Click here to switch to the map view.

The map label for this gene is ppiD [H]

Identifier: 157159968

GI number: 157159968

Start: 527980

End: 529851

Strand: Direct

Name: ppiD [H]

Synonym: EcHS_A0518

Alternate gene names: 157159968

Gene position: 527980-529851 (Clockwise)

Preceding gene: 157159967

Following gene: 157159969

Centisome position: 11.37

GC content: 52.35

Gene sequence:

>1872_bases
ATGATGGACAGCTTACGCACGGCTGCAAACAGTCTCGTGCTCAAGATTATTTTCGGTATCATTATCGTGTCGTTCATATT
GACCGGCGTGAGTGGTTACCTGATTGGCGGAGGCAATAACTACGCCGCAAAAGTGAATGACCAGAAAATCAGCCGTGGGC
AATTCGAGAACGCCTTCAACAGCGAGCGTAATCGCATGCAGCAACAGCTGGGCGATCAATACTCCGAGCTGGCAGCGAAC
GAAGGCTATATGAAAACCCTGCGTCAACAGGTGCTGAATCGTCTGATCGACGAGGCGCTGCTGGATCAGTACGCACGTGA
GCTGAAACTGGGTATCAGCGATGAGCAGGTTAAACAGGCGATTTTCGCGACCCCAGCCTTCCAGGTTGACGGCAAATTTG
ATAACAGCCGCTATAACGGTATCCTCAACCAGATGGGGATGACCGCCGATCAGTACGCCCAGGCGCTGCGTAACCAGCTC
ACTACCCAACAGCTGATTAACGGCGTTGCCGGTACCGATTTTATGCTGAAAGGTGAAACCGACGAGCTGGCGGCACTGGT
CGCGCAACAACGCGTGGTGCGTGAGGCGACTATCGATGTTAACGCGCTGGCGGCGAAGCAGCCTGTGACCGAACAGGAGA
TTGCCAGCTACTACGAACAAAACAAAAACAATTTCATGACGCCGGAACAATTCCGCGTGAGTTACATCAAGCTGGATGCC
GCAACGATGCAGCAACCGGTTAGCGATGCGGATATCCAGAGCTACTACGACCAGCATCAGGATCAATTCACCCAGCCGCA
GCGTACCCGCTACAGCATCATCCAGACCAAAACTGAAGATGAAGCGAAAGCGGTACTTGATGAGCTGAATAAAGGCGGTG
ATTTTGCTGCATTAGCCAAAGAAAAATCTGCCGATATTATCTCTGCTCGTAACGGCGGCGATATGGGTTGGTTAGAAGAT
GCCACTATCCCGGACGAACTGAAAAATGCTGGTCTGAAAGAAAAAGGCCAACTGTCTGGTGTCATCAAATCTTCGGTCGG
TTTCCTGATTGTACGTCTGGACGACATTCAGCCAGCGAAAGTGAAATCGTTAGACGAAGTACGTGACGACATTGCGGCGA
AAGTGAAACACGAAAAAGCCCTCGATGCGTACTACGCGCTGCAGCAGAAAGTGAGCGATGCGGCAAGCAACGACACCGAG
TCTCTGGCCGGTGCAGAGCAAGCTGCCGGCGTTAAAGCCACTCAGACGGGTTGGTTCAGCAAAGATAACCTGCCGGAAGA
GTTGAACTTCAAGCCGGTTGCCGACGCTATCTTTAACGGCGGTCTGGTAGGTGAAAACGGCGCGCCGGGCATCAACTCTG
ACATCATCACCGTAGACGGCGACCGCGCATTCGTGCTGCGCATCAGCGAGCACAAACCGGAAGCGGTGAAACCGTTGGCA
GATGTTCAGGAACAAGTTAAGGCACTGGTTCAGCACAACAAAGCTGAACAACAGGCGAAAGTGGATGCTGAGAAACTGCT
GGTTGATTTGAAAGCCGGCAAAGGTGCGGAAGCTATGCAGGCTGCCGGTCTGAAATTTGGCGAGCCGAAAACCTTAAGCC
GTTCCGGTCGTGACCCGATTAGCCAGGCGGCGTTTGCACTGCCACTGCCAGCGAAAGACAAACCGAGCTACGGTATGGCG
ACCGATATGCAAGGTAATGTGGTTCTGCTGGCGCTGGATGAAGTGAAACAAGGTTCAATGCCGGAAGATCAGAAAAAAGC
GATGGTGCAGGGTATCACCCAGAACAACGCACAAATCGTCTTTGAAGCTCTGATGAGTAACCTGCGTAAAGAGGCGAAAA
TCAAAATTGGCGATGCGCTGGAACAGCAATAA

Upstream 100 bases:

>100_bases
GGGCTGACAATTGCCCCCGTTTCTTGTCACAATAGGCCTTTGCGCGCATCGATACGTTGCGTGAGGTACACAGTCATCTA
CAGCGGAGTGTTGTTACACC

Downstream 100 bases:

>100_bases
TCCTGAAGCCGCCTCGCAAAAAAATGCGTTGCAGCTGTAACAAGAAAAGGTCGCTTTCGCGGCCTTTTCCATTTCTGAAC
ATTGCCATTTGTTTACTGTT

Product: peptidyl-prolyl cis-trans isomerase (rotamase D)

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 623; Mature: 623

Protein sequence:

>623_residues
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQKISRGQFENAFNSERNRMQQQLGDQYSELAAN
EGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQAIFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQL
TTQQLINGVAGTDFMLKGETDELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAKEKSADIISARNGGDMGWLED
ATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAKVKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTE
SLAGAEQAAGVKATQTGWFSKDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPISQAAFALPLPAKDKPSYGMA
TDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ

Sequences:

>Translated_623_residues
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQKISRGQFENAFNSERNRMQQQLGDQYSELAAN
EGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQAIFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQL
TTQQLINGVAGTDFMLKGETDELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAKEKSADIISARNGGDMGWLED
ATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAKVKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTE
SLAGAEQAAGVKATQTGWFSKDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPISQAAFALPLPAKDKPSYGMA
TDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ
>Mature_623_residues
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQKISRGQFENAFNSERNRMQQQLGDQYSELAAN
EGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQAIFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQL
TTQQLINGVAGTDFMLKGETDELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAKEKSADIISARNGGDMGWLED
ATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAKVKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTE
SLAGAEQAAGVKATQTGWFSKDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPISQAAFALPLPAKDKPSYGMA
TDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=623, Percent_Identity=99.8394863563403, Blast_Score=1261, Evalue=0.0,
Organism=Escherichia coli, GI1786238, Length=273, Percent_Identity=27.1062271062271, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 68150; Mature: 68150

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQKISRGQFENAFN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCHHHHHHHHHHHHHH
SERNRMQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQLTTQQLINGVAGTDFMLKGET
HHCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCH
DELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHEEEEEEECH
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAK
HHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHH
EKSADIISARNGGDMGWLEDATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAK
HCCCCEEECCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCHH
VKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTESLAGAEQAAGVKATQTGWFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHCCCCCCCCCCCC
KDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
CCCCCCCCCCCHHHHHHHCCCEECCCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHH
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCH
SQAAFALPLPAKDKPSYGMATDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIV
HHHHEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHH
FEALMSNLRKEAKIKIGDALEQQ
HHHHHHHHHHHHEEEECHHHCCC
>Mature Secondary Structure
MMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNDQKISRGQFENAFN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEECCHHHHHHHHHHHHHH
SERNRMQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYARELKLGISDEQVKQA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
IFATPAFQVDGKFDNSRYNGILNQMGMTADQYAQALRNQLTTQQLINGVAGTDFMLKGET
HHCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCH
DELAALVAQQRVVREATIDVNALAAKQPVTEQEIASYYEQNKNNFMTPEQFRVSYIKLDA
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCHHHHEEEEEEECH
ATMQQPVSDADIQSYYDQHQDQFTQPQRTRYSIIQTKTEDEAKAVLDELNKGGDFAALAK
HHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHH
EKSADIISARNGGDMGWLEDATIPDELKNAGLKEKGQLSGVIKSSVGFLIVRLDDIQPAK
HCCCCEEECCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCEEEEEECCCCCHH
VKSLDEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTESLAGAEQAAGVKATQTGWFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHCCCCCCCCCCCC
KDNLPEELNFKPVADAIFNGGLVGENGAPGINSDIITVDGDRAFVLRISEHKPEAVKPLA
CCCCCCCCCCCHHHHHHHCCCEECCCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHH
DVQEQVKALVQHNKAEQQAKVDAEKLLVDLKAGKGAEAMQAAGLKFGEPKTLSRSGRDPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHCCCCCCCCCCCCCCCCCCH
SQAAFALPLPAKDKPSYGMATDMQGNVVLLALDEVKQGSMPEDQKKAMVQGITQNNAQIV
HHHHEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCHHHH
FEALMSNLRKEAKIKIGDALEQQ
HHHHHHHHHHHHEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]