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The map label for this gene is ffh [H]

Identifier: 157369096

GI number: 157369096

Start: 948555

End: 949916

Strand: Direct

Name: ffh [H]

Synonym: Spro_0851

Alternate gene names: 157369096

Gene position: 948555-949916 (Clockwise)

Preceding gene: 157369093

Following gene: 157369097

Centisome position: 17.41

GC content: 55.95

Gene sequence:

>1362_bases
ATGTTTGAAAATTTAACCGATCGTTTGTCGCGCACCCTGCGCAATATCAGCGGCCGTGGGCGGCTGACCGAAGAAAATAT
CAAGGAAACCCTGCGTGAAGTGCGCATGGCATTGCTGGAAGCGGACGTTGCGCTGCCGGTGGTGCGGGACTTTATCAATC
GCGTAAAAGAAAGCGCGGTAGGTCATGAAGTCAACAAAAGCCTGACGCCGGGGCAAGAGTTCGTAAAAATCGTCAAGAGC
GAACTGATTTCCGCGATGGGCGAAGTGAACACCGAGCTGAACCTGGCGGCACAGCCGCCAGCAGTGGTGCTGATGGCGGG
CCTGCAGGGCGCCGGTAAAACCACCAGCGTTGCCAAGCTCGGTAAGTTCCTGAAAGAAAAACAGAAGAAAAAAGTGTTGG
TGGTTTCCGCTGACGTTTATCGCCCAGCGGCGATCAAACAGTTGGAAACGCTGGCGGAAAGCGTCGGCATCGACTTCTTC
CCGTCCGATGTTAAAGAAAAGCCGATCGACATCGTTAACCGTGCACTGCAACAGGCCAAGCTGAAATTCTACGATGTTCT
GATCGTCGATACCGCTGGCCGTTTGCACGTTGACGAAGCGATGATGGATGAGATCAAACAGGTGCACGCGGCGATCAAGC
CGGTGGAAACCCTGTTTGTGGTCGACGCCATGACCGGCCAGGATGCGGCCAACACCGCCAAGGCCTTTAACGAGGCGCTG
CCGCTGACCGGCGTGGTGCTGACCAAGGTCGATGGTGACGCGCGCGGCGGTGCTGCGCTGTCCATCCGTCACATTACCGG
CAAACCGATCAAGTTCCTCGGCGTGGGCGAGAAAACCGAAGCGCTGGAGCCATTCCATCCGGACCGCGTGGCGTCACGCA
TTCTCGGCATGGGCGACGTACTGTCGCTGATCGAAGATATCGAAAGCAAAGTTGACCGTGAACAGGCGGAAAAACTGGCT
AACAAGCTGAAGAAGGGCGACGGTTTCGATCTGACCGACTTCCTGGAGCAGCTCAAACAGATGCGTAACATGGGCGGTAT
GGCCAGCATGCTGAGCAAACTGCCCGGCGCCGGCCAACTGCCGGACAATGTAAAATCGCAGATGGACGACAAGGTTTTGG
TGCGTATGGAGGCGATGATCAACTCGATGACGCTGAAAGAGCGCGCCAAACCGGAAATCATCAAAGGTTCGCGCAAGCGT
CGTATTGCGGTGGGTTCCGGCATGCAGGTGCAGGATGTTAACCGCTTGTTAAAGCAGTTCGACGACATGCAACGCATGAT
GAAAAAGATGAAGAAAGGTGGAATGGCGAAGATGATGCGCGGCATGAAAGGTATGATGCCGCCGGGCTTCCCAGGCCGCT
GA

Upstream 100 bases:

>100_bases
CGATCTCCAACGCTGAGGCAGAGATCCTCTTAGCTTCGTGTTATAATCGCCGCAATTATGTCGCCAGAGCGGCCTGTCAT
TACACGTTGAGCAAGAGACG

Downstream 100 bases:

>100_bases
CAGCCGCTTGCCCTCTGGGGTGAGCCTGTTTAAGCATTTGCCGTTCGCGGTGAAAACCGCCCGAAATATTACCGGCGAAA
AAAAGTAGTTGACGACGAAC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKESAVGHEVNKSLTPGQEFVKIVKS
ELISAMGEVNTELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAESVGIDFF
PSDVKEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDIESKVDREQAEKLA
NKLKKGDGFDLTDFLEQLKQMRNMGGMASMLSKLPGAGQLPDNVKSQMDDKVLVRMEAMINSMTLKERAKPEIIKGSRKR
RIAVGSGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRGMKGMMPPGFPGR

Sequences:

>Translated_453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKESAVGHEVNKSLTPGQEFVKIVKS
ELISAMGEVNTELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAESVGIDFF
PSDVKEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDIESKVDREQAEKLA
NKLKKGDGFDLTDFLEQLKQMRNMGGMASMLSKLPGAGQLPDNVKSQMDDKVLVRMEAMINSMTLKERAKPEIIKGSRKR
RIAVGSGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRGMKGMMPPGFPGR
>Mature_453_residues
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKESAVGHEVNKSLTPGQEFVKIVKS
ELISAMGEVNTELNLAAQPPAVVLMAGLQGAGKTTSVAKLGKFLKEKQKKKVLVVSADVYRPAAIKQLETLAESVGIDFF
PSDVKEKPIDIVNRALQQAKLKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDVLSLIEDIESKVDREQAEKLA
NKLKKGDGFDLTDFLEQLKQMRNMGGMASMLSKLPGAGQLPDNVKSQMDDKVLVRMEAMINSMTLKERAKPEIIKGSRKR
RIAVGSGMQVQDVNRLLKQFDDMQRMMKKMKKGGMAKMMRGMKGMMPPGFPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=475, Percent_Identity=32, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI226371618, Length=349, Percent_Identity=34.9570200573066, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=38.75, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI23308697, Length=222, Percent_Identity=29.7297297297297, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI295424842, Length=222, Percent_Identity=29.7297297297297, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1788963, Length=453, Percent_Identity=90.5077262693157, Blast_Score=808, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=36.2204724409449, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=450, Percent_Identity=30.4444444444444, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=33.0232558139535, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=444, Percent_Identity=31.3063063063063, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320498, Length=314, Percent_Identity=25.4777070063694, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647949, Length=468, Percent_Identity=30.3418803418803, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=28.1818181818182, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49863; Mature: 49863

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKESAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVKSELISAMGEVNTELNLAAQPPAVVLMAGLQGAGKTTSVAKL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHEECCCCCCCCHHHHHH
GKFLKEKQKKKVLVVSADVYRPAAIKQLETLAESVGIDFFPSDVKEKPIDIVNRALQQAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDREQAEKLANKLKKGDGFDLTDFLEQLKQMRNMGGMASMLSKLPGAGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
PDNVKSQMDDKVLVRMEAMINSMTLKERAKPEIIKGSRKRRIAVGSGMQVQDVNRLLKQF
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHH
DDMQRMMKKMKKGGMAKMMRGMKGMMPPGFPGR
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSRTLRNISGRGRLTEENIKETLREVRMALLEADVALPVVRDFINRVKESAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GHEVNKSLTPGQEFVKIVKSELISAMGEVNTELNLAAQPPAVVLMAGLQGAGKTTSVAKL
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHEECCCCCCCCHHHHHH
GKFLKEKQKKKVLVVSADVYRPAAIKQLETLAESVGIDFFPSDVKEKPIDIVNRALQQAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHH
LKFYDVLIVDTAGRLHVDEAMMDEIKQVHAAIKPVETLFVVDAMTGQDAANTAKAFNEAL
HHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRVASRILGMGDV
CCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLIEDIESKVDREQAEKLANKLKKGDGFDLTDFLEQLKQMRNMGGMASMLSKLPGAGQL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
PDNVKSQMDDKVLVRMEAMINSMTLKERAKPEIIKGSRKRRIAVGSGMQVQDVNRLLKQF
CHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHH
DDMQRMMKKMKKGGMAKMMRGMKGMMPPGFPGR
HHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]