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The map label for this gene is ftsI [H]

Identifier: 157369000

GI number: 157369000

Start: 841391

End: 843154

Strand: Direct

Name: ftsI [H]

Synonym: Spro_0755

Alternate gene names: 157369000

Gene position: 841391-843154 (Clockwise)

Preceding gene: 157368999

Following gene: 157369001

Centisome position: 15.44

GC content: 56.8

Gene sequence:

>1764_bases
ATGAAAGCAGCACGGCCCGGTAAGTTGAAACGCCAGGAAGATCAGGCCAGCTTTGTAAGCTGGCGTTTTGCGTTGCTGTG
CGGCTGTATTTTGCTGGCGTTGGTTGGGTTGATGCTGCGTGTGGCTTATCTGCAGGTGATTAATCCGGACCGCCTGGTGA
AAGAAGGCGACATGCGTTCACTGCGCGTGCAGGAAGTGCCCACTTCGCGCGGCATGATCAGCGATCGCTCAGGGCGGCCG
CTGGCGGTGAGCGTGCCGGTGAACGCCATTTGGGCCGACCCGAAAGAGCTCAATGAGCGCGGTGGCATAACGCTGGACAG
CCGTTGGAAGGCACTGTCTGATGCGCTGAATATCCCGCTGGATCAGCTTTCTACCCGCATTAACGCCAACCCGAAAGGGC
GCTTTGTCTACCTGGCGCGCCAGGTGAATCCGGCGATTGGCGACTACATCCACAAGCTGAAACTGCCGGGAATTTACCTG
CGTCAGGAGTCTCGCCGCTACTATCCGTCCGGCCAGGTGACCTCGCATATTATCGGCGTGACCAACATCGACGGTCAGGG
GATTGAAGGCGTAGAGAAGAGCTTCGACCGCTGGCTGACCGGGCAACCGGGCGAAAGAACCGTACGTAAAGACCGCTTTG
GCAGGGTGATCGAGGACATTTCTTCGGTCGACAGTCAGGCGGCGCATAACCTGGTGCTGAGCGTCGACGAACGTCTGCAG
GCGCTGGTTTATCGCGAACTGAACAACGCCGTGGCGTTCAACAAGGCTGAATCCGGTACCGCGGTACTGGTGGACGTGAA
CACCGGCGAAGTGTTGGCGATGGCCAACAGCCCGTCTTATAACCCGAACAATATGGCCGGTACGCCGAAAGAAACCATGC
GTAACCGTGCTATCACCGATATTTTTGAACCCGGCTCCACCGTAAAACCTATGGTGGTCATGACGGCATTGCAGCACGGC
ATTGTGAAAGAAAACAGCGTGCTCAATACCGTCCCTTACCGTATCAACGGCAAGGAAATCAGGGACGTTGCGCGTTACGC
GGAACTCTCCCTGACCGGGATCTTGCAGAAGTCGAGTAACGTCGGTGTTTCACGACTGGCGTTATCGATGCCGTCCTCAG
CGTTAGTAGATACTTACTCTCGTTTTGGATTGGGAAAAGCGACCAATTTGGGGCTGGTCGGAGAAAGCAGTGGCATATAC
CCAAAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTCTCTTTCGGCTATGGGCTAATGGTAACCCCGTTACAGTT
AGCGCGAGTCTACGCCACGATCGGCAGCCTGGGCGTTTATCGTCCGCTGTCGATTACCAAAGTTGACCCACCGGTTGCCG
GTGAGCGCGTCTTCCCTGAACCTCTGGTGCGCACCGTGGTGCACATGATGGAAAGCGTTGCCCTGCCGGGCGGCGGTGGG
GTGAAAGCCGCGATCAAGGGCTACCGAATTGCCATTAAAACCGGTACCGCCAAAAAGGTGGGCCCGGACGGCAAATACGT
CAACCGATACATCGCTTATACCGCCGGCGTTGCGCCGGCGAGTAATCCCCGTTTTGCTCTGGTGGTGGTCATCAATGACC
CACAGGGTGGGAAGTACTACGGTGGTGCGATCTCCGCACCGGTATTTGGCGCCATCATGGGCGGCGTGTTGCGCACCATG
AACGTCGAGCCGGACGCGTTGCCTACCGGTGAGAAAAGCGATTTTGTAATTAACAGAAAAGAGGGTTCAGGTGGCCGATC
GTAA

Upstream 100 bases:

>100_bases
AAAACTGCAGATGCAACATGTTGATCCATCGCAGGAAAATATCATCGTTAAACAATGAATGGTTTAACTGAAATCACTAC
ACGGAGTAGAAAGGGAACGC

Downstream 100 bases:

>100_bases
TTTGCGCGACTTACTCGCTCCGTGGGTGCCAACGGCGCCCGGGCGCGCGCTGCGGGAAATGACATTAGACAGCCGTATTG
CGGCTGCCGGGGATCTGTTT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MKAARPGKLKRQEDQASFVSWRFALLCGCILLALVGLMLRVAYLQVINPDRLVKEGDMRSLRVQEVPTSRGMISDRSGRP
LAVSVPVNAIWADPKELNERGGITLDSRWKALSDALNIPLDQLSTRINANPKGRFVYLARQVNPAIGDYIHKLKLPGIYL
RQESRRYYPSGQVTSHIIGVTNIDGQGIEGVEKSFDRWLTGQPGERTVRKDRFGRVIEDISSVDSQAAHNLVLSVDERLQ
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNMAGTPKETMRNRAITDIFEPGSTVKPMVVMTALQHG
IVKENSVLNTVPYRINGKEIRDVARYAELSLTGILQKSSNVGVSRLALSMPSSALVDTYSRFGLGKATNLGLVGESSGIY
PKKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSLGVYRPLSITKVDPPVAGERVFPEPLVRTVVHMMESVALPGGGG
VKAAIKGYRIAIKTGTAKKVGPDGKYVNRYIAYTAGVAPASNPRFALVVVINDPQGGKYYGGAISAPVFGAIMGGVLRTM
NVEPDALPTGEKSDFVINRKEGSGGRS

Sequences:

>Translated_587_residues
MKAARPGKLKRQEDQASFVSWRFALLCGCILLALVGLMLRVAYLQVINPDRLVKEGDMRSLRVQEVPTSRGMISDRSGRP
LAVSVPVNAIWADPKELNERGGITLDSRWKALSDALNIPLDQLSTRINANPKGRFVYLARQVNPAIGDYIHKLKLPGIYL
RQESRRYYPSGQVTSHIIGVTNIDGQGIEGVEKSFDRWLTGQPGERTVRKDRFGRVIEDISSVDSQAAHNLVLSVDERLQ
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNMAGTPKETMRNRAITDIFEPGSTVKPMVVMTALQHG
IVKENSVLNTVPYRINGKEIRDVARYAELSLTGILQKSSNVGVSRLALSMPSSALVDTYSRFGLGKATNLGLVGESSGIY
PKKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSLGVYRPLSITKVDPPVAGERVFPEPLVRTVVHMMESVALPGGGG
VKAAIKGYRIAIKTGTAKKVGPDGKYVNRYIAYTAGVAPASNPRFALVVVINDPQGGKYYGGAISAPVFGAIMGGVLRTM
NVEPDALPTGEKSDFVINRKEGSGGRS
>Mature_587_residues
MKAARPGKLKRQEDQASFVSWRFALLCGCILLALVGLMLRVAYLQVINPDRLVKEGDMRSLRVQEVPTSRGMISDRSGRP
LAVSVPVNAIWADPKELNERGGITLDSRWKALSDALNIPLDQLSTRINANPKGRFVYLARQVNPAIGDYIHKLKLPGIYL
RQESRRYYPSGQVTSHIIGVTNIDGQGIEGVEKSFDRWLTGQPGERTVRKDRFGRVIEDISSVDSQAAHNLVLSVDERLQ
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNMAGTPKETMRNRAITDIFEPGSTVKPMVVMTALQHG
IVKENSVLNTVPYRINGKEIRDVARYAELSLTGILQKSSNVGVSRLALSMPSSALVDTYSRFGLGKATNLGLVGESSGIY
PKKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSLGVYRPLSITKVDPPVAGERVFPEPLVRTVVHMMESVALPGGGG
VKAAIKGYRIAIKTGTAKKVGPDGKYVNRYIAYTAGVAPASNPRFALVVVINDPQGGKYYGGAISAPVFGAIMGGVLRTM
NVEPDALPTGEKSDFVINRKEGSGGRS

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=585, Percent_Identity=84.957264957265, Blast_Score=1044, Evalue=0.0,
Organism=Escherichia coli, GI1786854, Length=619, Percent_Identity=25.686591276252, Blast_Score=142, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63731; Mature: 63731

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAARPGKLKRQEDQASFVSWRFALLCGCILLALVGLMLRVAYLQVINPDRLVKEGDMRS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
LRVQEVPTSRGMISDRSGRPLAVSVPVNAIWADPKELNERGGITLDSRWKALSDALNIPL
EEEEECCCCCCCCCCCCCCCEEEECCCCEEECCHHHHHHCCCEEECHHHHHHHHHHCCCH
DQLSTRINANPKGRFVYLARQVNPAIGDYIHKLKLPGIYLRQESRRYYPSGQVTSHIIGV
HHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEE
TNIDGQGIEGVEKSFDRWLTGQPGERTVRKDRFGRVIEDISSVDSQAAHNLVLSVDERLQ
ECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHH
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNMAGTPKETMRNRAITD
HHHHHHHHCCEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCHHH
IFEPGSTVKPMVVMTALQHGIVKENSVLNTVPYRINGKEIRDVARYAELSLTGILQKSSN
HHCCCCCCCHHHHHHHHHHCCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCCC
VGVSRLALSMPSSALVDTYSRFGLGKATNLGLVGESSGIYPKKQRWSDIERATFSFGYGL
CCHHHHEECCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCH
MVTPLQLARVYATIGSLGVYRPLSITKVDPPVAGERVFPEPLVRTVVHMMESVALPGGGG
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
VKAAIKGYRIAIKTGTAKKVGPDGKYVNRYIAYTAGVAPASNPRFALVVVINDPQGGKYY
CEEEECCEEEEEEECCCCCCCCCCHHHHHHHHEECCCCCCCCCCEEEEEEEECCCCCCEE
GGAISAPVFGAIMGGVLRTMNVEPDALPTGEKSDFVINRKEGSGGRS
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MKAARPGKLKRQEDQASFVSWRFALLCGCILLALVGLMLRVAYLQVINPDRLVKEGDMRS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
LRVQEVPTSRGMISDRSGRPLAVSVPVNAIWADPKELNERGGITLDSRWKALSDALNIPL
EEEEECCCCCCCCCCCCCCCEEEECCCCEEECCHHHHHHCCCEEECHHHHHHHHHHCCCH
DQLSTRINANPKGRFVYLARQVNPAIGDYIHKLKLPGIYLRQESRRYYPSGQVTSHIIGV
HHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEE
TNIDGQGIEGVEKSFDRWLTGQPGERTVRKDRFGRVIEDISSVDSQAAHNLVLSVDERLQ
ECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHH
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNMAGTPKETMRNRAITD
HHHHHHHHCCEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCHHH
IFEPGSTVKPMVVMTALQHGIVKENSVLNTVPYRINGKEIRDVARYAELSLTGILQKSSN
HHCCCCCCCHHHHHHHHHHCCCCCCCEEECCCEEECCHHHHHHHHHHHHHHHHHHHCCCC
VGVSRLALSMPSSALVDTYSRFGLGKATNLGLVGESSGIYPKKQRWSDIERATFSFGYGL
CCHHHHEECCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCH
MVTPLQLARVYATIGSLGVYRPLSITKVDPPVAGERVFPEPLVRTVVHMMESVALPGGGG
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
VKAAIKGYRIAIKTGTAKKVGPDGKYVNRYIAYTAGVAPASNPRFALVVVINDPQGGKYY
CEEEECCEEEEEEECCCCCCCCCCHHHHHHHHEECCCCCCCCCCEEEEEEEECCCCCCEE
GGAISAPVFGAIMGGVLRTMNVEPDALPTGEKSDFVINRKEGSGGRS
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]