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The map label for this gene is clpP [H]

Identifier: 157370220

GI number: 157370220

Start: 2164467

End: 2165060

Strand: Direct

Name: clpP [H]

Synonym: Spro_1978

Alternate gene names: 157370220

Gene position: 2164467-2165060 (Clockwise)

Preceding gene: 157370219

Following gene: 157370225

Centisome position: 39.72

GC content: 56.06

Gene sequence:

>594_bases
ATGCGTGAATCGATGCTGCTCGTCCCTATGGTGGTTGAACAGACCAGCCAGGGCGAACGTTCTTTCGACATTTATTCGAG
ATTGCTGCGTGACCGCATCGTTTTCCTGAACGGAGAGGTCAACGATCAGATTGCCGAAGTGCTGTGCGCCCAGTTGCTGT
TTCTGGAGGCCGAAAACCCGGAGAAACCGATCCATCTGTATATCAATTCACCGGGCGGGGTGATCACCAGCGGTTTCGCC
ATCTATGACACCATGAATTACATCAATGCACCGGTGCATACCCTGTGTATGGGCACTGCGCGTTCGATGGGTTCCTTCCT
GTTGATGGCCGGGGAGGCGGGGCATCGCATGGTGCTGCCCAATGCCAGTTTGCATGTGCATCAGCCGCTGGGCGGCTTTC
AGGGCCAGGCGTCGGATATTCTGATCCACGCCGAAGAGATGAAACGCACCAAGCACAGCGTCATCACGCTATATGCCAAA
CATTGTGGACGCAGCTATGAAGAGGTCGAACGAGCACTCGACCGCGACCATTTTATGAGTGCCGACGAAGCGGTGGAGTG
GGGGCTGGTGGATAAGGTGCTGCGGGGACGGTGA

Upstream 100 bases:

>100_bases
GATGCCCGGCTGACGGCGGCGAACGACAGCGGACGGCACCTGATGCGCGCCGCCTGACGGCCAACCTTTCCCATTCCACA
CCTGAAACAGGAGTTCACCC

Downstream 100 bases:

>100_bases
GGGTTAAATTAAAGCCGCGCGGTTGCGCGGCTTTGGGAGATGGCGGGTAATAATGATTACCACTCGGTAATTACGCCGTC
CTGAACTGGGCGAGTGTAGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MRESMLLVPMVVEQTSQGERSFDIYSRLLRDRIVFLNGEVNDQIAEVLCAQLLFLEAENPEKPIHLYINSPGGVITSGFA
IYDTMNYINAPVHTLCMGTARSMGSFLLMAGEAGHRMVLPNASLHVHQPLGGFQGQASDILIHAEEMKRTKHSVITLYAK
HCGRSYEEVERALDRDHFMSADEAVEWGLVDKVLRGR

Sequences:

>Translated_197_residues
MRESMLLVPMVVEQTSQGERSFDIYSRLLRDRIVFLNGEVNDQIAEVLCAQLLFLEAENPEKPIHLYINSPGGVITSGFA
IYDTMNYINAPVHTLCMGTARSMGSFLLMAGEAGHRMVLPNASLHVHQPLGGFQGQASDILIHAEEMKRTKHSVITLYAK
HCGRSYEEVERALDRDHFMSADEAVEWGLVDKVLRGR
>Mature_197_residues
MRESMLLVPMVVEQTSQGERSFDIYSRLLRDRIVFLNGEVNDQIAEVLCAQLLFLEAENPEKPIHLYINSPGGVITSGFA
IYDTMNYINAPVHTLCMGTARSMGSFLLMAGEAGHRMVLPNASLHVHQPLGGFQGQASDILIHAEEMKRTKHSVITLYAK
HCGRSYEEVERALDRDHFMSADEAVEWGLVDKVLRGR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=54.9738219895288, Blast_Score=227, Evalue=5e-60,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=61.6580310880829, Blast_Score=254, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=56.5445026178011, Blast_Score=226, Evalue=5e-60,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=56.9148936170213, Blast_Score=236, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22088; Mature: 22088

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRESMLLVPMVVEQTSQGERSFDIYSRLLRDRIVFLNGEVNDQIAEVLCAQLLFLEAENP
CCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCC
EKPIHLYINSPGGVITSGFAIYDTMNYINAPVHTLCMGTARSMGSFLLMAGEAGHRMVLP
CCCEEEEEECCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECCCCCEEECC
NASLHVHQPLGGFQGQASDILIHAEEMKRTKHSVITLYAKHCGRSYEEVERALDRDHFMS
CCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
ADEAVEWGLVDKVLRGR
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRESMLLVPMVVEQTSQGERSFDIYSRLLRDRIVFLNGEVNDQIAEVLCAQLLFLEAENP
CCCCEEEHHHHHHHCCCCCCHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCC
EKPIHLYINSPGGVITSGFAIYDTMNYINAPVHTLCMGTARSMGSFLLMAGEAGHRMVLP
CCCEEEEEECCCCEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEECCCCCEEECC
NASLHVHQPLGGFQGQASDILIHAEEMKRTKHSVITLYAKHCGRSYEEVERALDRDHFMS
CCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
ADEAVEWGLVDKVLRGR
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]