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The map label for this gene is srpS [H]

Identifier: 157369577

GI number: 157369577

Start: 1465503

End: 1466282

Strand: Direct

Name: srpS [H]

Synonym: Spro_1334

Alternate gene names: 157369577

Gene position: 1465503-1466282 (Clockwise)

Preceding gene: 157369574

Following gene: 157369578

Centisome position: 26.9

GC content: 59.74

Gene sequence:

>780_bases
ATGTCCGAACCCTCAACATGTTGTGATGATGAAAAAACCGGCGGTATTCAGGTCATTACCCGTGCGGCTAAAATCCTCGA
TGCGCTGGGCGCCAAGCCCAATGGCATGAGCCTGGGCGAAATAGCGCTGGCGGTCGATCTGCCGCGTTCCACCGTGCAAC
GTATCGTCAACGCGCTGGACTCCGTGCAATTGGTGCGCGGCGGTGCCGGTGGTGTGCGCCTCGGACCGTCGTTGCTGCGG
CTGATTGCCAGCGTGCATACCGAAATGGTGTCGATTGCGACCCCCTGGCTGCAGGCTTTATGTGACGCCACCGGTGAGAC
GGTATCGCTGGGGCGCGCCAGCGGTTTGCAACTGGCGGTAGTGCACTACATTGTGGCGGATCGTGAGCTGCGAGTGGTGC
CACGCATCGGCATGAATCTGCCGCTGTACAGCACCTCCGGCGGGCGAGCGCTGCTGGCGTTGAACAGCGACGATGCGGCC
CGGGATTTACTGGGTGAGGCCTATAGGGCGGTGACGGATCTGACGGTGCGTGATTTTCCGGCACTGCTGCAGCACCTGAC
CGAAATACGCCGTACCGGCCTGTCCTTCGATCGGGAAGAAACGCTGGAAGGCGTCTCTACCATGGCGGTGGCTATCGACA
CCATTCTGGGGCGTTTCTCCATCAGTCTGTTAGTGCCCAGCACTCGTTTGGCCAAGAATGAAGCTCGCTTCCGCGAGGAG
ATCCTTAAGTGTAAAGACGCGTTGATCGATGAGATTGGCAAGGTGGCGTCGCGAGATTAA

Upstream 100 bases:

>100_bases
CATGCTACATTGTGATGCACTGTATTGCAATGTGGTACATCGTGCCGCCTGACCGGAAAAAATGTTACAGTGTGGTCAAA
AGCAAGGAAAAGAGCCTTCC

Downstream 100 bases:

>100_bases
CCGGAGAAGATAATGAAAACGCTGTTGGTTGCGGTTGATAATTCCGCTAATGCTCGTAAGGTCATTTCACTGGCTGCCGA
ACAGGCATTGGCGCAACAGG

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: Solvent efflux pump srpABC operon corepressor [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSEPSTCCDDEKTGGIQVITRAAKILDALGAKPNGMSLGEIALAVDLPRSTVQRIVNALDSVQLVRGGAGGVRLGPSLLR
LIASVHTEMVSIATPWLQALCDATGETVSLGRASGLQLAVVHYIVADRELRVVPRIGMNLPLYSTSGGRALLALNSDDAA
RDLLGEAYRAVTDLTVRDFPALLQHLTEIRRTGLSFDREETLEGVSTMAVAIDTILGRFSISLLVPSTRLAKNEARFREE
ILKCKDALIDEIGKVASRD

Sequences:

>Translated_259_residues
MSEPSTCCDDEKTGGIQVITRAAKILDALGAKPNGMSLGEIALAVDLPRSTVQRIVNALDSVQLVRGGAGGVRLGPSLLR
LIASVHTEMVSIATPWLQALCDATGETVSLGRASGLQLAVVHYIVADRELRVVPRIGMNLPLYSTSGGRALLALNSDDAA
RDLLGEAYRAVTDLTVRDFPALLQHLTEIRRTGLSFDREETLEGVSTMAVAIDTILGRFSISLLVPSTRLAKNEARFREE
ILKCKDALIDEIGKVASRD
>Mature_258_residues
SEPSTCCDDEKTGGIQVITRAAKILDALGAKPNGMSLGEIALAVDLPRSTVQRIVNALDSVQLVRGGAGGVRLGPSLLRL
IASVHTEMVSIATPWLQALCDATGETVSLGRASGLQLAVVHYIVADRELRVVPRIGMNLPLYSTSGGRALLALNSDDAAR
DLLGEAYRAVTDLTVRDFPALLQHLTEIRRTGLSFDREETLEGVSTMAVAIDTILGRFSISLLVPSTRLAKNEARFREEI
LKCKDALIDEIGKVASRD

Specific function: In conjunction with srpR represses the srpABC operon [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1789999, Length=258, Percent_Identity=27.5193798449612, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1786715, Length=230, Percent_Identity=29.1304347826087, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788131, Length=242, Percent_Identity=28.099173553719, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87082359, Length=212, Percent_Identity=27.3584905660377, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786468, Length=252, Percent_Identity=28.1746031746032, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27730; Mature: 27599

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPSTCCDDEKTGGIQVITRAAKILDALGAKPNGMSLGEIALAVDLPRSTVQRIVNALD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEECCHHHHHHHHHHHH
SVQLVRGGAGGVRLGPSLLRLIASVHTEMVSIATPWLQALCDATGETVSLGRASGLQLAV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHH
VHYIVADRELRVVPRIGMNLPLYSTSGGRALLALNSDDAARDLLGEAYRAVTDLTVRDFP
HHHHHHCCCEEEECCCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ALLQHLTEIRRTGLSFDREETLEGVSTMAVAIDTILGRFSISLLVPSTRLAKNEARFREE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHH
ILKCKDALIDEIGKVASRD
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEPSTCCDDEKTGGIQVITRAAKILDALGAKPNGMSLGEIALAVDLPRSTVQRIVNALD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEECCHHHHHHHHHHHH
SVQLVRGGAGGVRLGPSLLRLIASVHTEMVSIATPWLQALCDATGETVSLGRASGLQLAV
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHH
VHYIVADRELRVVPRIGMNLPLYSTSGGRALLALNSDDAARDLLGEAYRAVTDLTVRDFP
HHHHHHCCCEEEECCCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
ALLQHLTEIRRTGLSFDREETLEGVSTMAVAIDTILGRFSISLLVPSTRLAKNEARFREE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHH
ILKCKDALIDEIGKVASRD
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA