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The map label for this gene is yqaB

Identifier: 157162141

GI number: 157162141

Start: 2834487

End: 2835053

Strand: Reverse

Name: yqaB

Synonym: EcHS_A2826

Alternate gene names: 157162141

Gene position: 2835053-2834487 (Counterclockwise)

Preceding gene: 157162142

Following gene: 157162140

Centisome position: 61.05

GC content: 53.44

Gene sequence:

>567_bases
ATGTACGAGCGTTATGCAGGTTTAATTTTTGATATGGATGGCACAATCCTGGATACGGAGCCTACGCACCGTAAAGCGTG
GCGCGAAGTATTAGGGCACTACGGTCTTCAGTACGATATTCAGGCGATGATTGCGCTTAATGGATCGCCCACCTGGCGTA
TTGCTCAGGCAATTATTGAGCTGAATCAGGCCGATCTCGACCCGCATGCGTTAGCGCGTGAAAAAACAGAAGCAGTAAGA
AGTATGCTGCTGGATAGCGTCGAACCGCTTCCTCTTGTTGATGTGGTGAAAAGTTGGCATGGTCGTCGCCCAATGGCTGT
AGGAACGGGGAGTGAAAGCGCCATCGCTGAGGCATTGCTGGCGCACCTGGGATTACGCCATTATTTTGACGCCGTCGTCG
CTGCCGATCACGTCAAACACCATAAACCCGCGCCAGACACATTTTTGTTGTGCGCGCAGCGTATGGGCGTGCAACCGACG
CAGTGTGTGGTCTTTGAAGATGCCGATTTCGGTATTCAGGCGGCCCGTGCAGCAGGCATGGACGCCGTGGATGTTCGCTT
GCTGTGA

Upstream 100 bases:

>100_bases
CCTTTATCCATTTCCTGAATTTTCTTCTCCTTCGCCATCAGCGACAAAATCAAGCAATTACGCTAAAGTAGCGTCATATT
TTTCGACTTGCGAGAAGACC

Downstream 100 bases:

>100_bases
GTGAAGCGTTATCGCTTTTCTCGTTGTTTGCCAGTAGTTTTCTCAGCGCTACACTATTACCCGGCAACTCCGAAGTCGTG
CTGGTGGCAATGTTGCTTTC

Product: fructose-1-phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MYERYAGLIFDMDGTILDTEPTHRKAWREVLGHYGLQYDIQAMIALNGSPTWRIAQAIIELNQADLDPHALAREKTEAVR
SMLLDSVEPLPLVDVVKSWHGRRPMAVGTGSESAIAEALLAHLGLRHYFDAVVAADHVKHHKPAPDTFLLCAQRMGVQPT
QCVVFEDADFGIQAARAAGMDAVDVRLL

Sequences:

>Translated_188_residues
MYERYAGLIFDMDGTILDTEPTHRKAWREVLGHYGLQYDIQAMIALNGSPTWRIAQAIIELNQADLDPHALAREKTEAVR
SMLLDSVEPLPLVDVVKSWHGRRPMAVGTGSESAIAEALLAHLGLRHYFDAVVAADHVKHHKPAPDTFLLCAQRMGVQPT
QCVVFEDADFGIQAARAAGMDAVDVRLL
>Mature_188_residues
MYERYAGLIFDMDGTILDTEPTHRKAWREVLGHYGLQYDIQAMIALNGSPTWRIAQAIIELNQADLDPHALAREKTEAVR
SMLLDSVEPLPLVDVVKSWHGRRPMAVGTGSESAIAEALLAHLGLRHYFDAVVAADHVKHHKPAPDTFLLCAQRMGVQPT
QCVVFEDADFGIQAARAAGMDAVDVRLL

Specific function: Catalyzes the dephosphorylation of the artificial chromogenic substrate p-nitrophenyl phosphate (pNPP) and of the natural substrates fructose 1-phosphate and 6-phosphogluconate

COG id: COG0637

COG function: function code R; Predicted phosphatase/phosphohexomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family

Homologues:

Organism=Homo sapiens, GI197382691, Length=190, Percent_Identity=34.7368421052632, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI207113149, Length=213, Percent_Identity=30.9859154929577, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1789046, Length=188, Percent_Identity=100, Blast_Score=386, Evalue=1e-109,
Organism=Escherichia coli, GI1787576, Length=191, Percent_Identity=29.3193717277487, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788021, Length=184, Percent_Identity=31.5217391304348, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1789787, Length=207, Percent_Identity=25.6038647342995, Blast_Score=64, Evalue=9e-12,
Organism=Drosophila melanogaster, GI17137324, Length=185, Percent_Identity=31.8918918918919, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116008157, Length=188, Percent_Identity=29.7872340425532, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YQAB_ECOLI (P77475)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   C65049
- RefSeq:   AP_003262.1
- RefSeq:   NP_417175.1
- ProteinModelPortal:   P77475
- SMR:   P77475
- DIP:   DIP-12842N
- IntAct:   P77475
- MINT:   MINT-1265616
- STRING:   P77475
- EnsemblBacteria:   EBESCT00000001473
- EnsemblBacteria:   EBESCT00000015289
- GeneID:   945776
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2665
- KEGG:   eco:b2690
- EchoBASE:   EB3301
- EcoGene:   EG13530
- eggNOG:   COG0637
- GeneTree:   EBGT00050000009691
- HOGENOM:   HBG742904
- OMA:   HELFDES
- ProtClustDB:   PRK10725
- BioCyc:   EcoCyc:G7408-MONOMER
- BioCyc:   MetaCyc:G7408-MONOMER
- Genevestigator:   P77475
- InterPro:   IPR010976
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006402
- InterPro:   IPR005833
- Gene3D:   G3DSA:3.40.50.1000
- PRINTS:   PR00413
- TIGRFAMs:   TIGR01509
- TIGRFAMs:   TIGR02009

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: NA

Molecular weight: Translated: 20780; Mature: 20780

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: ACT_SITE 11-11

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYERYAGLIFDMDGTILDTEPTHRKAWREVLGHYGLQYDIQAMIALNGSPTWRIAQAIIE
CCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
LNQADLDPHALAREKTEAVRSMLLDSVEPLPLVDVVKSWHGRRPMAVGTGSESAIAEALL
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHH
AHLGLRHYFDAVVAADHVKHHKPAPDTFLLCAQRMGVQPTQCVVFEDADFGIQAARAAGM
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCC
DAVDVRLL
CCEEEEEC
>Mature Secondary Structure
MYERYAGLIFDMDGTILDTEPTHRKAWREVLGHYGLQYDIQAMIALNGSPTWRIAQAIIE
CCCCCCCEEEECCCCEECCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
LNQADLDPHALAREKTEAVRSMLLDSVEPLPLVDVVKSWHGRRPMAVGTGSESAIAEALL
HCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHH
AHLGLRHYFDAVVAADHVKHHKPAPDTFLLCAQRMGVQPTQCVVFEDADFGIQAARAAGM
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCC
DAVDVRLL
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503