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The map label for this gene is pheA [H]

Identifier: 157369126

GI number: 157369126

Start: 975484

End: 976641

Strand: Reverse

Name: pheA [H]

Synonym: Spro_0881

Alternate gene names: 157369126

Gene position: 976641-975484 (Counterclockwise)

Preceding gene: 157369127

Following gene: 157369123

Centisome position: 17.92

GC content: 54.92

Gene sequence:

>1158_bases
ATGACTGACAACCCATTACTCGTGCTGCGCGAACGCATCAGCGCACTGGATCTGAAACTGCTGTCCCTGCTGGCAGAACG
CCGTGAGCTGGCGGTAGAGGTAGGGAAAACCAAGCTGCACTCTCATCGTCCAATTCGGGATAAAGAGCGTGAGCGCGACC
TGCTGGACGCCCTGATCGCCGCCGCCAAACCCTACGATCTGGACGGGTTCTACGTCACCCGCCTGTTCCAGCTAATTATC
GAAGACTCGGTATTAACCCAGCAGTCGTTACTGCAAAACCAACTCAATCAAGTCAGTCAGCATTCAGCCCGCATCGCTTT
CCTCGGCCCGAAAGGCTCTTATTCACACCTGGCCGCACGCCAATATGCTGCTCGTCATTTCGACCAGTTGATCGAGTGCG
GTTGCCAGAAATTCCAGGACATATTTACCCAGGTCGAAACCGGCCAGGCGGATTACGCCATTCTGCCGATCGAAAATACC
AGCTCAGGTTCGATTAACGATGTCTACGATCTGCTGCAGCACACCAGCCTGTCGATCGTCGGCGAACTAACCAACCCTAT
CGATCACTGCGTCCTGGTAGCCAGCGATACCGATCTTGCCCAGATTGAAACCGTGTATAGCCACCCGCAGCCGTTCCAGC
AATGCAGCCAGTTCATTAATCGTTATCCGCACTGGAAAATCGAATATTGTGAAAGCACTGCCGCAGCGATGGAAAAAGTC
GCCAAATTGAACTCGCCAAAAGCCGCAGCGCTGGGCAGCGAAGCCGGCGGGGCACTGTATGGCCTGCAGGTGCTGGAGCA
CAATCTGGCCAATCAACAGCAGAACATCACCCGCTTCATCGTGCTGGCGCGTAAGGCTATCGACGTCTCCGAGCAAGTGC
CGGCTAAAACCACGCTGATCATGGCCACCGGGCAGCAGTCTGGTGCACTGGTTGAAGCGCTGCTGGTGCTGCGCGAAAAC
GGCATCATTATGACCAAACTGGAATCTCGCCCGATTAACGGCAATCCGTGGGAAGAAATGTTTTATATCGATGTGCAGGC
TAACCTGCGTTCTGAATCAATGCAGAAAGCATTGAGGGATCTGACGCCGATAACTCGCTCGCTGAAGGTGTTGGGCTGCT
ACCCCAGCGACAACGTGGTGCCGGTCAACCCATCCTGA

Upstream 100 bases:

>100_bases
TGATAAAGAATGCGAAGACGAACAGCAAAGCCTCCTGAAATCAGGGGGCTTTTTTTATGGCTATTTACGACGTATAAAAA
ATATAAGGCAGAAGCTGATT

Downstream 100 bases:

>100_bases
ATGAGATAAAAAAGGGTTCGGCATTGCCGAACCCTGATACTTTATTGTCGACTGTCGTTCGCCTGGCGCAACAACGAACG
GCTTTCCACCAGGAAACGCT

Product: bifunctional chorismate mutase/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTDNPLLVLRERISALDLKLLSLLAERRELAVEVGKTKLHSHRPIRDKERERDLLDALIAAAKPYDLDGFYVTRLFQLII
EDSVLTQQSLLQNQLNQVSQHSARIAFLGPKGSYSHLAARQYAARHFDQLIECGCQKFQDIFTQVETGQADYAILPIENT
SSGSINDVYDLLQHTSLSIVGELTNPIDHCVLVASDTDLAQIETVYSHPQPFQQCSQFINRYPHWKIEYCESTAAAMEKV
AKLNSPKAAALGSEAGGALYGLQVLEHNLANQQQNITRFIVLARKAIDVSEQVPAKTTLIMATGQQSGALVEALLVLREN
GIIMTKLESRPINGNPWEEMFYIDVQANLRSESMQKALRDLTPITRSLKVLGCYPSDNVVPVNPS

Sequences:

>Translated_385_residues
MTDNPLLVLRERISALDLKLLSLLAERRELAVEVGKTKLHSHRPIRDKERERDLLDALIAAAKPYDLDGFYVTRLFQLII
EDSVLTQQSLLQNQLNQVSQHSARIAFLGPKGSYSHLAARQYAARHFDQLIECGCQKFQDIFTQVETGQADYAILPIENT
SSGSINDVYDLLQHTSLSIVGELTNPIDHCVLVASDTDLAQIETVYSHPQPFQQCSQFINRYPHWKIEYCESTAAAMEKV
AKLNSPKAAALGSEAGGALYGLQVLEHNLANQQQNITRFIVLARKAIDVSEQVPAKTTLIMATGQQSGALVEALLVLREN
GIIMTKLESRPINGNPWEEMFYIDVQANLRSESMQKALRDLTPITRSLKVLGCYPSDNVVPVNPS
>Mature_384_residues
TDNPLLVLRERISALDLKLLSLLAERRELAVEVGKTKLHSHRPIRDKERERDLLDALIAAAKPYDLDGFYVTRLFQLIIE
DSVLTQQSLLQNQLNQVSQHSARIAFLGPKGSYSHLAARQYAARHFDQLIECGCQKFQDIFTQVETGQADYAILPIENTS
SGSINDVYDLLQHTSLSIVGELTNPIDHCVLVASDTDLAQIETVYSHPQPFQQCSQFINRYPHWKIEYCESTAAAMEKVA
KLNSPKAAALGSEAGGALYGLQVLEHNLANQQQNITRFIVLARKAIDVSEQVPAKTTLIMATGQQSGALVEALLVLRENG
IIMTKLESRPINGNPWEEMFYIDVQANLRSESMQKALRDLTPITRSLKVLGCYPSDNVVPVNPS

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=384, Percent_Identity=77.34375, Blast_Score=630, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324013, Length=326, Percent_Identity=23.3128834355828, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010952
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 42922; Mature: 42790

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNPLLVLRERISALDLKLLSLLAERRELAVEVGKTKLHSHRPIRDKERERDLLDALIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AAKPYDLDGFYVTRLFQLIIEDSVLTQQSLLQNQLNQVSQHSARIAFLGPKGSYSHLAAR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
QYAARHFDQLIECGCQKFQDIFTQVETGQADYAILPIENTSSGSINDVYDLLQHTSLSIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHHH
GELTNPIDHCVLVASDTDLAQIETVYSHPQPFQQCSQFINRYPHWKIEYCESTAAAMEKV
HHHCCCCHHEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
AKLNSPKAAALGSEAGGALYGLQVLEHNLANQQQNITRFIVLARKAIDVSEQVPAKTTLI
HHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEE
MATGQQSGALVEALLVLRENGIIMTKLESRPINGNPWEEMFYIDVQANLRSESMQKALRD
EEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHH
LTPITRSLKVLGCYPSDNVVPVNPS
HHHHHHCCEEEEECCCCCEEECCCC
>Mature Secondary Structure 
TDNPLLVLRERISALDLKLLSLLAERRELAVEVGKTKLHSHRPIRDKERERDLLDALIA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AAKPYDLDGFYVTRLFQLIIEDSVLTQQSLLQNQLNQVSQHSARIAFLGPKGSYSHLAAR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
QYAARHFDQLIECGCQKFQDIFTQVETGQADYAILPIENTSSGSINDVYDLLQHTSLSIV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHHH
GELTNPIDHCVLVASDTDLAQIETVYSHPQPFQQCSQFINRYPHWKIEYCESTAAAMEKV
HHHCCCCHHEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHH
AKLNSPKAAALGSEAGGALYGLQVLEHNLANQQQNITRFIVLARKAIDVSEQVPAKTTLI
HHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEE
MATGQQSGALVEALLVLRENGIIMTKLESRPINGNPWEEMFYIDVQANLRSESMQKALRD
EEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHH
LTPITRSLKVLGCYPSDNVVPVNPS
HHHHHHCCEEEEECCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]