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The map label for this gene is thyA [H]

Identifier: 157368568

GI number: 157368568

Start: 371991

End: 372968

Strand: Reverse

Name: thyA [H]

Synonym: Spro_0319

Alternate gene names: 157368568

Gene position: 372968-371991 (Counterclockwise)

Preceding gene: 157368577

Following gene: 157368567

Centisome position: 6.84

GC content: 46.42

Gene sequence:

>978_bases
ATGACTCTTCTGGTGACAGCTGAATGTGTTGACGATCTGTTAAACGATGTCCATCAGGCGATCCTGACTGACGGACTCTG
GAATACTCCCACTAAAGGAGCAAATATTGAGATTCTGGGAGCCTACCTGATTCTCACCGATCCTCGCCGCAGAATAAGCA
GGACAGAATCCCGCGGTAAAATTATCAGCTGTCTGGGGGAATTGCTGTGGTACCTCTCAGCCCAGAACGATCTCGATTTC
ATCCGGCACTTCATACCTCGCTACGTAAAATACGCTGAATCCGATGGCAGAATACACGGGGGATATGGTCCGAGATTATT
TAGTATGCACGGGCTGTATAATCAGCTGGAAAATGTCATCAGTCTGCTGCAGGAGAAAAGAACTACTCGACGCGCACTGA
TACAACTGTTTGATGCCTCAGATCTGGTTACGGATAATCCAGAACAAACAGAATATGCCGATATTCCGTGCACGATATCG
TTGCAATTTATTGTCAGACAAGACGCACTGCATCTTTTTGTCTGTATGCGCTCTAACGATGCCTTTATGGGCTTACCCCA
TGATGTGTTCGCCTTCACGATGTTGCAGGAACTGGTCGCCCGCCTCACCGGGTGCAAACTGGGTCATTATCATCACTTCG
TCTCAAGCCTCCATATCTATGAAGAACATTTTGAACAAGTAAAAGCGCTACAGCAAGAAGGCTTTATGAGTACCTTGCCG
GTGATGGGTGATATGCCTGAAATTCAATCCTTAAAGGACATTACAGTCATCCTTGAAGCAGAAAAGGCTCTGCGGGAAAA
CAAGGAATTTGATATCGATACTATGCCCCTGAGTGACTACTGGAAGGATATGCTGCGCGTGATAAAGACCCATTTTTTGT
TGCGTTCACATACGTCGGCACACGATGAGCTGGCCCGCCAGGAGCTGACTGCACTGAATAATCAGGAATACCGATTTATT
TTTGACGGGAAAATATAA

Upstream 100 bases:

>100_bases
GTGTCATAGCTGCTATAGCCCTGTTTGTACTAATGTCATATTGACTCTTTATCGTACGGGTGGTAATGATTTGTTACATT
CATAATATAACAGGCAGTAT

Downstream 100 bases:

>100_bases
TGAACAGACACAGTCAGGCCAGCCAGCTGGTCGCAGCTCTTCAAAACTTCAGTCGCGATGAACATCCCCTGAACGGACTG
AGTTCTCCGGCTCACTATAA

Product: thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTLLVTAECVDDLLNDVHQAILTDGLWNTPTKGANIEILGAYLILTDPRRRISRTESRGKIISCLGELLWYLSAQNDLDF
IRHFIPRYVKYAESDGRIHGGYGPRLFSMHGLYNQLENVISLLQEKRTTRRALIQLFDASDLVTDNPEQTEYADIPCTIS
LQFIVRQDALHLFVCMRSNDAFMGLPHDVFAFTMLQELVARLTGCKLGHYHHFVSSLHIYEEHFEQVKALQQEGFMSTLP
VMGDMPEIQSLKDITVILEAEKALRENKEFDIDTMPLSDYWKDMLRVIKTHFLLRSHTSAHDELARQELTALNNQEYRFI
FDGKI

Sequences:

>Translated_325_residues
MTLLVTAECVDDLLNDVHQAILTDGLWNTPTKGANIEILGAYLILTDPRRRISRTESRGKIISCLGELLWYLSAQNDLDF
IRHFIPRYVKYAESDGRIHGGYGPRLFSMHGLYNQLENVISLLQEKRTTRRALIQLFDASDLVTDNPEQTEYADIPCTIS
LQFIVRQDALHLFVCMRSNDAFMGLPHDVFAFTMLQELVARLTGCKLGHYHHFVSSLHIYEEHFEQVKALQQEGFMSTLP
VMGDMPEIQSLKDITVILEAEKALRENKEFDIDTMPLSDYWKDMLRVIKTHFLLRSHTSAHDELARQELTALNNQEYRFI
FDGKI
>Mature_324_residues
TLLVTAECVDDLLNDVHQAILTDGLWNTPTKGANIEILGAYLILTDPRRRISRTESRGKIISCLGELLWYLSAQNDLDFI
RHFIPRYVKYAESDGRIHGGYGPRLFSMHGLYNQLENVISLLQEKRTTRRALIQLFDASDLVTDNPEQTEYADIPCTISL
QFIVRQDALHLFVCMRSNDAFMGLPHDVFAFTMLQELVARLTGCKLGHYHHFVSSLHIYEEHFEQVKALQQEGFMSTLPV
MGDMPEIQSLKDITVILEAEKALRENKEFDIDTMPLSDYWKDMLRVIKTHFLLRSHTSAHDELARQELTALNNQEYRFIF
DGKI

Specific function: Provides the sole de novo source of dTMP for DNA biosynthesis [H]

COG id: COG0207

COG function: function code F; Thymidylate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate synthase family. Bacterial- type thyA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: 391 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000398
- InterPro:   IPR020940 [H]

Pfam domain/function: PF00303 Thymidylat_synt [H]

EC number: =2.1.1.45 [H]

Molecular weight: Translated: 37494; Mature: 37362

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLVTAECVDDLLNDVHQAILTDGLWNTPTKGANIEILGAYLILTDPRRRISRTESRGK
CEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCHHHHHHHHHCCH
IISCLGELLWYLSAQNDLDFIRHFIPRYVKYAESDGRIHGGYGPRLFSMHGLYNQLENVI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHH
SLLQEKRTTRRALIQLFDASDLVTDNPEQTEYADIPCTISLQFIVRQDALHLFVCMRSND
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCCEEEEEEEECCC
AFMGLPHDVFAFTMLQELVARLTGCKLGHYHHFVSSLHIYEEHFEQVKALQQEGFMSTLP
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
VMGDMPEIQSLKDITVILEAEKALRENKEFDIDTMPLSDYWKDMLRVIKTHFLLRSHTSA
CCCCCHHHHHHHHHHHHEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
HDELARQELTALNNQEYRFIFDGKI
HHHHHHHHHHHCCCCCEEEEECCCC
>Mature Secondary Structure 
TLLVTAECVDDLLNDVHQAILTDGLWNTPTKGANIEILGAYLILTDPRRRISRTESRGK
EEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEECCHHHHHHHHHCCH
IISCLGELLWYLSAQNDLDFIRHFIPRYVKYAESDGRIHGGYGPRLFSMHGLYNQLENVI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHH
SLLQEKRTTRRALIQLFDASDLVTDNPEQTEYADIPCTISLQFIVRQDALHLFVCMRSND
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCCEEEEEEEECCC
AFMGLPHDVFAFTMLQELVARLTGCKLGHYHHFVSSLHIYEEHFEQVKALQQEGFMSTLP
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
VMGDMPEIQSLKDITVILEAEKALRENKEFDIDTMPLSDYWKDMLRVIKTHFLLRSHTSA
CCCCCHHHHHHHHHHHHEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
HDELARQELTALNNQEYRFIFDGKI
HHHHHHHHHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA