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The map label for this gene is clcA [H]

Identifier: 157369027

GI number: 157369027

Start: 871835

End: 873274

Strand: Direct

Name: clcA [H]

Synonym: Spro_0782

Alternate gene names: 157369027

Gene position: 871835-873274 (Clockwise)

Preceding gene: 157369025

Following gene: 157369028

Centisome position: 16.0

GC content: 59.24

Gene sequence:

>1440_bases
ATGACTGAATTACAGCAACAACCGCCGCTAGCGCGTGCTCCGCGCCTGAAACGTAGCGACGCGGTGCGCCAGCTTATACG
CCGGGATAAAACGCCGGTGGCGATCCTGTTGATGGCGGCACTGGTGGGAACCCTGGCGGGTTTGCTCGGCGTGGCCTTTG
ATAAAGCGGTGGATTGGGTGCAGCAACAGCGTTTGTCCGGGCTGGCACAGGTCGCCGATTATTGGATCCTGGTCTGGCCG
CTGGCCTTTATTCTTTCCGCCGCGTTGGCGGTGTTGGGGTACTACCTGGTGCATCGTTTTGCCCCGGAGGCGGGCGGTTC
GGGTATCCCGGAGATCGAAGGGGCGTTGGAAGAGTTGCGCCCGGTGCGCTGGTGGCGGGTGATCCCGGTGAAGTTTATCG
GTGGCATGGGCACGCTGGGGGCAGGCATGGTGCTGGGGCGTGAAGGGCCAACGGTACAAATGGGCGGCAATGTCGGGCGT
ATGGTGCTGGATATTTTCCGCCTGCGCGGTGCCGAAGCACGTCATTCGCTATTGGCTACCGGTGCGGCTGCCGGCCTTTC
CGCCGCCTTCAACGCACCGCTGGCAGGCATTTTGTTTATCATTGAAGAGATGCGTCCGCAGTTCCGCTATAACCTGATCT
CGATTAAAGCGGTATTTATCGGCGTCATTATGTCGAGCGTGGTGTTCCAGCTGTTCAACGGCGAGGGTTCGGTGATCGCG
GTGGGCAAGCTCTCTTCGGCACCGATTAACACCCTTTGGCTGTACTTGGTGCTGGGGGCGATCTTTGGTGCGGTGGGCGT
GATGTTCAACGCGCTGATTTTCCGCACCCAGGACATGTTCGCTCGCCTGCACGGCGGCAAAATGCGTAAGGTTTTGCTGA
TAGGCGGATTGCTTGGCGGCATTTGCGGCATTCTGGGGCTGATCCAGCCGGAAGCCGCAGGCGGGGGTTTTGGGCTGATC
CCGATCGCCGCGGCAGGTAACTACAGCGTCGGCATGCTGATGTTTATTTTTATTACCCGGGTGATCACCACGCTGTTATG
TTTTGGCTCCGGCGCGCCGGGCGGGATTTTTGCGCCGATGCTGGCGCTGGGTACGCTGTTTGGCACCGCCTTTGGCCTGG
CCGGTGCCCATCTGTTCCCAGCCTACGGTATCGAGGCCGGTACCTTTGCCATTGCCGGAATGGGCGCCCTGTTTGCCGCC
ACGGTGCGTGCGCCGCTGACCGGCATTGTGCTGGTGCTGGAAATGTCCGATAACTACCAGCTGATACTGCCAATGATTAT
TACCTGCCTGGGGGCTACCTTGGTAGCACAGTTCCTCGGCGGTAAGCCGTTGTATTCCTCAATATTGGCCCGTACCTTAC
AGCGTCAGGAAGCGCTGCAGGCGCGTGAAGCGGCAGATAAAACAGGTAAAGAAGATACAACAAATGCGGTGAATACTTGA

Upstream 100 bases:

>100_bases
GTCAGATACCTATTTAGAGGGGCGGTCAGTCAGCGGGTAGGCTAGAATAATCAGCTGGCCTATTTGTATTACATTTGATT
CCATTAATGAATAACCCATT

Downstream 100 bases:

>100_bases
ACGCAACACTCAGGTATTAGATAATCAATAACATTAATCCGGCCGCCATTGTAGCGACCTGATGCAGAACAATGTTGGGA
GTAAAGAGTATGAGTGATGA

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MTELQQQPPLARAPRLKRSDAVRQLIRRDKTPVAILLMAALVGTLAGLLGVAFDKAVDWVQQQRLSGLAQVADYWILVWP
LAFILSAALAVLGYYLVHRFAPEAGGSGIPEIEGALEELRPVRWWRVIPVKFIGGMGTLGAGMVLGREGPTVQMGGNVGR
MVLDIFRLRGAEARHSLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFIGVIMSSVVFQLFNGEGSVIA
VGKLSSAPINTLWLYLVLGAIFGAVGVMFNALIFRTQDMFARLHGGKMRKVLLIGGLLGGICGILGLIQPEAAGGGFGLI
PIAAAGNYSVGMLMFIFITRVITTLLCFGSGAPGGIFAPMLALGTLFGTAFGLAGAHLFPAYGIEAGTFAIAGMGALFAA
TVRAPLTGIVLVLEMSDNYQLILPMIITCLGATLVAQFLGGKPLYSSILARTLQRQEALQAREAADKTGKEDTTNAVNT

Sequences:

>Translated_479_residues
MTELQQQPPLARAPRLKRSDAVRQLIRRDKTPVAILLMAALVGTLAGLLGVAFDKAVDWVQQQRLSGLAQVADYWILVWP
LAFILSAALAVLGYYLVHRFAPEAGGSGIPEIEGALEELRPVRWWRVIPVKFIGGMGTLGAGMVLGREGPTVQMGGNVGR
MVLDIFRLRGAEARHSLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFIGVIMSSVVFQLFNGEGSVIA
VGKLSSAPINTLWLYLVLGAIFGAVGVMFNALIFRTQDMFARLHGGKMRKVLLIGGLLGGICGILGLIQPEAAGGGFGLI
PIAAAGNYSVGMLMFIFITRVITTLLCFGSGAPGGIFAPMLALGTLFGTAFGLAGAHLFPAYGIEAGTFAIAGMGALFAA
TVRAPLTGIVLVLEMSDNYQLILPMIITCLGATLVAQFLGGKPLYSSILARTLQRQEALQAREAADKTGKEDTTNAVNT
>Mature_478_residues
TELQQQPPLARAPRLKRSDAVRQLIRRDKTPVAILLMAALVGTLAGLLGVAFDKAVDWVQQQRLSGLAQVADYWILVWPL
AFILSAALAVLGYYLVHRFAPEAGGSGIPEIEGALEELRPVRWWRVIPVKFIGGMGTLGAGMVLGREGPTVQMGGNVGRM
VLDIFRLRGAEARHSLLATGAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFIGVIMSSVVFQLFNGEGSVIAV
GKLSSAPINTLWLYLVLGAIFGAVGVMFNALIFRTQDMFARLHGGKMRKVLLIGGLLGGICGILGLIQPEAAGGGFGLIP
IAAAGNYSVGMLMFIFITRVITTLLCFGSGAPGGIFAPMLALGTLFGTAFGLAGAHLFPAYGIEAGTFAIAGMGALFAAT
VRAPLTGIVLVLEMSDNYQLILPMIITCLGATLVAQFLGGKPLYSSILARTLQRQEALQAREAADKTGKEDTTNAVNT

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557473, Length=483, Percent_Identity=26.9151138716356, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI189217923, Length=483, Percent_Identity=26.9151138716356, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI189217921, Length=483, Percent_Identity=26.9151138716356, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI55770840, Length=457, Percent_Identity=24.507658643326, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI55770838, Length=456, Percent_Identity=24.5614035087719, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI153252026, Length=510, Percent_Identity=23.1372549019608, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786350, Length=447, Percent_Identity=70.4697986577181, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI87081943, Length=254, Percent_Identity=27.9527559055118, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17532615, Length=407, Percent_Identity=23.8329238329238, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17559050, Length=472, Percent_Identity=25.2118644067797, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980828, Length=486, Percent_Identity=22.6337448559671, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71980824, Length=486, Percent_Identity=22.6337448559671, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71980820, Length=492, Percent_Identity=22.9674796747967, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665008, Length=475, Percent_Identity=25.8947368421053, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45551566, Length=461, Percent_Identity=26.6811279826464, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI281361606, Length=454, Percent_Identity=25.9911894273128, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161078208, Length=454, Percent_Identity=25.9911894273128, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573073, Length=454, Percent_Identity=25.9911894273128, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281361608, Length=454, Percent_Identity=25.9911894273128, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573075, Length=454, Percent_Identity=25.9911894273128, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573071, Length=454, Percent_Identity=25.9911894273128, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 50613; Mature: 50482

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELQQQPPLARAPRLKRSDAVRQLIRRDKTPVAILLMAALVGTLAGLLGVAFDKAVDWV
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQQRLSGLAQVADYWILVWPLAFILSAALAVLGYYLVHRFAPEAGGSGIPEIEGALEELR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
PVRWWRVIPVKFIGGMGTLGAGMVLGREGPTVQMGGNVGRMVLDIFRLRGAEARHSLLAT
HHHHHEEEHHHHHCCCCCCCCCEEECCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHH
GAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFIGVIMSSVVFQLFNGEGSVIA
HHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VGKLSSAPINTLWLYLVLGAIFGAVGVMFNALIFRTQDMFARLHGGKMRKVLLIGGLLGG
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ICGILGLIQPEAAGGGFGLIPIAAAGNYSVGMLMFIFITRVITTLLCFGSGAPGGIFAPM
HHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTLFGTAFGLAGAHLFPAYGIEAGTFAIAGMGALFAATVRAPLTGIVLVLEMSDNYQ
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCE
LILPMIITCLGATLVAQFLGGKPLYSSILARTLQRQEALQAREAADKTGKEDTTNAVNT
EHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TELQQQPPLARAPRLKRSDAVRQLIRRDKTPVAILLMAALVGTLAGLLGVAFDKAVDWV
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQQRLSGLAQVADYWILVWPLAFILSAALAVLGYYLVHRFAPEAGGSGIPEIEGALEELR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
PVRWWRVIPVKFIGGMGTLGAGMVLGREGPTVQMGGNVGRMVLDIFRLRGAEARHSLLAT
HHHHHEEEHHHHHCCCCCCCCCEEECCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHH
GAAAGLSAAFNAPLAGILFIIEEMRPQFRYNLISIKAVFIGVIMSSVVFQLFNGEGSVIA
HHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VGKLSSAPINTLWLYLVLGAIFGAVGVMFNALIFRTQDMFARLHGGKMRKVLLIGGLLGG
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ICGILGLIQPEAAGGGFGLIPIAAAGNYSVGMLMFIFITRVITTLLCFGSGAPGGIFAPM
HHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LALGTLFGTAFGLAGAHLFPAYGIEAGTFAIAGMGALFAATVRAPLTGIVLVLEMSDNYQ
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCE
LILPMIITCLGATLVAQFLGGKPLYSSILARTLQRQEALQAREAADKTGKEDTTNAVNT
EHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA