Click here to switch to the map view.

The map label for this gene is mdtJ

Identifier: 157161060

GI number: 157161060

Start: 1695271

End: 1695636

Strand: Reverse

Name: mdtJ

Synonym: EcHS_A1674

Alternate gene names: 157161060

Gene position: 1695636-1695271 (Counterclockwise)

Preceding gene: 157161062

Following gene: 157161059

Centisome position: 36.52

GC content: 42.35

Gene sequence:

>366_bases
ATGTATATTTATTGGATTTTATTAGGTCTGGCTATTGCTACAGAAATTACCGGTACGCTGTCAATGAAATGGGCGAGCGT
CAGTGAGGGAAATGGCGGCTTTATTTTAATGCTGGTGATGATTTCTCTGTCGTATATATTTCTCTCTTTCGCCGTTAAAA
AAATCGCCTTAGGCGTAGCTTATGCGCTGTGGGAAGGTATCGGTATTTTATTTATTACCTTGTTTAGCGTTTTGTTATTC
GACGAAAGTTTATCGCTGATGAAAATTGCCGGGTTAACCACCCTGGTCGCCGGGATTGTGTTGATAAAATCAGGTACCCG
TAAAGCGCGTAAACCTGAACTGGAGGTGAACCATGGCGCAGTTTGA

Upstream 100 bases:

>100_bases
CTTCTGCCAAAGCTTGCGCTATGCGCGGGGCTTGACCACTTTACTTTGGTTTCGCTGAATTAAGCGAAAATTAAAATAAT
TCTCTTGCAGGAGAAGGACA

Downstream 100 bases:

>100_bases
ATGGGTTCACGCCGCCTGGCTGGCATTGGCAATCGTGCTGGAAATCGTTGCTAACGTCTTTTTGAAATTTTCTGACGGCT
TTCGTCGCAAAATATTTGGC

Product: multidrug efflux system protein MdtJ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 121; Mature: 121

Protein sequence:

>121_residues
MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLF
DESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV

Sequences:

>Translated_121_residues
MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLF
DESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV
>Mature_121_residues
MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLF
DESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGAV

Specific function: Catalyzes the excretion of spermidine

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family. MdtJ subfamily

Homologues:

Organism=Escherichia coli, GI1787884, Length=121, Percent_Identity=100, Blast_Score=232, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MDTJ_ECO24 (A7ZM59)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001462888.1
- ProteinModelPortal:   A7ZM59
- STRING:   A7ZM59
- EnsemblBacteria:   EBESCT00000021658
- GeneID:   5586220
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_1807
- eggNOG:   COG2076
- GeneTree:   EBGT00050000009344
- HOGENOM:   HBG740972
- OMA:   AFWEGLG
- ProtClustDB:   PRK10452
- BioCyc:   ECOL331111:ECE24377A_1807-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01598
- InterPro:   IPR000390

Pfam domain/function: PF00893 Multi_Drug_Res

EC number: NA

Molecular weight: Translated: 13115; Mature: 13115

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14cef9fc)-; HASH(0x143f01e8)-; HASH(0x144a56b4)-; HASH(0x1454fddc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVA
CCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
V
H
>Mature Secondary Structure
MYIYWILLGLAIATEITGTLSMKWASVSEGNGGFILMLVMISLSYIFLSFAVKKIALGVA
CCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLIKSGTRKARKPELEVNHGA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
V
H

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA