALRYE
ECHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]