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The map label for this gene is pgpA

Identifier: 157159939

GI number: 157159939

Start: 500381

End: 500899

Strand: Direct

Name: pgpA

Synonym: EcHS_A0489

Alternate gene names: 157159939

Gene position: 500381-500899 (Clockwise)

Preceding gene: 157159938

Following gene: 157159944

Centisome position: 10.78

GC content: 52.79

Gene sequence:

>519_bases
ATGACCATTTTGCCACGCCATAAAGATGTCGCGAAAAGTCGCCTGAAGATGAGTAATCCGTGGCATCTGCTTGCTGTCGG
ATTCGGAAGTGGATTAAGCCCAATCGTTCCTGGCACGATGGGATCGCTGGCAGCGATTCCGTTCTGGTATCTGATGACCT
TTTTACCCTGGCAGCTCTACTCGCTGGTGGTGATGTTGGGGATCTGTATCGGCGTCTATCTTTGTCATCAAACGGCGAAA
GATATGGGCGTGCACGATCACGGCAGCATTGTCTGGGACGAATTTATTGGTATGTGGATCACGCTCATGGCGCTGCCGAC
CAATGACTGGCAGTGGGTTGCCGCCGGGTTTGTGATTTTCCGTATTCTGGATATGTGGAAGCCGTGGCCGATCCGCTGGT
TTGATCGCAATGTACATGGCGGCATGGGGATCATGATCGACGATATTGTCGCCGGGGTGATTTCCGCAGGCATCCTGTAC
TTTATCGGTCATCACTGGCCGCTGGGTATTCTGTCGTAG

Upstream 100 bases:

>100_bases
CTGGGCGTACCGTTTACCTGTATCGGGCAAATGACCGCCGATATCGAAGGGCTTTGTTTTATTCGTGACGGCGAACCTGT
CACGTTTGACTGGAAAGGAT

Downstream 100 bases:

>100_bases
TTGTGCACCGATGCCTGATGTGACGCTTGTCACGTCTCATCAGGCCTGGACTCTTATTTAAATCCTACGACCGCATGCGG
TTTATACGGCGTTTCCAGTT

Product: phosphatidylglycerophosphatase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MTILPRHKDVAKSRLKMSNPWHLLAVGFGSGLSPIVPGTMGSLAAIPFWYLMTFLPWQLYSLVVMLGICIGVYLCHQTAK
DMGVHDHGSIVWDEFIGMWITLMALPTNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILY
FIGHHWPLGILS

Sequences:

>Translated_172_residues
MTILPRHKDVAKSRLKMSNPWHLLAVGFGSGLSPIVPGTMGSLAAIPFWYLMTFLPWQLYSLVVMLGICIGVYLCHQTAK
DMGVHDHGSIVWDEFIGMWITLMALPTNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILY
FIGHHWPLGILS
>Mature_171_residues
TILPRHKDVAKSRLKMSNPWHLLAVGFGSGLSPIVPGTMGSLAAIPFWYLMTFLPWQLYSLVVMLGICIGVYLCHQTAKD
MGVHDHGSIVWDEFIGMWITLMALPTNDWQWVAAGFVIFRILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYF
IGHHWPLGILS

Specific function: One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate

COG id: COG1267

COG function: function code I; Phosphatidylglycerophosphatase A and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786620, Length=172, Percent_Identity=100, Blast_Score=345, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PGPA_ECOLI (P18200)

Other databases:

- EMBL:   M23546
- EMBL:   D17333
- EMBL:   U82664
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   A30192
- PIR:   B64771
- RefSeq:   AP_001068.1
- RefSeq:   NP_414952.1
- ProteinModelPortal:   P18200
- SMR:   P18200
- STRING:   P18200
- EnsemblBacteria:   EBESCT00000003945
- EnsemblBacteria:   EBESCT00000016039
- GeneID:   947542
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW0408
- KEGG:   eco:b0418
- EchoBASE:   EB0698
- EcoGene:   EG10704
- eggNOG:   COG1267
- GeneTree:   EBGT00050000009609
- HOGENOM:   HBG708347
- OMA:   GLGIMVD
- ProtClustDB:   PRK11068
- BioCyc:   EcoCyc:PGPPHOSPHAA-MONOMER
- BioCyc:   MetaCyc:PGPPHOSPHAA-MONOMER
- Genevestigator:   P18200
- InterPro:   IPR007686

Pfam domain/function: PF04608 PgpA; SSF101307 PgpA

EC number: =3.1.3.27

Molecular weight: Translated: 19418; Mature: 19287

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x12d0f6d4)-; HASH(0x12fbb2a8)-; HASH(0x124407f4)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILPRHKDVAKSRLKMSNPWHLLAVGFGSGLSPIVPGTMGSLAAIPFWYLMTFLPWQLY
CCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SLVVMLGICIGVYLCHQTAKDMGVHDHGSIVWDEFIGMWITLMALPTNDWQWVAAGFVIF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFIGHHWPLGILS
HHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure 
TILPRHKDVAKSRLKMSNPWHLLAVGFGSGLSPIVPGTMGSLAAIPFWYLMTFLPWQLY
CCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SLVVMLGICIGVYLCHQTAKDMGVHDHGSIVWDEFIGMWITLMALPTNDWQWVAAGFVIF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
RILDMWKPWPIRWFDRNVHGGMGIMIDDIVAGVISAGILYFIGHHWPLGILS
HHHHHCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2846510; 9278503