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The map label for this gene is xdhA [H]

Identifier: 157162327

GI number: 157162327

Start: 3027820

End: 3030117

Strand: Direct

Name: xdhA [H]

Synonym: EcHS_A3026

Alternate gene names: 157162327

Gene position: 3027820-3030117 (Clockwise)

Preceding gene: 157162316

Following gene: 157162328

Centisome position: 65.21

GC content: 53.05

Gene sequence:

>2298_bases
ATGGAAGCGCGGGAAGCAACCGCTACGGGTGAATCATGCATGCGCGTCGATGCCATTGCTAAGGTCACCGGGCGGGCACG
ATATACTGACGATTATGTTATGGCGGGCATGTGTTATGCGAAATATGTACGTAGCCCTATCGCACATGGTTATGCCGTAA
GTATTAATGATGAACAAGCCAGAAGTTTGCCGGGCGTACTGGCGATTTTTACCTGGGAAGATGTGCCTGATATTCCATTC
GCTACAGCTGGGCATGCCTGGACACTTGACGAAAACAAGCGCGATACCGCCGATCGCGCACTGCTAACTCGCCATGTTCG
TCATCATGGTGACGCCGTTGCCATCGTCGTGGCCCGCGATGAACTCACGGCAGAAAAAGCGGCGCAATTGGTCAGCATTG
AGTGGCAAGAATTACCCGTTATCACCACGCCAGAAGCGGCGCTGGCAGAAGACGCTGCACCAATCCATAACGGTGGCAAT
TTACTGAAACAAAGCACGATGTCGACGGGTAATGTCCAACAAACAATCGATGCCGCCGACTACCAGGTACAGGGGCACTA
TCAGACCCCCGTTATTCAACATTGTCACATGGAAAGCGTAACATCGCTGGCGTGGATGGAGGATGACTCGCGAATTACCA
TCGTTTCCAGCACCCAGATCCCGCACATTGTTCGCCGCGTGGTTGGTCAGGCGCTGGATATTCCCTGGTCATGCGTACGA
GTCATCAAACCATTTGTCGGTGGCGGTTTTGGTAATAAACAGGATGTACTGGAAGAGCCAATGGCGGCATTCCTGACCAG
CAAGCTTGGCGGCATTCCGGTGAAAGTTTCCCTTAGCCGTGAAGAGTGTTTCCTCGCAACCCGTACCCGCCACGCTTTTA
CCATTGACGGGCAAATGGGCGTGAACCGCGACGGAACATTGAAAGGTTATAGTCTGGATGTTCTGTCTAACATCGGCGCT
TATGCATCTCACGGGCACTCCATCGCTTCTGCGGGGGGGAATAAAGTCGCTTACCTTTATCCTCGTTGTGCCTACGCTTA
CAGTTCAAAGACCTGCTATACCAACCTCCCCTCGGCTGGTGCGATGCGTGGTTATGGCGCGCCACAAGTCGTATTTGCCG
TTGAGTCTATGCTTGATGACGCCGCGACAGCGTTAGGTATTGATCCTGTTGAAATTCGTTTACGCAACGCCGCCCGCGAA
GGAGATGCTAATCCGCTCACGGGCAAACGTATTTACAGCGCAGGGTTGCCGGAGTGTCTTGAAAAAGGCCGGAAAATCTT
TGAATGGGAAAAACGCCGTGCAGAATGCCAGAACCAGCAAGGCAATTTGCGCCGCGGCGTTGGCGTCGCCTGTTTTAGCT
ACACCTCTAACACCTGGCCTGTCGGCGTAGAAATAGCAGGCGCGCGCCTTCTGATGAATCAGGATGGAACCATCAACGTG
CAAAGCGGCGCGACGGAAATCGGTCAGGGTGCCGACACCGTCTTCTCGCAAATGGTGGCAGAAACCGTGGGGGTTCCGGT
CAGCGACGTTCGCGTTATTTCAACTCAAGATACCGACGTTACGCCGTTCGATCCCGGCGCATTTGCCTCACGCCAGAGCT
ATGTTGCCGCGCCTGCGCTGCGCAGTGCGGCACTATTATTAAAAGAGAAAATCATCGCTCACGCCGCAGTCATGCTACAT
CAGTCAGCGATGAATCTGACCCTGATAAAAGGCCATATCGTGCTGGTTGAACGACCGGAAGAGCCGTTAATGTCGTTAAA
AGATTTGGCGATGGACGCTTTCTACCACCCTGAACGCGGCGGGCAGCTCTCTGCTGAAAGCTCCATCAAAACCACCACTA
ACCCACCGGCGTTTGGCTGTACCTTTGTTGATCTGACGGTCGATATTGCGCTGTGCAAAGTCACCATCAACCGCATCCTC
AACGTTCATGATTCAGGGCATATTCTTAATCCACTGCTGGCAGAAGGTCAGGTACACGGCGGAATGGGAATGGGCATTGG
CTGGGCGCTATTTGAAGAGATGATCATCGATGCTAAAAGCGGCGTGGTCCGTAACCCCAATCTGCTGGATTACAAAATGC
CGACCATGCCGGATCTGCCACAACTGGAAAGCGCGTTCGTCGAAATCAATGAGCCGCAATCCGCATACGGACATAAGTCA
CTGGGTGAGCCACCAATAATTCCTGTTGCCGCTGCTATTCGTAACGCGGTGAAGATGGCTACCGGTGTTGCAATCAATAC
ACTGCCGCTGACGCCAAAACGGTTATATGAAGAGTTCCATCTGGCAGGATTGATTTGA

Upstream 100 bases:

>100_bases
CTACCTCCCCTAACGCTTATCGTCGTTTCTGGCGTAAATCTTGCCTGCTTAGACTAAATCTTTGCCATAAGAACCAAATG
TTCAAATCGAGGGGATTTCT

Downstream 100 bases:

>100_bases
GGATAACATCATGTTTGATTTTGCTTCTTACCATCGCGCAGCAACCCTTGCCGATGCCATCAACCTGCTGGCTGACAACC
CGCAGGCCAAACTGCTCGCC

Product: xanthine dehydrogenase subunit XdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNIGA
YASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAARE
GDANPLTGKRIYSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Sequences:

>Translated_765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNIGA
YASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAARE
GDANPLTGKRIYSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
>Mature_765_residues
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQARSLPGVLAIFTWEDVPDIPF
ATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARDELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGN
LLKQSTMSTGNVQQTIDAADYQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMGVNRDGTLKGYSLDVLSNIGA
YASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAARE
GDANPLTGKRIYSAGLPECLEKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPALRSAALLLKEKIIAHAAVMLH
QSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERGGQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRIL
NVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=793, Percent_Identity=26.4817150063052, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI91823271, Length=764, Percent_Identity=24.738219895288, Blast_Score=169, Evalue=6e-42,
Organism=Escherichia coli, GI1789230, Length=752, Percent_Identity=99.8670212765958, Blast_Score=1558, Evalue=0.0,
Organism=Escherichia coli, GI1789246, Length=798, Percent_Identity=29.6992481203008, Blast_Score=308, Evalue=8e-85,
Organism=Escherichia coli, GI1786478, Length=763, Percent_Identity=28.9646133682831, Blast_Score=221, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17540638, Length=779, Percent_Identity=26.7008985879332, Blast_Score=188, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17539860, Length=729, Percent_Identity=23.4567901234568, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI32566215, Length=734, Percent_Identity=23.5694822888283, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI17737937, Length=743, Percent_Identity=26.1103633916555, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24647193, Length=769, Percent_Identity=24.1872561768531, Blast_Score=143, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24647199, Length=749, Percent_Identity=23.3644859813084, Blast_Score=132, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24647201, Length=754, Percent_Identity=23.474801061008, Blast_Score=124, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24647195, Length=722, Percent_Identity=22.0221606648199, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24647197, Length=718, Percent_Identity=22.1448467966574, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 82671; Mature: 82671

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQA
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHH
RSLPGVLAIFTWEDVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARD
HCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECC
ELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQQTIDAAD
HHCHHHHHHEEEEEHHHCCEEECCCHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCCC
YQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
EEEECCCCCHHHHHHCHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHH
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHEEEEECCCEEEEECCCCC
VNRDGTLKGYSLDVLSNIGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAG
CCCCCCCCCEEHHHHHHCCHHHHCCCHHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCC
AMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYSAGLPECL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHH
EKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
HHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEE
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPAL
CCCCCHHCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
RSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERG
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
GQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHG
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
GMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCC
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
CCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MEAREATATGESCMRVDAIAKVTGRARYTDDYVMAGMCYAKYVRSPIAHGYAVSINDEQA
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCHHH
RSLPGVLAIFTWEDVPDIPFATAGHAWTLDENKRDTADRALLTRHVRHHGDAVAIVVARD
HCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEECC
ELTAEKAAQLVSIEWQELPVITTPEAALAEDAAPIHNGGNLLKQSTMSTGNVQQTIDAAD
HHCHHHHHHEEEEEHHHCCEEECCCHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCCC
YQVQGHYQTPVIQHCHMESVTSLAWMEDDSRITIVSSTQIPHIVRRVVGQALDIPWSCVR
EEEECCCCCHHHHHHCHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHH
VIKPFVGGGFGNKQDVLEEPMAAFLTSKLGGIPVKVSLSREECFLATRTRHAFTIDGQMG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECHHHEEEEECCCEEEEECCCCC
VNRDGTLKGYSLDVLSNIGAYASHGHSIASAGGNKVAYLYPRCAYAYSSKTCYTNLPSAG
CCCCCCCCCEEHHHHHHCCHHHHCCCHHHCCCCCEEEEECCCEEEHCCCCCEECCCCCCC
AMRGYGAPQVVFAVESMLDDAATALGIDPVEIRLRNAAREGDANPLTGKRIYSAGLPECL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHCCCHHHH
EKGRKIFEWEKRRAECQNQQGNLRRGVGVACFSYTSNTWPVGVEIAGARLLMNQDGTINV
HHCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEECEEEEECCCCEEEE
QSGATEIGQGADTVFSQMVAETVGVPVSDVRVISTQDTDVTPFDPGAFASRQSYVAAPAL
CCCCCHHCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
RSAALLLKEKIIAHAAVMLHQSAMNLTLIKGHIVLVERPEEPLMSLKDLAMDAFYHPERG
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCC
GQLSAESSIKTTTNPPAFGCTFVDLTVDIALCKVTINRILNVHDSGHILNPLLAEGQVHG
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCC
GMGMGIGWALFEEMIIDAKSGVVRNPNLLDYKMPTMPDLPQLESAFVEINEPQSAYGHKS
CCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHEEEECCCHHHCCCCC
LGEPPIIPVAAAIRNAVKMATGVAINTLPLTPKRLYEEFHLAGLI
CCCCCCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]