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The map label for this gene is fabF [H]

Identifier: 157369145

GI number: 157369145

Start: 999542

End: 1000711

Strand: Direct

Name: fabF [H]

Synonym: Spro_0900

Alternate gene names: 157369145

Gene position: 999542-1000711 (Clockwise)

Preceding gene: 157369144

Following gene: 157369146

Centisome position: 18.34

GC content: 61.71

Gene sequence:

>1170_bases
ATGGTTTACTTCTCTGCCGTAGGGATGGTGAATGCGTTGGGCAACAGCCTGTCGCAGATTGCGGAAAATCTGGCGCTTGG
CGTGTCGCCCGGCATGCAGCAGCAGGCGCAGTGGCTGCTGGGCGGGGAAACTTCCTGGTTCGGTAACGTACAGGGCGAAC
TGCCCGCCATTCCTGAACCTCTCAAACGCCATAACTCGCGCAATAACCGCCTGCTGTTGGCGGCGCTGGCACAGATCGAC
ACGCCAGTGCGCGCAGCCATCGCCCGCTACGGTGCGGATCGCGTCGCGGTGATTATGGGCACCAGCACCTCCGGTATCCA
TGAAGGCGAGCTGGCGCTGCAACAGTATCAGGCAGGGCAGTGGCCGCAGGGCTATGACTATCGGCAGCAGGAGCTGGGCG
ATCCGGGGTTGTTTCTTAGCGCTTTTCTCGCGACCCGTGGCCCGGCCTATACCCTGTCTACGGCCTGTTCTTCCAGCGCA
CGGGCCATCATCAGCGGTAAGCGGCTGATCGACGCCGGGCTGGTGGATGCGGCGATTGTTGGCGGTGCCGACAGCCTGTG
CCAAATGCCCATTAACGGGTTCAACAGCCTGGAATCACTGTCCGCACAACGTTGCACGCCATTTGCGGCGGGGCGCAGTG
GCATTAATATCGGCGAGGCAGCGGCGTTGATGCTGTTAACGCGGGAGCCGGCAGCGGTAGCGCTGTTGGGGGTTGGCGAA
TCATCTGATGCCTGGCATATGTCAGCACCGCATCCCGCCGGTGAGGGCGCCGAGCGGGCCATCAACATGGCGCTGCGGCA
GGCCGGTCTCAATGCCGGACAAATTGGTTATATTAATCTGCACGGCACGGCTACGCGGCTGAACGATCAGGTTGAAGCGC
GGGTCATCAATCGCCTGTTTGGCACCGAGACGCCCTGCAGTTCTACCAAACATCTCACAGGCCACACGCTGGGCGCGGCC
GGTGCGGTGGAGGCGGCGCTGAGTTGGTTATTGTTGACTCAGCCATTGCCGCTGCCGCAGCAGGATTTCAGCCGCGTGCC
GCGCGATGCCGAATTGGCACCGATCGGTCTGGTTTGCCAGCCACAATTGCTGGGGCAGCGTGCGATTTTGTCCAATTCGT
TTGCCTTTGGCGGTAACAATGCTTGTCTGCTGCTGGGGGACGCCCGATGA

Upstream 100 bases:

>100_bases
AAATCCGTTACCAGCAGGCCGACGGCCGGCGCGAACCGCAGTCGATTGCCCAATCCGCCTTCCACTATCGCATCGCTATT
CAGAATCTGGGGAGCGAATA

Downstream 100 bases:

>100_bases
TTCATTATCACGCCGCCGAATACTATCTGCCCCATGCCTCTCCAATGGTACTGCTGGAGCAGGTGCTTGAAGTGGGGGAA
GAACATGCCCGATGCGCCGT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MVYFSAVGMVNALGNSLSQIAENLALGVSPGMQQQAQWLLGGETSWFGNVQGELPAIPEPLKRHNSRNNRLLLAALAQID
TPVRAAIARYGADRVAVIMGTSTSGIHEGELALQQYQAGQWPQGYDYRQQELGDPGLFLSAFLATRGPAYTLSTACSSSA
RAIISGKRLIDAGLVDAAIVGGADSLCQMPINGFNSLESLSAQRCTPFAAGRSGINIGEAAALMLLTREPAAVALLGVGE
SSDAWHMSAPHPAGEGAERAINMALRQAGLNAGQIGYINLHGTATRLNDQVEARVINRLFGTETPCSSTKHLTGHTLGAA
GAVEAALSWLLLTQPLPLPQQDFSRVPRDAELAPIGLVCQPQLLGQRAILSNSFAFGGNNACLLLGDAR

Sequences:

>Translated_389_residues
MVYFSAVGMVNALGNSLSQIAENLALGVSPGMQQQAQWLLGGETSWFGNVQGELPAIPEPLKRHNSRNNRLLLAALAQID
TPVRAAIARYGADRVAVIMGTSTSGIHEGELALQQYQAGQWPQGYDYRQQELGDPGLFLSAFLATRGPAYTLSTACSSSA
RAIISGKRLIDAGLVDAAIVGGADSLCQMPINGFNSLESLSAQRCTPFAAGRSGINIGEAAALMLLTREPAAVALLGVGE
SSDAWHMSAPHPAGEGAERAINMALRQAGLNAGQIGYINLHGTATRLNDQVEARVINRLFGTETPCSSTKHLTGHTLGAA
GAVEAALSWLLLTQPLPLPQQDFSRVPRDAELAPIGLVCQPQLLGQRAILSNSFAFGGNNACLLLGDAR
>Mature_389_residues
MVYFSAVGMVNALGNSLSQIAENLALGVSPGMQQQAQWLLGGETSWFGNVQGELPAIPEPLKRHNSRNNRLLLAALAQID
TPVRAAIARYGADRVAVIMGTSTSGIHEGELALQQYQAGQWPQGYDYRQQELGDPGLFLSAFLATRGPAYTLSTACSSSA
RAIISGKRLIDAGLVDAAIVGGADSLCQMPINGFNSLESLSAQRCTPFAAGRSGINIGEAAALMLLTREPAAVALLGVGE
SSDAWHMSAPHPAGEGAERAINMALRQAGLNAGQIGYINLHGTATRLNDQVEARVINRLFGTETPCSSTKHLTGHTLGAA
GAVEAALSWLLLTQPLPLPQQDFSRVPRDAELAPIGLVCQPQLLGQRAILSNSFAFGGNNACLLLGDAR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=260, Percent_Identity=39.6153846153846, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI223972627, Length=148, Percent_Identity=43.9189189189189, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI41872631, Length=261, Percent_Identity=31.8007662835249, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787337, Length=274, Percent_Identity=36.1313868613139, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1788663, Length=267, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71983541, Length=407, Percent_Identity=27.5184275184275, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=31.1538461538462, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=261, Percent_Identity=29.1187739463602, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212642053, Length=260, Percent_Identity=28.0769230769231, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320904, Length=261, Percent_Identity=30.6513409961686, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24644341, Length=259, Percent_Identity=32.8185328185328, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI221330659, Length=258, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19920632, Length=258, Percent_Identity=27.906976744186, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24581345, Length=264, Percent_Identity=27.6515151515151, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 40815; Mature: 40815

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYFSAVGMVNALGNSLSQIAENLALGVSPGMQQQAQWLLGGETSWFGNVQGELPAIPEP
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCH
LKRHNSRNNRLLLAALAQIDTPVRAAIARYGADRVAVIMGTSTSGIHEGELALQQYQAGQ
HHHCCCCCCEEEEEEHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCC
WPQGYDYRQQELGDPGLFLSAFLATRGPAYTLSTACSSSARAIISGKRLIDAGLVDAAIV
CCCCCCHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHCCCCHHHHCCCHHHHHHHHHHHHH
GGADSLCQMPINGFNSLESLSAQRCTPFAAGRSGINIGEAAALMLLTREPAAVALLGVGE
CCCHHHHHCCCCCCHHHHHHHHHCCCCHHCCCCCCCHHHHEEEEEEECCCCEEEEEECCC
SSDAWHMSAPHPAGEGAERAINMALRQAGLNAGQIGYINLHGTATRLNDQVEARVINRLF
CCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
GTETPCSSTKHLTGHTLGAAGAVEAALSWLLLTQPLPLPQQDFSRVPRDAELAPIGLVCQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCEEEEEC
PQLLGQRAILSNSFAFGGNNACLLLGDAR
HHHHCCHHHHCCCCEECCCCEEEEEECCC
>Mature Secondary Structure
MVYFSAVGMVNALGNSLSQIAENLALGVSPGMQQQAQWLLGGETSWFGNVQGELPAIPEP
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCH
LKRHNSRNNRLLLAALAQIDTPVRAAIARYGADRVAVIMGTSTSGIHEGELALQQYQAGQ
HHHCCCCCCEEEEEEHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCC
WPQGYDYRQQELGDPGLFLSAFLATRGPAYTLSTACSSSARAIISGKRLIDAGLVDAAIV
CCCCCCHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHCCCCHHHHCCCHHHHHHHHHHHHH
GGADSLCQMPINGFNSLESLSAQRCTPFAAGRSGINIGEAAALMLLTREPAAVALLGVGE
CCCHHHHHCCCCCCHHHHHHHHHCCCCHHCCCCCCCHHHHEEEEEEECCCCEEEEEECCC
SSDAWHMSAPHPAGEGAERAINMALRQAGLNAGQIGYINLHGTATRLNDQVEARVINRLF
CCCCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHH
GTETPCSSTKHLTGHTLGAAGAVEAALSWLLLTQPLPLPQQDFSRVPRDAELAPIGLVCQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCEEEEEC
PQLLGQRAILSNSFAFGGNNACLLLGDAR
HHHHCCHHHHCCCCEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]