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The map label for this gene is alsR [H]

Identifier: 157369648

GI number: 157369648

Start: 1530897

End: 1531805

Strand: Direct

Name: alsR [H]

Synonym: Spro_1405

Alternate gene names: 157369648

Gene position: 1530897-1531805 (Clockwise)

Preceding gene: 157369646

Following gene: 157369649

Centisome position: 28.1

GC content: 62.49

Gene sequence:

>909_bases
GTGATTGAACTACGCCAACTGCGGCAATTTATTGCCGTCGCGGAAGAAATGAGCTTTCACCGCGCCGCCGAGCGCTTGCA
TATGGCACAACCCCCGCTGACTGCCGCTATCCGAAAGATTGAGCAGGAGCTGGGCGTGCTGCTGCTGGAGCGCGGCAACC
GCGTCACCAGGATCACCGAAGCGGGGCAAGTGTTTCTGATTGAGGCGCGGCGAACGCTGGCGCAGTTTGAGCGCACCCTC
GGCAATACCCGCCGTGCGGCACGCGGTCTGACCGAATCGCTGCGCCTGACCTTCGTCGACAGCACGGTAAACGCTTTGTT
ACCGGGCATCCTGCGGCAGTTTCGTCAGGCGCATCCGCAGGCGGAGTTTCATTTGCAGGAGGCAACTACTGCCGAGCAAT
TGATCGCACTGCGCGATGACCGCGCCGACATTGGCATGGTGGTGCTGCCGGTAACGCCGCAAGAGGGCTTGCAGATCTTG
CCTTTCCTGTTCGATCGCATGGTGTTGGCATTGCCGGAAAACCACCCGCTGGCGACGCAGCAGCAAGTGACGTTGAGCAG
CCTGGCCGATCAACCCTGGGTGCTGTTTCCGGCGCATTACGGCCCCGGTATGCACACGGCGATCCTGCAGGCCTGTGCGG
TGGCGGGATTCAGTCCGCGTATCGTGCAGGAGGCACGGCAGATGCAGACCATCGGCGGGCTGGTGGCGGGCGGTGTGGGG
ATCGCGTTGATGCCGGCCCTGTTTGCAAGACTGCAATCCCCTGGCGTGGTGTTCCGCGAACTGAGCGGCGCAGGCAGCCC
GGTAGCCTATACGCTGGCGCTGGCGTGGCGCACGGCTTCACCGCTGACTGACGCTTTTTGTCGTATTGCCGCTGAACAGG
CGCTGAATTTGGCAACCTGCGGTGATTGA

Upstream 100 bases:

>100_bases
CCGGAATGGCGCAGCACTGTGCGGTCGGGAAAGTATTGGCTTTTGCTATTGATACATCCAATACTCTATTTATGCTTTCA
AAATACGAAAAAGGTATTGC

Downstream 100 bases:

>100_bases
CAACGCCCATACTGGGGGATACCTTAAAAGCATGAATATACCGATGCAATCCACACTCAATCAGTCCTGGTGGCGCCTCT
TCTAAAGGCGGCACGGGTAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MIELRQLRQFIAVAEEMSFHRAAERLHMAQPPLTAAIRKIEQELGVLLLERGNRVTRITEAGQVFLIEARRTLAQFERTL
GNTRRAARGLTESLRLTFVDSTVNALLPGILRQFRQAHPQAEFHLQEATTAEQLIALRDDRADIGMVVLPVTPQEGLQIL
PFLFDRMVLALPENHPLATQQQVTLSSLADQPWVLFPAHYGPGMHTAILQACAVAGFSPRIVQEARQMQTIGGLVAGGVG
IALMPALFARLQSPGVVFRELSGAGSPVAYTLALAWRTASPLTDAFCRIAAEQALNLATCGD

Sequences:

>Translated_302_residues
MIELRQLRQFIAVAEEMSFHRAAERLHMAQPPLTAAIRKIEQELGVLLLERGNRVTRITEAGQVFLIEARRTLAQFERTL
GNTRRAARGLTESLRLTFVDSTVNALLPGILRQFRQAHPQAEFHLQEATTAEQLIALRDDRADIGMVVLPVTPQEGLQIL
PFLFDRMVLALPENHPLATQQQVTLSSLADQPWVLFPAHYGPGMHTAILQACAVAGFSPRIVQEARQMQTIGGLVAGGVG
IALMPALFARLQSPGVVFRELSGAGSPVAYTLALAWRTASPLTDAFCRIAAEQALNLATCGD
>Mature_302_residues
MIELRQLRQFIAVAEEMSFHRAAERLHMAQPPLTAAIRKIEQELGVLLLERGNRVTRITEAGQVFLIEARRTLAQFERTL
GNTRRAARGLTESLRLTFVDSTVNALLPGILRQFRQAHPQAEFHLQEATTAEQLIALRDDRADIGMVVLPVTPQEGLQIL
PFLFDRMVLALPENHPLATQQQVTLSSLADQPWVLFPAHYGPGMHTAILQACAVAGFSPRIVQEARQMQTIGGLVAGGVG
IALMPALFARLQSPGVVFRELSGAGSPVAYTLALAWRTASPLTDAFCRIAAEQALNLATCGD

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=36.7588932806324, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI2367136, Length=260, Percent_Identity=31.9230769230769, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1788887, Length=297, Percent_Identity=32.6599326599327, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790399, Length=291, Percent_Identity=29.8969072164948, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI157672245, Length=249, Percent_Identity=32.9317269076305, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=29.7959183673469, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788748, Length=258, Percent_Identity=30.6201550387597, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87081904, Length=221, Percent_Identity=32.579185520362, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787530, Length=252, Percent_Identity=25.7936507936508, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788296, Length=238, Percent_Identity=28.1512605042017, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790262, Length=302, Percent_Identity=27.1523178807947, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=25.296442687747, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787806, Length=249, Percent_Identity=25.3012048192771, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790208, Length=297, Percent_Identity=26.5993265993266, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788481, Length=194, Percent_Identity=29.3814432989691, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787589, Length=173, Percent_Identity=29.4797687861272, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=204, Percent_Identity=23.0392156862745, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789506, Length=243, Percent_Identity=23.0452674897119, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786401, Length=173, Percent_Identity=30.0578034682081, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33068; Mature: 33068

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELRQLRQFIAVAEEMSFHRAAERLHMAQPPLTAAIRKIEQELGVLLLERGNRVTRITE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHCCCCEEEEEC
AGQVFLIEARRTLAQFERTLGNTRRAARGLTESLRLTFVDSTVNALLPGILRQFRQAHPQ
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCC
AEFHLQEATTAEQLIALRDDRADIGMVVLPVTPQEGLQILPFLFDRMVLALPENHPLATQ
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
QQVTLSSLADQPWVLFPAHYGPGMHTAILQACAVAGFSPRIVQEARQMQTIGGLVAGGVG
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IALMPALFARLQSPGVVFRELSGAGSPVAYTLALAWRTASPLTDAFCRIAAEQALNLATC
HHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
GD
CC
>Mature Secondary Structure
MIELRQLRQFIAVAEEMSFHRAAERLHMAQPPLTAAIRKIEQELGVLLLERGNRVTRITE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHCCCCEEEEEC
AGQVFLIEARRTLAQFERTLGNTRRAARGLTESLRLTFVDSTVNALLPGILRQFRQAHPQ
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCC
AEFHLQEATTAEQLIALRDDRADIGMVVLPVTPQEGLQILPFLFDRMVLALPENHPLATQ
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCH
QQVTLSSLADQPWVLFPAHYGPGMHTAILQACAVAGFSPRIVQEARQMQTIGGLVAGGVG
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IALMPALFARLQSPGVVFRELSGAGSPVAYTLALAWRTASPLTDAFCRIAAEQALNLATC
HHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCC
GD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]