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The map label for this gene is nadA

Identifier: 157369525

GI number: 157369525

Start: 1409507

End: 1410568

Strand: Direct

Name: nadA

Synonym: Spro_1282

Alternate gene names: 157369525

Gene position: 1409507-1410568 (Clockwise)

Preceding gene: 157369524

Following gene: 157369526

Centisome position: 25.87

GC content: 58.0

Gene sequence:

>1062_bases
ATGAGTGAAATGTTTGATGTTAATGCGGCGGTGTACCCGTTCCCGCCCAAGCCGGTACCGCTGGACGACGCGCAGAAGGC
GTTTTACCGCGAGAAGATTAAAATCCTGCTCAAGCAGCGTAATGCGGTGATGGTAGCCCATTACTATACCGATCCGGAGA
TCCAGGCGCTGGCGGAAGAAACCGGTGGCTGCGTGGCGGACTCGCTGGAGATGGCGCGCTTTGGCAGCAATCATCCGGCT
TCGACCCTGCTGGTTGCCGGGGTGCGTTTTATGGGGGAAACCGCCAAGATCCTCAGCCCCGAAAAACGGGTGCTGATGCC
GACGCTGAACGCGGAGTGCTCGCTGGATCTCGGTTGCCCGGAAGAAGAATTCAATGCCTTTTGCGACAGCCACCCGGACA
GAACCGTGGTGGTCTACGCTAATACCTCAGCGGCGGTAAAAGCTCGGGCGGACTGGGTGGTCACCTCCAGTATCGCCGTT
GAACTGATTGAACATCTCGACAGCCTGGGTGAGAAAATCATCTGGGCGCCGGATCGCCATCTGGGGAGCTATGTGCAAAA
GCAAACCGGTGCAGATATGCTGTGCTGGCAGGGGGCCTGTATCGTCCATGACGAGTTTAAAACCCAGGCCCTGATGCGGA
TGAAGGCCTTGTACCCGAACGCGGCGATACTGGTGCATCCGGAGTCACCACAGGCGGTGGTCAGCCTGGCCGATGCGGTA
GGCTCAACCAGCCAATTGATTCAGGCGGCGAAAACCCTGCCTAATTCGCAGCTGATTGTTGCCACCGATCGCGGTATTTT
TTATAAGATGCAACAGGCCTGCCCGGACAAAGAGTTGTTCGAAGCGCCAACCGCCGGGGAAGGTGCCACCTGTCGCAGCT
GCGCACACTGCCCGTGGATGGCGATGAATGGCCTGAAGGCTATCGCCGATGGGCTGGAGCACGGTGGTGTACTGCATGAG
ATCCATGTCGATGCCGCGTTGCGTCAGAAGGCGCTGATCCCGCTGAACCGGATGTTGGATTTCGCCGCTGAGTTAAGGGT
GCAGGTTAAAGGGAACGCTTAA

Upstream 100 bases:

>100_bases
GCACAAATAAAGGTATTTTGTTTAGTATATAAAACGAAGGGGGTTGCGATGGGGTGATACCCGGGCAGCAGACACCCAGC
CTAGCACAGAGATTGCAGCG

Downstream 100 bases:

>100_bases
CCATTTAATAAGGAAGATAAAATGAGCTTTTTCAGTACCAGCAATATCCTGGTGCATATCCCGCTGGGAGCGGGGGGCTA
CGATCTGTCATGGATTGAGG

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSEMFDVNAAVYPFPPKPVPLDDAQKAFYREKIKILLKQRNAVMVAHYYTDPEIQALAEETGGCVADSLEMARFGSNHPA
STLLVAGVRFMGETAKILSPEKRVLMPTLNAECSLDLGCPEEEFNAFCDSHPDRTVVVYANTSAAVKARADWVVTSSIAV
ELIEHLDSLGEKIIWAPDRHLGSYVQKQTGADMLCWQGACIVHDEFKTQALMRMKALYPNAAILVHPESPQAVVSLADAV
GSTSQLIQAAKTLPNSQLIVATDRGIFYKMQQACPDKELFEAPTAGEGATCRSCAHCPWMAMNGLKAIADGLEHGGVLHE
IHVDAALRQKALIPLNRMLDFAAELRVQVKGNA

Sequences:

>Translated_353_residues
MSEMFDVNAAVYPFPPKPVPLDDAQKAFYREKIKILLKQRNAVMVAHYYTDPEIQALAEETGGCVADSLEMARFGSNHPA
STLLVAGVRFMGETAKILSPEKRVLMPTLNAECSLDLGCPEEEFNAFCDSHPDRTVVVYANTSAAVKARADWVVTSSIAV
ELIEHLDSLGEKIIWAPDRHLGSYVQKQTGADMLCWQGACIVHDEFKTQALMRMKALYPNAAILVHPESPQAVVSLADAV
GSTSQLIQAAKTLPNSQLIVATDRGIFYKMQQACPDKELFEAPTAGEGATCRSCAHCPWMAMNGLKAIADGLEHGGVLHE
IHVDAALRQKALIPLNRMLDFAAELRVQVKGNA
>Mature_352_residues
SEMFDVNAAVYPFPPKPVPLDDAQKAFYREKIKILLKQRNAVMVAHYYTDPEIQALAEETGGCVADSLEMARFGSNHPAS
TLLVAGVRFMGETAKILSPEKRVLMPTLNAECSLDLGCPEEEFNAFCDSHPDRTVVVYANTSAAVKARADWVVTSSIAVE
LIEHLDSLGEKIIWAPDRHLGSYVQKQTGADMLCWQGACIVHDEFKTQALMRMKALYPNAAILVHPESPQAVVSLADAVG
STSQLIQAAKTLPNSQLIVATDRGIFYKMQQACPDKELFEAPTAGEGATCRSCAHCPWMAMNGLKAIADGLEHGGVLHEI
HVDAALRQKALIPLNRMLDFAAELRVQVKGNA

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=346, Percent_Identity=83.5260115606936, Blast_Score=615, Evalue=1e-177,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_SERP5 (A8GB96)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477514.1
- STRING:   A8GB96
- GeneID:   5605367
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1282
- eggNOG:   COG0379
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- BioCyc:   SPRO399741:SPRO_1282-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00567
- InterPro:   IPR003473
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 38504; Mature: 38372

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: BINDING 47-47 BINDING 68-68 BINDING 139-139 BINDING 156-156 BINDING 226-226 BINDING 243-243

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMFDVNAAVYPFPPKPVPLDDAQKAFYREKIKILLKQRNAVMVAHYYTDPEIQALAEE
CCCCEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHH
TGGCVADSLEMARFGSNHPASTLLVAGVRFMGETAKILSPEKRVLMPTLNAECSLDLGCP
HCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCEEEECCCC
EEEFNAFCDSHPDRTVVVYANTSAAVKARADWVVTSSIAVELIEHLDSLGEKIIWAPDRH
HHHHHHHHCCCCCCEEEEEECCCCEEEECCCEEEHHHHHHHHHHHHHHHCCEEEECCCHH
LGSYVQKQTGADMLCWQGACIVHDEFKTQALMRMKALYPNAAILVHPESPQAVVSLADAV
HHHHHHHHCCCCEEEECCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
GSTSQLIQAAKTLPNSQLIVATDRGIFYKMQQACPDKELFEAPTAGEGATCRSCAHCPWM
CCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHCCCCCCCCCCCHHHCCCCHH
AMNGLKAIADGLEHGGVLHEIHVDAALRQKALIPLNRMLDFAAELRVQVKGNA
HHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHEEEEEECCC
>Mature Secondary Structure 
SEMFDVNAAVYPFPPKPVPLDDAQKAFYREKIKILLKQRNAVMVAHYYTDPEIQALAEE
CCCEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHH
TGGCVADSLEMARFGSNHPASTLLVAGVRFMGETAKILSPEKRVLMPTLNAECSLDLGCP
HCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCEEEECCCC
EEEFNAFCDSHPDRTVVVYANTSAAVKARADWVVTSSIAVELIEHLDSLGEKIIWAPDRH
HHHHHHHHCCCCCCEEEEEECCCCEEEECCCEEEHHHHHHHHHHHHHHHCCEEEECCCHH
LGSYVQKQTGADMLCWQGACIVHDEFKTQALMRMKALYPNAAILVHPESPQAVVSLADAV
HHHHHHHHCCCCEEEECCEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHH
GSTSQLIQAAKTLPNSQLIVATDRGIFYKMQQACPDKELFEAPTAGEGATCRSCAHCPWM
CCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCHHHHCCCCCCCCCCCHHHCCCCHH
AMNGLKAIADGLEHGGVLHEIHVDAALRQKALIPLNRMLDFAAELRVQVKGNA
HHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHCCCHHHHHHHHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA