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The map label for this gene is atpA [H]

Identifier: 157368255

GI number: 157368255

Start: 3168

End: 4709

Strand: Direct

Name: atpA [H]

Synonym: Spro_0006

Alternate gene names: 157368255

Gene position: 3168-4709 (Clockwise)

Preceding gene: 157368254

Following gene: 157368256

Centisome position: 0.06

GC content: 54.6

Gene sequence:

>1542_bases
ATGCAACTGAATTCCACCGAAATCAGCGAACTGATCAAGCAGCGCATTGCTCAGTTCAATGTGGTGAGCGAAGCTCACAA
TGAAGGTACTATTGTTTCCGTCAGTGACGGGATCATCCGCGTACACGGTCTGGCCGAAGTTATGCAGGGCGAAATGATCG
CACTGCCAGGCAACCGTTACGCAATCGCATTGAACCTGGAGCGCGACTCCGTAGGTGCTGTGGTTATGGGTCCGTACGCG
GATCTGGCCGAAGGCATGAAGGTAAAATGTACCGGCCGTATTCTGGAAGTTCCGGTTGGCCGTGGCCTGCTGGGCCGTGT
AGTTAACACCCTGGGCGCACCTATTGACGGTAAAGGCCCGGTTGATAACGACGGTTTCTCCCCGGTTGAAGCTATTGCCC
CTGGTGTTATCGAGCGTCAGTCCGTAGATCAGCCGGTTCAAACTGGCTATAAATCTGTTGACGCCATGATCCCAATCGGC
CGTGGCCAGCGTGAGCTGGTGATCGGTGACCGTCAGACAGGTAAAACTGCCCTGGCGATCGATGCGATCATCAACCAACG
CGATTCCGGCATCAAATGTGTTTACGTGGCTATCGGCCAGAAAGCGTCCACCATCGCTAACGTGGTGCGCAAACTGGAAG
AGCACGGCGCACTGGCAAACACCATCGTTGTGGTTGCTACCGCGTCTGAATCCGCTGCATTGCAATACCTGGCGCCATAT
GCCGGTTGTGCGATGGGTGAATACTTCCGTGACCGCGGTGAAGATGCGCTGATTGTTTATGATGACCTGTCCAAACAGGC
CGTTGCATACCGTCAGATCTCCCTGCTGCTTCGTCGTCCACCAGGTCGTGAAGCTTACCCAGGCGACGTATTCTATCTCC
ACTCCCGTTTGCTGGAGCGTGCTGCGCGTGTTAACGCCGAATACGTTGAAGCCTTCACCAAAGGTGAAGTCAAAGGCCAA
ACCGGTTCACTGACTGCTCTGCCGATCATTGAAACCCAGGCGGGTGACGTTTCCGCGTTCGTTCCGACCAACGTAATCTC
GATTACCGATGGTCAGATCTTCCTGGAATCCAACCTGTTTAACTCCGGTATTCGTCCGGCAGTTAACCCGGGTATCTCCG
TATCCCGTGTGGGCGGTGCAGCGCAAACCAAGATCATGAAAAAACTGTCCGGTGGTATTCGTACCGCGCTGGCACAGTAT
CGTGAACTGGCTGCGTTCTCTCAGTTCGCTTCCGATCTGGATGATGCGACCCGCAAACAGCTGAGCCACGGTCAGAAAGT
GACCGAGCTGCTGAAACAGAAACAGTATGCGCCGATGTCCGTCGCACAACAGTCTCTGGTGCTGTTTGCCGCAGAACGTG
GCTTCCTGAACGACGTTGAAGTCGCGAAAGTCGTGAGCTTCGAAGCCGCGCTGGTTGCTTACGCAGACCGCGAGCATGCC
GAGTTGCTGAACCACATCAACCAAACTGGCAATTTCAACGATGAGATCGAGGGCAAGCTGAAAGGCATCCTCGAGACCTT
CAAGAAAACCCAGTCCTGGTAA

Upstream 100 bases:

>100_bases
CGGCGTAATTATCCGTGCTGGCGATATGGTGATTGATGGCAGCGTTCGCGGTCGTCTTGAACGCCTGACAGACGTCTTGC
AGTCTTAAGGGGACTGGAGC

Downstream 100 bases:

>100_bases
CGCTCAGCGGCCTGCAGTTGTAAAACAGCAGGCCGTCTGGCAATGAGGAGAAGCAGACATGGCCGGCGCAAAAGAGATAC
GTAGTAAGATCGCGAGCGTG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGIIRVHGLAEVMQGEMIALPGNRYAIALNLERDSVGAVVMGPYA
DLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPVDNDGFSPVEAIAPGVIERQSVDQPVQTGYKSVDAMIPIG
RGQRELVIGDRQTGKTALAIDAIINQRDSGIKCVYVAIGQKASTIANVVRKLEEHGALANTIVVVATASESAALQYLAPY
AGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQY
RELAAFSQFASDLDDATRKQLSHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGFLNDVEVAKVVSFEAALVAYADREHA
ELLNHINQTGNFNDEIEGKLKGILETFKKTQSW

Sequences:

>Translated_513_residues
MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGIIRVHGLAEVMQGEMIALPGNRYAIALNLERDSVGAVVMGPYA
DLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPVDNDGFSPVEAIAPGVIERQSVDQPVQTGYKSVDAMIPIG
RGQRELVIGDRQTGKTALAIDAIINQRDSGIKCVYVAIGQKASTIANVVRKLEEHGALANTIVVVATASESAALQYLAPY
AGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQY
RELAAFSQFASDLDDATRKQLSHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGFLNDVEVAKVVSFEAALVAYADREHA
ELLNHINQTGNFNDEIEGKLKGILETFKKTQSW
>Mature_513_residues
MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGIIRVHGLAEVMQGEMIALPGNRYAIALNLERDSVGAVVMGPYA
DLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGPVDNDGFSPVEAIAPGVIERQSVDQPVQTGYKSVDAMIPIG
RGQRELVIGDRQTGKTALAIDAIINQRDSGIKCVYVAIGQKASTIANVVRKLEEHGALANTIVVVATASESAALQYLAPY
AGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAARVNAEYVEAFTKGEVKGQ
TGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQY
RELAAFSQFASDLDDATRKQLSHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGFLNDVEVAKVVSFEAALVAYADREHA
ELLNHINQTGNFNDEIEGKLKGILETFKKTQSW

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=511, Percent_Identity=55.7729941291585, Blast_Score=560, Evalue=1e-160,
Organism=Homo sapiens, GI4757810, Length=511, Percent_Identity=55.7729941291585, Blast_Score=560, Evalue=1e-160,
Organism=Homo sapiens, GI19913426, Length=331, Percent_Identity=27.7945619335347, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI32189394, Length=397, Percent_Identity=25.1889168765743, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI19913428, Length=314, Percent_Identity=28.0254777070064, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI19913424, Length=267, Percent_Identity=27.7153558052434, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1790172, Length=513, Percent_Identity=92.7875243664717, Blast_Score=986, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=428, Percent_Identity=25.2336448598131, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788251, Length=345, Percent_Identity=24.3478260869565, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=515, Percent_Identity=54.1747572815534, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71988080, Length=515, Percent_Identity=54.1747572815534, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71988074, Length=515, Percent_Identity=50.4854368932039, Blast_Score=504, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17510931, Length=368, Percent_Identity=26.0869565217391, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17570191, Length=313, Percent_Identity=27.4760383386581, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=467, Percent_Identity=24.1970021413276, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17565854, Length=262, Percent_Identity=27.0992366412214, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17509265, Length=47, Percent_Identity=65.9574468085106, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319370, Length=513, Percent_Identity=53.2163742690059, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322581, Length=471, Percent_Identity=25.6900212314225, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319603, Length=377, Percent_Identity=26.790450928382, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24658560, Length=514, Percent_Identity=54.4747081712062, Blast_Score=548, Evalue=1e-156,
Organism=Drosophila melanogaster, GI281361666, Length=313, Percent_Identity=26.8370607028754, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24646341, Length=313, Percent_Identity=26.8370607028754, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17136796, Length=313, Percent_Identity=26.8370607028754, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24638766, Length=324, Percent_Identity=26.5432098765432, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574560, Length=321, Percent_Identity=26.1682242990654, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24583988, Length=267, Percent_Identity=27.3408239700375, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583986, Length=267, Percent_Identity=27.3408239700375, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583984, Length=267, Percent_Identity=27.3408239700375, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583992, Length=344, Percent_Identity=25.2906976744186, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55269; Mature: 55269

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGIIRVHGLAEVMQGEMIALPGNRY
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEHHHHHHHCCCEEEECCCEE
AIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGP
EEEEEECCCCCCEEEECCCHHHHCCCEEEECCEEEECCCCCCHHHHHHHHHCCCCCCCCC
VDNDGFSPVEAIAPGVIERQSVDQPVQTGYKSVDAMIPIGRGQRELVIGDRQTGKTALAI
CCCCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHEEECCCCCEEEEECCCCCCCHHEEH
DAIINQRDSGIKCVYVAIGQKASTIANVVRKLEEHGALANTIVVVATASESAALQYLAPY
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHH
AGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLER
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARVNAEYVEAFTKGEVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLF
HHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCC
NSGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQ
CCCCCCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGFLNDVEVAKVVSFEAALVAYADREHA
HHCCHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHH
ELLNHINQTGNFNDEIEGKLKGILETFKKTQSW
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLNSTEISELIKQRIAQFNVVSEAHNEGTIVSVSDGIIRVHGLAEVMQGEMIALPGNRY
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEHHHHHHHCCCEEEECCCEE
AIALNLERDSVGAVVMGPYADLAEGMKVKCTGRILEVPVGRGLLGRVVNTLGAPIDGKGP
EEEEEECCCCCCEEEECCCHHHHCCCEEEECCEEEECCCCCCHHHHHHHHHCCCCCCCCC
VDNDGFSPVEAIAPGVIERQSVDQPVQTGYKSVDAMIPIGRGQRELVIGDRQTGKTALAI
CCCCCCCCHHHHCCCHHHHHCCCCHHHHHHHHHHHEEECCCCCEEEEECCCCCCCHHEEH
DAIINQRDSGIKCVYVAIGQKASTIANVVRKLEEHGALANTIVVVATASESAALQYLAPY
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHH
AGCAMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLER
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AARVNAEYVEAFTKGEVKGQTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLESNLF
HHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCC
NSGIRPAVNPGISVSRVGGAAQTKIMKKLSGGIRTALAQYRELAAFSQFASDLDDATRKQ
CCCCCCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSHGQKVTELLKQKQYAPMSVAQQSLVLFAAERGFLNDVEVAKVVSFEAALVAYADREHA
HHCCHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHH
ELLNHINQTGNFNDEIEGKLKGILETFKKTQSW
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA