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The map label for this gene is iucD [H]

Identifier: 157368274

GI number: 157368274

Start: 23811

End: 25124

Strand: Reverse

Name: iucD [H]

Synonym: Spro_0025

Alternate gene names: 157368274

Gene position: 25124-23811 (Counterclockwise)

Preceding gene: 157368275

Following gene: 157368273

Centisome position: 0.46

GC content: 54.11

Gene sequence:

>1314_bases
ATGAATGAACCACTGGATTTACTGGGTGTCGGCCTTGGCCCCTTCAACCTCAGCCTGGCCGCGCTGGCCTATGAAAGTGG
CGTCCTCAATTACACCTTTCTCGATCGAAACGCCAGCTTCCGCTGGCACCCCGGCATGCTGCTGCCTTCCGCCTATATGC
AGACCTATGTACTGCAGGACCTGGTTACGGCGGTAACACCCCGTAGCCAATTCTCCTTTATCAATTACCTGGTCGAGCAG
AAAAAAATCTATCGTTTTTTGATCACCGAACAGCAAATTATCAGCCGTGAAGAGTTCTCCGACTACCTGAGTTGGGCCTG
CGATAGATTAGATGGGCTACAGTTTTCACAGTCGGTTGAAAGTATTGATTTTGACGATGACAAGCAGCTGTTCGAAGTCC
GCACCATCAACCAGACTTTGTGGGCAAAGAATATCTGCCTGGGTACCGGCCACGACCCCTGGCTGCCGGAGGAGTTTTAC
CCTGCGCTGGGCGAAAACTGCCTGCATGCCGCCGAAATTGCCATTCGCAACCCGGATCTGACCGGTAAGCGGGTCACCGT
TGTCGGGGGAGGCCAAAGTGGTGCAGATATTTTCCTGAACGCGCTACGCGGCCATTGGGGAGAAGCCGCACAGCTGGACT
GGATTTCCCGCCGGCCTAACTTCCAACCGCTGGACGAGTCCGCCTTCACCAATGAATATTTCACCCCGGAATACGTCGAT
TATTTTTATACGCTGCCGCAGGAAATCCGCGAACGCGAAATTAAGGCTCAGAAGTTACCTGCAGACGGCATCAGTAATCA
TACGCTGCGTACGCTGTACCGCGAGTTGTACCTGCGTTTCGACGTAATGCACCAGCCGCGTAATGTGCGTCTTTTACCAC
ACCGTACGCTGCTGGCGATCGAACCGACGGACAAAGGCTATCAATTACGCACCCGCCACGGTTTGGAAAACCGCCAGGAA
GGGTTTCACGCCGACGTCGTCATTTTAGCGACAGGTTACCGCCCTTCGCTGCCGTCCTGCCTAAAGCCGCTGCTGTCACG
CATTCCTTTCGACAACAAACAGCGCTTGCCGCTACAGCCGGATTTTAACCTTGAGTGGCAGGGGCCTGAACAGAATCGTA
TTTATGCGGTGAATGCCGGAATACATAGCCACGGCAGCGCAGAAGGGGGACTCAGCCTGATGGCCTGGCGCTCGGCCCGC
ATCCTCAATCATCTGCTCGGCAAACCCCATTTTGATCTGACGCCGAACGCATCGATGATCCAATGGTGGAGTGATGCTCC
TCCGGACAATGATATTGCTTATCCAGATAAATAG

Upstream 100 bases:

>100_bases
TTTACCGCCCTACCACTGAACAACAATCGCTATCTCCCCTGGCTTGCCAAAAATCACCTAAGCTTATCTCAGCGATTTTT
GGCGGGAGAGATAAGAAAAA

Downstream 100 bases:

>100_bases
GATAAAACGCATACTGTTTTTTAATGATAAATCCTCGACTTATGCTTAATCTAACTCCCCAGCGTTTTCAGCGCCCCCTC
TGTCACGGAGTGAATAATGG

Product: L-lysine 6-monooxygenase (NADPH)

Products: NA

Alternate protein names: Lysine 6-N-hydroxylase; Lysine N(6)-hydroxylase; Lysine-N-oxygenase [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MNEPLDLLGVGLGPFNLSLAALAYESGVLNYTFLDRNASFRWHPGMLLPSAYMQTYVLQDLVTAVTPRSQFSFINYLVEQ
KKIYRFLITEQQIISREEFSDYLSWACDRLDGLQFSQSVESIDFDDDKQLFEVRTINQTLWAKNICLGTGHDPWLPEEFY
PALGENCLHAAEIAIRNPDLTGKRVTVVGGGQSGADIFLNALRGHWGEAAQLDWISRRPNFQPLDESAFTNEYFTPEYVD
YFYTLPQEIREREIKAQKLPADGISNHTLRTLYRELYLRFDVMHQPRNVRLLPHRTLLAIEPTDKGYQLRTRHGLENRQE
GFHADVVILATGYRPSLPSCLKPLLSRIPFDNKQRLPLQPDFNLEWQGPEQNRIYAVNAGIHSHGSAEGGLSLMAWRSAR
ILNHLLGKPHFDLTPNASMIQWWSDAPPDNDIAYPDK

Sequences:

>Translated_437_residues
MNEPLDLLGVGLGPFNLSLAALAYESGVLNYTFLDRNASFRWHPGMLLPSAYMQTYVLQDLVTAVTPRSQFSFINYLVEQ
KKIYRFLITEQQIISREEFSDYLSWACDRLDGLQFSQSVESIDFDDDKQLFEVRTINQTLWAKNICLGTGHDPWLPEEFY
PALGENCLHAAEIAIRNPDLTGKRVTVVGGGQSGADIFLNALRGHWGEAAQLDWISRRPNFQPLDESAFTNEYFTPEYVD
YFYTLPQEIREREIKAQKLPADGISNHTLRTLYRELYLRFDVMHQPRNVRLLPHRTLLAIEPTDKGYQLRTRHGLENRQE
GFHADVVILATGYRPSLPSCLKPLLSRIPFDNKQRLPLQPDFNLEWQGPEQNRIYAVNAGIHSHGSAEGGLSLMAWRSAR
ILNHLLGKPHFDLTPNASMIQWWSDAPPDNDIAYPDK
>Mature_437_residues
MNEPLDLLGVGLGPFNLSLAALAYESGVLNYTFLDRNASFRWHPGMLLPSAYMQTYVLQDLVTAVTPRSQFSFINYLVEQ
KKIYRFLITEQQIISREEFSDYLSWACDRLDGLQFSQSVESIDFDDDKQLFEVRTINQTLWAKNICLGTGHDPWLPEEFY
PALGENCLHAAEIAIRNPDLTGKRVTVVGGGQSGADIFLNALRGHWGEAAQLDWISRRPNFQPLDESAFTNEYFTPEYVD
YFYTLPQEIREREIKAQKLPADGISNHTLRTLYRELYLRFDVMHQPRNVRLLPHRTLLAIEPTDKGYQLRTRHGLENRQE
GFHADVVILATGYRPSLPSCLKPLLSRIPFDNKQRLPLQPDFNLEWQGPEQNRIYAVNAGIHSHGSAEGGLSLMAWRSAR
ILNHLLGKPHFDLTPNASMIQWWSDAPPDNDIAYPDK

Specific function: This is one of the proteins involved in the biosynthesis of siderophores (such as the dihydroxamate siderophore, aerobactin), which are chelators that mediate the high-affinity iron transport systems induced by the organism under iron-stressed conditions

COG id: COG3486

COG function: function code Q; Lysine/ornithine N-monooxygenase

Gene ontology:

Cell location: Cytoplasm. Cell membrane [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027 [H]

Pfam domain/function: PF07992 Pyr_redox_2 [H]

EC number: =1.14.13.59 [H]

Molecular weight: Translated: 50080; Mature: 50080

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPLDLLGVGLGPFNLSLAALAYESGVLNYTFLDRNASFRWHPGMLLPSAYMQTYVLQD
CCCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHH
LVTAVTPRSQFSFINYLVEQKKIYRFLITEQQIISREEFSDYLSWACDRLDGLQFSQSVE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SIDFDDDKQLFEVRTINQTLWAKNICLGTGHDPWLPEEFYPALGENCLHAAEIAIRNPDL
CCCCCCCHHEEEHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHCHHHHHHHHEEEECCCC
TGKRVTVVGGGQSGADIFLNALRGHWGEAAQLDWISRRPNFQPLDESAFTNEYFTPEYVD
CCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCCHHHHH
YFYTLPQEIREREIKAQKLPADGISNHTLRTLYRELYLRFDVMHQPRNVRLLPHRTLLAI
HHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEE
EPTDKGYQLRTRHGLENRQEGFHADVVILATGYRPSLPSCLKPLLSRIPFDNKQRLPLQP
CCCCCCCEEHHHCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCC
DFNLEWQGPEQNRIYAVNAGIHSHGSAEGGLSLMAWRSARILNHLLGKPHFDLTPNASMI
CCCEEECCCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHE
QWWSDAPPDNDIAYPDK
EECCCCCCCCCCCCCCC
>Mature Secondary Structure
MNEPLDLLGVGLGPFNLSLAALAYESGVLNYTFLDRNASFRWHPGMLLPSAYMQTYVLQD
CCCCCCEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCCCHHHHHHHHHHHH
LVTAVTPRSQFSFINYLVEQKKIYRFLITEQQIISREEFSDYLSWACDRLDGLQFSQSVE
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SIDFDDDKQLFEVRTINQTLWAKNICLGTGHDPWLPEEFYPALGENCLHAAEIAIRNPDL
CCCCCCCHHEEEHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHCHHHHHHHHEEEECCCC
TGKRVTVVGGGQSGADIFLNALRGHWGEAAQLDWISRRPNFQPLDESAFTNEYFTPEYVD
CCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEHHHHCCCCCCCCCCCCCCCCCCCHHHHH
YFYTLPQEIREREIKAQKLPADGISNHTLRTLYRELYLRFDVMHQPRNVRLLPHRTLLAI
HHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEE
EPTDKGYQLRTRHGLENRQEGFHADVVILATGYRPSLPSCLKPLLSRIPFDNKQRLPLQP
CCCCCCCEEHHHCCCCHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCC
DFNLEWQGPEQNRIYAVNAGIHSHGSAEGGLSLMAWRSARILNHLLGKPHFDLTPNASMI
CCCEEECCCCCCEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCCHHE
QWWSDAPPDNDIAYPDK
EECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3275632; 10064136 [H]