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The map label for this gene is fucP

Identifier: 157162255

GI number: 157162255

Start: 2952444

End: 2953760

Strand: Direct

Name: fucP

Synonym: EcHS_A2945

Alternate gene names: 157162255

Gene position: 2952444-2953760 (Clockwise)

Preceding gene: 157162252

Following gene: 157162256

Centisome position: 63.58

GC content: 47.61

Gene sequence:

>1317_bases
ATGGGAAACACATCAATACAAACGCAGAGTTACCGTGCGGTAGATAAAGATGCAGGGCAAAGCAGAAGTTACATTATTCC
ATTCGCGCTGCTGTGCTCACTGTTTTTTCTTTGGGCGGTAGCCAATAACCTTAACGACATTTTATTACCTCAATTCCAGC
AGGCTTTTACGCTGACAAATTTCCAGGCTGGCCTGATCCAATCGGCCTTTTACTTTGGTTATTTCATTATCCCAATCCCT
GCTGGGATATTGATGAAAAAACTCAGTTATAAAGCAGGGATTATTACCGGATTATTTTTATATGCCTTGGGCGCTGCATT
ATTCTGGCCCGCTGCAGAAATAATGAACTACACCTTATTTTTAGTTGGCCTATTTATTATTGCAGCCGGATTAGGTTGTC
TGGAAACTGCCGCAAACCCTTTTGTTACGGTATTAGGGCCGGAAAGCAGTGGTCACTTCCGCTTAAATCTTGCGCAAACA
TTTAACTCGTTTGGCGCAATTATCGCGGTTGTCTTTGGGCAAAGTCTTATTTTGTCTAACGTGCCACATCAATCGCAAGA
CGTTCTCGATAAAATGTCTCCAGAGCAATTGAGTGCGTATAAACACAGCCTGGTATTATCGGTACAGACACCTTATATGA
TCATCGTGGCTATCGTGTTACTGGTCGCCCTGCTGATCATGCTGACGAAATTCCCGGCATTGCAGAGTGATAATCACAGT
GACGCCAAACAAGGATCGTTCTCCGCATCGCTTTCTCGTCTGGCGCGTATTCGTCACTGGCGCTGGGCGGTATTAGCGCA
ATTCTGCTATGTCGGCGCACAAACGGCCTGCTGGAGCTATTTGATTCGCTACGCTGTAGAAGAAATTCCAGGTATGACTG
CAGGCTTTGCCGCTAACTATTTAACCGGAACCATGGTGTGCTTCTTTATTGGTCGTTTCACCGGTACCTGGCTCATCAGT
CGCTTCGCACCACACAAAGTCCTGGCCGCCTACGCATTAATCGCTATGGCACTGTGCCTGATCTCAGCCTTCGCTGGCGG
TCATGTGGGCTTAATAGCCCTGACTTTATGCAGCGCCTTTATGTCGATTCAGTACCCAACAATCTTCTCGCTGGGCATTA
AGAATCTCGGCCAGGACACCAAATACGGTTCGTCCTTCATCGTTATGACCATCATTGGCGGCGGTATTGTCACTCCGGTC
ATGGGTTTTGTCAGTGACGCGGCGGGCAACATCCCCACTGCTGAACTGATCCCCGCACTCTGCTTCGCGGTCATCTTTAT
CTTTGCCCGTTTCCGTTCTCAAACGGCAACTAACTGA

Upstream 100 bases:

>100_bases
CAGGCAAATATTCACTGATATGAAGCCCGAACTCGCTGGTTTTGCACTTTTGAAAACATAACCGATTACGTGCTTAAGCT
TCTGAACCTAAGAGGATGCT

Downstream 100 bases:

>100_bases
ACATATTTTCCGAATAAAGTGAGGAATCTGTAATGAAAAAAATCAGCTTACCGAAAATTGGTATCCGCCCGGTTATTGAC
GGTCGTCGCATGGGTGTTCG

Product: L-fucose transporter

Products: Proton [Cytoplasm]; L-fucose [Cytoplasm] [C]

Alternate protein names: 6-deoxy-L-galactose permease; L-fucose permease

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MGNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIP
AGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQT
FNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHS
DAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLIS
RFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPV
MGFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN

Sequences:

>Translated_438_residues
MGNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIP
AGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQT
FNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHS
DAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLIS
RFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPV
MGFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN
>Mature_437_residues
GNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPA
GILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTF
NSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSD
AKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISR
FAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVM
GFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN

Specific function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-

COG id: COG0738

COG function: function code G; Fucose permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family

Homologues:

Organism=Escherichia coli, GI1789166, Length=438, Percent_Identity=100, Blast_Score=886, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FUCP_ECOLI (P11551)

Other databases:

- EMBL:   X15025
- EMBL:   U29581
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   M31059
- PIR:   JS0184
- RefSeq:   AP_003367.1
- RefSeq:   NP_417281.1
- PDB:   3O7P
- PDB:   3O7Q
- PDBsum:   3O7P
- PDBsum:   3O7Q
- ProteinModelPortal:   P11551
- SMR:   P11551
- STRING:   P11551
- EnsemblBacteria:   EBESCT00000003186
- EnsemblBacteria:   EBESCT00000015043
- GeneID:   947487
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2772
- KEGG:   eco:b2801
- EchoBASE:   EB0348
- EcoGene:   EG10352
- eggNOG:   COG0738
- GeneTree:   EBGT00050000008834
- HOGENOM:   HBG735535
- OMA:   FINYVTE
- ProtClustDB:   PRK10133
- BioCyc:   EcoCyc:FUCP-MONOMER
- Genevestigator:   P11551
- InterPro:   IPR005275
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- TIGRFAMs:   TIGR00885

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 47545; Mature: 47414

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x166dd2ac)-; HASH(0x170a12a0)-; HASH(0x16ca5b3c)-; HASH(0x16a8c1a8)-; HASH(0x170f0cf0)-; HASH(0x167ebad0)-; HASH(0x16a3fb64)-; HASH(0x15d338b4)-; HASH(0x164ebd50)-; HASH(0x170f0b64)-; HASH(0x170abcd8)-; HASH(0x17062bc8)-;

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCH
>Mature Secondary Structure 
GNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTN
CCCCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSN
HHHHHHHHHCCHHHHHCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHCC
VPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHS
CCCCHHHHHHCCCHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
DAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANY
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
LTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAF
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAELIPAL
HHCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHH
CFAVIFIFARFRSQTATN
HHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-fucose [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-fucose [Periplasm] = Proton [Cytoplasm] + L-fucose [Cytoplasm] [C]

General reaction: Permease [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2664711; 9278503; 2553671; 8052131; 2829831; 7783647