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The map label for this gene is xseA [H]

Identifier: 157161984

GI number: 157161984

Start: 2671872

End: 2673242

Strand: Direct

Name: xseA [H]

Synonym: EcHS_A2660

Alternate gene names: 157161984

Gene position: 2671872-2673242 (Clockwise)

Preceding gene: 157161979

Following gene: 157161996

Centisome position: 57.54

GC content: 53.39

Gene sequence:

>1371_bases
ATGTTACCTTCTCAATCCCCTGCAATTTTTACCGTTAGTCGCCTGAATCAAACGGTTCGTCTGCTGCTTGAGCATGAGAT
GGGACAGGTTTGGATCAGCGGCGAAATCTCTAATTTCACACAACCGGCTTCCGGTCACTGGTACTTTACACTCAAAGACG
ACACCGCCCAGGTACGCTGCGCGATGTTCCGCAACAGCAACCGCCGGGTGACCTTCCGCCCACAGCATGGGCAACAAGTT
TTAGTTCGCGCCAATATTACGCTCTACGAGCCGCGCGGCGACTACCAGATAATCGTTGAGAGTATGCAGCCGGCCGGTGA
AGGGCTGCTGCAACAGAAGTACGAACAGCTCAAAGCGAAGTTGCAGGCTGAAGGTTTGTTCGATCAGCAATACAAAAAAC
CACTTCCCTCCCCTGCGCATTGCGTTGGTGTGATCACCTCAAAAACCGGTGCTGCGCTACATGATATTTTGCATGTGTTA
AAACGTCGCGATCCTTCTCTACCGGTGATCATCTACCCCACCGCCGTTCAGGGCGATGACGCGCCGGGGCAAATTGTTCG
CGCCATTGAACTGGCGAATCAGCGCAATGAGTGCGACGTGTTGATCGTTGGGCGCGGCGGCGGTTCGCTGGAAGATTTAT
GGAGTTTTAACGACGAACGCGTAGCGCGGGCTATTTTTGCCAGCCGCATTCCGGTCGTCAGCGCCGTCGGGCATGAGACG
GATGTGACCATTGCCGATTTTGTTGCCGATCTGCGTGCGCCAACGCCGTCTGCCGCCGCTGAAGTAGTAAGCCGTAATCA
GCAAGAGTTACTGCGCCAGGTGCAATCGGCCCGTCAACGGCTGGAGATGGCGATGGATTATTATCTCGCCAACCGTACGC
GTCGCTTTACGCAGATTCATCATCGCTTGCAGCAGCAGCATCCGCAGCTCCGGCTGGCACGCCAGCAAACCATGCTTGAA
CGCCTGAAAAAACGGATGAGCTTTGCGCTGGAAAATCAGCTTAAGCGTGCCGGGCAACAGCAGCAGCGATTAACACAGCG
GCTGAATCAGCAAAATCCACAGCCGAAGATTCATCGCGCGCAAACGCGCATTCAGCAACTGGAATATCGTTTAGCAGAAA
TCCTGCGCGCACAGCTTAGCGCCACGCGTGAACGTTTCGGTAATGCAGTAACGCACCTCGAAGCCGTAAGCCCACTGTCA
ACGCTGGCGCGTGGATACAGCGTTACTACTGCTACTGACGGCAATGTACTGAAAAAAGTGAAGCAAGTTAAAGCGGGTGA
AATGCTAACCACACGTCTGGAAGACGGCTGGATAGAAAGTGAAGTAAAAAACATCCAGCCGGTAAAAAAATCGCGTAAAA
AGGTTCATTAA

Upstream 100 bases:

>100_bases
GATTGCATCTACCCCTTTTTGCAAAAAATGCTTGCTATCCCCGGAGGGCGGGTTACTATCGACTGAATAACCTGCTGATT
TAGAATTTGATCTCGCTCAC

Downstream 100 bases:

>100_bases
GCCAGCACGAATTCAACGCGTTTTTTCGATATCAAGCCATGCCCGTGCTGACAGAAGTAATCTACTGCACCGCAGGCTTT
TAACACCTGCAACGGTTGAT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQV
LVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVL
KRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHET
DVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSARQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLE
RLKKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAEILRAQLSATRERFGNAVTHLEAVSPLS
TLARGYSVTTATDGNVLKKVKQVKAGEMLTTRLEDGWIESEVKNIQPVKKSRKKVH

Sequences:

>Translated_456_residues
MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQV
LVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVL
KRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHET
DVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSARQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLE
RLKKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAEILRAQLSATRERFGNAVTHLEAVSPLS
TLARGYSVTTATDGNVLKKVKQVKAGEMLTTRLEDGWIESEVKNIQPVKKSRKKVH
>Mature_456_residues
MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQV
LVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAEGLFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVL
KRRDPSLPVIIYPTAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHET
DVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSARQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLE
RLKKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAEILRAQLSATRERFGNAVTHLEAVSPLS
TLARGYSVTTATDGNVLKKVKQVKAGEMLTTRLEDGWIESEVKNIQPVKKSRKKVH

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=456, Percent_Identity=98.6842105263158, Blast_Score=930, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 51785; Mature: 51785

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRC
CCCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEECCCHHHHH
AMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAK
HHHCCCCCEEEECCCCCCEEEEEEEEEEECCCCCHHHHEEHHCCCCCHHHHHHHHHHHHH
LQAEGLFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDD
HHHCCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
APGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHET
CHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCC
DVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSARQRLEMAMDYYLANRTRRFTQIH
CCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLQQQHPQLRLARQQTMLERLKKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QTRIQQLEYRLAEILRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGNVLKKV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHH
KQVKAGEMLTTRLEDGWIESEVKNIQPVKKSRKKVH
HHHHHCHHHHHHHHCCHHHHHHHHCHHHHHHHCCCC
>Mature Secondary Structure
MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRC
CCCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCEEEEEECCCHHHHH
AMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAK
HHHCCCCCEEEECCCCCCEEEEEEEEEEECCCCCHHHHEEHHCCCCCHHHHHHHHHHHHH
LQAEGLFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTAVQGDD
HHHCCCHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
APGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHET
CHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCC
DVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSARQRLEMAMDYYLANRTRRFTQIH
CCHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLQQQHPQLRLARQQTMLERLKKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRA
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QTRIQQLEYRLAEILRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGNVLKKV
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHH
KQVKAGEMLTTRLEDGWIESEVKNIQPVKKSRKKVH
HHHHHCHHHHHHHHCCHHHHHHHHCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA