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The map label for this gene is mtnC

Identifier: 157369188

GI number: 157369188

Start: 1041205

End: 1041894

Strand: Direct

Name: mtnC

Synonym: Spro_0943

Alternate gene names: 157369188

Gene position: 1041205-1041894 (Clockwise)

Preceding gene: 157369187

Following gene: 157369189

Centisome position: 19.11

GC content: 54.93

Gene sequence:

>690_bases
ATGATCCGCGCCATCGTTACCGACATTGAAGGTACCACCAGCGATATCCGTTTCGTTCATCAGGTGCTGTTCCCTTACGC
ACGTGAACGCCTGGCCACCTTTCTCCGTCTTCACGCTGAAGATGCCGAAGTCGCCGCGCCACTGACCGCCTTACGCCAGG
AGCTTGACCAACCGCAGGCGGATATTGAGCAACTGATTGCTGCGCTGTACCGCTTTATGGACGAAGACCGCAAATCCACC
GCGCTGAAGGCGCTGCAAGGTATCATCTGGCGCAGTGGTTATCAGAACGGCGATTTTCGCGGACATTTGTACCCTGAAGT
AGCCGGGCAGTTAGCCGCCTGGCAGCAGCAGGGGCTGAAGCTGTACGTCTATTCTTCCGGCTCGGTAGAGGCGCAAAAGC
TGCTGTTCGGCTACAGCGATGCCGGGGATCTGCAGCCATTGTTCAGCGGTTATTTCGATACTCACGTCGGTGCCAAGCGT
GAAACCGCTTCGTACCTTAATATCGCGGGTAAAATCGGTATTGCAGCTGATGAACTGTTATTTCTTTCCGACATTCATCA
AGAGCTGGACGCCGCGCGTGCCGCTGGTTGGCATACCTGCCAACTGATCCGCGATGAAGCCGATAGCCAAAGCCAGCATC
CGCAGGTTAACCGTTTTGATCAAATCGATTTAGGGGAGTTTGCCTCATGA

Upstream 100 bases:

>100_bases
TGTATTGCTGGGGTCGCCAGGTCGCGGAAGCTCGTCGTCATCTTGAAGGGCTGGAATTCCTGTTCCAGTGCGAACTGCAA
CGCCGTTTACTGGAGGCCAA

Downstream 100 bases:

>100_bases
GTGGATTGACCATTTTCAGCGATCAAGAGCCGCAACAGCCGCTGTGGCAGAGCCGTGACGCGCAGGCCATTGGGCAGCAA
CTGGCACAGATTGGCGTACG

Product: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MIRAIVTDIEGTTSDIRFVHQVLFPYARERLATFLRLHAEDAEVAAPLTALRQELDQPQADIEQLIAALYRFMDEDRKST
ALKALQGIIWRSGYQNGDFRGHLYPEVAGQLAAWQQQGLKLYVYSSGSVEAQKLLFGYSDAGDLQPLFSGYFDTHVGAKR
ETASYLNIAGKIGIAADELLFLSDIHQELDAARAAGWHTCQLIRDEADSQSQHPQVNRFDQIDLGEFAS

Sequences:

>Translated_229_residues
MIRAIVTDIEGTTSDIRFVHQVLFPYARERLATFLRLHAEDAEVAAPLTALRQELDQPQADIEQLIAALYRFMDEDRKST
ALKALQGIIWRSGYQNGDFRGHLYPEVAGQLAAWQQQGLKLYVYSSGSVEAQKLLFGYSDAGDLQPLFSGYFDTHVGAKR
ETASYLNIAGKIGIAADELLFLSDIHQELDAARAAGWHTCQLIRDEADSQSQHPQVNRFDQIDLGEFAS
>Mature_229_residues
MIRAIVTDIEGTTSDIRFVHQVLFPYARERLATFLRLHAEDAEVAAPLTALRQELDQPQADIEQLIAALYRFMDEDRKST
ALKALQGIIWRSGYQNGDFRGHLYPEVAGQLAAWQQQGLKLYVYSSGSVEAQKLLFGYSDAGDLQPLFSGYFDTHVGAKR
ETASYLNIAGKIGIAADELLFLSDIHQELDAARAAGWHTCQLIRDEADSQSQHPQVNRFDQIDLGEFAS

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family

Homologues:

Organism=Homo sapiens, GI10864017, Length=223, Percent_Identity=39.0134529147982, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI115533232, Length=215, Percent_Identity=39.5348837209302, Blast_Score=153, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6320797, Length=201, Percent_Identity=37.8109452736318, Blast_Score=120, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281360080, Length=213, Percent_Identity=45.5399061032864, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24644163, Length=213, Percent_Identity=45.5399061032864, Blast_Score=181, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNC_SERP5 (A8GAA9)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477177.1
- ProteinModelPortal:   A8GAA9
- SMR:   A8GAA9
- STRING:   A8GAA9
- GeneID:   5605062
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0943
- eggNOG:   COG4229
- HOGENOM:   HBG294242
- OMA:   TTDLNFI
- ProtClustDB:   CLSK866737
- BioCyc:   SPRO399741:SPRO_0943-MONOMER
- HAMAP:   MF_01681
- InterPro:   IPR010041
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR005833
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR20371
- PRINTS:   PR00413
- TIGRFAMs:   TIGR01691
- TIGRFAMs:   TIGR01549

Pfam domain/function: SSF56784 SSF56784

EC number: =3.1.3.77

Molecular weight: Translated: 25619; Mature: 25619

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRAIVTDIEGTTSDIRFVHQVLFPYARERLATFLRLHAEDAEVAAPLTALRQELDQPQA
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHH
DIEQLIAALYRFMDEDRKSTALKALQGIIWRSGYQNGDFRGHLYPEVAGQLAAWQQQGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCE
LYVYSSGSVEAQKLLFGYSDAGDLQPLFSGYFDTHVGAKRETASYLNIAGKIGIAADELL
EEEEECCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHH
FLSDIHQELDAARAAGWHTCQLIRDEADSQSQHPQVNRFDQIDLGEFAS
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIRAIVTDIEGTTSDIRFVHQVLFPYARERLATFLRLHAEDAEVAAPLTALRQELDQPQA
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHH
DIEQLIAALYRFMDEDRKSTALKALQGIIWRSGYQNGDFRGHLYPEVAGQLAAWQQQGLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCE
LYVYSSGSVEAQKLLFGYSDAGDLQPLFSGYFDTHVGAKRETASYLNIAGKIGIAADELL
EEEEECCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHH
FLSDIHQELDAARAAGWHTCQLIRDEADSQSQHPQVNRFDQIDLGEFAS
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA