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The map label for this gene is cusC [C]

Identifier: 157370103

GI number: 157370103

Start: 2045647

End: 2047011

Strand: Reverse

Name: cusC [C]

Synonym: Spro_1861

Alternate gene names: 157370103

Gene position: 2047011-2045647 (Counterclockwise)

Preceding gene: 157370104

Following gene: 157370102

Centisome position: 37.57

GC content: 56.04

Gene sequence:

>1365_bases
ATGAAAATTTTATCCCCCCTGATGTTATGCCTCGCAGCCCTGCTCAGTACCGGCTGCGGTAATGCGTTGAAAAGCGAATA
TCAATCTCCGAAGGTGGACTATCCGACCCAATGGCAACCCAGTGCCGATGCCGCTACGTCAGTCCCTTTTGCCTGGCACG
ATTTCCACGATCCCCAGCTAGAACGCTGGCTACAACAGGTGATGCTGGCTAATAACGATCTGGCCGCTGCCGCATTGCGT
GTCTATCGTGCCCAGTTGATGGCCCAACGGGTCGACATCGGCACCGCTCCCAGCGTAAACGCGACGCTCAATACCGGCGC
CAGCACCGCCCTGTCCAATTCGTCCCCGTGGAATAAAAACAGCAGCGCTAGCCTCGGCGTCAGCTATGAGGTCGATCTGT
GGGGCAAACTGGCAAGACAGCGTGATGCCGCAGAATGGGCCAGTCAGGCAACTCAACAAGATTTGCAAAGTGCGCGTTTG
GCATTGCTCGCCAACGCCAGCAAAAATTACTGGCGCCTCGGTTTTATCAATCAAAGGATCGGCGTCAGTCAGCAAAATAT
CGCTTACTCCAGGCAGACCTTAGAGTTGGTCAATGCCCGCTACCGTGCCGGCAGCATCTCTTCACTGGACGTGGTGGATG
CCGAGCAGAATCTGATCAATCAGGAGAGCAGCCATCTGGCGCTGTTACGTGAGCGTCAGCAAGCCTTGAACGAACAAACC
GTGTTATTGGGCTCACCACCGGGCAAGGCTTTGGTTGAACCCGCCCGTTTACCCACCGGCCCGCTGCCGCAAATCAATGC
CGGTATCCCGGTCAACGTGCTGCGCCACCGGCCGGATATCAGCGCCAAAGAGTTGCGGCTGCGTGAAGCATTGGCCAACG
TCGATGTAAAGCGTACCCAGTACTATCCGGCATTTAGCCTGACCGGTTCATTGGGTGCCAGCAGTACCGCCTTGCTGGAA
TTTTTGCGCAATCCGTTGGCCTCGGTGGGGGCTGGGTTGTCGCTGCCGTTCCTTGAATGGCGGCAGATGGATGTGGATAT
CAAAATTGCCCGCAGTGACTACGAGCTGCAGGTGCTGGAATTCAAACAGGCGCTGTATAAGGCCATGGCCGATGTGGCCG
ATGCCCTGTCGCTGCGTAGCCAATTGATAGCTCAGGAAAAACACTTACGGGCTTCGTTAGCCTTGGCGCAAAAATCTGAA
CGCTTGAATGAGAGCCGCTACCGGCAAGGTGCCGTCCCCATCAGCTTCTGGCTGGATGCGCAAAATCGCCGCAGGCTGGC
AGAACTGGCGCTGGATGAAAACCGTTTCGGCCAATATCAGAACCTGGCGCAACTCTATCTGGAATTTGGCGGCTCAGCTC
AATAA

Upstream 100 bases:

>100_bases
CTTTTGCTGCTCCACTCTGATCGGCATGATCTTCGGTTATCTCCCGGCCCGCAAAGCGGCGCGGATGGATCCGGTCATTT
CACTGGCCAGCGAGTAACTT

Downstream 100 bases:

>100_bases
CTCTCTCCGGCCTGACGTCTGCGTCAGGCTTTTTTTCAGCCGCAGAACGCATTAATTTTGCCGGTTTTTACCACAATTCT
TCCTATACTTAACCTATCCC

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKILSPLMLCLAALLSTGCGNALKSEYQSPKVDYPTQWQPSADAATSVPFAWHDFHDPQLERWLQQVMLANNDLAAAALR
VYRAQLMAQRVDIGTAPSVNATLNTGASTALSNSSPWNKNSSASLGVSYEVDLWGKLARQRDAAEWASQATQQDLQSARL
ALLANASKNYWRLGFINQRIGVSQQNIAYSRQTLELVNARYRAGSISSLDVVDAEQNLINQESSHLALLRERQQALNEQT
VLLGSPPGKALVEPARLPTGPLPQINAGIPVNVLRHRPDISAKELRLREALANVDVKRTQYYPAFSLTGSLGASSTALLE
FLRNPLASVGAGLSLPFLEWRQMDVDIKIARSDYELQVLEFKQALYKAMADVADALSLRSQLIAQEKHLRASLALAQKSE
RLNESRYRQGAVPISFWLDAQNRRRLAELALDENRFGQYQNLAQLYLEFGGSAQ

Sequences:

>Translated_454_residues
MKILSPLMLCLAALLSTGCGNALKSEYQSPKVDYPTQWQPSADAATSVPFAWHDFHDPQLERWLQQVMLANNDLAAAALR
VYRAQLMAQRVDIGTAPSVNATLNTGASTALSNSSPWNKNSSASLGVSYEVDLWGKLARQRDAAEWASQATQQDLQSARL
ALLANASKNYWRLGFINQRIGVSQQNIAYSRQTLELVNARYRAGSISSLDVVDAEQNLINQESSHLALLRERQQALNEQT
VLLGSPPGKALVEPARLPTGPLPQINAGIPVNVLRHRPDISAKELRLREALANVDVKRTQYYPAFSLTGSLGASSTALLE
FLRNPLASVGAGLSLPFLEWRQMDVDIKIARSDYELQVLEFKQALYKAMADVADALSLRSQLIAQEKHLRASLALAQKSE
RLNESRYRQGAVPISFWLDAQNRRRLAELALDENRFGQYQNLAQLYLEFGGSAQ
>Mature_454_residues
MKILSPLMLCLAALLSTGCGNALKSEYQSPKVDYPTQWQPSADAATSVPFAWHDFHDPQLERWLQQVMLANNDLAAAALR
VYRAQLMAQRVDIGTAPSVNATLNTGASTALSNSSPWNKNSSASLGVSYEVDLWGKLARQRDAAEWASQATQQDLQSARL
ALLANASKNYWRLGFINQRIGVSQQNIAYSRQTLELVNARYRAGSISSLDVVDAEQNLINQESSHLALLRERQQALNEQT
VLLGSPPGKALVEPARLPTGPLPQINAGIPVNVLRHRPDISAKELRLREALANVDVKRTQYYPAFSLTGSLGASSTALLE
FLRNPLASVGAGLSLPFLEWRQMDVDIKIARSDYELQVLEFKQALYKAMADVADALSLRSQLIAQEKHLRASLALAQKSE
RLNESRYRQGAVPISFWLDAQNRRRLAELALDENRFGQYQNLAQLYLEFGGSAQ

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=470, Percent_Identity=25.531914893617, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI2367348, Length=437, Percent_Identity=22.6544622425629, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50210; Mature: 50210

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILSPLMLCLAALLSTGCGNALKSEYQSPKVDYPTQWQPSADAATSVPFAWHDFHDPQL
CCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHH
ERWLQQVMLANNDLAAAALRVYRAQLMAQRVDIGTAPSVNATLNTGASTALSNSSPWNKN
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHCCCCCCCCCC
SSASLGVSYEVDLWGKLARQRDAAEWASQATQQDLQSARLALLANASKNYWRLGFINQRI
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHC
GVSQQNIAYSRQTLELVNARYRAGSISSLDVVDAEQNLINQESSHLALLRERQQALNEQT
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHCCCHHHHHHHHHHHHHCCCCE
VLLGSPPGKALVEPARLPTGPLPQINAGIPVNVLRHRPDISAKELRLREALANVDVKRTQ
EEEECCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCHHHC
YYPAFSLTGSLGASSTALLEFLRNPLASVGAGLSLPFLEWRQMDVDIKIARSDYELQVLE
CCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEECCCCCHHHHH
FKQALYKAMADVADALSLRSQLIAQEKHLRASLALAQKSERLNESRYRQGAVPISFWLDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
QNRRRLAELALDENRFGQYQNLAQLYLEFGGSAQ
HHHHHHHHHHHCCHHCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKILSPLMLCLAALLSTGCGNALKSEYQSPKVDYPTQWQPSADAATSVPFAWHDFHDPQL
CCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCHHH
ERWLQQVMLANNDLAAAALRVYRAQLMAQRVDIGTAPSVNATLNTGASTALSNSSPWNKN
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHCCCCCCCCCC
SSASLGVSYEVDLWGKLARQRDAAEWASQATQQDLQSARLALLANASKNYWRLGFINQRI
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHC
GVSQQNIAYSRQTLELVNARYRAGSISSLDVVDAEQNLINQESSHLALLRERQQALNEQT
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCHHHHHCCCHHHHHHHHHHHHHCCCCE
VLLGSPPGKALVEPARLPTGPLPQINAGIPVNVLRHRPDISAKELRLREALANVDVKRTQ
EEEECCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCHHHC
YYPAFSLTGSLGASSTALLEFLRNPLASVGAGLSLPFLEWRQMDVDIKIARSDYELQVLE
CCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEECCCCCHHHHH
FKQALYKAMADVADALSLRSQLIAQEKHLRASLALAQKSERLNESRYRQGAVPISFWLDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
QNRRRLAELALDENRFGQYQNLAQLYLEFGGSAQ
HHHHHHHHHHHCCHHCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]