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The map label for this gene is fadE [H]

Identifier: 157159704

GI number: 157159704

Start: 270417

End: 272861

Strand: Reverse

Name: fadE [H]

Synonym: EcHS_A0249

Alternate gene names: 157159704

Gene position: 272861-270417 (Counterclockwise)

Preceding gene: 157159707

Following gene: 157159702

Centisome position: 5.88

GC content: 56.85

Gene sequence:

>2445_bases
ATGATGATTTTGAGTATTCTCGCTACGGTTGTCCTGCTCGGCGCGTTGTTCTATCACCGCGTGAGCTTATTTATCAGCAG
TCTGATTTTGCTCGCCTGGACAGCCGCCCTCGGCGTTGCTGGTCTGTGGTCGGCGTGGGTACTGGTGCCTCTGGCCATTA
TCCTCGTGCCATTTAACTTTGCGCCTATGCGTAAGTCGATGATTTCCGCGCCGGTATTTCGCGGTTTCCGTAAGGTGATG
CCGCCGATGTCGCGCACTGAGAAAGAAGCGATTGATGCGGGCACCACCTGGTGGGAGGGCGACTTGTTCCAGGGCAAGCC
GGACTGGAAAAAGCTGCATAACTATCCGCAGCCGCGCCTGACCGCCGAAGAGCAAGCGTTTCTCGACGGCCCGGTAGAAG
AAGCCTGCCGGATGGCGAATGATTTCCAGATCACCCATGAGCTGGCGGATCTGCCGCCGGAGTTGTGGGCGTACCTTAAA
GAGCATCGTTTCTTCGCGATGATCATCAAAAAAGAGTACGGCGGGCTGGAGTTCTCGGCTTATGCCCAGTCTCGCGTGCT
GCAAAAACTCTCCGGCGTGAGCGGGATCCTGGCGATTACCGTCGGCGTGCCAAACTCATTAGGCCCGGGCGAACTGTTGC
AACATTACGGCACTGACGAGCAGAAAGATCACTATCTGCCGCGTCTGGCGCGTGGTCAGGAGATCCCCTGCTTTGCACTG
ACCAGCCCGGAAGCGGGTTCCGATGCGGGCGCGATTCCGGACACCGGGATTGTCTGCATGGGCGAATGGCAGGGCCAGCA
GGTGCTGGGGATGCGTCTGACCTGGAACAAACGCTACATTACGCTGGCACCGATTGCGACTGTGCTTGGGCTGGCGTTTA
AACTCTCCGACCCGGAAAAGCTGCTGGGTGGCGCAGAAGATTTAGGTATTACCTGTGCGCTGATCCCGACCACCACGCCG
GGCGTGGAAATTGGTCGTCGCCACTTCCCGCTGAACGTACCGTTCCAGAACGGACCGACGCGCGGTAAAGATGTCTTCGT
ACCGATCGATTACATCATCGGTGGGCCGAAAATGGCCGGGCAAGGCTGGCGGATGCTGGTGGAGTGCCTCTCGGTAGGCC
GCGGCATCACCCTGCCTTCCAACTCAACCGGCGGCGTGAAATCGGTAGCGCTGGCAACGGGCGCGTATGCTCACATTCGC
CGTCAGTTCAAAATCTCTATCGGTAAGATGGAAGGGATTGAAGAGCCGCTGGCGCGTATTGCCGGTAATGCCTACGTGAT
GGATGCTGCGGCATCGCTGATTACCTACGGCATTATGCTCGGCGAAAAACCTGCCGTGCTGTCGGCTATCGTTAAGTATC
ACTGTACCCACCGCGGGCAGCAGTCGATTATTGATGCGATGGATATCACTGGTGGCAAAGGCATTATGCTCGGGCAGAGC
AACTTCCTGGCGCGTGCTTACCAGGGCGCACCGATTGCCATCACCGTTGAAGGGGCCAACATTCTGACCCGCAGCATGAT
GATCTTCGGACAAGGAGCGATTCGTTGCCATCCGTACGTGCTGGAAGAGATGGAAGCAGCGAAGAACAATGACGTCAACG
CGTTCGATAAACTGTTGTTCAAACATATCGGTCACGTCGGTAGCAACAAAGTTCGCAGCTTCTGGCTGGGCCTGACGCGC
GGTTTAACCAGCAGCACGCCAACCGGCGATGCCACTAAACGCTACTATCAGCACCTGAACCGCCTGAGCGCCAACCTCGC
CCTGCTTTCTGATGTCTCGATGGCTGTGCTGGGCGGCAGCCTGAAACGTCGTGAGCGCATCTCGGCACGTCTGGGGGATA
TTTTAAGCCAGCTTTACCTCGCCTCTGCCGTTCTGAAGCGTTATGACGACGAAGGCCGTAATGAAGCCGACCTGCCGCTG
GTGCACTGGGGCGTACAAGATGCGCTGTATCAGGCTGAACAGGCGATGGATGATTTACTGCAAAACTTCCCGAACCGCGT
GGTTGCCGGGCTGCTGAATGTGGTGATCTTCCCGACCGGACGTCATTATCTGGCACCTTCTGACAAGCTGGATCATAAAG
TGGCGAAGATTTTACAAGTGCCGAACGCCACCCGTTCCCGCATTGGTCGCGGTCAGTACCTGACGCCGAGCGAGCATAAT
CCGGTTGGCTTGCTGGAAGAGGCGCTGGTGGATGTGATTGCCGCCGACCCAATTCATCAGCGGATCTGTAAAGAGCTGGG
TAAAAACCTGCCGTTTACCCGTCTGGATGAACTGGCGCACAACGCGCTGGCGAAGGGGCTGATTGATAAAGATGAAGCCG
CTATTCTGGTGAAAGCTGAAGAAAGCCGTCTGCGCAGTATTAACGTTGATGACTTTGATCCGGAAGAGCTGGCGACGAAG
CCGGTAAAGTTGCCGGAGAAAGTGCGGAAAGTTGAAGCCGCGTAA

Upstream 100 bases:

>100_bases
TTGTAATTATATTGTAAACACATTGCTAAATGTTTTTACATCCACTACAACCATATCATCACAAGTGGTCAGACCTCCTA
CAAGTAAGGGGCTTTTCGTT

Downstream 100 bases:

>100_bases
TTGAATAACGGAGCCGAAAGGCTCCGTTTCTTTATCCGCTAATTATTTAAAATTAAAGCCATCCGGATGGTTTTCCAGGC
TGCCGGTCAACGCCGCGAAC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 814; Mature: 814

Protein sequence:

>814_residues
MMILSILATVVLLGALFYHRVSLFISSLILLAWTAALGVAGLWSAWVLVPLAIILVPFNFAPMRKSMISAPVFRGFRKVM
PPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPRLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLEFSAYAQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKDHYLPRLARGQEIPCFAL
TSPEAGSDAGAIPDTGIVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEKLLGGAEDLGITCALIPTTTP
GVEIGRRHFPLNVPFQNGPTRGKDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIR
RQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGQS
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMEAAKNNDVNAFDKLLFKHIGHVGSNKVRSFWLGLTR
GLTSSTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISARLGDILSQLYLASAVLKRYDDEGRNEADLPL
VHWGVQDALYQAEQAMDDLLQNFPNRVVAGLLNVVIFPTGRHYLAPSDKLDHKVAKILQVPNATRSRIGRGQYLTPSEHN
PVGLLEEALVDVIAADPIHQRICKELGKNLPFTRLDELAHNALAKGLIDKDEAAILVKAEESRLRSINVDDFDPEELATK
PVKLPEKVRKVEAA

Sequences:

>Translated_814_residues
MMILSILATVVLLGALFYHRVSLFISSLILLAWTAALGVAGLWSAWVLVPLAIILVPFNFAPMRKSMISAPVFRGFRKVM
PPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPRLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLEFSAYAQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKDHYLPRLARGQEIPCFAL
TSPEAGSDAGAIPDTGIVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEKLLGGAEDLGITCALIPTTTP
GVEIGRRHFPLNVPFQNGPTRGKDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIR
RQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGQS
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMEAAKNNDVNAFDKLLFKHIGHVGSNKVRSFWLGLTR
GLTSSTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISARLGDILSQLYLASAVLKRYDDEGRNEADLPL
VHWGVQDALYQAEQAMDDLLQNFPNRVVAGLLNVVIFPTGRHYLAPSDKLDHKVAKILQVPNATRSRIGRGQYLTPSEHN
PVGLLEEALVDVIAADPIHQRICKELGKNLPFTRLDELAHNALAKGLIDKDEAAILVKAEESRLRSINVDDFDPEELATK
PVKLPEKVRKVEAA
>Mature_814_residues
MMILSILATVVLLGALFYHRVSLFISSLILLAWTAALGVAGLWSAWVLVPLAIILVPFNFAPMRKSMISAPVFRGFRKVM
PPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPRLTAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLK
EHRFFAMIIKKEYGGLEFSAYAQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKDHYLPRLARGQEIPCFAL
TSPEAGSDAGAIPDTGIVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEKLLGGAEDLGITCALIPTTTP
GVEIGRRHFPLNVPFQNGPTRGKDVFVPIDYIIGGPKMAGQGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIR
RQFKISIGKMEGIEEPLARIAGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGQS
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMEAAKNNDVNAFDKLLFKHIGHVGSNKVRSFWLGLTR
GLTSSTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGSLKRRERISARLGDILSQLYLASAVLKRYDDEGRNEADLPL
VHWGVQDALYQAEQAMDDLLQNFPNRVVAGLLNVVIFPTGRHYLAPSDKLDHKVAKILQVPNATRSRIGRGQYLTPSEHN
PVGLLEEALVDVIAADPIHQRICKELGKNLPFTRLDELAHNALAKGLIDKDEAAILVKAEESRLRSINVDDFDPEELATK
PVKLPEKVRKVEAA

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=542, Percent_Identity=26.5682656826568, Blast_Score=121, Evalue=3e-27,
Organism=Homo sapiens, GI4557235, Length=405, Percent_Identity=25.1851851851852, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI4557233, Length=419, Percent_Identity=26.9689737470167, Blast_Score=87, Evalue=7e-17,
Organism=Homo sapiens, GI76496475, Length=384, Percent_Identity=25.5208333333333, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI4501859, Length=337, Percent_Identity=25.8160237388724, Blast_Score=72, Evalue=3e-12,
Organism=Homo sapiens, GI226958412, Length=344, Percent_Identity=24.1279069767442, Blast_Score=69, Evalue=3e-11,
Organism=Homo sapiens, GI226958414, Length=329, Percent_Identity=24.3161094224924, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI87081702, Length=814, Percent_Identity=99.8771498771499, Blast_Score=1671, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=410, Percent_Identity=24.6341463414634, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71985192, Length=356, Percent_Identity=23.876404494382, Blast_Score=83, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=332, Percent_Identity=25.3012048192771, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=283, Percent_Identity=25.7950530035336, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=277, Percent_Identity=27.4368231046931, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32563615, Length=236, Percent_Identity=27.1186440677966, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281363737, Length=452, Percent_Identity=27.212389380531, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646207, Length=280, Percent_Identity=26.7857142857143, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356377, Length=303, Percent_Identity=26.4026402640264, Blast_Score=73, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666513, Length=328, Percent_Identity=26.219512195122, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355753, Length=348, Percent_Identity=22.4137931034483, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 89198; Mature: 89198

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMILSILATVVLLGALFYHRVSLFISSLILLAWTAALGVAGLWSAWVLVPLAIILVPFNF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APMRKSMISAPVFRGFRKVMPPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPRL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCCCCCCCCHHHHCCCCCCCC
TAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLEFSA
CCHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHCCCCCHHH
YAQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKDHYLPRLARGQEIPCFAL
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCHHCCHHHHCCCCCCEEEE
TSPEAGSDAGAIPDTGIVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEK
CCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHCCCCHHH
LLGGAEDLGITCALIPTTTPGVEIGRRHFPLNVPFQNGPTRGKDVFVPIDYIIGGPKMAG
HHCCCCCCCEEEEEECCCCCCHHHCCCCCCEECCCCCCCCCCCEEEEEHHHEECCCCCCC
QGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIRRQFKISIGKMEGIEEPLARI
HHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHH
AGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGQS
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCC
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMEAAKNNDVNAFDKLLF
HHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCEECHHHHHHHHHHCCCCCHHHHHHHH
KHIGHVGSNKVRSFWLGLTRGLTSSTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGS
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LKRRERISARLGDILSQLYLASAVLKRYDDEGRNEADLPLVHWGVQDALYQAEQAMDDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHH
QNFPNRVVAGLLNVVIFPTGRHYLAPSDKLDHKVAKILQVPNATRSRIGRGQYLTPSEHN
HHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
PVGLLEEALVDVIAADPIHQRICKELGKNLPFTRLDELAHNALAKGLIDKDEAAILVKAE
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
ESRLRSINVDDFDPEELATKPVKLPEKVRKVEAA
HHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MMILSILATVVLLGALFYHRVSLFISSLILLAWTAALGVAGLWSAWVLVPLAIILVPFNF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
APMRKSMISAPVFRGFRKVMPPMSRTEKEAIDAGTTWWEGDLFQGKPDWKKLHNYPQPRL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCEECCCCCCCCCCHHHHCCCCCCCC
TAEEQAFLDGPVEEACRMANDFQITHELADLPPELWAYLKEHRFFAMIIKKEYGGLEFSA
CCHHHHHCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHCCCCCHHH
YAQSRVLQKLSGVSGILAITVGVPNSLGPGELLQHYGTDEQKDHYLPRLARGQEIPCFAL
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCHHCCHHHHCCCCCCEEEE
TSPEAGSDAGAIPDTGIVCMGEWQGQQVLGMRLTWNKRYITLAPIATVLGLAFKLSDPEK
CCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCEEEHHHHHHHHHHHHCCCCHHH
LLGGAEDLGITCALIPTTTPGVEIGRRHFPLNVPFQNGPTRGKDVFVPIDYIIGGPKMAG
HHCCCCCCCEEEEEECCCCCCHHHCCCCCCEECCCCCCCCCCCEEEEEHHHEECCCCCCC
QGWRMLVECLSVGRGITLPSNSTGGVKSVALATGAYAHIRRQFKISIGKMEGIEEPLARI
HHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHH
AGNAYVMDAAASLITYGIMLGEKPAVLSAIVKYHCTHRGQQSIIDAMDITGGKGIMLGQS
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEECCC
NFLARAYQGAPIAITVEGANILTRSMMIFGQGAIRCHPYVLEEMEAAKNNDVNAFDKLLF
HHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCCEECHHHHHHHHHHCCCCCHHHHHHHH
KHIGHVGSNKVRSFWLGLTRGLTSSTPTGDATKRYYQHLNRLSANLALLSDVSMAVLGGS
HHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LKRRERISARLGDILSQLYLASAVLKRYDDEGRNEADLPLVHWGVQDALYQAEQAMDDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHH
QNFPNRVVAGLLNVVIFPTGRHYLAPSDKLDHKVAKILQVPNATRSRIGRGQYLTPSEHN
HHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCC
PVGLLEEALVDVIAADPIHQRICKELGKNLPFTRLDELAHNALAKGLIDKDEAAILVKAE
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEC
ESRLRSINVDDFDPEELATKPVKLPEKVRKVEAA
HHHHHCCCCCCCCHHHHCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]