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The map label for this gene is tdcB [H]

Identifier: 157370241

GI number: 157370241

Start: 2189969

End: 2190952

Strand: Reverse

Name: tdcB [H]

Synonym: Spro_1999

Alternate gene names: 157370241

Gene position: 2190952-2189969 (Counterclockwise)

Preceding gene: 157370249

Following gene: 157370240

Centisome position: 40.21

GC content: 60.57

Gene sequence:

>984_bases
ATGAGTTCAACGCCCCACTGTATCACCGCCGCCGATATCTCTACTGCCGCAGAAATCCTGGCCGGACATGCCATCCGCAC
GCCGGTCATGACCTCGCAGCAGGCCGATCGCCTCACCGGCGCGCAACTTTTCTTTAAATGCGAGAATTTCCAGCGCGTCG
GCGCCTTCAAGTTTCGCGGCGCATACAATTCGATTGCTCAATTGAGTGATGCACAGCGCAAGGCTGGGGTGATTGCCTTC
TCCTCCGGCAACCACGCGCAGGCCATGGCGTTAGCAGCCCGGGAACTGGGGGTTAGCGTAACCATAGTGATGCCGCACGA
CGCCCCTGCGGCCAAACTGGCGGCAACGCGCGGTTACGGCGCCAAGGTGGTGATTTATCAGCGTCACAGTGAAGACCGCG
CCGCCATTACTCAGCGACTGGCGGCCGAACAGGGTCTGACCATAATCCCTCCCTATGATTACCCGCAGGTGATCGCCGGT
CAGGGCACGGCCACCAAAGAACTGATTGAGGAAGTCGGTCCTTTGGATGTGTTGCTGGTCTGCACCGGCGGCGGTGGCTT
GCTGGCCGGCAGCGCGGTCGCAGCGCACCACTGGTCGCCGGGCTGTAGGGTATTTGGCGTGGAGCCACAGGCGGGCAACG
ACGTGCAGCAGGCATTCCGCAGCGGTCATCCGGTACAGATCCCGGTACCGAAGACCATCGCCGACGGCGCACAGACTCAG
CAGGTAGGCGCGTTGACCTTCCCAATCATTCAGCAGTACGTCGAGGATATCCTGACGGTCAGCGACCAACAGCTGTGTCG
GCAAATGCGCTTCTTTATGGAGCGAATGAAAATGGTGGTCGAGCCGACCGGTTGCCTGGCCGCAGCGGCGGCGATGAATT
CGCTGCTCGATTTGCGCGGCAAAAAGGTCGGGGTGATCGTCAGCGGTGGCAACGTTGACGTCGATAAAATCGCCGACTAT
CTCGCCATGGCGGCGCAAGAATAA

Upstream 100 bases:

>100_bases
CTGAGATCGCTCATTAACTTAACCATTTGACAATAACTTAACAAAGAGTAAATTAAAATTTCCGGGTAATCAATCAACCT
TTCACCAGCGCGAGGTCGCC

Downstream 100 bases:

>100_bases
CGCCATCAGGTGGTTAAACATACGCCAATAGACCGCCGCATCGCGCTTTTACCTGTGTCAGTTTACTGCCCAGTGGGCTA
GTATTAGCGGGTAAAGGCGC

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSSTPHCITAADISTAAEILAGHAIRTPVMTSQQADRLTGAQLFFKCENFQRVGAFKFRGAYNSIAQLSDAQRKAGVIAF
SSGNHAQAMALAARELGVSVTIVMPHDAPAAKLAATRGYGAKVVIYQRHSEDRAAITQRLAAEQGLTIIPPYDYPQVIAG
QGTATKELIEEVGPLDVLLVCTGGGGLLAGSAVAAHHWSPGCRVFGVEPQAGNDVQQAFRSGHPVQIPVPKTIADGAQTQ
QVGALTFPIIQQYVEDILTVSDQQLCRQMRFFMERMKMVVEPTGCLAAAAAMNSLLDLRGKKVGVIVSGGNVDVDKIADY
LAMAAQE

Sequences:

>Translated_327_residues
MSSTPHCITAADISTAAEILAGHAIRTPVMTSQQADRLTGAQLFFKCENFQRVGAFKFRGAYNSIAQLSDAQRKAGVIAF
SSGNHAQAMALAARELGVSVTIVMPHDAPAAKLAATRGYGAKVVIYQRHSEDRAAITQRLAAEQGLTIIPPYDYPQVIAG
QGTATKELIEEVGPLDVLLVCTGGGGLLAGSAVAAHHWSPGCRVFGVEPQAGNDVQQAFRSGHPVQIPVPKTIADGAQTQ
QVGALTFPIIQQYVEDILTVSDQQLCRQMRFFMERMKMVVEPTGCLAAAAAMNSLLDLRGKKVGVIVSGGNVDVDKIADY
LAMAAQE
>Mature_326_residues
SSTPHCITAADISTAAEILAGHAIRTPVMTSQQADRLTGAQLFFKCENFQRVGAFKFRGAYNSIAQLSDAQRKAGVIAFS
SGNHAQAMALAARELGVSVTIVMPHDAPAAKLAATRGYGAKVVIYQRHSEDRAAITQRLAAEQGLTIIPPYDYPQVIAGQ
GTATKELIEEVGPLDVLLVCTGGGGLLAGSAVAAHHWSPGCRVFGVEPQAGNDVQQAFRSGHPVQIPVPKTIADGAQTQQ
VGALTFPIIQQYVEDILTVSDQQLCRQMRFFMERMKMVVEPTGCLAAAAAMNSLLDLRGKKVGVIVSGGNVDVDKIADYL
AMAAQE

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=329, Percent_Identity=36.7781155015198, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI33469958, Length=309, Percent_Identity=27.831715210356, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI19923959, Length=302, Percent_Identity=27.8145695364238, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI295821202, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI295821200, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4557415, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789505, Length=309, Percent_Identity=38.5113268608414, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1790207, Length=289, Percent_Identity=37.0242214532872, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=32.5949367088608, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=311, Percent_Identity=33.7620578778135, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17537387, Length=311, Percent_Identity=33.1189710610932, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=60.1910828025478, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6320930, Length=287, Percent_Identity=35.191637630662, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=268, Percent_Identity=25.3731343283582, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355833, Length=310, Percent_Identity=34.8387096774194, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24645328, Length=211, Percent_Identity=33.175355450237, Blast_Score=98, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34644; Mature: 34513

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00435 PEROXIDASE_1 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTPHCITAADISTAAEILAGHAIRTPVMTSQQADRLTGAQLFFKCENFQRVGAFKFRG
CCCCCCEEEEHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHEEEECCCHHCCCEEECC
AYNSIAQLSDAQRKAGVIAFSSGNHAQAMALAARELGVSVTIVMPHDAPAAKLAATRGYG
HHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHCCCCC
AKVVIYQRHSEDRAAITQRLAAEQGLTIIPPYDYPQVIAGQGTATKELIEEVGPLDVLLV
EEEEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCHHHHHHHHCCCCEEEEE
CTGGGGLLAGSAVAAHHWSPGCRVFGVEPQAGNDVQQAFRSGHPVQIPVPKTIADGAQTQ
EECCCCEEECCCCEECCCCCCCEEEEECCCCCCHHHHHHHCCCCEEECCCHHHHCCCCHH
QVGALTFPIIQQYVEDILTVSDQQLCRQMRFFMERMKMVVEPTGCLAAAAAMNSLLDLRG
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KKVGVIVSGGNVDVDKIADYLAMAAQE
CEEEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSTPHCITAADISTAAEILAGHAIRTPVMTSQQADRLTGAQLFFKCENFQRVGAFKFRG
CCCCCEEEEHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHEEEECCCHHCCCEEECC
AYNSIAQLSDAQRKAGVIAFSSGNHAQAMALAARELGVSVTIVMPHDAPAAKLAATRGYG
HHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHCCCCC
AKVVIYQRHSEDRAAITQRLAAEQGLTIIPPYDYPQVIAGQGTATKELIEEVGPLDVLLV
EEEEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCHHHHHHHHCCCCEEEEE
CTGGGGLLAGSAVAAHHWSPGCRVFGVEPQAGNDVQQAFRSGHPVQIPVPKTIADGAQTQ
EECCCCEEECCCCEECCCCCCCEEEEECCCCCCHHHHHHHCCCCEEECCCHHHHCCCCHH
QVGALTFPIIQQYVEDILTVSDQQLCRQMRFFMERMKMVVEPTGCLAAAAAMNSLLDLRG
HCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
KKVGVIVSGGNVDVDKIADYLAMAAQE
CEEEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA