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The map label for this gene is mscM [H]

Identifier: 157369291

GI number: 157369291

Start: 1152819

End: 1154084

Strand: Reverse

Name: mscM [H]

Synonym: Spro_1048

Alternate gene names: 157369291

Gene position: 1154084-1152819 (Counterclockwise)

Preceding gene: 157369293

Following gene: 157369290

Centisome position: 21.18

GC content: 56.79

Gene sequence:

>1266_bases
ATGCAACAACAGATAACCCTGTGGCTGGAGAAGTTCGGGCTGGAATTTAGCGGGGTGATGTCTCTGCTGATGGTGCTGGG
GCTGATCGTCCTGATTTCGGTGGTGATCCATCTGGTGCTGCACCGCGTAGTGCTGAGGGCAATCCAGCGCCGTGGCCAGC
AATCGCAACGCGTATGGCAACAGGCAATCACCCAATACAAGCTGTTCCAGCGTATGGCGTTGTTATTGCAGGGGGTGATC
ATTAATCTGCAGGCGGTGCTGTGGTTACACGCCGGTGGCCAGACGCAGGCGGTTATCGTCACCGCCGCCCAGGTGTGGAT
CATGGGCTTCGCCCTGCTGTCGTTGTTTTCCCTGTTGGATACGCTGTTGGCGATGCTGCGCCAAAGCCCGATTTCAAACC
AGTTGCCGCTGCGTGGCATTTTCCAGGGGCTGAAGCTGGTAGCCGCCATCCTGATCGGCATCATGATCGTCTCCTTGCTG
ATGGGTAAGTCACCCTTGCTGCTGCTCAGCGGTCTGGGTGCAATGACCGCGGTGCTGATGTTGGTGTTTAAAGACCCGAT
CCTCGGTCTGGTGGCCGGTATTCAGCTTTCCGCCAACGATATGCTTAGCATCGGCGACTGGCTGGAGATGCCGAAATACG
GCGCAGACGGTGCGGTCACCGACATCGGCCTGACCACGGTAAAAGTGCGCAACTGGGATAACACCGTCACCACCATCCCG
ACCTACGCGCTGATCTCCGACTCTTTTAAAAACTGGCGCTCCATGTCGGAATCCGGCGGGCGTCGCATCAAGCGCAGCAT
CAATATCGACACCACCAGCGTCCATTTCTTGTCGGATGAAGAACAGCAGCGGCTGAACCGCAACCCACTGCTGCAACGCT
ATCTGAACGATAAAACGCAGGAGTTAAGCCAACATAACCAGCAGATTGCCGTAGATCTCAGTTCCCCCCTCAACGGCCGC
CGCCTGACCAACCTTGGCACGCTGCGCGCTTATCTGGTGGCATACCTGCGCGCCCACCCGAATATTCATCAGAATATGAC
GCTGATGGTGCGCCAATTAGCGCCAACGCCGGAGGGCCTGCCGCTGGAGATTTACGCCTTCACCAACACCACGGTCTGGG
CGGAATACGAAAGTATTCAATCAGATATCTTCGACCATATTCTGGCGGTGATTAACGAATTCGACCTGCGTGTCCATCAA
ACGCCAACCGGCAACGATATGCGCAGCATGCTGAGCCAAATGCGCCAGGCGCCCGACCTTTCCTGA

Upstream 100 bases:

>100_bases
GTAAAAAAGGGTAAAAAGACGCACATTGTGGCCCGCAGCCATTAGGCTAACGTGTTTTGAGTCTATTGGATATTTTTTGC
ACATTTTTTAAGGAGCGGCA

Downstream 100 bases:

>100_bases
CGCAGGTTGACGTAACTGTTTCTGCCGGTAATGACTCTCAACCCAGGGACAACGGATGTCTCGGTCCGCTTCTCTTTCGG
CATAAAAACCGCGTTAATGC

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MQQQITLWLEKFGLEFSGVMSLLMVLGLIVLISVVIHLVLHRVVLRAIQRRGQQSQRVWQQAITQYKLFQRMALLLQGVI
INLQAVLWLHAGGQTQAVIVTAAQVWIMGFALLSLFSLLDTLLAMLRQSPISNQLPLRGIFQGLKLVAAILIGIMIVSLL
MGKSPLLLLSGLGAMTAVLMLVFKDPILGLVAGIQLSANDMLSIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSDEEQQRLNRNPLLQRYLNDKTQELSQHNQQIAVDLSSPLNGR
RLTNLGTLRAYLVAYLRAHPNIHQNMTLMVRQLAPTPEGLPLEIYAFTNTTVWAEYESIQSDIFDHILAVINEFDLRVHQ
TPTGNDMRSMLSQMRQAPDLS

Sequences:

>Translated_421_residues
MQQQITLWLEKFGLEFSGVMSLLMVLGLIVLISVVIHLVLHRVVLRAIQRRGQQSQRVWQQAITQYKLFQRMALLLQGVI
INLQAVLWLHAGGQTQAVIVTAAQVWIMGFALLSLFSLLDTLLAMLRQSPISNQLPLRGIFQGLKLVAAILIGIMIVSLL
MGKSPLLLLSGLGAMTAVLMLVFKDPILGLVAGIQLSANDMLSIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSDEEQQRLNRNPLLQRYLNDKTQELSQHNQQIAVDLSSPLNGR
RLTNLGTLRAYLVAYLRAHPNIHQNMTLMVRQLAPTPEGLPLEIYAFTNTTVWAEYESIQSDIFDHILAVINEFDLRVHQ
TPTGNDMRSMLSQMRQAPDLS
>Mature_421_residues
MQQQITLWLEKFGLEFSGVMSLLMVLGLIVLISVVIHLVLHRVVLRAIQRRGQQSQRVWQQAITQYKLFQRMALLLQGVI
INLQAVLWLHAGGQTQAVIVTAAQVWIMGFALLSLFSLLDTLLAMLRQSPISNQLPLRGIFQGLKLVAAILIGIMIVSLL
MGKSPLLLLSGLGAMTAVLMLVFKDPILGLVAGIQLSANDMLSIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSDEEQQRLNRNPLLQRYLNDKTQELSQHNQQIAVDLSSPLNGR
RLTNLGTLRAYLVAYLRAHPNIHQNMTLMVRQLAPTPEGLPLEIYAFTNTTVWAEYESIQSDIFDHILAVINEFDLRVHQ
TPTGNDMRSMLSQMRQAPDLS

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=404, Percent_Identity=63.3663366336634, Blast_Score=544, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 47170; Mature: 47170

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQQITLWLEKFGLEFSGVMSLLMVLGLIVLISVVIHLVLHRVVLRAIQRRGQQSQRVWQ
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QAITQYKLFQRMALLLQGVIINLQAVLWLHAGGQTQAVIVTAAQVWIMGFALLSLFSLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
TLLAMLRQSPISNQLPLRGIFQGLKLVAAILIGIMIVSLLMGKSPLLLLSGLGAMTAVLM
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVFKDPILGLVAGIQLSANDMLSIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
HHHHHHHHHHHHCCEECCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEEECCCCCCHHCC
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSDEEQQRLNRNPLLQRYLNDKTQ
HHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHH
ELSQHNQQIAVDLSSPLNGRRLTNLGTLRAYLVAYLRAHPNIHQNMTLMVRQLAPTPEGL
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
PLEIYAFTNTTVWAEYESIQSDIFDHILAVINEFDLRVHQTPTGNDMRSMLSQMRQAPDL
CEEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCC
S
C
>Mature Secondary Structure
MQQQITLWLEKFGLEFSGVMSLLMVLGLIVLISVVIHLVLHRVVLRAIQRRGQQSQRVWQ
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QAITQYKLFQRMALLLQGVIINLQAVLWLHAGGQTQAVIVTAAQVWIMGFALLSLFSLLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
TLLAMLRQSPISNQLPLRGIFQGLKLVAAILIGIMIVSLLMGKSPLLLLSGLGAMTAVLM
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVFKDPILGLVAGIQLSANDMLSIGDWLEMPKYGADGAVTDIGLTTVKVRNWDNTVTTIP
HHHHHHHHHHHHCCEECCCCHHHHHHHHHCCCCCCCCCEEECCEEEEEEECCCCCCHHCC
TYALISDSFKNWRSMSESGGRRIKRSINIDTTSVHFLSDEEQQRLNRNPLLQRYLNDKTQ
HHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEECCHHHHHCCCCHHHHHHHHHHHH
ELSQHNQQIAVDLSSPLNGRRLTNLGTLRAYLVAYLRAHPNIHQNMTLMVRQLAPTPEGL
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
PLEIYAFTNTTVWAEYESIQSDIFDHILAVINEFDLRVHQTPTGNDMRSMLSQMRQAPDL
CEEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]