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The map label for this gene is cynR [H]

Identifier: 157369778

GI number: 157369778

Start: 1671956

End: 1672858

Strand: Direct

Name: cynR [H]

Synonym: Spro_1535

Alternate gene names: 157369778

Gene position: 1671956-1672858 (Clockwise)

Preceding gene: 157369774

Following gene: 157369779

Centisome position: 30.68

GC content: 57.14

Gene sequence:

>903_bases
ATGCTGTTGCGACATATTCGTTATTTTCTGGCCGTTGCCGAGCAGGGCAACTTCACACGCGCTGCCGAAGTGCTGCACGT
TTCGCAGCCCACGCTGTCACAGCAAATCAAACAGCTGGAGGAAACGCTGGGTACGCCGCTGTTGGATCGCAGTGGCCGAA
CCGTGCGCCTGACCGATGCCGGTGCGGCCTGGATGCGCTATGCCCGCCGGGCATTACAGGATCTCGACGAAGGTGCGCGC
GCGATCCATGACGTGGCGACGCTGGAGCGCGGCAATCTGAGGTTGGCAATGACGCCGACCTTTAGCGCCTACCTGGTTGG
CCCGGTTATCGATGCCTTTTATCGGCGTTATCCGGGTATATCGCTAAGTATTCAAGAAATGACTCAGGACAGAATCGAGG
CGTTGCTGGCGGAGGATCAGTTGGATTTGGGTATTGCTTTTGGCCAGGCGCAGTCGCCAGATATCGAGGCCAACGACCTG
TTTAGTGAATCGTTGAATATGGTGGTTGGCGCAGATCATCTTTTGGCCCAACGGCAACATCCTTTGACGGCGGAAGAGCT
TGAACGGCAACCCCTGGCTTTACTGAGCGAAGATTTTGCTACCCGTCAGTTCATCGACGGTTATTGTCGCCAGCAGAGTA
TCTGCCCATGGGTGGCGGTAGAAGCCAATGCGATTGGTGCTATCCTCGAGATTGTGCGCCGTGGTCAGCTTGCCACCATT
CTACCGGCGGCGATCGCCCAGGCGGATCCGCAGTTGCGGTCGGTACAACTTGCCGTTGCCCTGCCAGCCCGTCGGGCGGT
ATTACTGCAACGCAAAAGCGCTTACCGCAGCGCGGCATCGCAGGCGTTTGTTGCGGTTTTACATCAGCAGACTTTTATGT
CGACACACGCCAACCCGGTATAA

Upstream 100 bases:

>100_bases
GGTGCTGTTAAGCGATGGACGTATCTTGCGCCGCTCTGGCTATAGGGTCTAAGACCCATTTATAATGATAGCTATAGGCA
TTACTAATAGTAGGGGCGCT

Downstream 100 bases:

>100_bases
AACCGCTTGAATAGAGAAATTTTTATGAAAATGATTTTGCGCGTTGTGGCTTTGCTTGTTGTTTCTTTCTGTTCCCTCTC
CGGCTACGCCGCTGAGCAAA

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MLLRHIRYFLAVAEQGNFTRAAEVLHVSQPTLSQQIKQLEETLGTPLLDRSGRTVRLTDAGAAWMRYARRALQDLDEGAR
AIHDVATLERGNLRLAMTPTFSAYLVGPVIDAFYRRYPGISLSIQEMTQDRIEALLAEDQLDLGIAFGQAQSPDIEANDL
FSESLNMVVGADHLLAQRQHPLTAEELERQPLALLSEDFATRQFIDGYCRQQSICPWVAVEANAIGAILEIVRRGQLATI
LPAAIAQADPQLRSVQLAVALPARRAVLLQRKSAYRSAASQAFVAVLHQQTFMSTHANPV

Sequences:

>Translated_300_residues
MLLRHIRYFLAVAEQGNFTRAAEVLHVSQPTLSQQIKQLEETLGTPLLDRSGRTVRLTDAGAAWMRYARRALQDLDEGAR
AIHDVATLERGNLRLAMTPTFSAYLVGPVIDAFYRRYPGISLSIQEMTQDRIEALLAEDQLDLGIAFGQAQSPDIEANDL
FSESLNMVVGADHLLAQRQHPLTAEELERQPLALLSEDFATRQFIDGYCRQQSICPWVAVEANAIGAILEIVRRGQLATI
LPAAIAQADPQLRSVQLAVALPARRAVLLQRKSAYRSAASQAFVAVLHQQTFMSTHANPV
>Mature_300_residues
MLLRHIRYFLAVAEQGNFTRAAEVLHVSQPTLSQQIKQLEETLGTPLLDRSGRTVRLTDAGAAWMRYARRALQDLDEGAR
AIHDVATLERGNLRLAMTPTFSAYLVGPVIDAFYRRYPGISLSIQEMTQDRIEALLAEDQLDLGIAFGQAQSPDIEANDL
FSESLNMVVGADHLLAQRQHPLTAEELERQPLALLSEDFATRQFIDGYCRQQSICPWVAVEANAIGAILEIVRRGQLATI
LPAAIAQADPQLRSVQLAVALPARRAVLLQRKSAYRSAASQAFVAVLHQQTFMSTHANPV

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=284, Percent_Identity=55.9859154929578, Blast_Score=321, Evalue=3e-89,
Organism=Escherichia coli, GI1787879, Length=287, Percent_Identity=32.7526132404181, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788887, Length=295, Percent_Identity=29.4915254237288, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI145693105, Length=291, Percent_Identity=28.5223367697594, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081904, Length=215, Percent_Identity=31.1627906976744, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790399, Length=263, Percent_Identity=28.8973384030418, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=31.7269076305221, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789173, Length=210, Percent_Identity=34.2857142857143, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787530, Length=258, Percent_Identity=29.4573643410853, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788297, Length=169, Percent_Identity=30.7692307692308, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788748, Length=291, Percent_Identity=26.8041237113402, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1789204, Length=285, Percent_Identity=27.719298245614, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786401, Length=183, Percent_Identity=30.6010928961749, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790208, Length=281, Percent_Identity=27.0462633451957, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788296, Length=193, Percent_Identity=31.6062176165803, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081978, Length=196, Percent_Identity=30.1020408163265, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693193, Length=183, Percent_Identity=31.1475409836066, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787589, Length=179, Percent_Identity=26.8156424581006, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1786713, Length=189, Percent_Identity=31.7460317460317, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787601, Length=143, Percent_Identity=31.4685314685315, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789639, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789440, Length=301, Percent_Identity=24.5847176079734, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787949, Length=192, Percent_Identity=27.6041666666667, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082132, Length=171, Percent_Identity=28.0701754385965, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1787806, Length=292, Percent_Identity=24.6575342465753, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788706, Length=182, Percent_Identity=33.5164835164835, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786448, Length=164, Percent_Identity=29.8780487804878, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=263, Percent_Identity=27.3764258555133, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1790262, Length=190, Percent_Identity=22.6315789473684, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33191; Mature: 33191

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHIRYFLAVAEQGNFTRAAEVLHVSQPTLSQQIKQLEETLGTPLLDRSGRTVRLTDA
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GAAWMRYARRALQDLDEGARAIHDVATLERGNLRLAMTPTFSAYLVGPVIDAFYRRYPGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCC
SLSIQEMTQDRIEALLAEDQLDLGIAFGQAQSPDIEANDLFSESLNMVVGADHLLAQRQH
EEEHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHCCC
PLTAEELERQPLALLSEDFATRQFIDGYCRQQSICPWVAVEANAIGAILEIVRRGQLATI
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHCCCHHHH
LPAAIAQADPQLRSVQLAVALPARRAVLLQRKSAYRSAASQAFVAVLHQQTFMSTHANPV
HHHHHHHCCCCHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLLRHIRYFLAVAEQGNFTRAAEVLHVSQPTLSQQIKQLEETLGTPLLDRSGRTVRLTDA
CHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEECC
GAAWMRYARRALQDLDEGARAIHDVATLERGNLRLAMTPTFSAYLVGPVIDAFYRRYPGI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCC
SLSIQEMTQDRIEALLAEDQLDLGIAFGQAQSPDIEANDLFSESLNMVVGADHLLAQRQH
EEEHHHHHHHHHHHHHHHCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHCCC
PLTAEELERQPLALLSEDFATRQFIDGYCRQQSICPWVAVEANAIGAILEIVRRGQLATI
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHCCCHHHH
LPAAIAQADPQLRSVQLAVALPARRAVLLQRKSAYRSAASQAFVAVLHQQTFMSTHANPV
HHHHHHHCCCCHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]