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The map label for this gene is slyA

Identifier: 157161104

GI number: 157161104

Start: 1742343

End: 1742777

Strand: Reverse

Name: slyA

Synonym: EcHS_A1718

Alternate gene names: 157161104

Gene position: 1742777-1742343 (Counterclockwise)

Preceding gene: 157161105

Following gene: 157161102

Centisome position: 37.53

GC content: 48.28

Gene sequence:

>435_bases
TTGGAATCGCCACTAGGTTCTGATCTGGCACGGTTGGTGCGCATATGGCGTGCTCTGATAGACCATCGCCTGAAACCGCT
GGAGTTAACACAAACCCATTGGGTTACGTTACACAATATCCATCAGTTACCTCCAGACCAGTCGCAAATTCAACTGGCAA
AAGCGATTGGCATCGAGCAGCCATCACTGGTCCGTACTCTGGACCAACTGGAAGAAAAAGGGTTAATTTCGCGTCAAACT
TGTGCCAGCGATCGTCGGGCTAAACGTATTAAACTGACGGAAAAGGCAGAGCCGCTGATCAGCGAAATGGAAGCTGTTAT
TAACAAAACCCGCGCGGAAATATTACATGGCATCTCCGCAGAGGAACTGGAGCAACTGATTACGCTCATCGCAAAACTTG
AGCATAATATCATTGAGTTACAGGCCAAAGGGTGA

Upstream 100 bases:

>100_bases
TAACCAAATGCAGCAATACATTTGTTTTAGCAATACAATTGCTGCACACTATTCTAAAAGCCGCATAATATCTTAGCAAG
CTAATTATAAGGAGATGAAA

Downstream 100 bases:

>100_bases
AATGAAGGGGGCGTGTGGTCAGTAACCTGACCACACGCAAACTTATTTAGCGCGGAGAAACGGTCACCTGACTGCCATTG
CTGGCCAGTACGACACGTTG

Product: transcriptional regulator SlyA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT
CASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLITLIAKLEHNIIELQAKG

Sequences:

>Translated_144_residues
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT
CASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLITLIAKLEHNIIELQAKG
>Mature_144_residues
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQPSLVRTLDQLEEKGLISRQT
CASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISAEELEQLITLIAKLEHNIIELQAKG

Specific function: Transcription regulator that can both activate or repress expression

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI87081950, Length=144, Percent_Identity=100, Blast_Score=284, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SLYA_ECO24 (A7ZMA4)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001462933.1
- ProteinModelPortal:   A7ZMA4
- SMR:   A7ZMA4
- STRING:   A7ZMA4
- EnsemblBacteria:   EBESCT00000021171
- GeneID:   5586230
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_1852
- eggNOG:   COG1846
- GeneTree:   EBGT00050000010900
- HOGENOM:   HBG728159
- OMA:   DEHRFGM
- ProtClustDB:   PRK03573
- BioCyc:   ECOL331111:ECE24377A_1852-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_01819
- InterPro:   IPR000835
- InterPro:   IPR023071
- InterPro:   IPR023187
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00598
- SMART:   SM00347

Pfam domain/function: PF01047 MarR

EC number: NA

Molecular weight: Translated: 16353; Mature: 16353

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS01117 HTH_MARR_1; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQ
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
PSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EELEQLITLIAKLEHNIIELQAKG
HHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MESPLGSDLARLVRIWRALIDHRLKPLELTQTHWVTLHNIHQLPPDQSQIQLAKAIGIEQ
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
PSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEMEAVINKTRAEILHGISA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EELEQLITLIAKLEHNIIELQAKG
HHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA