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The map label for this gene is uvrB

Identifier: 157369560

GI number: 157369560

Start: 1447442

End: 1449454

Strand: Direct

Name: uvrB

Synonym: Spro_1317

Alternate gene names: 157369560

Gene position: 1447442-1449454 (Clockwise)

Preceding gene: 157369557

Following gene: 157369561

Centisome position: 26.56

GC content: 56.63

Gene sequence:

>2013_bases
ATGAGTAAAGTTTTCAAACTGCATTCCGAATTCAAACCGGCCGGCGATCAGCCGCAGGCCATCAGCAAGCTGGAAGAGGG
CCTGGAAGACGGCCTGGCACACCAGACGCTGCTGGGCGTTACCGGGTCGGGCAAGACATTTACCGTCGCCAATGTGATAG
CCGATCTGAACCGGCCCACCATGGTGCTGGCACCTAACAAAACGCTGGCGGCGCAGCTGTACGGCGAGATGAAAGAGTTC
TTTCCCGAGAATGCGGTCGAGTATTTTGTCTCTTACTACGACTACTATCAGCCGGAAGCCTACGTACCCAGCTCCGACAC
CTTTATCGAAAAAGACGCTGCGGTGAACGAACACATCGAGCAGATGCGTCTTTCCGCGACCAAAGCATTGCTGGAGCGCC
GCGATGTGATCGTGGTGGCGTCGGTCTCGGCGATCTACGGTCTGGGCGATCCTGATCTGTATCTGAAGATGATGTTGCAC
CTGACCAAGGGCATGATCATCGATCAGCGTTCGATCCTGCGTCGTTTGGCGGAGCTGCAATATGCCCGTAACGATCAGGC
CTTCCAGCGCGCGACCTTCCGCGTGCGTGGCGAGGTGATCGACGTCTTTCCGGCGGAGTCGGACGAGCTGGCGCTGCGTA
TTGAACTGTTTGATGAGGAGGTCGAGCGGCTTTCGCTGTTTGATCCTTTGACCGGCCAGATCGAACAGGTGGTCCAGCGT
TTTACCATTTATCCGAAGTCGCACTACGTGACGCCGCGTGAGCGGATCCTGCAGGCGATGGAAGAGATCAAAGTGGATCT
GGCCGAACGGCGCAAGGTGCTGTTGGCCAATAACAAACTGCTGGAAGAGCAGCGCCTGACGCAGCGCACCCAGTTTGATC
TGGAGATGATGAAAGAACTGGGCTACTGCTCCGGTATTGAAAACTACTCGCGCTACCTGTCCGGACGTAAAGAGGGCGAG
CCACCGCCGACGCTGTTTGATTATTTACCGGCGGATGGCCTGCTGGTGGTCGATGAATCCCACGTCACCATTCCGCAAAT
CGGCGCTATGTACAAGGGCGACCGTTCGCGCAAAGAGACGCTGGTGGAATACGGTTTCCGCCTGCCGTCGGCGCTGGACA
ACCGCCCGATGCGTTTTGAAGAGTTCGAAGCGCTGGCCCCACAGACGATCTACGTGTCTGCCACGCCGGGCAAATATGAG
CTGGAGAAGTCCGGCGACGATATTATCGATCAGGTGGTGCGCCCTACCGGCTTGCTGGATCCACTAATAGAAGTCAGGCC
GGTGACCACCCAGGTGGATGACCTGCTGTCTGAAATTCGCAAGCGGGTGGCAATCAACGAGCGCGTACTGGTCACCACCC
TGACCAAACGCATGGCGGAAGACCTGACCGAATATCTCGAAGAGCACGGCGAGCGGGTACGCTATCTGCACTCGGACATA
GATACCGTGGAAAGGGTCGAAATCATTCGTGACCTGCGCCTGGGTGAGTTTGACGTGCTGGTGGGTATCAACCTGTTGCG
TGAGGGGCTGGACATGCCTGAGGTGTCGCTGGTGGCGATTCTGGACGCAGATAAAGAAGGCTTCCTGCGTTCCGAACGTT
CGCTAATCCAGACTATTGGTCGTGCGGCGCGTAACCTCAATGGTAAAGCGATCCTCTACGGTGACAGAATTACCGACTCG
ATGGCCAGGGCGATTAGCGAGACCGAACGTCGTCGCGCCAAACAGCAGGCGTTCAACGAAGAAAATGGCATCGTGCCGCA
GGGCCTGAACAAGAAAGTTTCCGATGTATTGCAGCTGGGCAAACCGGGTAATCGCGGCAAGGGCAGAGGGAAGGGCAAGG
CGGCGGAAAACGTTGGGCAATACAAAAATCTCACGCCAAAAGCCCTGGATCAAAAAATCCGCGAGCTGGAAGCGCAGATG
TATACCCACGCACAGAATCTGGAGTTCGAGTTGGCGGCAGGCTTGCGTGATGAGATCCACCAGCTGCGCGAGCAGTTTAT
CGCTATTTCGTGA

Upstream 100 bases:

>100_bases
TGGCAAAAATCGCCGGGGCTTTCCATAATTAGAGGCCATCAATTGAGCATTAGCTCTATGGCCGCCTGAGCGCGCACATC
TCCACAGGGTAGCCGAGTCC

Downstream 100 bases:

>100_bases
CCGGTTGGGGCGCCGCCAGGGGTGGCGCTGCCAAACATAAAATCCTTGTCGCCTCCGCCAAAGCTGATTATGGTGTGCGG
CCAATTGACTACTACGAGCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 670; Mature: 669

Protein sequence:

>670_residues
MSKVFKLHSEFKPAGDQPQAISKLEEGLEDGLAHQTLLGVTGSGKTFTVANVIADLNRPTMVLAPNKTLAAQLYGEMKEF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAVNEHIEQMRLSATKALLERRDVIVVASVSAIYGLGDPDLYLKMMLH
LTKGMIIDQRSILRRLAELQYARNDQAFQRATFRVRGEVIDVFPAESDELALRIELFDEEVERLSLFDPLTGQIEQVVQR
FTIYPKSHYVTPRERILQAMEEIKVDLAERRKVLLANNKLLEEQRLTQRTQFDLEMMKELGYCSGIENYSRYLSGRKEGE
PPPTLFDYLPADGLLVVDESHVTIPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFEEFEALAPQTIYVSATPGKYE
LEKSGDDIIDQVVRPTGLLDPLIEVRPVTTQVDDLLSEIRKRVAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
DTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDRITDS
MARAISETERRRAKQQAFNEENGIVPQGLNKKVSDVLQLGKPGNRGKGRGKGKAAENVGQYKNLTPKALDQKIRELEAQM
YTHAQNLEFELAAGLRDEIHQLREQFIAIS

Sequences:

>Translated_670_residues
MSKVFKLHSEFKPAGDQPQAISKLEEGLEDGLAHQTLLGVTGSGKTFTVANVIADLNRPTMVLAPNKTLAAQLYGEMKEF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAVNEHIEQMRLSATKALLERRDVIVVASVSAIYGLGDPDLYLKMMLH
LTKGMIIDQRSILRRLAELQYARNDQAFQRATFRVRGEVIDVFPAESDELALRIELFDEEVERLSLFDPLTGQIEQVVQR
FTIYPKSHYVTPRERILQAMEEIKVDLAERRKVLLANNKLLEEQRLTQRTQFDLEMMKELGYCSGIENYSRYLSGRKEGE
PPPTLFDYLPADGLLVVDESHVTIPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFEEFEALAPQTIYVSATPGKYE
LEKSGDDIIDQVVRPTGLLDPLIEVRPVTTQVDDLLSEIRKRVAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
DTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDRITDS
MARAISETERRRAKQQAFNEENGIVPQGLNKKVSDVLQLGKPGNRGKGRGKGKAAENVGQYKNLTPKALDQKIRELEAQM
YTHAQNLEFELAAGLRDEIHQLREQFIAIS
>Mature_669_residues
SKVFKLHSEFKPAGDQPQAISKLEEGLEDGLAHQTLLGVTGSGKTFTVANVIADLNRPTMVLAPNKTLAAQLYGEMKEFF
PENAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAVNEHIEQMRLSATKALLERRDVIVVASVSAIYGLGDPDLYLKMMLHL
TKGMIIDQRSILRRLAELQYARNDQAFQRATFRVRGEVIDVFPAESDELALRIELFDEEVERLSLFDPLTGQIEQVVQRF
TIYPKSHYVTPRERILQAMEEIKVDLAERRKVLLANNKLLEEQRLTQRTQFDLEMMKELGYCSGIENYSRYLSGRKEGEP
PPTLFDYLPADGLLVVDESHVTIPQIGAMYKGDRSRKETLVEYGFRLPSALDNRPMRFEEFEALAPQTIYVSATPGKYEL
EKSGDDIIDQVVRPTGLLDPLIEVRPVTTQVDDLLSEIRKRVAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDID
TVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNLNGKAILYGDRITDSM
ARAISETERRRAKQQAFNEENGIVPQGLNKKVSDVLQLGKPGNRGKGRGKGKAAENVGQYKNLTPKALDQKIRELEAQMY
THAQNLEFELAAGLRDEIHQLREQFIAIS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=675, Percent_Identity=85.4814814814815, Blast_Score=1157, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=22.1498371335505, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_SERP5 (A8GBD1)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477549.1
- ProteinModelPortal:   A8GBD1
- STRING:   A8GBD1
- GeneID:   5605516
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1317
- eggNOG:   COG0556
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   SPRO399741:SPRO_1317-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76135; Mature: 76004

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVFKLHSEFKPAGDQPQAISKLEEGLEDGLAHQTLLGVTGSGKTFTVANVIADLNRPT
CCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHEEECCCCCEEHHHHHHHHCCCCE
MVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAVNEHIE
EEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
QMRLSATKALLERRDVIVVASVSAIYGLGDPDLYLKMMLHLTKGMIIDQRSILRRLAELQ
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCEECHHHHHHHHHHHH
YARNDQAFQRATFRVRGEVIDVFPAESDELALRIELFDEEVERLSLFDPLTGQIEQVVQR
HHCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHH
FTIYPKSHYVTPRERILQAMEEIKVDLAERRKVLLANNKLLEEQRLTQRTQFDLEMMKEL
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
GYCSGIENYSRYLSGRKEGEPPPTLFDYLPADGLLVVDESHVTIPQIGAMYKGDRSRKET
HHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHH
LVEYGFRLPSALDNRPMRFEEFEALAPQTIYVSATPGKYELEKSGDDIIDQVVRPTGLLD
HHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCEECCCCCHHHHHHHHCCCCHHC
PLIEVRPVTTQVDDLLSEIRKRVAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
HHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLNGKAILYGDRITDSMARAISETERRRAKQQAFNEENGIVPQGLNKKVSDVLQLG
HHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
KPGNRGKGRGKGKAAENVGQYKNLTPKALDQKIRELEAQMYTHAQNLEFELAAGLRDEIH
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHH
QLREQFIAIS
HHHHHHHCCC
>Mature Secondary Structure 
SKVFKLHSEFKPAGDQPQAISKLEEGLEDGLAHQTLLGVTGSGKTFTVANVIADLNRPT
CCHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHEEECCCCCEEHHHHHHHHCCCCE
MVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDAAVNEHIE
EEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
QMRLSATKALLERRDVIVVASVSAIYGLGDPDLYLKMMLHLTKGMIIDQRSILRRLAELQ
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHCCEECHHHHHHHHHHHH
YARNDQAFQRATFRVRGEVIDVFPAESDELALRIELFDEEVERLSLFDPLTGQIEQVVQR
HHCCCHHHHHHHHHCCCCEEEECCCCCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHH
FTIYPKSHYVTPRERILQAMEEIKVDLAERRKVLLANNKLLEEQRLTQRTQFDLEMMKEL
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
GYCSGIENYSRYLSGRKEGEPPPTLFDYLPADGLLVVDESHVTIPQIGAMYKGDRSRKET
HHHCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCHHHHH
LVEYGFRLPSALDNRPMRFEEFEALAPQTIYVSATPGKYELEKSGDDIIDQVVRPTGLLD
HHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCEECCCCCHHHHHHHHCCCCHHC
PLIEVRPVTTQVDDLLSEIRKRVAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
HHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTVERVEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNLNGKAILYGDRITDSMARAISETERRRAKQQAFNEENGIVPQGLNKKVSDVLQLG
HHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCC
KPGNRGKGRGKGKAAENVGQYKNLTPKALDQKIRELEAQMYTHAQNLEFELAAGLRDEIH
CCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHH
QLREQFIAIS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA