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The map label for this gene is betA

Identifier: 157369758

GI number: 157369758

Start: 1651113

End: 1652780

Strand: Direct

Name: betA

Synonym: Spro_1515

Alternate gene names: 157369758

Gene position: 1651113-1652780 (Clockwise)

Preceding gene: 157369757

Following gene: 157369762

Centisome position: 30.3

GC content: 58.69

Gene sequence:

>1668_bases
ATGGAATACGATTACATCATTATCGGGGCCGGCTCGGCCGGTAACGTATTAGCCACCCGCTTAACCGAAGACGCTGACGT
CAGCGTGCTGCTGCTGGAAGCCGGCGGCCCGGACTATCGGATGGATTTTCGCACTCAGATGCCGGCGGCGTTGGCTTTCC
CGCTGCAGGGGCGCCGTTACAACTGGGCCTATGAAACCGACCCTGAGCCGCACATGAACAATCGCCGCATGGAATGTGGC
CGTGGTAAGGGACTGGGCGGTTCATCGCTGATAAACGGCATGTGCTACATCCGCGGCAACGCGATGGATTTCGATAACTG
GGCGAAGGCACCGGGTCTGGAAGACTGGAGCTACCTGGATTGTCTGCCGTATTTCCGCAAGGCGGAAACCCGCGATATCG
GGCCGAACGATTTTCACGGCGGTGATGGCCCGGTCAGCGTTACCACGCCGAAAGCCGGTAACAACGAATTATTCCACGCG
ATGGTGGAGGCTGGTGTTCAGGCAGGCTACCCGCGTACCGAGGATCTGAACGGCTACCAGCAGGAAGGCTTCGGCCCGAT
GGATCGCACCGTAACGCCGAAAGGTCGTCGTGCCAGCACCGCTCGCGGTTATCTGGATCAGGCGCGTTCTCGCCCTAATT
TGAAGATTGTGACCCACGCGCTGACCGATCGCATCCGCTTCGACGGCAAGCGGGCGGTGGGCGTTGACTACTTGCAGGGT
GAAGCAAAGGATGTCACCAGTGCCCGTGCGCGTCGGGAAGTGCTGCTGTGCGCCGGGGCGATCGCCTCGCCACAGATCCT
GCAGCGCTCCGGCGTGGGACCGGCCGCCTTGCTGAACCGTCTGGATATTGATCTGGTACACGAACTGCCGGGTGTGGGTG
AAAACCTGCAAGACCATCTGGAAATGTACCTGCAGTACGCCTGTAAAAAACCGGTGTCGCTGTACCCGGCGTTGCAATGG
TTTAACCAGCCTAAAATCGGTGCGGAATGGCTATTCAATGGCAGCGGTATTGGTGCCAGTAACCAATTTGAAGCCGGTGG
TTTTATCCGCAGCCGTGAAGAGTTTGCCTGGCCGAACATTCAGTATCATTTCCTGCCGGTAGCAATTAACTACAACGGCA
GTAATGCGGTGAAAGAGCACGGTTTCCAGGCACACGTCGGTTCGATGCGCTCCCCGAGCCGTGGCCGGGTGCAGGTCAAA
TCCAAAGATCCGCGCCAGCACCCGAGCATCTTGTTCAACTATATGGCGACCGAGCAGGACTGGCAGGAGTTCCGCGATGC
CATCCGCATCACGCGTGAAATCATGGCGCAACCGGCGTTGGATGAATACCGTGGTCGTGAGATAAGCCCAGGGCCGGAAG
TGCAGACCGACGAGCAGTTGGACGCTTTTGTTCGTGAACATGCCGAAACCGCCTTCCATCCTTCCTGCTCATGCAAAATG
GGTGAAGACGAAATGGCGGTGGTGGATGGTCAGGGCCGGGTGCACGGCCTGGAAGGGCTGCGGGTGGTGGATGCGTCAAT
TATGCCGTTGATCATTACCGGTAATCTGAATGCCACCACTATCATGATCGCCGAGAAAATCGCCGACCGCATCCGCCAAC
GCACGCCGCTGCCGCGCAGCACCGCAGAATACTACGTGGCCGGTAACGCCCCGGCGCGTAAACAGTAA

Upstream 100 bases:

>100_bases
GAGTTAGGCGAATACGCCTCGGTATTTTAACTATCCCCGCTTTTTCTTTCTTTCGCCTGGCGCGTTCGCGTCAGGCGCAT
TGCCTATCAGGAGATAATCG

Downstream 100 bases:

>100_bases
CCAACATGTCCTCTCGCCACCGAGGGGGAGGGCTGCTGTAGCAAGCAACCCCCTCTCCAAAGTCCTTCCCTGAGGCGAGG
GGACAATCCACCGCTTAAAC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MEYDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRMDFRTQMPAALAFPLQGRRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDNWAKAPGLEDWSYLDCLPYFRKAETRDIGPNDFHGGDGPVSVTTPKAGNNELFHA
MVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARSRPNLKIVTHALTDRIRFDGKRAVGVDYLQG
EAKDVTSARARREVLLCAGAIASPQILQRSGVGPAALLNRLDIDLVHELPGVGENLQDHLEMYLQYACKKPVSLYPALQW
FNQPKIGAEWLFNGSGIGASNQFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRVQVK
SKDPRQHPSILFNYMATEQDWQEFRDAIRITREIMAQPALDEYRGREISPGPEVQTDEQLDAFVREHAETAFHPSCSCKM
GEDEMAVVDGQGRVHGLEGLRVVDASIMPLIITGNLNATTIMIAEKIADRIRQRTPLPRSTAEYYVAGNAPARKQ

Sequences:

>Translated_555_residues
MEYDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRMDFRTQMPAALAFPLQGRRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDNWAKAPGLEDWSYLDCLPYFRKAETRDIGPNDFHGGDGPVSVTTPKAGNNELFHA
MVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARSRPNLKIVTHALTDRIRFDGKRAVGVDYLQG
EAKDVTSARARREVLLCAGAIASPQILQRSGVGPAALLNRLDIDLVHELPGVGENLQDHLEMYLQYACKKPVSLYPALQW
FNQPKIGAEWLFNGSGIGASNQFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRVQVK
SKDPRQHPSILFNYMATEQDWQEFRDAIRITREIMAQPALDEYRGREISPGPEVQTDEQLDAFVREHAETAFHPSCSCKM
GEDEMAVVDGQGRVHGLEGLRVVDASIMPLIITGNLNATTIMIAEKIADRIRQRTPLPRSTAEYYVAGNAPARKQ
>Mature_555_residues
MEYDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRMDFRTQMPAALAFPLQGRRYNWAYETDPEPHMNNRRMECG
RGKGLGGSSLINGMCYIRGNAMDFDNWAKAPGLEDWSYLDCLPYFRKAETRDIGPNDFHGGDGPVSVTTPKAGNNELFHA
MVEAGVQAGYPRTEDLNGYQQEGFGPMDRTVTPKGRRASTARGYLDQARSRPNLKIVTHALTDRIRFDGKRAVGVDYLQG
EAKDVTSARARREVLLCAGAIASPQILQRSGVGPAALLNRLDIDLVHELPGVGENLQDHLEMYLQYACKKPVSLYPALQW
FNQPKIGAEWLFNGSGIGASNQFEAGGFIRSREEFAWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRVQVK
SKDPRQHPSILFNYMATEQDWQEFRDAIRITREIMAQPALDEYRGREISPGPEVQTDEQLDAFVREHAETAFHPSCSCKM
GEDEMAVVDGQGRVHGLEGLRVVDASIMPLIITGNLNATTIMIAEKIADRIRQRTPLPRSTAEYYVAGNAPARKQ

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family

Homologues:

Organism=Homo sapiens, GI217272839, Length=543, Percent_Identity=48.8029465930018, Blast_Score=506, Evalue=1e-143,
Organism=Escherichia coli, GI1786503, Length=555, Percent_Identity=83.2432432432432, Blast_Score=970, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=560, Percent_Identity=45.5357142857143, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24642048, Length=600, Percent_Identity=36.1666666666667, Blast_Score=304, Evalue=8e-83,
Organism=Drosophila melanogaster, GI24642059, Length=573, Percent_Identity=35.6020942408377, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI45549471, Length=573, Percent_Identity=34.2059336823735, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI45551458, Length=573, Percent_Identity=34.2059336823735, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24642042, Length=573, Percent_Identity=34.9040139616056, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24642055, Length=577, Percent_Identity=34.8353552859619, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI17137792, Length=560, Percent_Identity=34.1071428571429, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI24650267, Length=577, Percent_Identity=33.1022530329289, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24642051, Length=572, Percent_Identity=31.993006993007, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24642039, Length=573, Percent_Identity=34.7294938917976, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI18859995, Length=574, Percent_Identity=33.7979094076655, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24642035, Length=579, Percent_Identity=32.9879101899827, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI18859993, Length=575, Percent_Identity=33.2173913043478, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24642037, Length=309, Percent_Identity=42.0711974110032, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24645930, Length=578, Percent_Identity=28.0276816608997, Blast_Score=165, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24642057, Length=583, Percent_Identity=28.4734133790738, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BETA_SERP5 (A8GBX9)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477747.1
- ProteinModelPortal:   A8GBX9
- SMR:   A8GBX9
- STRING:   A8GBX9
- GeneID:   5603625
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1515
- eggNOG:   COG2303
- HOGENOM:   HBG734713
- OMA:   EISPGAH
- ProtClustDB:   PRK02106
- BioCyc:   SPRO399741:SPRO_1515-MONOMER
- HAMAP:   MF_00750
- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867
- PIRSF:   PIRSF000137
- TIGRFAMs:   TIGR01810

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N

EC number: =1.1.99.1

Molecular weight: Translated: 61627; Mature: 61627

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00623 GMC_OXRED_1; PS00624 GMC_OXRED_2

Important sites: ACT_SITE 473-473

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRMDFRTQMPAALAFPLQGRRY
CCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEHHHCCCCEEECCCCCCEE
NWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDNWAKAPGLEDWSYLD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCHHHCCCCCCCCCHHH
CLPYFRKAETRDIGPNDFHGGDGPVSVTTPKAGNNELFHAMVEAGVQAGYPRTEDLNGYQ
HHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPKGRRASTARGYLDQARSRPNLKIVTHALTDRIRFDGKRAVGVDYLQG
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCEECCHHHCC
EAKDVTSARARREVLLCAGAIASPQILQRSGVGPAALLNRLDIDLVHELPGVGENLQDHL
CHHHHHHHHHHHHEEEEECCCCCHHHHHHCCCCHHHHHHHCCHHHHHHCCCCCCCHHHHH
EMYLQYACKKPVSLYPALQWFNQPKIGAEWLFNGSGIGASNQFEAGGFIRSREEFAWPNI
HHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCHHHCCCCC
QYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRVQVKSKDPRQHPSILFNYMATEQD
EEEEEEEEEEECCCHHHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCHHH
WQEFRDAIRITREIMAQPALDEYRGREISPGPEVQTDEQLDAFVREHAETAFHPSCSCKM
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GEDEMAVVDGQGRVHGLEGLRVVDASIMPLIITGNLNATTIMIAEKIADRIRQRTPLPRS
CCCCEEEECCCCCEECCCCEEEECCCCEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCCC
TAEYYVAGNAPARKQ
CCCEEEECCCCCCCC
>Mature Secondary Structure
MEYDYIIIGAGSAGNVLATRLTEDADVSVLLLEAGGPDYRMDFRTQMPAALAFPLQGRRY
CCCEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEHHHCCCCEEECCCCCCEE
NWAYETDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDFDNWAKAPGLEDWSYLD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCHHHCCCCCCCCCHHH
CLPYFRKAETRDIGPNDFHGGDGPVSVTTPKAGNNELFHAMVEAGVQAGYPRTEDLNGYQ
HHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHH
QEGFGPMDRTVTPKGRRASTARGYLDQARSRPNLKIVTHALTDRIRFDGKRAVGVDYLQG
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCEECCHHHCC
EAKDVTSARARREVLLCAGAIASPQILQRSGVGPAALLNRLDIDLVHELPGVGENLQDHL
CHHHHHHHHHHHHEEEEECCCCCHHHHHHCCCCHHHHHHHCCHHHHHHCCCCCCCHHHHH
EMYLQYACKKPVSLYPALQWFNQPKIGAEWLFNGSGIGASNQFEAGGFIRSREEFAWPNI
HHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCEECCHHHCCCCC
QYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRVQVKSKDPRQHPSILFNYMATEQD
EEEEEEEEEEECCCHHHHHCCCHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCHHH
WQEFRDAIRITREIMAQPALDEYRGREISPGPEVQTDEQLDAFVREHAETAFHPSCSCKM
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
GEDEMAVVDGQGRVHGLEGLRVVDASIMPLIITGNLNATTIMIAEKIADRIRQRTPLPRS
CCCCEEEECCCCCEECCCCEEEECCCCEEEEEECCCCCEEEHHHHHHHHHHHHCCCCCCC
TAEYYVAGNAPARKQ
CCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA