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The map label for this gene is cpdB [H]

Identifier: 157368700

GI number: 157368700

Start: 501039

End: 502991

Strand: Reverse

Name: cpdB [H]

Synonym: Spro_0453

Alternate gene names: 157368700

Gene position: 502991-501039 (Counterclockwise)

Preceding gene: 157368702

Following gene: 157368698

Centisome position: 9.23

GC content: 55.56

Gene sequence:

>1953_bases
ATGATGAAGCGTCCGCTGACGTTGTCTGCCCTCGCTATGCTGGTGTGCGCCTCCGCACAAGCGGCAACGGTCGATCTGCG
CGTGCTGGAAACCACCGACCTGCACAGCAACATGATGGACTTCGATTACTACAAGGATAAACCGACCGATAAATTCGGTC
TGGTACGTACCGCCAGCCTGATTGAACAGGCCCGTCAGCAGGCAGCCAATACGGTGCTGGTGGACAACGGCGACATTATT
CAGGGCAGCCCGCTCGGCGATTATATGGCGGCCAAGGGCCTGAAACCCGGTGATGTACACCCGGTGTATAAGGCGATGAA
TACCCTGAATTATGTGGTCGGCAATATCGGCAACCATGAGTTCAACTACGGGCTCGATTACCTGAAAAACGCCATTGCCG
GTGCCAAATTCCCGTATATCAACGCCAACGTGATCGACGCTAAAACACAAAAACCCCTGTTCACTCCTTACATTATCGTC
GATACGCCGGTAAAAGACCGTGACGGCAAAGAACATAGTTTGCGCATCGGTTATATCGGCTTTGTGCCACCACAAATCCT
GGTGTGGGATAAAGCCAATCTGCAGGGCAAGGTCACCGTTAACGACATCACCGAAACGGCTAAACGTTACGTGCCGGAAA
TGCGCAAACAGGGCGCCGATCTGGTGGTGGCTATCCCGCACTCCGGCCTGTCCAGCGAGCCGTACAAGGCCATGGCGGAA
AACTCGGTGTACTACCTCAGCCAGGTACCGGGCATCGACGCCATCATGTTCGGCCACGCTCACGCCGTGTTCCCTAGCAA
GGACTTCGCCAATATCAAAGGGGCTGACATCGCACAGGGTACGCTGAACGGCATCCCGGCAGTGATGCCGGGCCAGTGGG
GCGATCATCTCGGCGTGGTCGACCTGCAATTGAATAACGACAGCGGCACCTGGAAAGTCACGGCGGCCAAGGCGCAAGCT
CGGCCGATTTACGACAAAGAGAACAAGAAATCGCTGGCGGCGGAAGACGCCAACCTGCTGAAAGTGCTGGCGGAAGATCA
CAAAGGCACGCGAGATTTCGTCAGCAAGCCCGTCGGCAAGGCCGACGACAACATGTACAGCTATCTGGCGCTGGTGCAGG
ATGATCCGACGGTGCAGATCGTCAATAACGCGCAAAAGGCCTACGTCGAGCACTATATTCAGGGCGATCCGGATCTGGCT
GACCTGCCGGTGCTGTCAGCCGCGGCCCCGTTCAAGGTGGGCGGGCGCAAAAACGATCCGGCCAGCTTCGTTGAGGTGGA
AAAAGGTCAGCTCACCTTCCGTAACGCTTCAGACCTCTACCTTTATCCCAACACACTGGTGGTGGTGAAAGCCAGCGGCA
AAGAAGTGAAGGAATGGCTGGAGTGTTCCGCCGGTCAGTTCAACCAGATCGACGTCAACAGCAGCAAACCACAAGGCCTG
ATCAACTGGGATGGTTTCCGCACCTATAACTTCGATGTGATTGACGGAGTCAATTATCAGGTCGACGTCAGCCAACCGGC
GCGTTACGACGGCGAATGCCAGTTAATTAACGACAAGGCGCAGCGCATCAAGGAACTGACGTTCAAAGGCAAACCGATCG
ATCCAAACGCCACTTTCCTGGTTGCCACCAATAACTACCGCGCCTACGGCGGCAAGTTTGCCGGCACCGGCGATCAACAC
ATTGCTTTTGCTTCACCGGATGAGAACCGTTCGGTACTGGCGGCTTATATCAGCGCTGAAACCAGGCAACACGGCGCAGT
GAAGCCACAGGTGGATAATAACTGGCGCCTGGCGACGTTCAGCAGCCCGCAGCCGCTGGATATCCGCTTTGAAACCTCGC
CGAGTGACAAAGCCAACGCGTTTATCAAAACGCACGCCCAGTACCCGATGAAAGCTGAAGGGACAGACAGCATCGGCTTT
GCGGTTTATCAGATTGATTTGCAGAAGAAATAA

Upstream 100 bases:

>100_bases
GCTTATTTTCTGCCACACTTCACAGTTTGGTGAGACAACCAATGTTAATTACATGTTCCTCTGCGATAAAACTCGAAAAA
TGGAATGGAGAAAACTAAAA

Downstream 100 bases:

>100_bases
ACAATAAGGGCGCCGTTAAGGCGCCCTTGAAAAACTCTGCGGTGACTTACAGAATTTCCAACAGCTCGACGTCAAACACC
AGCGCGCTGAATGGCGGGAT

Product: bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MMKRPLTLSALAMLVCASAQAATVDLRVLETTDLHSNMMDFDYYKDKPTDKFGLVRTASLIEQARQQAANTVLVDNGDII
QGSPLGDYMAAKGLKPGDVHPVYKAMNTLNYVVGNIGNHEFNYGLDYLKNAIAGAKFPYINANVIDAKTQKPLFTPYIIV
DTPVKDRDGKEHSLRIGYIGFVPPQILVWDKANLQGKVTVNDITETAKRYVPEMRKQGADLVVAIPHSGLSSEPYKAMAE
NSVYYLSQVPGIDAIMFGHAHAVFPSKDFANIKGADIAQGTLNGIPAVMPGQWGDHLGVVDLQLNNDSGTWKVTAAKAQA
RPIYDKENKKSLAAEDANLLKVLAEDHKGTRDFVSKPVGKADDNMYSYLALVQDDPTVQIVNNAQKAYVEHYIQGDPDLA
DLPVLSAAAPFKVGGRKNDPASFVEVEKGQLTFRNASDLYLYPNTLVVVKASGKEVKEWLECSAGQFNQIDVNSSKPQGL
INWDGFRTYNFDVIDGVNYQVDVSQPARYDGECQLINDKAQRIKELTFKGKPIDPNATFLVATNNYRAYGGKFAGTGDQH
IAFASPDENRSVLAAYISAETRQHGAVKPQVDNNWRLATFSSPQPLDIRFETSPSDKANAFIKTHAQYPMKAEGTDSIGF
AVYQIDLQKK

Sequences:

>Translated_650_residues
MMKRPLTLSALAMLVCASAQAATVDLRVLETTDLHSNMMDFDYYKDKPTDKFGLVRTASLIEQARQQAANTVLVDNGDII
QGSPLGDYMAAKGLKPGDVHPVYKAMNTLNYVVGNIGNHEFNYGLDYLKNAIAGAKFPYINANVIDAKTQKPLFTPYIIV
DTPVKDRDGKEHSLRIGYIGFVPPQILVWDKANLQGKVTVNDITETAKRYVPEMRKQGADLVVAIPHSGLSSEPYKAMAE
NSVYYLSQVPGIDAIMFGHAHAVFPSKDFANIKGADIAQGTLNGIPAVMPGQWGDHLGVVDLQLNNDSGTWKVTAAKAQA
RPIYDKENKKSLAAEDANLLKVLAEDHKGTRDFVSKPVGKADDNMYSYLALVQDDPTVQIVNNAQKAYVEHYIQGDPDLA
DLPVLSAAAPFKVGGRKNDPASFVEVEKGQLTFRNASDLYLYPNTLVVVKASGKEVKEWLECSAGQFNQIDVNSSKPQGL
INWDGFRTYNFDVIDGVNYQVDVSQPARYDGECQLINDKAQRIKELTFKGKPIDPNATFLVATNNYRAYGGKFAGTGDQH
IAFASPDENRSVLAAYISAETRQHGAVKPQVDNNWRLATFSSPQPLDIRFETSPSDKANAFIKTHAQYPMKAEGTDSIGF
AVYQIDLQKK
>Mature_650_residues
MMKRPLTLSALAMLVCASAQAATVDLRVLETTDLHSNMMDFDYYKDKPTDKFGLVRTASLIEQARQQAANTVLVDNGDII
QGSPLGDYMAAKGLKPGDVHPVYKAMNTLNYVVGNIGNHEFNYGLDYLKNAIAGAKFPYINANVIDAKTQKPLFTPYIIV
DTPVKDRDGKEHSLRIGYIGFVPPQILVWDKANLQGKVTVNDITETAKRYVPEMRKQGADLVVAIPHSGLSSEPYKAMAE
NSVYYLSQVPGIDAIMFGHAHAVFPSKDFANIKGADIAQGTLNGIPAVMPGQWGDHLGVVDLQLNNDSGTWKVTAAKAQA
RPIYDKENKKSLAAEDANLLKVLAEDHKGTRDFVSKPVGKADDNMYSYLALVQDDPTVQIVNNAQKAYVEHYIQGDPDLA
DLPVLSAAAPFKVGGRKNDPASFVEVEKGQLTFRNASDLYLYPNTLVVVKASGKEVKEWLECSAGQFNQIDVNSSKPQGL
INWDGFRTYNFDVIDGVNYQVDVSQPARYDGECQLINDKAQRIKELTFKGKPIDPNATFLVATNNYRAYGGKFAGTGDQH
IAFASPDENRSVLAAYISAETRQHGAVKPQVDNNWRLATFSSPQPLDIRFETSPSDKANAFIKTHAQYPMKAEGTDSIGF
AVYQIDLQKK

Specific function: This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'- cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Escherichia coli, GI1790658, Length=649, Percent_Identity=77.9661016949153, Blast_Score=1082, Evalue=0.0,
Organism=Escherichia coli, GI1786687, Length=590, Percent_Identity=24.0677966101695, Blast_Score=102, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24652512, Length=214, Percent_Identity=25.2336448598131, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921980, Length=214, Percent_Identity=25.2336448598131, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161076508, Length=214, Percent_Identity=25.2336448598131, Blast_Score=73, Evalue=7e-13,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR006294
- InterPro:   IPR004843 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.1.3.6; =3.1.4.16 [H]

Molecular weight: Translated: 71429; Mature: 71429

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00785 5_NUCLEOTIDASE_1 ; PS00786 5_NUCLEOTIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKRPLTLSALAMLVCASAQAATVDLRVLETTDLHSNMMDFDYYKDKPTDKFGLVRTASL
CCCCCCHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
IEQARQQAANTVLVDNGDIIQGSPLGDYMAAKGLKPGDVHPVYKAMNTLNYVVGNIGNHE
HHHHHHHHCCEEEECCCCEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
FNYGLDYLKNAIAGAKFPYINANVIDAKTQKPLFTPYIIVDTPVKDRDGKEHSLRIGYIG
CCCCHHHHHHHHCCCCCCEECCEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEE
FVPPQILVWDKANLQGKVTVNDITETAKRYVPEMRKQGADLVVAIPHSGLSSEPYKAMAE
CCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHC
NSVYYLSQVPGIDAIMFGHAHAVFPSKDFANIKGADIAQGTLNGIPAVMPGQWGDHLGVV
CCEEEEECCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEE
DLQLNNDSGTWKVTAAKAQARPIYDKENKKSLAAEDANLLKVLAEDHKGTRDFVSKPVGK
EEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCHHHHHCCCCC
ADDNMYSYLALVQDDPTVQIVNNAQKAYVEHYIQGDPDLADLPVLSAAAPFKVGGRKNDP
CCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEECCCCCEECCCCCCCC
ASFVEVEKGQLTFRNASDLYLYPNTLVVVKASGKEVKEWLECSAGQFNQIDVNSSKPQGL
CCEEEEECCEEEEECCCCEEECCCEEEEEECCCHHHHHHHHCCCCCCEEEECCCCCCCCE
INWDGFRTYNFDVIDGVNYQVDVSQPARYDGECQLINDKAQRIKELTFKGKPIDPNATFL
EECCCEEEEEEEEECCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCEEE
VATNNYRAYGGKFAGTGDQHIAFASPDENRSVLAAYISAETRQHGAVKPQVDNNWRLATF
EEECCEEECCCEECCCCCCEEEEECCCCCCEEEEEEEEHHHHHCCCCCCCCCCCEEEEEE
SSPQPLDIRFETSPSDKANAFIKTHAQYPMKAEGTDSIGFAVYQIDLQKK
CCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure
MMKRPLTLSALAMLVCASAQAATVDLRVLETTDLHSNMMDFDYYKDKPTDKFGLVRTASL
CCCCCCHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
IEQARQQAANTVLVDNGDIIQGSPLGDYMAAKGLKPGDVHPVYKAMNTLNYVVGNIGNHE
HHHHHHHHCCEEEECCCCEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
FNYGLDYLKNAIAGAKFPYINANVIDAKTQKPLFTPYIIVDTPVKDRDGKEHSLRIGYIG
CCCCHHHHHHHHCCCCCCEECCEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEEEE
FVPPQILVWDKANLQGKVTVNDITETAKRYVPEMRKQGADLVVAIPHSGLSSEPYKAMAE
CCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHC
NSVYYLSQVPGIDAIMFGHAHAVFPSKDFANIKGADIAQGTLNGIPAVMPGQWGDHLGVV
CCEEEEECCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEE
DLQLNNDSGTWKVTAAKAQARPIYDKENKKSLAAEDANLLKVLAEDHKGTRDFVSKPVGK
EEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCHHHHHCCCCC
ADDNMYSYLALVQDDPTVQIVNNAQKAYVEHYIQGDPDLADLPVLSAAAPFKVGGRKNDP
CCCCCEEEEEEECCCCEEEEECCHHHHHHHHHHCCCCCCCCCCEECCCCCEECCCCCCCC
ASFVEVEKGQLTFRNASDLYLYPNTLVVVKASGKEVKEWLECSAGQFNQIDVNSSKPQGL
CCEEEEECCEEEEECCCCEEECCCEEEEEECCCHHHHHHHHCCCCCCEEEECCCCCCCCE
INWDGFRTYNFDVIDGVNYQVDVSQPARYDGECQLINDKAQRIKELTFKGKPIDPNATFL
EECCCEEEEEEEEECCCCEEEECCCCCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCEEE
VATNNYRAYGGKFAGTGDQHIAFASPDENRSVLAAYISAETRQHGAVKPQVDNNWRLATF
EEECCEEECCCEECCCCCCEEEEECCCCCCEEEEEEEEHHHHHCCCCCCCCCCCEEEEEE
SSPQPLDIRFETSPSDKANAFIKTHAQYPMKAEGTDSIGFAVYQIDLQKK
CCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA