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The map label for this gene is kefC [H]

Identifier: 157368961

GI number: 157368961

Start: 793181

End: 795034

Strand: Direct

Name: kefC [H]

Synonym: Spro_0716

Alternate gene names: 157368961

Gene position: 793181-795034 (Clockwise)

Preceding gene: 157368960

Following gene: 157368963

Centisome position: 14.56

GC content: 58.09

Gene sequence:

>1854_bases
ATGGATAATCACCATATGATGATTGAGGGGCTGATCTATCTGGGATCGGCCGCGCTGTTCGTGCCGATCGCGGTGCGGCT
GGGGTTGGGCTCGGTACTGGGTTATCTGATCGCCGGCTGTATTATTGGTCCCTGGGGGCTGAAACTGGTCTCTGATGCCG
AGTCGATCCTCACCTTTGCCGAGATTGGCGTGGTGCTGATGCTGTTTATCATCGGGCTGGAGCTGGATCCGAAACGGCTG
TGGACACTGCGTGCTTCGGTGTTTGGCGGCGGTATTATCCAGATGGCGGCCTGCGGGTTGGCGCTGAGTGCCTTTTGCTA
TTTCCTCGGGCTGGACTGGAAGGTGGCACTGCTGATTGGCCTGACGCTGGCTCTGTCCTCCACCGCCATTGCCATGCAGG
CGATGAGTGAACGTAACCTGACACCCTCACCGATTGGTCGCAGCGCGTTTGCGGCCTTGCTATTCCAGGATATTGCGGCG
ATCCCGCTGGTGGCGATGATCCCATTGTTGGCCAGCAGCGGCGCCGTCACCACGTTAGCGACCTTCGCCCTGTCGGCGGC
CAAGGTCGTCGGCGCGCTGGTGATTGTGGTGCTGCTCGGCCGCTATGTGACCCGGCCACTGCTGCACTTTGTCGCCCGCT
CCGGCATGCGTGAAGTTTTTAGCGCCGTGGCGCTGTTCCTGGTGTTTGGCTTTGGCATCCTGCTGGAAATGGCCGGGCTG
TCGATGGCGATGGGCGCCTTCCTTGCCGGGGTGATGCTGGCGAGCTCCGAATACCGTCATGCATTGGAAAGTGATATTCA
GCCGTTCAAAGGCCTGCTGCTCGGGCTGTTCTTTATCGGTGTTGGCATGTCGATCGACTTCGGCACCCTGTTCCATCATC
CGCTGTTGATTGCCTCGCTGCTGTTGGGCTTTATGCTGATCAAAGCGGCGCTGTTGTGGTTGATTGCTCCCTGGCTCGGC
GTACCGAAACGCCAGCGCGGCATGTTCGCCATTTTATTAGGTCAGGGCAGTGAGTTTGCCTTCGTGATCTTCGGGGCCGC
ACAGCTGGCCGGGGTGTTGCCGCCGGAGTGGGCAAAATCCTTGACGCTGGCGGTGGCCTTGTCGATGGCGGTGACGCCGC
TGTTGCTGGTGGTGGCTGCAAGGATTGAGAAAAACGCGCCGAAAGATGAACGTCCGGCGGATGAAATCGATGATGAGAAT
GCCAGTGTGATCATTGCCGGATTTGGCCGTTTTGGCCAGATCGCCGGCCGTTTGCTGTTGGCCAATGGTGTGCATACCGT
GGTACTGGATCACGATCCGGACCATATTGAAACGCTGCGCAAATTCGATACCAAGGTGTTTTATGGTGATGCCACCCGCG
CCGATCTGCTGGAGGCCGCAGGCGCCGAGCATGCCAAGGTACTGATCAATGCTATCGATGATGTGGAGGCCAATCTGCAA
TTGACCGAACTGGCCAAGCGGCATTTCCCACACCTGAAGGTGGTGGCGCGCGCACGCGATGTTGACCATTGGTATCAGTT
GCGCCAGTTAGGGGTGGAAAGTCCGGAGCGTGAAACCTTTGAAAGCTCGTTGCGCATTGGTCGCGAAACGCTGGAACTTT
TGGGGTTGGATGCTTACGAGGCACGTGAAAAAGCGGATACCTTCCGGCGCTACAACCTGAAAATGCTCGAGGAAACGCTG
GAGAATTATCAGGATACCGAATTCCGTCTCGCGGGTCTGCAACGGGCCAAAGAGATGCTCAGTGCGGCTATCGAGCAGGA
TCAGAATCGGTTGGCACGGGTACAGCAGAGTGGCTGGCGTGGCAGTATTGACGGCAAGGCACCAGAGGATGAGGTAGTGG
AAGCCAAGGGGTAA

Upstream 100 bases:

>100_bases
TGCAATGAACCGGCGCTGATTGCCGCCGGAGAAGCCTACCGGCGGCGGCTGGTGGATTACCTGATGGAACACAGTGAACC
GGCGGAGCAGGGAGTAGAAC

Downstream 100 bases:

>100_bases
ACCCGATGGGCGCAGCACGGTGCTGCGCCCCATTCTGGAAGAGTTAGCTCAGTGCGACTTTGATGCCCAGGGCAATCAAC
ATGCCGCCCAGCAATTTATC

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MDNHHMMIEGLIYLGSAALFVPIAVRLGLGSVLGYLIAGCIIGPWGLKLVSDAESILTFAEIGVVLMLFIIGLELDPKRL
WTLRASVFGGGIIQMAACGLALSAFCYFLGLDWKVALLIGLTLALSSTAIAMQAMSERNLTPSPIGRSAFAALLFQDIAA
IPLVAMIPLLASSGAVTTLATFALSAAKVVGALVIVVLLGRYVTRPLLHFVARSGMREVFSAVALFLVFGFGILLEMAGL
SMAMGAFLAGVMLASSEYRHALESDIQPFKGLLLGLFFIGVGMSIDFGTLFHHPLLIASLLLGFMLIKAALLWLIAPWLG
VPKRQRGMFAILLGQGSEFAFVIFGAAQLAGVLPPEWAKSLTLAVALSMAVTPLLLVVAARIEKNAPKDERPADEIDDEN
ASVIIAGFGRFGQIAGRLLLANGVHTVVLDHDPDHIETLRKFDTKVFYGDATRADLLEAAGAEHAKVLINAIDDVEANLQ
LTELAKRHFPHLKVVARARDVDHWYQLRQLGVESPERETFESSLRIGRETLELLGLDAYEAREKADTFRRYNLKMLEETL
ENYQDTEFRLAGLQRAKEMLSAAIEQDQNRLARVQQSGWRGSIDGKAPEDEVVEAKG

Sequences:

>Translated_617_residues
MDNHHMMIEGLIYLGSAALFVPIAVRLGLGSVLGYLIAGCIIGPWGLKLVSDAESILTFAEIGVVLMLFIIGLELDPKRL
WTLRASVFGGGIIQMAACGLALSAFCYFLGLDWKVALLIGLTLALSSTAIAMQAMSERNLTPSPIGRSAFAALLFQDIAA
IPLVAMIPLLASSGAVTTLATFALSAAKVVGALVIVVLLGRYVTRPLLHFVARSGMREVFSAVALFLVFGFGILLEMAGL
SMAMGAFLAGVMLASSEYRHALESDIQPFKGLLLGLFFIGVGMSIDFGTLFHHPLLIASLLLGFMLIKAALLWLIAPWLG
VPKRQRGMFAILLGQGSEFAFVIFGAAQLAGVLPPEWAKSLTLAVALSMAVTPLLLVVAARIEKNAPKDERPADEIDDEN
ASVIIAGFGRFGQIAGRLLLANGVHTVVLDHDPDHIETLRKFDTKVFYGDATRADLLEAAGAEHAKVLINAIDDVEANLQ
LTELAKRHFPHLKVVARARDVDHWYQLRQLGVESPERETFESSLRIGRETLELLGLDAYEAREKADTFRRYNLKMLEETL
ENYQDTEFRLAGLQRAKEMLSAAIEQDQNRLARVQQSGWRGSIDGKAPEDEVVEAKG
>Mature_617_residues
MDNHHMMIEGLIYLGSAALFVPIAVRLGLGSVLGYLIAGCIIGPWGLKLVSDAESILTFAEIGVVLMLFIIGLELDPKRL
WTLRASVFGGGIIQMAACGLALSAFCYFLGLDWKVALLIGLTLALSSTAIAMQAMSERNLTPSPIGRSAFAALLFQDIAA
IPLVAMIPLLASSGAVTTLATFALSAAKVVGALVIVVLLGRYVTRPLLHFVARSGMREVFSAVALFLVFGFGILLEMAGL
SMAMGAFLAGVMLASSEYRHALESDIQPFKGLLLGLFFIGVGMSIDFGTLFHHPLLIASLLLGFMLIKAALLWLIAPWLG
VPKRQRGMFAILLGQGSEFAFVIFGAAQLAGVLPPEWAKSLTLAVALSMAVTPLLLVVAARIEKNAPKDERPADEIDDEN
ASVIIAGFGRFGQIAGRLLLANGVHTVVLDHDPDHIETLRKFDTKVFYGDATRADLLEAAGAEHAKVLINAIDDVEANLQ
LTELAKRHFPHLKVVARARDVDHWYQLRQLGVESPERETFESSLRIGRETLELLGLDAYEAREKADTFRRYNLKMLEETL
ENYQDTEFRLAGLQRAKEMLSAAIEQDQNRLARVQQSGWRGSIDGKAPEDEVVEAKG

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=422, Percent_Identity=25.8293838862559, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786232, Length=604, Percent_Identity=72.8476821192053, Blast_Score=874, Evalue=0.0,
Organism=Escherichia coli, GI1789749, Length=604, Percent_Identity=42.3841059602649, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1786685, Length=537, Percent_Identity=29.0502793296089, Blast_Score=169, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 66916; Mature: 66916

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNHHMMIEGLIYLGSAALFVPIAVRLGLGSVLGYLIAGCIIGPWGLKLVSDAESILTFA
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EIGVVLMLFIIGLELDPKRLWTLRASVFGGGIIQMAACGLALSAFCYFLGLDWKVALLIG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LTLALSSTAIAMQAMSERNLTPSPIGRSAFAALLFQDIAAIPLVAMIPLLASSGAVTTLA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TFALSAAKVVGALVIVVLLGRYVTRPLLHFVARSGMREVFSAVALFLVFGFGILLEMAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMAMGAFLAGVMLASSEYRHALESDIQPFKGLLLGLFFIGVGMSIDFGTLFHHPLLIASL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLGFMLIKAALLWLIAPWLGVPKRQRGMFAILLGQGSEFAFVIFGAAQLAGVLPPEWAKS
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEEHHHHHCCCCHHHHHH
LTLAVALSMAVTPLLLVVAARIEKNAPKDERPADEIDDENASVIIAGFGRFGQIAGRLLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHE
ANGVHTVVLDHDPDHIETLRKFDTKVFYGDATRADLLEAAGAEHAKVLINAIDDVEANLQ
ECCCEEEEECCCCHHHHHHHHHCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCH
LTELAKRHFPHLKVVARARDVDHWYQLRQLGVESPERETFESSLRIGRETLELLGLDAYE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
AREKADTFRRYNLKMLEETLENYQDTEFRLAGLQRAKEMLSAAIEQDQNRLARVQQSGWR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSIDGKAPEDEVVEAKG
CCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDNHHMMIEGLIYLGSAALFVPIAVRLGLGSVLGYLIAGCIIGPWGLKLVSDAESILTFA
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EIGVVLMLFIIGLELDPKRLWTLRASVFGGGIIQMAACGLALSAFCYFLGLDWKVALLIG
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LTLALSSTAIAMQAMSERNLTPSPIGRSAFAALLFQDIAAIPLVAMIPLLASSGAVTTLA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TFALSAAKVVGALVIVVLLGRYVTRPLLHFVARSGMREVFSAVALFLVFGFGILLEMAGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMAMGAFLAGVMLASSEYRHALESDIQPFKGLLLGLFFIGVGMSIDFGTLFHHPLLIASL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLGFMLIKAALLWLIAPWLGVPKRQRGMFAILLGQGSEFAFVIFGAAQLAGVLPPEWAKS
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEEHHHHHCCCCHHHHHH
LTLAVALSMAVTPLLLVVAARIEKNAPKDERPADEIDDENASVIIAGFGRFGQIAGRLLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHE
ANGVHTVVLDHDPDHIETLRKFDTKVFYGDATRADLLEAAGAEHAKVLINAIDDVEANLQ
ECCCEEEEECCCCHHHHHHHHHCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCH
LTELAKRHFPHLKVVARARDVDHWYQLRQLGVESPERETFESSLRIGRETLELLGLDAYE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
AREKADTFRRYNLKMLEETLENYQDTEFRLAGLQRAKEMLSAAIEQDQNRLARVQQSGWR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSIDGKAPEDEVVEAKG
CCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA