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The map label for this gene is alsR [H]

Identifier: 157369729

GI number: 157369729

Start: 1620863

End: 1621738

Strand: Direct

Name: alsR [H]

Synonym: Spro_1486

Alternate gene names: 157369729

Gene position: 1620863-1621738 (Clockwise)

Preceding gene: 157369727

Following gene: 157369736

Centisome position: 29.75

GC content: 61.99

Gene sequence:

>876_bases
ATGGATATTCGACAACTGCGCGCCTTTGTGGTGCTGGCTGAACAGGGCAATTATCACCTGGCGGCAGAACGGCTGTGTAT
CACCCAGCCGGCACTGAGCAAACAGATCCAGGCGCTGGAAGCGCTGCTGGGCGCCCGGTTGTTTAACCGTGGTCGCCAGG
GGGCACAGCTCACCGCCAGCGGACAGCGACTCTACCCCGAGGCACAGGCGCTGGTGGGGCAGCATTTACAGTTTCAACAG
CGTGCTTTGAGGATCGTGCAAGGCGAGGCGGGGCGGTTGGCAATTGGATTCGGGCTGTCCAGTTTTCACCTGGCACCGCA
ACTGGTTGCCGCCTTCCGCCAGCGTTTTCCCGAGGTTGCCGTGGGGCTGGAGGATTTGCCTTCGGAGCGGCAGTATCAGT
TGTTATTGCAAGGAGAGCTGCAGGTGGGGTTCGTGCGGTTGCCGGTCAGCAAACCGCTGCGGGCCAGCGCGCTGCTGAGC
GATCGGTTGGTGCTGGCGGCACCCGCAGCGTTGGCGCTGAAGGCGGAGGCGATCATCGGGCAATTCAACACCCTGCCGCT
GCTGCAGCTGACGCCAAAACGCGGACGCGGTCTGAGCGAACAGTCGCTGCGTTTTATTGCCGCCCATCAACTGGTGCCGA
ATGTGGTGCAACAGGCGGGGGATATCCAGACGCTGTTGGCGTTGGTTGCCGCCGGCATTGGCGTTGCCCTGTTGCCGCAC
AGCGTCAGCCATATTATTCCGGCGGGTATCGATATTCTGCCGCTCAGCGGTGAACAGACCGAGTGGCAGGTCGGCATTGC
CTGGAACCCGCAGCAGGCTGATGCGCTGCGGGATAATTTTATCCAGGTTGCGTTGGCCGCGGCGTCGGTGCGTTAA

Upstream 100 bases:

>100_bases
TTGTCATAAGGTTACCTTTGGTCGTTGTCTGGCGTTGATTACAGCAAAGCTATTGATTACTGTATAATCAATTAAATTCT
TAATTTGATAACCAAACGGA

Downstream 100 bases:

>100_bases
CGGCCTGGTTTACAACGGGCAGTGCATCACCAGTATCGGGTTCTGATGGTACTCGCTGCGGTGGCTTTCGCTAAAACCGA
CCTTCTTCGCCAGCGCCACT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MDIRQLRAFVVLAEQGNYHLAAERLCITQPALSKQIQALEALLGARLFNRGRQGAQLTASGQRLYPEAQALVGQHLQFQQ
RALRIVQGEAGRLAIGFGLSSFHLAPQLVAAFRQRFPEVAVGLEDLPSERQYQLLLQGELQVGFVRLPVSKPLRASALLS
DRLVLAAPAALALKAEAIIGQFNTLPLLQLTPKRGRGLSEQSLRFIAAHQLVPNVVQQAGDIQTLLALVAAGIGVALLPH
SVSHIIPAGIDILPLSGEQTEWQVGIAWNPQQADALRDNFIQVALAAASVR

Sequences:

>Translated_291_residues
MDIRQLRAFVVLAEQGNYHLAAERLCITQPALSKQIQALEALLGARLFNRGRQGAQLTASGQRLYPEAQALVGQHLQFQQ
RALRIVQGEAGRLAIGFGLSSFHLAPQLVAAFRQRFPEVAVGLEDLPSERQYQLLLQGELQVGFVRLPVSKPLRASALLS
DRLVLAAPAALALKAEAIIGQFNTLPLLQLTPKRGRGLSEQSLRFIAAHQLVPNVVQQAGDIQTLLALVAAGIGVALLPH
SVSHIIPAGIDILPLSGEQTEWQVGIAWNPQQADALRDNFIQVALAAASVR
>Mature_291_residues
MDIRQLRAFVVLAEQGNYHLAAERLCITQPALSKQIQALEALLGARLFNRGRQGAQLTASGQRLYPEAQALVGQHLQFQQ
RALRIVQGEAGRLAIGFGLSSFHLAPQLVAAFRQRFPEVAVGLEDLPSERQYQLLLQGELQVGFVRLPVSKPLRASALLS
DRLVLAAPAALALKAEAIIGQFNTLPLLQLTPKRGRGLSEQSLRFIAAHQLVPNVVQQAGDIQTLLALVAAGIGVALLPH
SVSHIIPAGIDILPLSGEQTEWQVGIAWNPQQADALRDNFIQVALAAASVR

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=287, Percent_Identity=30.6620209059233, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1788887, Length=288, Percent_Identity=32.2916666666667, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=29.5719844357977, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=29.6296296296296, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI157672245, Length=246, Percent_Identity=29.6747967479675, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI2367136, Length=262, Percent_Identity=28.6259541984733, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787601, Length=184, Percent_Identity=34.7826086956522, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=26.530612244898, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790399, Length=298, Percent_Identity=25.1677852348993, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI87082132, Length=274, Percent_Identity=29.1970802919708, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081904, Length=147, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788481, Length=246, Percent_Identity=24.7967479674797, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=268, Percent_Identity=24.6268656716418, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790208, Length=279, Percent_Identity=26.8817204301075, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31437; Mature: 31437

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRQLRAFVVLAEQGNYHLAAERLCITQPALSKQIQALEALLGARLFNRGRQGAQLTAS
CCHHHEEEEEEEECCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
GQRLYPEAQALVGQHLQFQQRALRIVQGEAGRLAIGFGLSSFHLAPQLVAAFRQRFPEVA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCHHHH
VGLEDLPSERQYQLLLQGELQVGFVRLPVSKPLRASALLSDRLVLAAPAALALKAEAIIG
CCHHHCCCCCEEEEEEECCEEEEEEEECCCCCHHHHHHHHCCHHEECCHHHHHHHHHHHC
QFNTLPLLQLTPKRGRGLSEQSLRFIAAHQLVPNVVQQAGDIQTLLALVAAGIGVALLPH
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHH
SVSHIIPAGIDILPLSGEQTEWQVGIAWNPQQADALRDNFIQVALAAASVR
HHHHHCCCCCEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDIRQLRAFVVLAEQGNYHLAAERLCITQPALSKQIQALEALLGARLFNRGRQGAQLTAS
CCHHHEEEEEEEECCCCEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
GQRLYPEAQALVGQHLQFQQRALRIVQGEAGRLAIGFGLSSFHLAPQLVAAFRQRFPEVA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCHHHH
VGLEDLPSERQYQLLLQGELQVGFVRLPVSKPLRASALLSDRLVLAAPAALALKAEAIIG
CCHHHCCCCCEEEEEEECCEEEEEEEECCCCCHHHHHHHHCCHHEECCHHHHHHHHHHHC
QFNTLPLLQLTPKRGRGLSEQSLRFIAAHQLVPNVVQQAGDIQTLLALVAAGIGVALLPH
CCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHH
SVSHIIPAGIDILPLSGEQTEWQVGIAWNPQQADALRDNFIQVALAAASVR
HHHHHCCCCCEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]