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The map label for this gene is fucP [H]

Identifier: 157368889

GI number: 157368889

Start: 708895

End: 710124

Strand: Direct

Name: fucP [H]

Synonym: Spro_0644

Alternate gene names: 157368889

Gene position: 708895-710124 (Clockwise)

Preceding gene: 157368888

Following gene: 157368891

Centisome position: 13.01

GC content: 56.75

Gene sequence:

>1230_bases
ATGCTTGCTGAAAAAACTGCAGCCCCACCTCAGGTGGGCGCCAAGGCGACGGCCAATCTGCGCTGGGCTTTTATCTTGGT
GACCAGCCTGTTCTTTATGTGGGGGCTGTCATATGGCCTGCTGGACGTATTAAATAAGCACTTTCAGGAAACGCTGCACG
TGACCAAGGCGCAGTCGGGATTATTACAGGCGGCATATTTTGGCGCCTACTTCCTGGTGGCGCTGCCCGCCGGCTATTTT
ATGGATAAAAAAGGCTACAAAGCCGGCATTCTGATCGGACTGTGCCTGTATGCGCTCGGGGCATTGCTGTTTGTACCGGC
GGCATCCGCCAACAGTTTTGGCATGTTCCTGTTTGCCCTGTTTGTGATTGCCTGCGGGCTGGGTTGCCTGGAAACCGCCG
CCAACCCTTACGCCACGGTATTGGGGGACGCAAAGGGGGCCGAATGGCGGCTGAACCTGTCCCAGTCGTTTAATGGGTTA
GGGCAGTTTATCGGCCCGATGATCGGCGGCACGCTGTTTTTCTCCGCCACCCAGGGGGCGGGCAGCGGTGACCAGAGTGC
GGTGAAGATGACCTATGTGGCGATCGCCGTGTTGGTACTGCTGATTGCCTTTTTGTTCAGCCGCACCCGGTTGCCGGACA
TCCGCGAGGAAGAGCAGCCGGAGCACGGTGAAATTGCTCAGGGGTTGTGGCAGCACAAGCACTTTGTTGGCGGGGTGATC
ACCCAGTTCTTCTACGTGGCGGCACAGGTCGGTGTTGGTGCGTTCTTTATTAACTACGCCACCGAACACTGGAGCGACGT
TTCCAACCAAAGCGCGTCCTATTTGCTCTCCATCGCCATGATTTGCTTTATGGTCGGGCGCTTCTTCAGCACCTGGCTGA
TGGGCAGGGTCAAACCGGCCACGCTGTTGATGGTTTACTCGTTGGTCAACATTGTGCTGTGCGGTGTCGTCATGCTCAGT
ATGGATGGCATCTCGGTGGTGGCGCTGATCGCCGTATTCTTCTTTATGTCGATTATGTTCCCGACCATTTTCGCCCTTGG
GGTGAAAAACATGGGCAAACACACCAAGCGCGCCAGCTCCTTTATGATCATGGCGATCGTTGGCGGTGCCATCATGCCTT
ACTTTATGGGGGCGCTGGCGGACAGGTATAGCACGGCGTTGTCGTATTGCCTGCCGCTGCTGTGCTTCGCCGTGGTGTTT
GCTTACGGCCTGCAGCAGCGCCGCCGCTAA

Upstream 100 bases:

>100_bases
AGGTGGCCACCCCCTGGACGCCGCAAGGCGAAAAATGGGTGGTGATGGAGCGGATATTCTCTTTGCAACAACAATAACTT
ACCCTACCGAGGATATATCA

Downstream 100 bases:

>100_bases
GCTCACAGCCCGCCGGCTCACACGGCGGCGGGTTGAACGTTTTGCGCCAGCTGAATATTATTGCGGCCGTTGTTTTTCGC
CTGATATAACGCGGCGTCGG

Product: L-fucose transporter

Products: Proton [Cytoplasm]; L-fucose [Cytoplasm] [C]

Alternate protein names: 6-deoxy-L-galactose permease; L-fucose permease [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MLAEKTAAPPQVGAKATANLRWAFILVTSLFFMWGLSYGLLDVLNKHFQETLHVTKAQSGLLQAAYFGAYFLVALPAGYF
MDKKGYKAGILIGLCLYALGALLFVPAASANSFGMFLFALFVIACGLGCLETAANPYATVLGDAKGAEWRLNLSQSFNGL
GQFIGPMIGGTLFFSATQGAGSGDQSAVKMTYVAIAVLVLLIAFLFSRTRLPDIREEEQPEHGEIAQGLWQHKHFVGGVI
TQFFYVAAQVGVGAFFINYATEHWSDVSNQSASYLLSIAMICFMVGRFFSTWLMGRVKPATLLMVYSLVNIVLCGVVMLS
MDGISVVALIAVFFFMSIMFPTIFALGVKNMGKHTKRASSFMIMAIVGGAIMPYFMGALADRYSTALSYCLPLLCFAVVF
AYGLQQRRR

Sequences:

>Translated_409_residues
MLAEKTAAPPQVGAKATANLRWAFILVTSLFFMWGLSYGLLDVLNKHFQETLHVTKAQSGLLQAAYFGAYFLVALPAGYF
MDKKGYKAGILIGLCLYALGALLFVPAASANSFGMFLFALFVIACGLGCLETAANPYATVLGDAKGAEWRLNLSQSFNGL
GQFIGPMIGGTLFFSATQGAGSGDQSAVKMTYVAIAVLVLLIAFLFSRTRLPDIREEEQPEHGEIAQGLWQHKHFVGGVI
TQFFYVAAQVGVGAFFINYATEHWSDVSNQSASYLLSIAMICFMVGRFFSTWLMGRVKPATLLMVYSLVNIVLCGVVMLS
MDGISVVALIAVFFFMSIMFPTIFALGVKNMGKHTKRASSFMIMAIVGGAIMPYFMGALADRYSTALSYCLPLLCFAVVF
AYGLQQRRR
>Mature_409_residues
MLAEKTAAPPQVGAKATANLRWAFILVTSLFFMWGLSYGLLDVLNKHFQETLHVTKAQSGLLQAAYFGAYFLVALPAGYF
MDKKGYKAGILIGLCLYALGALLFVPAASANSFGMFLFALFVIACGLGCLETAANPYATVLGDAKGAEWRLNLSQSFNGL
GQFIGPMIGGTLFFSATQGAGSGDQSAVKMTYVAIAVLVLLIAFLFSRTRLPDIREEEQPEHGEIAQGLWQHKHFVGGVI
TQFFYVAAQVGVGAFFINYATEHWSDVSNQSASYLLSIAMICFMVGRFFSTWLMGRVKPATLLMVYSLVNIVLCGVVMLS
MDGISVVALIAVFFFMSIMFPTIFALGVKNMGKHTKRASSFMIMAIVGGAIMPYFMGALADRYSTALSYCLPLLCFAVVF
AYGLQQRRR

Specific function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-

COG id: COG0738

COG function: function code G; Fucose permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family [H]

Homologues:

Organism=Escherichia coli, GI1789166, Length=404, Percent_Identity=38.8613861386139, Blast_Score=275, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005275
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44476; Mature: 44476

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-fucose [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-fucose [Periplasm] = Proton [Cytoplasm] + L-fucose [Cytoplasm] [C]

General reaction: Permease [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2664711; 9278503; 2553671; 8052131; 2829831; 7783647 [H]