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The map label for this gene is lspA

Identifier: 157368944

GI number: 157368944

Start: 772652

End: 773161

Strand: Direct

Name: lspA

Synonym: Spro_0699

Alternate gene names: 157368944

Gene position: 772652-773161 (Clockwise)

Preceding gene: 157368943

Following gene: 157368945

Centisome position: 14.18

GC content: 55.69

Gene sequence:

>510_bases
ATGAGTAAACCTATTTGTTCGACCGGCTTGCGCTGGCTATGGCTGGTAGTGGTAGTGCTGGTGCTGGATTTTGCCAGCAA
GCAGTGGATCCTCGGTAACTTCGTGCTGGGCCAGTCCCAGCCGCTGATCCCGTCGTTCAATCTGTTTTATGCGCGTAACT
ACGGTGCCGCATTCAGCTTCCTGGCCGATCACGGCGGTTGGCAGCGCTGGTTCTTCGCCGGTATTGCCGTCGCCATCGTG
GCGGTGCTGCTGGTGATGATGTACCGCAGTTCGGCGCAGCAAAAACTGAACAACATTGCCTATGCATTTATCATCGGTGG
AGCGCTCGGCAACCTGTTCGATCGCTTGTGGCACGGCTTCGTGGTCGATTTTATCGACTTCTATGTGGGCAACTGGCACT
ACCCGACCTTCAACCTGGCGGATAGCTTTATCTGCGTGGGGGCGGCGATGATCGTGCTGGAAGGCTTCTTGTCGCCGGCG
AACAAAAGTGCAAAGAGCAAAGGTGAGTAA

Upstream 100 bases:

>100_bases
ATTACACCACCGATATCGGCCTGGTGGCGGAGCACGCAGATCTCTGCGGCCGCTGTGTTGTCAACGTAGCCGGCGACGGC
GAAAAGCGTAAGTTTGCCTG

Downstream 100 bases:

>100_bases
TATGACGGCTCAGGTTAAGGGCGACAGCGAAGTATTGGTTCACTTCACGCTGAAACTGGAAGACGGAACGACGGCAGAAT
CCACTCGTGGCAACGGTAAA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSKPICSTGLRWLWLVVVVLVLDFASKQWILGNFVLGQSQPLIPSFNLFYARNYGAAFSFLADHGGWQRWFFAGIAVAIV
AVLLVMMYRSSAQQKLNNIAYAFIIGGALGNLFDRLWHGFVVDFIDFYVGNWHYPTFNLADSFICVGAAMIVLEGFLSPA
NKSAKSKGE

Sequences:

>Translated_169_residues
MSKPICSTGLRWLWLVVVVLVLDFASKQWILGNFVLGQSQPLIPSFNLFYARNYGAAFSFLADHGGWQRWFFAGIAVAIV
AVLLVMMYRSSAQQKLNNIAYAFIIGGALGNLFDRLWHGFVVDFIDFYVGNWHYPTFNLADSFICVGAAMIVLEGFLSPA
NKSAKSKGE
>Mature_168_residues
SKPICSTGLRWLWLVVVVLVLDFASKQWILGNFVLGQSQPLIPSFNLFYARNYGAAFSFLADHGGWQRWFFAGIAVAIVA
VLLVMMYRSSAQQKLNNIAYAFIIGGALGNLFDRLWHGFVVDFIDFYVGNWHYPTFNLADSFICVGAAMIVLEGFLSPAN
KSAKSKGE

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=163, Percent_Identity=76.6871165644172, Blast_Score=256, Evalue=4e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_SERP5 (A8G9L5)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001476933.1
- STRING:   A8G9L5
- MEROPS:   A08.001
- GeneID:   5605479
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_0699
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   ADSSGWQ
- ProtClustDB:   PRK00376
- BioCyc:   SPRO399741:SPRO_0699-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18842; Mature: 18711

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0x214e9fe8)-; HASH(0x228e9830)-; HASH(0x22a15340)-; HASH(0x22579b8c)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPICSTGLRWLWLVVVVLVLDFASKQWILGNFVLGQSQPLIPSFNLFYARNYGAAFSF
CCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEECCCCCCCCCCHHHEECCCCHHHHH
LADHGGWQRWFFAGIAVAIVAVLLVMMYRSSAQQKLNNIAYAFIIGGALGNLFDRLWHGF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVDFIDFYVGNWHYPTFNLADSFICVGAAMIVLEGFLSPANKSAKSKGE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure 
SKPICSTGLRWLWLVVVVLVLDFASKQWILGNFVLGQSQPLIPSFNLFYARNYGAAFSF
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHEEECCCCCCCCCCHHHEECCCCHHHHH
LADHGGWQRWFFAGIAVAIVAVLLVMMYRSSAQQKLNNIAYAFIIGGALGNLFDRLWHGF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVDFIDFYVGNWHYPTFNLADSFICVGAAMIVLEGFLSPANKSAKSKGE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA