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The map label for this gene is yjmD [H]

Identifier: 157163351

GI number: 157163351

Start: 4097482

End: 4098492

Strand: Direct

Name: yjmD [H]

Synonym: EcHS_A4106

Alternate gene names: 157163351

Gene position: 4097482-4098492 (Clockwise)

Preceding gene: 157163350

Following gene: 157163352

Centisome position: 88.24

GC content: 52.82

Gene sequence:

>1011_bases
ATGGATAAAATTACCCAGGTTTTATTTTCAGATATTGGGAAAGTCACCACTCAATATGTTGAAGTACCACACCAGGAACT
TAAACCGCACGAAGTGCGGATTGCGCCTGTGTTCTATGGGATATGCGGTTCGGATCTGCATGTTCTGAAAGGCGGTCATC
CGTTTGCTAAACCACCTGTCGTCCCCGGTCATGAAATTGCAGCGCGCGTTACGGAAGTTGGCAGCGACGTTAAAAATGTA
CAGCCGGGCGATCATGTTGTGGTCGATCCCATCATGGCTTGCATGGAATGCCGAGCCTGCAAAGCAGGACGTTTTAATCT
TTGTGAACCACCGCAGGTTGCTGGTTTTCGCGCACCGGGCTTTGCTCGCTCACAACACATTGTTCCTGCGCGTAATTGCC
ATGTCGCACCAGCCTCTTTACCGCTAAAAGTGTTGGCCTTTGCCGAACCGGCGGCTTGTGCCCGTCACTGCGTTAACCGA
ATGCCGAAAGCTTCTCTGGAAAGCGTACTGGTGATTGGTGCCGGAACGATAGGCTTATCCATCGTGCAGGCACTGCGCAT
TATGGGGGCAGGTAAGATTACCGTGATTGAACCTGACGCTGCCAAACGCGCGCTGGCGTTAAAGCTGGGCGCAGCAGAAG
TTTGGGCACCAGGTGAGCTGGCCGCAGATGTGCGATTTACGGGGGCGATTGATGTCGTTGCAGCGCAGGCCACGCTTAAC
GATGCATGTACCCGTGTATATGCCGGAGGCACCGTCGTGTGCATGGGCGTACCAAGTGGGCCGCGTGAAATACCATTACC
GATGATGCAACGTTTCGAGCGTGACTTGCTCAACTCTGGCATGTACATCCCTGAAGATTTCGATGCTGTTATCGAATGGC
TGGCGGATGGGCGGTTTGATACCAGTGAACTGATTACCGATTTATTTGCCATTGAGGATGCAGCGGCGGCATTCGAACGC
GCGCAGCAAAATGACTCCATAAAGGTCATGCTGCAATTTGCGCCGGAATGA

Upstream 100 bases:

>100_bases
GAGATGTCTCTGTTCCTCGTTTACAACGGTTGGCAGAAATTGTCGATGAAGGTATCGCGCAACGCTAATCCCCTATGGAT
ATCGATTCTGGAGAATAACA

Downstream 100 bases:

>100_bases
TTTTCTAAATCTCTGTCTGGCGCTGCGTCACGTCAGCGCCACCCTACAACAATTAAAAAGGACACTGCGATGAGTCAAAT
CACCAGTCCTGCAACTTATT

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPVVPGHEIAARVTEVGSDVKNV
QPGDHVVVDPIMACMECRACKAGRFNLCEPPQVAGFRAPGFARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNR
MPKASLESVLVIGAGTIGLSIVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFDTSELITDLFAIEDAAAAFER
AQQNDSIKVMLQFAPE

Sequences:

>Translated_336_residues
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPVVPGHEIAARVTEVGSDVKNV
QPGDHVVVDPIMACMECRACKAGRFNLCEPPQVAGFRAPGFARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNR
MPKASLESVLVIGAGTIGLSIVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFDTSELITDLFAIEDAAAAFER
AQQNDSIKVMLQFAPE
>Mature_336_residues
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPVVPGHEIAARVTEVGSDVKNV
QPGDHVVVDPIMACMECRACKAGRFNLCEPPQVAGFRAPGFARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNR
MPKASLESVLVIGAGTIGLSIVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFDTSELITDLFAIEDAAAAFER
AQQNDSIKVMLQFAPE

Specific function: Not Known; Probable Catabolic Enzyme. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=333, Percent_Identity=28.8288288288288, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI71743840, Length=350, Percent_Identity=25.4285714285714, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI262073058, Length=350, Percent_Identity=25.4285714285714, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=27.3743016759777, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501933, Length=355, Percent_Identity=27.0422535211268, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI34577061, Length=355, Percent_Identity=26.4788732394366, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI71565152, Length=356, Percent_Identity=23.0337078651685, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI71565154, Length=228, Percent_Identity=25.8771929824561, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1787863, Length=316, Percent_Identity=31.6455696202532, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI226510992, Length=306, Percent_Identity=31.6993464052288, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788073, Length=347, Percent_Identity=28.8184438040346, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788407, Length=203, Percent_Identity=32.512315270936, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1790045, Length=329, Percent_Identity=26.1398176291793, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1790718, Length=318, Percent_Identity=28.3018867924528, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786518, Length=268, Percent_Identity=31.3432835820896, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786552, Length=354, Percent_Identity=25.9887005649718, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786825, Length=184, Percent_Identity=30.9782608695652, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=24.4186046511628, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=353, Percent_Identity=30.8781869688385, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=348, Percent_Identity=29.0229885057471, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25146526, Length=349, Percent_Identity=25.5014326647564, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=351, Percent_Identity=25.3561253561254, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=350, Percent_Identity=24.8571428571429, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=318, Percent_Identity=25.4716981132075, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=25.6637168141593, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=363, Percent_Identity=31.6804407713499, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=368, Percent_Identity=29.3478260869565, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=354, Percent_Identity=26.8361581920904, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=349, Percent_Identity=27.2206303724928, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=354, Percent_Identity=26.5536723163842, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=347, Percent_Identity=26.2247838616715, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=270, Percent_Identity=30, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=273, Percent_Identity=28.2051282051282, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=274, Percent_Identity=28.1021897810219, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=273, Percent_Identity=26.7399267399267, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17737897, Length=361, Percent_Identity=28.5318559556787, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17137530, Length=362, Percent_Identity=27.9005524861878, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17737895, Length=353, Percent_Identity=26.628895184136, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 35980; Mature: 35980

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPV
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCC
VPGHEIAARVTEVGSDVKNVQPGDHVVVDPIMACMECRACKAGRFNLCEPPQVAGFRAPG
CCCHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
FARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNRMPKASLESVLVIGAGTIGLS
CCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCHHCCCEEEEEECCHHHHH
IVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
HHHHHHHHCCCEEEEECCCHHHHEEHEEECCHHCCCCCCCEECEEECCCEEEEEHHHHHH
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFD
HHHHHEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
TSELITDLFAIEDAAAAFERAQQNDSIKVMLQFAPE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
>Mature Secondary Structure
MDKITQVLFSDIGKVTTQYVEVPHQELKPHEVRIAPVFYGICGSDLHVLKGGHPFAKPPV
CCHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEEEEEECCCCCEEEEECCCCCCCCCC
VPGHEIAARVTEVGSDVKNVQPGDHVVVDPIMACMECRACKAGRFNLCEPPQVAGFRAPG
CCCHHHHHHHHHHCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
FARSQHIVPARNCHVAPASLPLKVLAFAEPAACARHCVNRMPKASLESVLVIGAGTIGLS
CCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCHHCCCEEEEEECCHHHHH
IVQALRIMGAGKITVIEPDAAKRALALKLGAAEVWAPGELAADVRFTGAIDVVAAQATLN
HHHHHHHHCCCEEEEECCCHHHHEEHEEECCHHCCCCCCCEECEEECCCEEEEEHHHHHH
DACTRVYAGGTVVCMGVPSGPREIPLPMMQRFERDLLNSGMYIPEDFDAVIEWLADGRFD
HHHHHEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
TSELITDLFAIEDAAAAFERAQQNDSIKVMLQFAPE
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]