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The map label for this gene is murC

Identifier: 157369007

GI number: 157369007

Start: 850735

End: 852213

Strand: Direct

Name: murC

Synonym: Spro_0762

Alternate gene names: 157369007

Gene position: 850735-852213 (Clockwise)

Preceding gene: 157369006

Following gene: 157369008

Centisome position: 15.61

GC content: 60.18

Gene sequence:

>1479_bases
ATGAATACACAACAACTGGCGAAACTACGTACTATCGTGCCCGAGATGCGACGCGTCCGGCACATTCACTTTGTCGGCAT
CGGTGGCGCCGGCATGGGTGGTATCGCCGAAGTGTTGGCTAACGAAGGTTATCAAATCAGCGGTTCTGACCTGGCGCCGA
ACCCGGTAACCCAACAGTTGAGCGCGCTCGGGGCGACGATTTACTTCCATCACCGCCCGGAAAACGTACTGGATGCCAGC
GTAGTGGTGGTTTCTACCGCCATTTCCGCCGACAACCCGGAGCTTGTCGCCGCCCGTGAGGCGCGTATCCCGGTGATCCG
TCGCGCAGAGATGCTGGCCGAACTGATGCGTTTCCGCCACGGTATCGCCGTTGCCGGTACGCACGGCAAGACCACCACCA
CGGCGATGGTGTCGAGCATTTATGCCGAAGCCGGCCTGGACCCGACCTTTGTCAACGGCGGGCTGGTGAAAGCGGCGGGT
ACCCATGCGCGTTTGGGTTCCAGCCGTTACCTGATTGCGGAAGCGGATGAGAGCGATGCGTCGTTCCTGCATTTGCAGCC
GATGGTGGCGATTGTCACCAATATCGAAGCCGACCATATGGAGACCTACCAGGGTGACTTCGAAAATCTGAAGCAGACGT
TTATTAACTTTTTGCACAACCTGCCGTTCTACGGTCGTGCGGTGATGTGTGTTGATGACCCGGTGGTGCGCGAACTGCTG
CCACGCGTGGGCCGCCATATCACCACCTACGGTTTCAGTGATGATGCCGACGTACGCATCGAGAGCTATCGCCAGGTAGG
GCCGCAGGGCCACTTTACGCTGAGCCGTCAGGACAAACCGTTAATGACGGTCACCCTGAATGCGCCGGGCCGTCACAACG
CGTTAAACGCCGCGGCGGCAGTGGCAGTGGCAACAGAGGAAGGCATTGACGACGCAGATATCCTGCGTGCGCTGGCCGGC
TTCCAGGGTACCGGTCGCCGCTTTGATTTCCTCGGCGAATTCCCGCTGGAGCCGGTCAACGGCAAAAGTGGCAGCGCGAT
GCTGGTCGACGACTATGGTCACCATCCGACCGAGGTTGACGCAACGCTGAAAGCCGCGCGTGCCGGTTGGCCGGACAAGC
GTCTGGTGATGGTTTTCCAGCCGCACCGTTACACCCGTACGCGCGATCTGTATGACGACTTCGCCAACGTGCTGTCGCAG
GTGGACGTGCTGCTGATGCTGGACGTGTATTCGGCGGGTGAAACGGCGATCCCAGGGGCGGACAGCCGCTCACTGTGCCG
GACTATCCGCAGCCGCGGCAAGCTGGATCCGATTCTGGTTTCCGATGCGGACACCGTGCCGGAAACCCTGGCGCAGTTGC
TGCAGGCCGATGATTTAGTGCTGGTGCAGGGCGCCGGCAACGTGGGCAAAGTTGCCCGTAAACTGGCTGAGCTGAAGCTG
CAGCCACAGAAAAAAGAGGAGGAACACCATGGCCGATAA

Upstream 100 bases:

>100_bases
TGCGGGTCGCCAAATAATTTGCAGGGGTTCGGTACGCCGGGCCTGAATTAAAGAATGTCATACAGGGGCCCGGTATGCCG
GACCCGGATTAGAGAGAGTG

Downstream 100 bases:

>100_bases
AGTTGCCGTACTGCTGGGTGGCACCTCTGCTGAACGTGAAGTGTCATTGCAATCCGGCGCCGCCGTGCTGGCCGGGCTGC
GTGAAGCCGGTATCGATGCC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSALGATIYFHHRPENVLDAS
VVVVSTAISADNPELVAAREARIPVIRRAEMLAELMRFRHGIAVAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
THARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMETYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVVRELL
PRVGRHITTYGFSDDADVRIESYRQVGPQGHFTLSRQDKPLMTVTLNAPGRHNALNAAAAVAVATEEGIDDADILRALAG
FQGTGRRFDFLGEFPLEPVNGKSGSAMLVDDYGHHPTEVDATLKAARAGWPDKRLVMVFQPHRYTRTRDLYDDFANVLSQ
VDVLLMLDVYSAGETAIPGADSRSLCRTIRSRGKLDPILVSDADTVPETLAQLLQADDLVLVQGAGNVGKVARKLAELKL
QPQKKEEEHHGR

Sequences:

>Translated_492_residues
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSALGATIYFHHRPENVLDAS
VVVVSTAISADNPELVAAREARIPVIRRAEMLAELMRFRHGIAVAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
THARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMETYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVVRELL
PRVGRHITTYGFSDDADVRIESYRQVGPQGHFTLSRQDKPLMTVTLNAPGRHNALNAAAAVAVATEEGIDDADILRALAG
FQGTGRRFDFLGEFPLEPVNGKSGSAMLVDDYGHHPTEVDATLKAARAGWPDKRLVMVFQPHRYTRTRDLYDDFANVLSQ
VDVLLMLDVYSAGETAIPGADSRSLCRTIRSRGKLDPILVSDADTVPETLAQLLQADDLVLVQGAGNVGKVARKLAELKL
QPQKKEEEHHGR
>Mature_492_residues
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLSALGATIYFHHRPENVLDAS
VVVVSTAISADNPELVAAREARIPVIRRAEMLAELMRFRHGIAVAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
THARLGSSRYLIAEADESDASFLHLQPMVAIVTNIEADHMETYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVVRELL
PRVGRHITTYGFSDDADVRIESYRQVGPQGHFTLSRQDKPLMTVTLNAPGRHNALNAAAAVAVATEEGIDDADILRALAG
FQGTGRRFDFLGEFPLEPVNGKSGSAMLVDDYGHHPTEVDATLKAARAGWPDKRLVMVFQPHRYTRTRDLYDDFANVLSQ
VDVLLMLDVYSAGETAIPGADSRSLCRTIRSRGKLDPILVSDADTVPETLAQLLQADDLVLVQGAGNVGKVARKLAELKL
QPQKKEEEHHGR

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=490, Percent_Identity=87.3469387755102, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=486, Percent_Identity=28.3950617283951, Blast_Score=148, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SERP5 (A8G9S8)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476996.1
- ProteinModelPortal:   A8G9S8
- SMR:   A8G9S8
- STRING:   A8G9S8
- GeneID:   5604639
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0762
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   SPRO399741:SPRO_0762-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 53567; Mature: 53567

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
SALGATIYFHHRPENVLDASVVVVSTAISADNPELVAAREARIPVIRRAEMLAELMRFRH
HHCCEEEEEEECCCCHHHHHEEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAVAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCHHCCCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMETYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVVRELL
CEEEHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRHITTYGFSDDADVRIESYRQVGPQGHFTLSRQDKPLMTVTLNAPGRHNALNAAAA
HHHCCEEEECCCCCCCCCHHHHHHHCCCCCCEEECCCCCCEEEEEECCCCCCCHHHHHHH
VAVATEEGIDDADILRALAGFQGTGRRFDFLGEFPLEPVNGKSGSAMLVDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATLKAARAGWPDKRLVMVFQPHRYTRTRDLYDDFANVLSQVDVLLMLDVYSAGETAIPGA
HHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
DSRSLCRTIRSRGKLDPILVSDADTVPETLAQLLQADDLVLVQGAGNVGKVARKLAELKL
CHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCC
QPQKKEEEHHGR
CCCCCCHHHCCC
>Mature Secondary Structure
MNTQQLAKLRTIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
SALGATIYFHHRPENVLDASVVVVSTAISADNPELVAAREARIPVIRRAEMLAELMRFRH
HHCCEEEEEEECCCCHHHHHEEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAVAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGTHARLGSSRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCHHCCCCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMETYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVVRELL
CEEEHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRHITTYGFSDDADVRIESYRQVGPQGHFTLSRQDKPLMTVTLNAPGRHNALNAAAA
HHHCCEEEECCCCCCCCCHHHHHHHCCCCCCEEECCCCCCEEEEEECCCCCCCHHHHHHH
VAVATEEGIDDADILRALAGFQGTGRRFDFLGEFPLEPVNGKSGSAMLVDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATLKAARAGWPDKRLVMVFQPHRYTRTRDLYDDFANVLSQVDVLLMLDVYSAGETAIPGA
HHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCC
DSRSLCRTIRSRGKLDPILVSDADTVPETLAQLLQADDLVLVQGAGNVGKVARKLAELKL
CHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCC
QPQKKEEEHHGR
CCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA