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The map label for this gene is mdeA [H]

Identifier: 157369043

GI number: 157369043

Start: 891338

End: 892528

Strand: Direct

Name: mdeA [H]

Synonym: Spro_0798

Alternate gene names: 157369043

Gene position: 891338-892528 (Clockwise)

Preceding gene: 157369042

Following gene: 157369053

Centisome position: 16.36

GC content: 60.54

Gene sequence:

>1191_bases
ATGTCTGTCACATTTAGGCACGGTTTTGCCACACGTGCGATCCACCATGGCTACGATCCCCAGCAATATCTGGGAGCGCT
CTGCCCGCCGGTGTTTATGAGTTCGACCTTTACCTTCCCGACGGCGGAATACGGCGGTGCCTGTTTTGCCGGTACTGAGC
CAGGTTATTTTTATTCGCGTATTGCCAATCCGACGGTCAATCTGCTGGAACAGCGAATTGCCGATCTGGAGGGCGGGGAG
GCGGCGGTGGCCTTTGCCTCCGGCATGGGCGCGATTACCGCCTGCTGCTGGACGCTGCTCAGTCCAGGGGATGAGCTGAT
CGTCGATGAAACCATTTATGGCTGCACTTTCAGCTATTTTCATCATGGGCTGGCGCGCTACGGCGTGAAAATCACCCACG
TTGACCTGACCCGGCCAGAGCGGTTGGCGGCGGCGATAGGCCCGCGTACCCGGCTGGTGTATTGCGAAACGCCGGCTAAC
CCCAATATGCGCCTGGTCGATATTGCCGCAGTGGCCGAAATTGCCCACCGTCAGGGAGCGCTGCTGCTGGTGGATAACAC
CTATTGCACGCCATACCTGCAACGGCCGCTGGAGTTGGGGGCGGACATTGTGGTGCATTCCGCCACCAAATACATCGGCG
GACACGGTGACTTACTGGCCGGTCTGGCGGTGACGCGTCAGGATCTGGCGCAGGACATTCGTTTGGTCGGGCTGAAAGAC
ATGAACGGGGCAGTGCTGTCGGCGCAGGATGCCGCACTGTTGCTGCGTGGGCTGAAAACCTTGCCGTTGCGTATGGAACG
CCACTGCGACAACGCTCAACGCCTGGCGGAAATGCTGGCGCAGCATTCGGCGGTGGAACGGGTTTATTATCCCGGTCTGG
AGGACTTCCCGCAGTATGCATTGGCGCAGCGGCAAATGGCGCGACCGGGGGGCATGCTGGCCTTTGAATTGAAAGGCGGC
ATGGCGGCGGGGATCCGCTTTCTCAATGGGTTGAGCCTAATCTTGCGTGCGGTCAGCCTGGGGGATTGCGAGTCTCTGGC
CCAGCACCCCGCCAGTATGACTCACTCGGCCTACAGCGCCGAGGAGCGGCAGCGCCACCATATCAGCGACGGTTTGGTGC
GGCTGTCTGCCGGACTCGAAGATCCTGACGATCTGCAGGCGGATATCCGTCAGGCCTTGGCCCAGCGCTAA

Upstream 100 bases:

>100_bases
CTGCAAATCATCGGCCAGCGGGTACGCAGCAGCGCGTTACCGCCGGACGTTTAAGCGAAATCATTGGAATTGCTTTCACT
CACTCAGGAAAGGAGTTGTC

Downstream 100 bases:

>100_bases
GCACGATGCCCCCGCCCTGTGGGTGTACAGAACGGGGGCAGGGGCGGGGATTACAGCAGCGTCGGGGCAATCTCCGCCAG
CGCCTGTTCATCCTGCAGCA

Product: methionine gamma-lyase

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSVTFRHGFATRAIHHGYDPQQYLGALCPPVFMSSTFTFPTAEYGGACFAGTEPGYFYSRIANPTVNLLEQRIADLEGGE
AAVAFASGMGAITACCWTLLSPGDELIVDETIYGCTFSYFHHGLARYGVKITHVDLTRPERLAAAIGPRTRLVYCETPAN
PNMRLVDIAAVAEIAHRQGALLLVDNTYCTPYLQRPLELGADIVVHSATKYIGGHGDLLAGLAVTRQDLAQDIRLVGLKD
MNGAVLSAQDAALLLRGLKTLPLRMERHCDNAQRLAEMLAQHSAVERVYYPGLEDFPQYALAQRQMARPGGMLAFELKGG
MAAGIRFLNGLSLILRAVSLGDCESLAQHPASMTHSAYSAEERQRHHISDGLVRLSAGLEDPDDLQADIRQALAQR

Sequences:

>Translated_396_residues
MSVTFRHGFATRAIHHGYDPQQYLGALCPPVFMSSTFTFPTAEYGGACFAGTEPGYFYSRIANPTVNLLEQRIADLEGGE
AAVAFASGMGAITACCWTLLSPGDELIVDETIYGCTFSYFHHGLARYGVKITHVDLTRPERLAAAIGPRTRLVYCETPAN
PNMRLVDIAAVAEIAHRQGALLLVDNTYCTPYLQRPLELGADIVVHSATKYIGGHGDLLAGLAVTRQDLAQDIRLVGLKD
MNGAVLSAQDAALLLRGLKTLPLRMERHCDNAQRLAEMLAQHSAVERVYYPGLEDFPQYALAQRQMARPGGMLAFELKGG
MAAGIRFLNGLSLILRAVSLGDCESLAQHPASMTHSAYSAEERQRHHISDGLVRLSAGLEDPDDLQADIRQALAQR
>Mature_395_residues
SVTFRHGFATRAIHHGYDPQQYLGALCPPVFMSSTFTFPTAEYGGACFAGTEPGYFYSRIANPTVNLLEQRIADLEGGEA
AVAFASGMGAITACCWTLLSPGDELIVDETIYGCTFSYFHHGLARYGVKITHVDLTRPERLAAAIGPRTRLVYCETPANP
NMRLVDIAAVAEIAHRQGALLLVDNTYCTPYLQRPLELGADIVVHSATKYIGGHGDLLAGLAVTRQDLAQDIRLVGLKDM
NGAVLSAQDAALLLRGLKTLPLRMERHCDNAQRLAEMLAQHSAVERVYYPGLEDFPQYALAQRQMARPGGMLAFELKGGM
AAGIRFLNGLSLILRAVSLGDCESLAQHPASMTHSAYSAEERQRHHISDGLVRLSAGLEDPDDLQADIRQALAQR

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=392, Percent_Identity=44.8979591836735, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI299473759, Length=392, Percent_Identity=41.5816326530612, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI25453487, Length=391, Percent_Identity=39.6419437340153, Blast_Score=218, Evalue=6e-57,
Organism=Escherichia coli, GI1790375, Length=385, Percent_Identity=38.7012987012987, Blast_Score=249, Evalue=1e-67,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=27.5510204081633, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17560056, Length=394, Percent_Identity=41.3705583756345, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=40.4312668463612, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17538055, Length=394, Percent_Identity=40.3553299492386, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=404, Percent_Identity=40.3465346534653, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6323333, Length=417, Percent_Identity=31.4148681055156, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321170, Length=338, Percent_Identity=29.2899408284024, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321254, Length=409, Percent_Identity=29.0953545232274, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6321904, Length=405, Percent_Identity=29.1358024691358, Blast_Score=132, Evalue=9e-32,
Organism=Drosophila melanogaster, GI19922554, Length=390, Percent_Identity=41.2820512820513, Blast_Score=286, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 43070; Mature: 42939

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTFRHGFATRAIHHGYDPQQYLGALCPPVFMSSTFTFPTAEYGGACFAGTEPGYFYSR
CCEEECCCCHHHHHHCCCCHHHHHHHHCCHHHHCCCCCCCCHHCCCEEECCCCCCHHHHH
IANPTVNLLEQRIADLEGGEAAVAFASGMGAITACCWTLLSPGDELIVDETIYGCTFSYF
HCCHHHHHHHHHHHHCCCCCEEEEHHCCCHHHHHHHHHHHCCCCCEEECCHHHHHHHHHH
HHGLARYGVKITHVDLTRPERLAAAIGPRTRLVYCETPANPNMRLVDIAAVAEIAHRQGA
HHHHHHHCEEEEEEECCCHHHHHHHCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCC
LLLVDNTYCTPYLQRPLELGADIVVHSATKYIGGHGDLLAGLAVTRQDLAQDIRLVGLKD
EEEEECCCCCHHHHHHHHCCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEECC
MNGAVLSAQDAALLLRGLKTLPLRMERHCDNAQRLAEMLAQHSAVERVYYPGLEDFPQYA
CCCCEECHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAQRQMARPGGMLAFELKGGMAAGIRFLNGLSLILRAVSLGDCESLAQHPASMTHSAYSA
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHH
EERQRHHISDGLVRLSAGLEDPDDLQADIRQALAQR
HHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVTFRHGFATRAIHHGYDPQQYLGALCPPVFMSSTFTFPTAEYGGACFAGTEPGYFYSR
CEEECCCCHHHHHHCCCCHHHHHHHHCCHHHHCCCCCCCCHHCCCEEECCCCCCHHHHH
IANPTVNLLEQRIADLEGGEAAVAFASGMGAITACCWTLLSPGDELIVDETIYGCTFSYF
HCCHHHHHHHHHHHHCCCCCEEEEHHCCCHHHHHHHHHHHCCCCCEEECCHHHHHHHHHH
HHGLARYGVKITHVDLTRPERLAAAIGPRTRLVYCETPANPNMRLVDIAAVAEIAHRQGA
HHHHHHHCEEEEEEECCCHHHHHHHCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHHCCC
LLLVDNTYCTPYLQRPLELGADIVVHSATKYIGGHGDLLAGLAVTRQDLAQDIRLVGLKD
EEEEECCCCCHHHHHHHHCCCCEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEECC
MNGAVLSAQDAALLLRGLKTLPLRMERHCDNAQRLAEMLAQHSAVERVYYPGLEDFPQYA
CCCCEECHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LAQRQMARPGGMLAFELKGGMAAGIRFLNGLSLILRAVSLGDCESLAQHPASMTHSAYSA
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHH
EERQRHHISDGLVRLSAGLEDPDDLQADIRQALAQR
HHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]