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The map label for this gene is bioC [H]

Identifier: 157369556

GI number: 157369556

Start: 1442234

End: 1443001

Strand: Direct

Name: bioC [H]

Synonym: Spro_1313

Alternate gene names: 157369556

Gene position: 1442234-1443001 (Clockwise)

Preceding gene: 157369555

Following gene: 157369557

Centisome position: 26.47

GC content: 61.59

Gene sequence:

>768_bases
ATGACGTCAGCGTTTGAACCGATCAATAAGCAGGCGGTGGCCTCGGCCTTCAGCCGTGCCGCTGGCAGCTATGACGCGGC
GGCGGTGCTGCAGCGTGAAGTTGGTGAGCGCTTGCTGGGGATGGGACGGGATCACCGGGGTGAACAACTGCTGGATGCGG
GCTGTGGCACCGGCCATTTCAGCCGCCGCTGGCGCGAACTCGGCAAACAGGTTACTGCACTGGATCTGGCACCGGGCATG
CTGGCGTTTGCCCGTCAGCAGCAGGCGGCGGATCATTATCTGCTGGGGGATATCGAAAATGTGCCCTTGCCCGACGCTGC
GGTGGATATCTGCTTCAGCAGCCTGGTAGTGCAATGGTGTAGCGACCTGCCGCGCGCCTTGGCGGAGCTATATCGGGTTA
CCCGCCCCGGCGGTGTGATCCTGTTTTCTACGCTGGCACAAGGATCGCTGGGCGAACTGGGTGACGCCTGGCAGCAGGTG
GACGGTGAACGCCATGTGAATGATTTTCTGCCGCTGGCGCAGATTAGCGCAGCCTGCGCCGACTATCGGCACCAGTTGGA
AGTGGAGTGGCAAACCCTGAATTACCCGGATGTGATGGCGCTGATGCGATCGCTCAAGGGGATCGGGGCGACCCATTTAC
ATCAGGGGCGTGATGCCGGGCTGCTGTCGCGCCGACGGCTTGCGGCCTTGCAGGCGGCTTACCCCTGCCGGCGCGGGCAA
TTCCCGCTCAGTTATCATCTGGTTTATGGAGTGATTTATCGTGATTAA

Upstream 100 bases:

>100_bases
ATCCGCCCGCCAACGGTGCCACCGGGCGGCGCGCGCTTGCGCATTACCCTGACGGCGGCACATCAGCCGCAGGATATCGA
TCGTCTGCTGGAGGTATTGC

Downstream 100 bases:

>100_bases
GCGTTGGTTTGTCACCGGCACCGATACCGAAGTGGGCAAAACCGTGGCCAGCAGCGCCTTGTTGCAGGCGGCGAATCTGG
CGGGTTACCGCACTGCCGGT

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MTSAFEPINKQAVASAFSRAAGSYDAAAVLQREVGERLLGMGRDHRGEQLLDAGCGTGHFSRRWRELGKQVTALDLAPGM
LAFARQQQAADHYLLGDIENVPLPDAAVDICFSSLVVQWCSDLPRALAELYRVTRPGGVILFSTLAQGSLGELGDAWQQV
DGERHVNDFLPLAQISAACADYRHQLEVEWQTLNYPDVMALMRSLKGIGATHLHQGRDAGLLSRRRLAALQAAYPCRRGQ
FPLSYHLVYGVIYRD

Sequences:

>Translated_255_residues
MTSAFEPINKQAVASAFSRAAGSYDAAAVLQREVGERLLGMGRDHRGEQLLDAGCGTGHFSRRWRELGKQVTALDLAPGM
LAFARQQQAADHYLLGDIENVPLPDAAVDICFSSLVVQWCSDLPRALAELYRVTRPGGVILFSTLAQGSLGELGDAWQQV
DGERHVNDFLPLAQISAACADYRHQLEVEWQTLNYPDVMALMRSLKGIGATHLHQGRDAGLLSRRRLAALQAAYPCRRGQ
FPLSYHLVYGVIYRD
>Mature_254_residues
TSAFEPINKQAVASAFSRAAGSYDAAAVLQREVGERLLGMGRDHRGEQLLDAGCGTGHFSRRWRELGKQVTALDLAPGML
AFARQQQAADHYLLGDIENVPLPDAAVDICFSSLVVQWCSDLPRALAELYRVTRPGGVILFSTLAQGSLGELGDAWQQVD
GERHVNDFLPLAQISAACADYRHQLEVEWQTLNYPDVMALMRSLKGIGATHLHQGRDAGLLSRRRLAALQAAYPCRRGQF
PLSYHLVYGVIYRD

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=242, Percent_Identity=28.5123966942149, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1786994, Length=248, Percent_Identity=53.2258064516129, Blast_Score=243, Evalue=1e-65,
Organism=Drosophila melanogaster, GI19922210, Length=265, Percent_Identity=26.4150943396226, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 28063; Mature: 27932

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAFEPINKQAVASAFSRAAGSYDAAAVLQREVGERLLGMGRDHRGEQLLDAGCGTGHF
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHH
SRRWRELGKQVTALDLAPGMLAFARQQQAADHYLLGDIENVPLPDAAVDICFSSLVVQWC
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHH
SDLPRALAELYRVTRPGGVILFSTLAQGSLGELGDAWQQVDGERHVNDFLPLAQISAACA
HHHHHHHHHHHHHCCCCCEEEEHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DYRHQLEVEWQTLNYPDVMALMRSLKGIGATHLHQGRDAGLLSRRRLAALQAAYPCRRGQ
HHHHHEEEEEEECCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
FPLSYHLVYGVIYRD
CCHHHHHHHEEEECC
>Mature Secondary Structure 
TSAFEPINKQAVASAFSRAAGSYDAAAVLQREVGERLLGMGRDHRGEQLLDAGCGTGHF
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHH
SRRWRELGKQVTALDLAPGMLAFARQQQAADHYLLGDIENVPLPDAAVDICFSSLVVQWC
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHH
SDLPRALAELYRVTRPGGVILFSTLAQGSLGELGDAWQQVDGERHVNDFLPLAQISAACA
HHHHHHHHHHHHHCCCCCEEEEHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
DYRHQLEVEWQTLNYPDVMALMRSLKGIGATHLHQGRDAGLLSRRRLAALQAAYPCRRGQ
HHHHHEEEEEEECCCHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
FPLSYHLVYGVIYRD
CCHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]