Click here to switch to the map view.

The map label for this gene is ilvY

Identifier: 157158220

GI number: 157158220

Start: 4278772

End: 4279662

Strand: Reverse

Name: ilvY

Synonym: EcE24377A_4283

Alternate gene names: 157158220

Gene position: 4279662-4278772 (Counterclockwise)

Preceding gene: 157159000

Following gene: 157156172

Centisome position: 85.94

GC content: 57.13

Gene sequence:

>891_bases
TTGGATTTACGCGATCTGAAAACCTTCCTGCATCTGGCGGAAAGCCGCCATTTTGGCCGCAGCGCGCGGGCGATGCATGT
TAGCCCATCCACGCTCTCACGGCAGATTCAGCGCCTGGAAGAAGATCTCGGTCAGCCGCTGTTTGTGCGCGATAACCGCA
CGGTAACGCTGACTGAAGCGGGCGAAGAGCTGCGCGTTTTCGCCCAGCAAACGCTGTTGCAGTATCAGCAGCTGCGCCAC
ACCATCGATCAGCAAGGGCCGTCGCTCTCTGGCGAGTTACATATTTTCTGCTCGGTGACCGCCGCTTACAGCCATCTACC
GCCGATTCTCGACCGCTTCCGCGCGGAACACCCGTCGGTGGAGATTAAACTTACTACTGGTGATGCGGCAGATGCGATGG
AAAAGGTGGTCACTGGTGAAGCGGATCTGGCGATTGCCGGGAAACCGGAGACGCTACCCGGCGCGGTGGCGTTTTCGATG
CTGGAGAATCTGGCAGTGGTGTTGATTGCACCCGCATTGCCCTGCCCGGTGCGTAATCAGGTTTCTGTCGAAAAGCCGGA
CTGGTCTACAGTGCCGTTTATCATGGCCGATCAGGGACCGGTACGCCGCCGCATTGAACTGTGGTTTCGACGCAATAAAA
TCAGCAACCCGATGATTTACGCCACGGTTGGCGGGCATGAAGCGATGGTATCGATGGTGGCGCTCGGCTGTGGCGTGGCA
TTGTTGCCGGAAGTGGTGCTGGAAAACAGCCCAGAACCGGTGCGTAACCGCGTGATGATTTTAGAGCGCAGCGATGAGAA
AACGCCGTTTGAGCTGGGGGTGTGTGCGCAAAAAAAGCGGCTACATGAGCCGCTGATTGAGGCATTCTGGAAGATTTTGC
CGAACCATTAA

Upstream 100 bases:

>100_bases
AGATTGAATTCACTATATGACAGGAAATTTATTGCGGAAATTGATATATTCACAACGTCACATTGCAATTTCTGCAACGT
CAACATTGAGGGCTGCGCCA

Downstream 100 bases:

>100_bases
CCCGCCAAAAAGAACCTGAACGCCGGGTTATTGGTTTCGTCGTGGCAATCGTAGCCCAGCTCATTTAGCCGGGTTTCGAA
ATCCGGTTCATGGTCGCCAA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH

Sequences:

>Translated_296_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH
>Mature_296_residues
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRH
TIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSM
LENLAVVLIAPALPCPVRNQVSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1790208, Length=296, Percent_Identity=100, Blast_Score=609, Evalue=1e-176,
Organism=Escherichia coli, GI1790399, Length=261, Percent_Identity=29.8850574712644, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=29.6747967479675, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI157672245, Length=182, Percent_Identity=32.4175824175824, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788887, Length=253, Percent_Identity=28.8537549407115, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=24.609375, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI145693105, Length=294, Percent_Identity=24.8299319727891, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=26.8292682926829, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=26.9076305220884, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=28.2758620689655, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=24.8995983935743, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790262, Length=299, Percent_Identity=25.0836120401338, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788296, Length=247, Percent_Identity=28.3400809716599, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788748, Length=303, Percent_Identity=25.0825082508251, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787530, Length=270, Percent_Identity=22.2222222222222, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI48994962, Length=82, Percent_Identity=39.0243902439024, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788706, Length=143, Percent_Identity=31.4685314685315, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789440, Length=168, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787589, Length=194, Percent_Identity=29.3814432989691, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=34.1463414634146, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVY_ECOLI (P05827)

Other databases:

- EMBL:   M11689
- EMBL:   M87049
- EMBL:   U00096
- EMBL:   AP009048
- EMBL:   M32253
- PIR:   B26287
- RefSeq:   AP_004023.1
- RefSeq:   NP_418221.1
- ProteinModelPortal:   P05827
- SMR:   P05827
- DIP:   DIP-10028N
- STRING:   P05827
- EnsemblBacteria:   EBESCT00000001898
- EnsemblBacteria:   EBESCT00000016615
- GeneID:   948284
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW3746
- KEGG:   eco:b3773
- EchoBASE:   EB0498
- EcoGene:   EG10503
- eggNOG:   COG0583
- GeneTree:   EBGT00070000031692
- HOGENOM:   HBG297011
- OMA:   VCVQKKR
- ProtClustDB:   PRK11716
- BioCyc:   EcoCyc:PD00200
- Genevestigator:   P05827
- GO:   GO:0005737
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00039

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 33077; Mature: 33077

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEECCCEEEEECC
GEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHCCCCCE
EIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQ
EEEEECCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCC
VSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCHH
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEEDLGQPLFVRDNRTVTLTEA
CCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHCCCCEEEECCCEEEEECC
GEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSV
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHCCHHHHHHHHCCCCCE
EIKLTTGDAADAMEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQ
EEEEECCCHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCC
VSVEKPDWSTVPFIMADQGPVRRRIELWFRRNKISNPMIYATVGGHEAMVSMVALGCGVA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCHH
LLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCAQKKRLHEPLIEAFWKILPNH
HHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695