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The map label for this gene is fucK [H]

Identifier: 157162257

GI number: 157162257

Start: 2955677

End: 2957095

Strand: Direct

Name: fucK [H]

Synonym: EcHS_A2947

Alternate gene names: 157162257

Gene position: 2955677-2957095 (Clockwise)

Preceding gene: 157162256

Following gene: 157162258

Centisome position: 63.65

GC content: 51.3

Gene sequence:

>1419_bases
ATGAAACAAGAAGTTATCCTGGTACTCGACTGTGGCGCGACCAATGTCAGGGCCATCGCGGTTAATCGGCAGGGAAAAAT
TGTTGCCCGCGCCTCAACGCCTAATGCCAGCGATATCGCGATGGAAAACAACACCTGGCACCAGTGGTCTTTAGACGCCA
TTTTGCAACGCTTTGCTGATTGCTGTCGGCAAATCAATAGTGAACTAACTGAATGCCACATCCGCGGTATCGCCGTCACC
ACCTTTGGTGTGGATGGCGCTCTGGTAGATAAGCAAGGCAATCTGCTCTATCCGATCATTAGCTGGAAATGTCCGCGAAC
AGCAGCGGTTATGGACAATATTGAACAGTTGATCTCCGCACAGCGGTTGCAGGCTATTTCTGGCGTCGGAGCCTTTAGTT
TCAATACGTTATATAAGTTGGTGTGGTTGAAAGAAAATCATCCACAACTGCTGGAACGCGCGCACGCCTGGCTCTTTATT
TCGTCGCTGATTAACCACCGTTTAACCGGCGAATTCACTACTGATATCACGATGGCCGGAACCAGCCAGATGCTGGATAT
CCAGCAACGCGATTTCAGTCCGCAAATTTTACAAGCCACCGGTATTCCACGCCGACTCTTCCCTCGTCTGGTGGAAGCGG
GTGAACAGATTGGTACGCTACAGAACAGCGCCGCAGCAATGCTCGGCTTACCCGTTGGCATACCGGTGATTTCCGCAGGT
CACGATACCCAGTTCGCCCTTTTTGGCGCTGGTGCCGACCAAAATGAACCCGTGCTCTCTTCCGGTACATGGGAAATTTT
AATGGTCCGTAGCGCCCAGGTTGATACTTCGCTGTTAAGTCAGTACGCCGGTTCCACCTGCGAACTGGATAGCCAGGCAG
GGTTGTATAACCCAGGTATGCAATGGCTGGCATCCGGCGTGCTGGAATGGGTGAGAAAACTGTTCTGGACGGCTGAAACA
CCCTGGCAAATGTTGATTGAAGAGGCTCGTCTGATCGCGCCTGGCGCGGATGGCGTAAAAATGCAGTGTGATTTATTGTC
GTGTCAGAACGCTGGCTGGCAAGGAGTGACGCTTAATACCACGCGGGGGCATTTCTATCGCGCGGCGCTGGAAGGGTTAA
CCGCGCAATTACAGCGCAATCTACAGATGCTGGAAAAAATCGGGCACTTTAAAGCCTCTGAATTATTGTTAGTCGGCGGA
GGAAGTCGCAACACATTGTGGAATCAGATTAAAGCCAATATGCTTGATATTCCGGTAAAAGTTCTCGACGACGCCGAAAC
GACCGTCGCAGGAGCTGCGCTGTTCGGTTGGTATGGCATAGGGGAATTTAACAGCCCGGAAGAAGCCCGCGCGCAGATTC
ATTATCAGTACCGTTATTTCTACCCGCAAACTGAACCTGAATTTATAGAGGAAGTGTGA

Upstream 100 bases:

>100_bases
TCCCTGATGTGATGCCCGGTCGCTCCGGCTACCGGGCCTGAACAAGCAAGAGTGGTTAGCCGGATAAGCAATGTTATCCG
GCTATATTGCAGGAGCGATT

Downstream 100 bases:

>100_bases
AATGCTGAAAACAATTTCGCCGTTAATTTCTCCCGAACTATTGAAAGTGCTGGCAGAGATGGGACATGGAGATGAAATTA
TTTTTTCCGATGCTCACTTT

Product: L-fuculokinase

Products: NA

Alternate protein names: L-fuculose kinase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MKQEVILVLDCGATNVRAIAVNRQGKIVARASTPNASDIAMENNTWHQWSLDAILQRFADCCRQINSELTECHIRGIAVT
TFGVDGALVDKQGNLLYPIISWKCPRTAAVMDNIEQLISAQRLQAISGVGAFSFNTLYKLVWLKENHPQLLERAHAWLFI
SSLINHRLTGEFTTDITMAGTSQMLDIQQRDFSPQILQATGIPRRLFPRLVEAGEQIGTLQNSAAAMLGLPVGIPVISAG
HDTQFALFGAGADQNEPVLSSGTWEILMVRSAQVDTSLLSQYAGSTCELDSQAGLYNPGMQWLASGVLEWVRKLFWTAET
PWQMLIEEARLIAPGADGVKMQCDLLSCQNAGWQGVTLNTTRGHFYRAALEGLTAQLQRNLQMLEKIGHFKASELLLVGG
GSRNTLWNQIKANMLDIPVKVLDDAETTVAGAALFGWYGIGEFNSPEEARAQIHYQYRYFYPQTEPEFIEEV

Sequences:

>Translated_472_residues
MKQEVILVLDCGATNVRAIAVNRQGKIVARASTPNASDIAMENNTWHQWSLDAILQRFADCCRQINSELTECHIRGIAVT
TFGVDGALVDKQGNLLYPIISWKCPRTAAVMDNIEQLISAQRLQAISGVGAFSFNTLYKLVWLKENHPQLLERAHAWLFI
SSLINHRLTGEFTTDITMAGTSQMLDIQQRDFSPQILQATGIPRRLFPRLVEAGEQIGTLQNSAAAMLGLPVGIPVISAG
HDTQFALFGAGADQNEPVLSSGTWEILMVRSAQVDTSLLSQYAGSTCELDSQAGLYNPGMQWLASGVLEWVRKLFWTAET
PWQMLIEEARLIAPGADGVKMQCDLLSCQNAGWQGVTLNTTRGHFYRAALEGLTAQLQRNLQMLEKIGHFKASELLLVGG
GSRNTLWNQIKANMLDIPVKVLDDAETTVAGAALFGWYGIGEFNSPEEARAQIHYQYRYFYPQTEPEFIEEV
>Mature_472_residues
MKQEVILVLDCGATNVRAIAVNRQGKIVARASTPNASDIAMENNTWHQWSLDAILQRFADCCRQINSELTECHIRGIAVT
TFGVDGALVDKQGNLLYPIISWKCPRTAAVMDNIEQLISAQRLQAISGVGAFSFNTLYKLVWLKENHPQLLERAHAWLFI
SSLINHRLTGEFTTDITMAGTSQMLDIQQRDFSPQILQATGIPRRLFPRLVEAGEQIGTLQNSAAAMLGLPVGIPVISAG
HDTQFALFGAGADQNEPVLSSGTWEILMVRSAQVDTSLLSQYAGSTCELDSQAGLYNPGMQWLASGVLEWVRKLFWTAET
PWQMLIEEARLIAPGADGVKMQCDLLSCQNAGWQGVTLNTTRGHFYRAALEGLTAQLQRNLQMLEKIGHFKASELLLVGG
GSRNTLWNQIKANMLDIPVKVLDDAETTVAGAALFGWYGIGEFNSPEEARAQIHYQYRYFYPQTEPEFIEEV

Specific function: Fucose metabolism; second step. [C]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Escherichia coli, GI1789168, Length=472, Percent_Identity=99.364406779661, Blast_Score=973, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=505, Percent_Identity=23.3663366336634, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1789987, Length=421, Percent_Identity=26.3657957244656, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790338, Length=417, Percent_Identity=25.4196642685851, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR013450 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.51 [H]

Molecular weight: Translated: 52231; Mature: 52231

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQEVILVLDCGATNVRAIAVNRQGKIVARASTPNASDIAMENNTWHQWSLDAILQRFAD
CCCCEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCEEECCCCCCEECHHHHHHHHHH
CCRQINSELTECHIRGIAVTTFGVDGALVDKQGNLLYPIISWKCPRTAAVMDNIEQLISA
HHHHHHHHHHHHHEEEEEEEEECCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHH
QRLQAISGVGAFSFNTLYKLVWLKENHPQLLERAHAWLFISSLINHRLTGEFTTDITMAG
HHHHHHHCCCCHHHHCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
TSQMLDIQQRDFSPQILQATGIPRRLFPRLVEAGEQIGTLQNSAAAMLGLPVGIPVISAG
CHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCHHCCCHHHEECCCCCCEEECC
HDTQFALFGAGADQNEPVLSSGTWEILMVRSAQVDTSLLSQYAGSTCELDSQAGLYNPGM
CCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCH
QWLASGVLEWVRKLFWTAETPWQMLIEEARLIAPGADGVKMQCDLLSCQNAGWQGVTLNT
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCCCEEEEEEECCCCCCCCCEEEEC
TRGHFYRAALEGLTAQLQRNLQMLEKIGHFKASELLLVGGGSRNTLWNQIKANMLDIPVK
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCHHHCCHH
VLDDAETTVAGAALFGWYGIGEFNSPEEARAQIHYQYRYFYPQTEPEFIEEV
EECCCHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEEEEECCCCCHHHHHCC
>Mature Secondary Structure
MKQEVILVLDCGATNVRAIAVNRQGKIVARASTPNASDIAMENNTWHQWSLDAILQRFAD
CCCCEEEEEECCCCCEEEEEEECCCCEEEEECCCCCCCEEECCCCCCEECHHHHHHHHHH
CCRQINSELTECHIRGIAVTTFGVDGALVDKQGNLLYPIISWKCPRTAAVMDNIEQLISA
HHHHHHHHHHHHHEEEEEEEEECCCCEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHH
QRLQAISGVGAFSFNTLYKLVWLKENHPQLLERAHAWLFISSLINHRLTGEFTTDITMAG
HHHHHHHCCCCHHHHCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
TSQMLDIQQRDFSPQILQATGIPRRLFPRLVEAGEQIGTLQNSAAAMLGLPVGIPVISAG
CHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCHHCCCHHHEECCCCCCEEECC
HDTQFALFGAGADQNEPVLSSGTWEILMVRSAQVDTSLLSQYAGSTCELDSQAGLYNPGM
CCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCH
QWLASGVLEWVRKLFWTAETPWQMLIEEARLIAPGADGVKMQCDLLSCQNAGWQGVTLNT
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHEECCCCCCCEEEEEEECCCCCCCCCEEEEC
TRGHFYRAALEGLTAQLQRNLQMLEKIGHFKASELLLVGGGSRNTLWNQIKANMLDIPVK
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHCCHHHCCHH
VLDDAETTVAGAALFGWYGIGEFNSPEEARAQIHYQYRYFYPQTEPEFIEEV
EECCCHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEEEEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]